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The map label for this gene is phoR [H]

Identifier: 187929099

GI number: 187929099

Start: 2126504

End: 2127832

Strand: Reverse

Name: phoR [H]

Synonym: Rpic_2020

Alternate gene names: 187929099

Gene position: 2127832-2126504 (Counterclockwise)

Preceding gene: 187929100

Following gene: 187929097

Centisome position: 53.97

GC content: 63.88

Gene sequence:

>1329_bases
ATGAACGTCTTCTGGACCCGCTTTGCCGTCTTTGCCGCCCTCATGGGCATCGTCACGGCATGCCTGTATATCTTCGTCGA
CCACGTCGCTGCGCTGGCGGTGCTCAGCGCCATGCTGTTAGCGATGCTCCTGTATTACATCTACCAGATCCAGCGCCTGT
GGCGCGTGCTGGACTCGCCGGCCTATGGCGAGATCCCCAGCGCGCTCGGCCTGTGGGGCGAGGTCTACTACCGCCTGCAC
CGTTTGATGAAGGGCTGGCGCACCCAGGTGCTGCAAGTCGAACAACAGCACAGCCGCTTCATCCAGGCCATTCAGGCATC
GCCCAACGGCGTGCTGATGCTTGACGGTGAAGACCAGATCGAATGGTGCAACGCGGTAGCCGAAGAGCACTTCGGGCTCT
CTGCCAAGCGTGATCTGCGCCAACGCATTACCCACCTGATCCGCCGACCGGAGTTCGTGCGCTACCTGGCGCGCGGCGAG
TTCGAGGAGCCGCTCACCATGCATGACGTGGGCCCGCACAAGCAAAGCATCATCTCCGCCCAGATCTTGCCGTATGGCGA
AGACCGCAAGCTGCTGGTGTCTCAGGACATCACCAAGCTGGAGAACACCGAAGCGATGCGCCGCGATTTCGTGGCCAACG
TCTCGCACGAGCTGAAGACACCGCTGACCGTGCTCTCGGGCTTTCTCGAGACGGTGCGCGATATCCCGCTGCCGGAAGAA
GACAAGCGGCGCTACCTGGACATGATGCACACGCAGGCCATGCGCATGCAGCATCTGGTGGAAGACTTGCTGGCGCTCGC
CACGCTCGAAGGCAATCCCGAGCCGCCGTCTCTGGCGCCGGTGCCGATGCAGCGCATGATGCTGCAGCTCCAGCACGATA
TCGAAGCGCTGTCGGCGGGCCGGCACACCGTCAGCATGACATGCGATCCGGCCGTGAGCGTGTGCGGCGCCGAGCTTGAA
TTGCTTTCCGCGTTCAGCAACCTGGCATCCAACGCGGTGCGCTATACGCCGGATGGCGGCACGATCCGTCTCGATTGGGG
CGTGCGCGACGGGCACGCGGTGTACTCCGTCACCGACACGGGGATTGGCATTGCACCCGAGCATATCCCGCGGCTGACCG
AGCGTTTCTATCGCGTGGACCGCAGCCGTTCACGCGACACCGGGGGTACCGGCCTAGGCTTGGCTATCGTCAAGCACGTG
CTGTCGCGCCACGGTGGAGAGTTGCAGGTGACCAGCGAGCACGGCAAGGGCAGCACCTTCCGCGCCGTCTTCCCGCCAGA
GCGCACGATCGTGCGCAGCGCCTCCGTTGCTGATGAGCGCGTCGCCTGA

Upstream 100 bases:

>100_bases
CAGTAACGCAATAACGCATCCGTCAGGCGAACGCGCGAGCCGGTTCTTTTTCCATCGCGCGTTCACACGCCCGTCGCGGT
CCAGCGCATAAAATGCTTTC

Downstream 100 bases:

>100_bases
TCGCCCGTACTTTCGATCCATTGATCCGATGAAAAACGCACGCTGGTGAGCGTGCGTTTTTGTTTGCCGGCAGGCCGGTG
GATCAGCCTGCGGAGATCTC

Product: multi-sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 442; Mature: 442

Protein sequence:

>442_residues
MNVFWTRFAVFAALMGIVTACLYIFVDHVAALAVLSAMLLAMLLYYIYQIQRLWRVLDSPAYGEIPSALGLWGEVYYRLH
RLMKGWRTQVLQVEQQHSRFIQAIQASPNGVLMLDGEDQIEWCNAVAEEHFGLSAKRDLRQRITHLIRRPEFVRYLARGE
FEEPLTMHDVGPHKQSIISAQILPYGEDRKLLVSQDITKLENTEAMRRDFVANVSHELKTPLTVLSGFLETVRDIPLPEE
DKRRYLDMMHTQAMRMQHLVEDLLALATLEGNPEPPSLAPVPMQRMMLQLQHDIEALSAGRHTVSMTCDPAVSVCGAELE
LLSAFSNLASNAVRYTPDGGTIRLDWGVRDGHAVYSVTDTGIGIAPEHIPRLTERFYRVDRSRSRDTGGTGLGLAIVKHV
LSRHGGELQVTSEHGKGSTFRAVFPPERTIVRSASVADERVA

Sequences:

>Translated_442_residues
MNVFWTRFAVFAALMGIVTACLYIFVDHVAALAVLSAMLLAMLLYYIYQIQRLWRVLDSPAYGEIPSALGLWGEVYYRLH
RLMKGWRTQVLQVEQQHSRFIQAIQASPNGVLMLDGEDQIEWCNAVAEEHFGLSAKRDLRQRITHLIRRPEFVRYLARGE
FEEPLTMHDVGPHKQSIISAQILPYGEDRKLLVSQDITKLENTEAMRRDFVANVSHELKTPLTVLSGFLETVRDIPLPEE
DKRRYLDMMHTQAMRMQHLVEDLLALATLEGNPEPPSLAPVPMQRMMLQLQHDIEALSAGRHTVSMTCDPAVSVCGAELE
LLSAFSNLASNAVRYTPDGGTIRLDWGVRDGHAVYSVTDTGIGIAPEHIPRLTERFYRVDRSRSRDTGGTGLGLAIVKHV
LSRHGGELQVTSEHGKGSTFRAVFPPERTIVRSASVADERVA
>Mature_442_residues
MNVFWTRFAVFAALMGIVTACLYIFVDHVAALAVLSAMLLAMLLYYIYQIQRLWRVLDSPAYGEIPSALGLWGEVYYRLH
RLMKGWRTQVLQVEQQHSRFIQAIQASPNGVLMLDGEDQIEWCNAVAEEHFGLSAKRDLRQRITHLIRRPEFVRYLARGE
FEEPLTMHDVGPHKQSIISAQILPYGEDRKLLVSQDITKLENTEAMRRDFVANVSHELKTPLTVLSGFLETVRDIPLPEE
DKRRYLDMMHTQAMRMQHLVEDLLALATLEGNPEPPSLAPVPMQRMMLQLQHDIEALSAGRHTVSMTCDPAVSVCGAELE
LLSAFSNLASNAVRYTPDGGTIRLDWGVRDGHAVYSVTDTGIGIAPEHIPRLTERFYRVDRSRSRDTGGTGLGLAIVKHV
LSRHGGELQVTSEHGKGSTFRAVFPPERTIVRSASVADERVA

Specific function: Member of the two-component regulatory system phoR/phoB involved in the phosphate regulon genes expression. PhoR may function as a membrane-associated protein kinase that phosphorylates phoB in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=403, Percent_Identity=37.9652605459057, Blast_Score=265, Evalue=5e-72,
Organism=Escherichia coli, GI1788393, Length=273, Percent_Identity=29.6703296703297, Blast_Score=122, Evalue=7e-29,
Organism=Escherichia coli, GI1786783, Length=240, Percent_Identity=35.4166666666667, Blast_Score=121, Evalue=9e-29,
Organism=Escherichia coli, GI48994928, Length=380, Percent_Identity=26.8421052631579, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI145693157, Length=344, Percent_Identity=27.3255813953488, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1790861, Length=220, Percent_Identity=33.1818181818182, Blast_Score=95, Evalue=8e-21,
Organism=Escherichia coli, GI1789149, Length=240, Percent_Identity=30, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1788713, Length=253, Percent_Identity=27.2727272727273, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1790346, Length=217, Percent_Identity=29.9539170506912, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI87082128, Length=237, Percent_Identity=28.6919831223629, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1789403, Length=215, Percent_Identity=28.3720930232558, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1787894, Length=222, Percent_Identity=27.9279279279279, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1790436, Length=246, Percent_Identity=26.0162601626016, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI87081816, Length=267, Percent_Identity=25.8426966292135, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1789808, Length=221, Percent_Identity=29.8642533936652, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788549, Length=357, Percent_Identity=23.5294117647059, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790551, Length=254, Percent_Identity=27.1653543307087, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR021766
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR014310 [H]

Pfam domain/function: PF11808 DUF3329; PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49761; Mature: 49761

Theoretical pI: Translated: 6.76; Mature: 6.76

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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EEECCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure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EEECCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10984043; 2115874 [H]