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The map label for this gene is ppx [H]

Identifier: 187929097

GI number: 187929097

Start: 2122542

End: 2124080

Strand: Reverse

Name: ppx [H]

Synonym: Rpic_2018

Alternate gene names: 187929097

Gene position: 2124080-2122542 (Counterclockwise)

Preceding gene: 187929099

Following gene: 187929092

Centisome position: 53.88

GC content: 63.35

Gene sequence:

>1539_bases
ATGAGTCCCACCCCCCGTCTGCTGGCTGCTGTCGACATGGGCTCCAACAGCTTCCGGCTGATGATCGGCCGCGTCGACGA
AACCCTTGGTGCCAACGGTGCCAGCAGTACCCAGATCTTCCAGGTCGATGCGCTGCGCGAACCGGTGCGTTTGGCTGCCG
GGCTTACGCAAGATAAATACCTGGATCAGCCCGCGCGCCGGCGCGGCGTCGACGCCTTGCGCCGCTTTGGCGATCGCTTG
CGTGATTTTTCCCCCGAGCATATCCGGGCCGTGGCCACTAACACCTTGCGCGTGGCCAAGAACGCGCAGGAATTCCTGAT
CGAGGCGGAAGCCGCGCTAGGGTTTCCCATCGAGGTGATTGCGGGCCGCGAAGAGGCACGCCTGATCTATCTCGGTGCAT
CGCATGACGCACCGGCGTGCCAGGGCAACCGGCTCGTCGTCGACATCGGCGGCGGCTCCACCGAGTTCATTATCGGCAAC
GGCTACAAGCCCAAGCTGATGGAGTCGCTGTACATCGGTTGCGTTTCGCACAGCCGGCATTTCTTTCCGAACGGCAACGT
TGATGAATACGCGATGAAGCAGGCCGAGCTGGCCGCGCGTCGCGAGATCCAGGTGCTCGTGCAGCAGTACCGCACGGCTG
GCTGGACGCAGGCCGTCGGGTCATCGGGGACGGCGCGTGCGCTGGCTGAGCTGATCGAGCTGAACGGCTTCAATGACAAG
AGCAACGAACACGGTATTACGCGTGAAGGGCTGGAGCGCCTGAAGCGCGCGCTCGTCAAGTCAGAGAACACCAACCGCCT
GAAGCTCAACGGCCTGAAGGCGGACCGGATTCCGGTGCTGCCGGGCGGCCTGTCGATCATGCTGGGCGTGTTTGCGGAAC
TCGATGTCGACCGTATGGACGTGACCGATGGCGCCTTGCGCCTGGGCGTGCTGTATGACCTGCTCGGCCGTACGCATCAT
GAAGACATGCGCACGGTGACGATCGAACAGTTCATGCGCCGTTACAACGTCGACCGTGCGCAGGCAAGCCGGGTACGCGA
TGCGGCGACGGCGCTGTTGTCGCAGTTTCCCGATCCGCCCGATGAGCGCCGCGAAGACAATCTCGCGCTGCTCGGTTGGG
CGGCAAACCTGCACGAGATCGGCATGAGCATCTCGCACAGCGGGTACCACAAGCACTCGGCGTACATCGCCAGCCATGCC
GATATGCCGGGTTTTTCCAGGACAGACCAAGCGCGCCTGGCAACGCTGCTGCTGGGCCACGCCGGCAAGCTGGGCAAGCT
TTCGGGCGGCGGCAAGTTCCTGGATTGGCGGATGCTGTTCAGCCTGCGTCTGGCGTTTGTGCTGTGCCGCAGGCGCGGAG
CGATCCAGTTGCCGGGCTTGCGCGTGCGCCATAGCGAGGGCGAACTGAACGAAGGCGGTTTCGAAGTCGAGCTGCCCAAG
AACTGGATCGAGCAGAATCCGCTGGTGGAATACAGCCTGACGAAGGAAGCCGATGAGTGGCAGCGCATCGGCCGCCGCTA
CAAGGTGGTGTACGTGTAA

Upstream 100 bases:

>100_bases
TTTGTCACGTTCGGGACACAATAAAGACATATTTTGTTGCGCATTGTTTCGAACGACAATACCCCGCGCCCCTGATTCTG
CTCCTCACCCGTTTTCATTC

Downstream 100 bases:

>100_bases
AGCGTCGCGCAGCATCCCAAGCAAAACGGCCCGGAGTGACCCGGGCCGTTTTATTTGATGTGGCGCTGTTCGGAGCGATA
TCAGCCGCGCAGGAAGTGGC

Product: Ppx/GppA phosphatase

Products: NA

Alternate protein names: ExopolyPase; Metaphosphatase [H]

Number of amino acids: Translated: 512; Mature: 511

Protein sequence:

>512_residues
MSPTPRLLAAVDMGSNSFRLMIGRVDETLGANGASSTQIFQVDALREPVRLAAGLTQDKYLDQPARRRGVDALRRFGDRL
RDFSPEHIRAVATNTLRVAKNAQEFLIEAEAALGFPIEVIAGREEARLIYLGASHDAPACQGNRLVVDIGGGSTEFIIGN
GYKPKLMESLYIGCVSHSRHFFPNGNVDEYAMKQAELAARREIQVLVQQYRTAGWTQAVGSSGTARALAELIELNGFNDK
SNEHGITREGLERLKRALVKSENTNRLKLNGLKADRIPVLPGGLSIMLGVFAELDVDRMDVTDGALRLGVLYDLLGRTHH
EDMRTVTIEQFMRRYNVDRAQASRVRDAATALLSQFPDPPDERREDNLALLGWAANLHEIGMSISHSGYHKHSAYIASHA
DMPGFSRTDQARLATLLLGHAGKLGKLSGGGKFLDWRMLFSLRLAFVLCRRRGAIQLPGLRVRHSEGELNEGGFEVELPK
NWIEQNPLVEYSLTKEADEWQRIGRRYKVVYV

Sequences:

>Translated_512_residues
MSPTPRLLAAVDMGSNSFRLMIGRVDETLGANGASSTQIFQVDALREPVRLAAGLTQDKYLDQPARRRGVDALRRFGDRL
RDFSPEHIRAVATNTLRVAKNAQEFLIEAEAALGFPIEVIAGREEARLIYLGASHDAPACQGNRLVVDIGGGSTEFIIGN
GYKPKLMESLYIGCVSHSRHFFPNGNVDEYAMKQAELAARREIQVLVQQYRTAGWTQAVGSSGTARALAELIELNGFNDK
SNEHGITREGLERLKRALVKSENTNRLKLNGLKADRIPVLPGGLSIMLGVFAELDVDRMDVTDGALRLGVLYDLLGRTHH
EDMRTVTIEQFMRRYNVDRAQASRVRDAATALLSQFPDPPDERREDNLALLGWAANLHEIGMSISHSGYHKHSAYIASHA
DMPGFSRTDQARLATLLLGHAGKLGKLSGGGKFLDWRMLFSLRLAFVLCRRRGAIQLPGLRVRHSEGELNEGGFEVELPK
NWIEQNPLVEYSLTKEADEWQRIGRRYKVVYV
>Mature_511_residues
SPTPRLLAAVDMGSNSFRLMIGRVDETLGANGASSTQIFQVDALREPVRLAAGLTQDKYLDQPARRRGVDALRRFGDRLR
DFSPEHIRAVATNTLRVAKNAQEFLIEAEAALGFPIEVIAGREEARLIYLGASHDAPACQGNRLVVDIGGGSTEFIIGNG
YKPKLMESLYIGCVSHSRHFFPNGNVDEYAMKQAELAARREIQVLVQQYRTAGWTQAVGSSGTARALAELIELNGFNDKS
NEHGITREGLERLKRALVKSENTNRLKLNGLKADRIPVLPGGLSIMLGVFAELDVDRMDVTDGALRLGVLYDLLGRTHHE
DMRTVTIEQFMRRYNVDRAQASRVRDAATALLSQFPDPPDERREDNLALLGWAANLHEIGMSISHSGYHKHSAYIASHAD
MPGFSRTDQARLATLLLGHAGKLGKLSGGGKFLDWRMLFSLRLAFVLCRRRGAIQLPGLRVRHSEGELNEGGFEVELPKN
WIEQNPLVEYSLTKEADEWQRIGRRYKVVYV

Specific function: Degradation of inorganic polyphosphates. Orthophosphate is released progressively from the ends of polyphosphate [H]

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family [H]

Homologues:

Organism=Escherichia coli, GI1788848, Length=516, Percent_Identity=38.7596899224806, Blast_Score=334, Evalue=7e-93,
Organism=Escherichia coli, GI48994966, Length=508, Percent_Identity=34.8425196850394, Blast_Score=282, Evalue=3e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022371
- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.11 [H]

Molecular weight: Translated: 56936; Mature: 56805

Theoretical pI: Translated: 8.96; Mature: 8.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPTPRLLAAVDMGSNSFRLMIGRVDETLGANGASSTQIFQVDALREPVRLAAGLTQDKY
CCCCCCEEEEEECCCCCEEEEEEEHHHHHCCCCCCCCEEEEEHHHHHHHHHHHCCCHHHH
LDQPARRRGVDALRRFGDRLRDFSPEHIRAVATNTLRVAKNAQEFLIEAEAALGFPIEVI
CCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
AGREEARLIYLGASHDAPACQGNRLVVDIGGGSTEFIIGNGYKPKLMESLYIGCVSHSRH
CCCCCCEEEEEECCCCCCCCCCCEEEEEECCCCEEEEEECCCCHHHHHHHHHHHHHCCCC
FFPNGNVDEYAMKQAELAARREIQVLVQQYRTAGWTQAVGSSGTARALAELIELNGFNDK
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHCCCCCC
SNEHGITREGLERLKRALVKSENTNRLKLNGLKADRIPVLPGGLSIMLGVFAELDVDRMD
CCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCEE
VTDGALRLGVLYDLLGRTHHEDMRTVTIEQFMRRYNVDRAQASRVRDAATALLSQFPDPP
CCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCC
DERREDNLALLGWAANLHEIGMSISHSGYHKHSAYIASHADMPGFSRTDQARLATLLLGH
CCCCCCCEEEEEECCCHHHHCCCCCCCCCCHHHHEEEECCCCCCCCCCHHHHHHHHHHHC
AGKLGKLSGGGKFLDWRMLFSLRLAFVLCRRRGAIQLPGLRVRHSEGELNEGGFEVELPK
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEECCCEEEECCCCCCCCCCEEEECCH
NWIEQNPLVEYSLTKEADEWQRIGRRYKVVYV
HHHCCCCCEEEECCCCHHHHHHHCCEEEEEEC
>Mature Secondary Structure 
SPTPRLLAAVDMGSNSFRLMIGRVDETLGANGASSTQIFQVDALREPVRLAAGLTQDKY
CCCCCEEEEEECCCCCEEEEEEEHHHHHCCCCCCCCEEEEEHHHHHHHHHHHCCCHHHH
LDQPARRRGVDALRRFGDRLRDFSPEHIRAVATNTLRVAKNAQEFLIEAEAALGFPIEVI
CCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
AGREEARLIYLGASHDAPACQGNRLVVDIGGGSTEFIIGNGYKPKLMESLYIGCVSHSRH
CCCCCCEEEEEECCCCCCCCCCCEEEEEECCCCEEEEEECCCCHHHHHHHHHHHHHCCCC
FFPNGNVDEYAMKQAELAARREIQVLVQQYRTAGWTQAVGSSGTARALAELIELNGFNDK
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHCCCCCC
SNEHGITREGLERLKRALVKSENTNRLKLNGLKADRIPVLPGGLSIMLGVFAELDVDRMD
CCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCEE
VTDGALRLGVLYDLLGRTHHEDMRTVTIEQFMRRYNVDRAQASRVRDAATALLSQFPDPP
CCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCC
DERREDNLALLGWAANLHEIGMSISHSGYHKHSAYIASHADMPGFSRTDQARLATLLLGH
CCCCCCCEEEEEECCCHHHHCCCCCCCCCCHHHHEEEECCCCCCCCCCHHHHHHHHHHHC
AGKLGKLSGGGKFLDWRMLFSLRLAFVLCRRRGAIQLPGLRVRHSEGELNEGGFEVELPK
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEECCCEEEECCCCCCCCCCEEEECCH
NWIEQNPLVEYSLTKEADEWQRIGRRYKVVYV
HHHCCCCCEEEECCCCHHHHHHHCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10382967; 10984043 [H]