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The map label for this gene is atzB [H]

Identifier: 187929338

GI number: 187929338

Start: 2376070

End: 2377488

Strand: Direct

Name: atzB [H]

Synonym: Rpic_2259

Alternate gene names: 187929338

Gene position: 2376070-2377488 (Clockwise)

Preceding gene: 187929337

Following gene: 187929339

Centisome position: 60.27

GC content: 67.44

Gene sequence:

>1419_bases
ATGAACGCCACTGTCGCGCACAACGACCCGCTTCTGATCGCCCGTCATGCGGACGTGCTGGTCACCATGGATGCGCAACG
CCGCGAGATCGCCGACGGCGCCCTGGTTGCGCGCGGTGGCGTAGTCGAATGGGTTGGCGCCTCGGCCGATCTGCCGTCGC
AGTACCGCGAGGCCATCGGGCAACCCAACGTACGTGTGATGGAACTGCGCGACCACGTGGTCACGCCGGGCTTCGTCAAC
ACGCACCATCACATGTATCAGAGCCTGACGCGTGCCCTGCCCGCCGCGCAGGACGCCGAACTGTTCGGCTGGCTGACCAA
CCTGTATCCGGTGTGGGCCGGCCTCACGCCCGAGATGGTGCGCGTGTCTACGCTCACGGCGATGGCGGAACTCCTGCTCT
CGGGTTGCACGACCTCCAGTGATCATCTGTACCTCTATCCGAACGGCAGCCGGCTCGACGATTCCATCGAAGCCGCACAG
CAGATCGGCATGCGCTTTCACGCGGCGCGCGGCAGCATGAGCGTCGGCCGCAGCCAGGGCGGTTTGCCGCCGGACCGCGT
GGTCGAAGGCGAAGAAGCCATCCTGAAGGAAACGCAGCGCCTGATCGAAACGTGGCACAACGCCGATCGCCATTCGATGC
TGCGCGTGGTGGTGGCGCCGTGCTCGCCCTTCTCCGTCTCGCGTGACCTGATGCGCGAATCGGCCAAGCTCGCGCGCAGC
TACGGTGTGTCGATGCACACCCACCTGGCCGAGAACGATAACGACATCGCTTACTCGCGCGAGAAGTTCGGCATGACGCC
GGCCGAGTACGCAGAAGACCTCGGCTGGGTCGGCCGCGATGTCTGGCATGCGCACTGCGTGAAGCTCGACGCGCACGGCA
TCGACGTGTTTGCACGCACCGGCACTGGCGTCGCGCATTGCCCGTGCTCGAACATGCGCCTGGCTTCCGGCATCGCCCCG
ATCCGCACCATGCGCGATGCCGGCGTGCCAGTCGGCCTTGGCGTGGATGGCAGCGCGTCGAACGATGGGGCGCACATGCT
CGGCGAAACGCGGCAGGCCATGCTGCTCGCACGCGTCGGCTTTGGTCCCGCGGCGATGAGCGCGCGCGAGGCGCTGGAGA
TCGCCACGCTCGGCGGCGCGCGCGTGCTCAACCGCGACGACATCGGCGCGCTTGCACCCGGCATGTCGGCCGACTTTGTC
AGCTTCGATCGTCACCAGGTCGGTTTTGCCGGCGCCGACCACGACCCGGTCGCGGCGCTGGTGTTCTGCGCCCCGTCCAA
CGTGGCGCACAGCGTGATCAATGGGCGCGTAGTCGTCGAAGACGGCCGCCTGACCACGCTGGAACTCGACGCCCATCTCA
CGGTTCACCGGAGGCTCGCGCTGGAACTCGCGCAGGCTGCCCGGGCAGTCCCGGCCTGA

Upstream 100 bases:

>100_bases
CTGGTCGCGGTCATCCTTAACCTGTACTACAACGGCATGCAGTCGGCCGAGCACGCCATGCGCGACGCTGCCGCCAACAC
CCACGGCACGGAGTAATTGC

Downstream 100 bases:

>100_bases
CGCGATGGCGCCTTGCCTCGTTCATGACGCCGCTGTGATGTCGTGAATTTGGAAAGCCGCATTCCACTGTCTGACCGGTG
TTGTATGAAGTCTCCTCGAC

Product: hydroxydechloroatrazine ethylaminohydrolase

Products: NA

Alternate protein names: Hydroxyatrazine hydrolase [H]

Number of amino acids: Translated: 472; Mature: 472

Protein sequence:

>472_residues
MNATVAHNDPLLIARHADVLVTMDAQRREIADGALVARGGVVEWVGASADLPSQYREAIGQPNVRVMELRDHVVTPGFVN
THHHMYQSLTRALPAAQDAELFGWLTNLYPVWAGLTPEMVRVSTLTAMAELLLSGCTTSSDHLYLYPNGSRLDDSIEAAQ
QIGMRFHAARGSMSVGRSQGGLPPDRVVEGEEAILKETQRLIETWHNADRHSMLRVVVAPCSPFSVSRDLMRESAKLARS
YGVSMHTHLAENDNDIAYSREKFGMTPAEYAEDLGWVGRDVWHAHCVKLDAHGIDVFARTGTGVAHCPCSNMRLASGIAP
IRTMRDAGVPVGLGVDGSASNDGAHMLGETRQAMLLARVGFGPAAMSAREALEIATLGGARVLNRDDIGALAPGMSADFV
SFDRHQVGFAGADHDPVAALVFCAPSNVAHSVINGRVVVEDGRLTTLELDAHLTVHRRLALELAQAARAVPA

Sequences:

>Translated_472_residues
MNATVAHNDPLLIARHADVLVTMDAQRREIADGALVARGGVVEWVGASADLPSQYREAIGQPNVRVMELRDHVVTPGFVN
THHHMYQSLTRALPAAQDAELFGWLTNLYPVWAGLTPEMVRVSTLTAMAELLLSGCTTSSDHLYLYPNGSRLDDSIEAAQ
QIGMRFHAARGSMSVGRSQGGLPPDRVVEGEEAILKETQRLIETWHNADRHSMLRVVVAPCSPFSVSRDLMRESAKLARS
YGVSMHTHLAENDNDIAYSREKFGMTPAEYAEDLGWVGRDVWHAHCVKLDAHGIDVFARTGTGVAHCPCSNMRLASGIAP
IRTMRDAGVPVGLGVDGSASNDGAHMLGETRQAMLLARVGFGPAAMSAREALEIATLGGARVLNRDDIGALAPGMSADFV
SFDRHQVGFAGADHDPVAALVFCAPSNVAHSVINGRVVVEDGRLTTLELDAHLTVHRRLALELAQAARAVPA
>Mature_472_residues
MNATVAHNDPLLIARHADVLVTMDAQRREIADGALVARGGVVEWVGASADLPSQYREAIGQPNVRVMELRDHVVTPGFVN
THHHMYQSLTRALPAAQDAELFGWLTNLYPVWAGLTPEMVRVSTLTAMAELLLSGCTTSSDHLYLYPNGSRLDDSIEAAQ
QIGMRFHAARGSMSVGRSQGGLPPDRVVEGEEAILKETQRLIETWHNADRHSMLRVVVAPCSPFSVSRDLMRESAKLARS
YGVSMHTHLAENDNDIAYSREKFGMTPAEYAEDLGWVGRDVWHAHCVKLDAHGIDVFARTGTGVAHCPCSNMRLASGIAP
IRTMRDAGVPVGLGVDGSASNDGAHMLGETRQAMLLARVGFGPAAMSAREALEIATLGGARVLNRDDIGALAPGMSADFV
SFDRHQVGFAGADHDPVAALVFCAPSNVAHSVINGRVVVEDGRLTTLELDAHLTVHRRLALELAQAARAVPA

Specific function: Catalyzes the deamination reaction of hydroxyatrazine to N-isopropylammelide (dihydroxy-isopropyl-atrazine). The enzyme is also capable of catalyzing some dechlorinating reactions [H]

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATZ/TRZ family [H]

Homologues:

Organism=Homo sapiens, GI4758426, Length=380, Percent_Identity=24.2105263157895, Blast_Score=88, Evalue=2e-17,
Organism=Escherichia coli, GI1789249, Length=429, Percent_Identity=29.1375291375291, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI87082177, Length=403, Percent_Identity=24.0694789081886, Blast_Score=71, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6319963, Length=334, Percent_Identity=27.2455089820359, Blast_Score=108, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24643849, Length=346, Percent_Identity=25.7225433526012, Blast_Score=87, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.99.3 [H]

Molecular weight: Translated: 50795; Mature: 50795

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNATVAHNDPLLIARHADVLVTMDAQRREIADGALVARGGVVEWVGASADLPSQYREAIG
CCCCCCCCCCEEEEECCCEEEEECCHHHHHCCCCEEECCCEEEEECCCCCCCHHHHHHHC
QPNVRVMELRDHVVTPGFVNTHHHMYQSLTRALPAAQDAELFGWLTNLYPVWAGLTPEMV
CCCEEEEEEHHHCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHH
RVSTLTAMAELLLSGCTTSSDHLYLYPNGSRLDDSIEAAQQIGMRFHAARGSMSVGRSQG
HHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCC
GLPPDRVVEGEEAILKETQRLIETWHNADRHSMLRVVVAPCSPFSVSRDLMRESAKLARS
CCCHHHHCCCHHHHHHHHHHHHHHHHCCCHHHEEEEEEECCCCHHHHHHHHHHHHHHHHH
YGVSMHTHLAENDNDIAYSREKFGMTPAEYAEDLGWVGRDVWHAHCVKLDAHGIDVFART
HCCEEEEEECCCCCCCEECHHHHCCCHHHHHHHHHHHHHHHHHHHEEEEECCCCEEEEEC
GTGVAHCPCSNMRLASGIAPIRTMRDAGVPVGLGVDGSASNDGAHMLGETRQAMLLARVG
CCCEEECCCCCCCHHCCCCHHHHHHHCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHCC
FGPAAMSAREALEIATLGGARVLNRDDIGALAPGMSADFVSFDRHQVGFAGADHDPVAAL
CCHHHHHHHHHHHHEECCCCEEECCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCEEEE
VFCAPSNVAHSVINGRVVVEDGRLTTLELDAHLTVHRRLALELAQAARAVPA
EEECCCHHHHHHHCCEEEEECCCEEEEEECCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNATVAHNDPLLIARHADVLVTMDAQRREIADGALVARGGVVEWVGASADLPSQYREAIG
CCCCCCCCCCEEEEECCCEEEEECCHHHHHCCCCEEECCCEEEEECCCCCCCHHHHHHHC
QPNVRVMELRDHVVTPGFVNTHHHMYQSLTRALPAAQDAELFGWLTNLYPVWAGLTPEMV
CCCEEEEEEHHHCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHH
RVSTLTAMAELLLSGCTTSSDHLYLYPNGSRLDDSIEAAQQIGMRFHAARGSMSVGRSQG
HHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCC
GLPPDRVVEGEEAILKETQRLIETWHNADRHSMLRVVVAPCSPFSVSRDLMRESAKLARS
CCCHHHHCCCHHHHHHHHHHHHHHHHCCCHHHEEEEEEECCCCHHHHHHHHHHHHHHHHH
YGVSMHTHLAENDNDIAYSREKFGMTPAEYAEDLGWVGRDVWHAHCVKLDAHGIDVFART
HCCEEEEEECCCCCCCEECHHHHCCCHHHHHHHHHHHHHHHHHHHEEEEECCCCEEEEEC
GTGVAHCPCSNMRLASGIAPIRTMRDAGVPVGLGVDGSASNDGAHMLGETRQAMLLARVG
CCCEEECCCCCCCHHCCCCHHHHHHHCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHCC
FGPAAMSAREALEIATLGGARVLNRDDIGALAPGMSADFVSFDRHQVGFAGADHDPVAAL
CCHHHHHHHHHHHHEECCCCEEECCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCEEEE
VFCAPSNVAHSVINGRVVVEDGRLTTLELDAHLTVHRRLALELAQAARAVPA
EEECCCHHHHHHHCCEEEEECCCEEEEEECCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9055410 [H]