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The map label for this gene is lrp [H]

Identifier: 187929083

GI number: 187929083

Start: 2111221

End: 2111742

Strand: Reverse

Name: lrp [H]

Synonym: Rpic_2003

Alternate gene names: 187929083

Gene position: 2111742-2111221 (Counterclockwise)

Preceding gene: 187929086

Following gene: 187929081

Centisome position: 53.56

GC content: 62.45

Gene sequence:

>522_bases
ATGAAAAAGAGCGAAACAAAATTGCAGGAGCGCCCTGACGCGTCGGCGGCTTCTGCGCGCCACGCCTTGGATCGCACTGA
TCGCGCGATTCTCAGGGCGCTCCAGCGCGATGCGTCTATCTCCAACGTGGCCCTCGCGGCCAAGGTAAACCTCAGCCCGC
CGGCCTGCCTGCGCCGCGTGGAACGGCTCAAGGAGCTGGGGCTGATCAAGGGGATTGTTGCGCTGCTCGATCCTCGTGCG
CTGGATCTGGGGTCGCTGGTGATGATCGGCGTCGTGCTGGATCGCTCGACGCCGGAATCGTTCACGGCATTTGAGAAAGC
GGTGCAGAAGGTGCCCGGTTGCCTGGAATGCCACGTCGTGACGGGCGAATTCGATTACTTCATGCTCGTGCGCACGAAAG
ACAACGAAGGCTACAACCGGCTCCACGCCGAACAGCTGCTGTATCTGCCGGGCGTGCGGCAGATCCGGACGTTCATGGTG
CTCAAGCAGGTGCTGTCGACGACGGAGCTGCCAGTGGCGTAG

Upstream 100 bases:

>100_bases
ATGGTACGCAGAGCGCTACGAAATAAGGTTGCAAAGATCGTCTACTATCCAGAACTTAGCTGATCGTAGATCGGATTAAT
AATCTCTTTATTTCTTAAAA

Downstream 100 bases:

>100_bases
CGTCGCTTGGCCGGGCGGGGCGGAGGTTCAGCCCTTGCGCTGGTCCATCAGGCGGTTCCAGAGCATGCCGGCCCGGTTGC
CGCTCCTGCAATACGCGAGG

Product: AsnC family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 173; Mature: 173

Protein sequence:

>173_residues
MKKSETKLQERPDASAASARHALDRTDRAILRALQRDASISNVALAAKVNLSPPACLRRVERLKELGLIKGIVALLDPRA
LDLGSLVMIGVVLDRSTPESFTAFEKAVQKVPGCLECHVVTGEFDYFMLVRTKDNEGYNRLHAEQLLYLPGVRQIRTFMV
LKQVLSTTELPVA

Sequences:

>Translated_173_residues
MKKSETKLQERPDASAASARHALDRTDRAILRALQRDASISNVALAAKVNLSPPACLRRVERLKELGLIKGIVALLDPRA
LDLGSLVMIGVVLDRSTPESFTAFEKAVQKVPGCLECHVVTGEFDYFMLVRTKDNEGYNRLHAEQLLYLPGVRQIRTFMV
LKQVLSTTELPVA
>Mature_173_residues
MKKSETKLQERPDASAASARHALDRTDRAILRALQRDASISNVALAAKVNLSPPACLRRVERLKELGLIKGIVALLDPRA
LDLGSLVMIGVVLDRSTPESFTAFEKAVQKVPGCLECHVVTGEFDYFMLVRTKDNEGYNRLHAEQLLYLPGVRQIRTFMV
LKQVLSTTELPVA

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=150, Percent_Identity=46, Blast_Score=140, Evalue=5e-35,
Organism=Escherichia coli, GI87081742, Length=150, Percent_Identity=32.6666666666667, Blast_Score=95, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 19183; Mature: 19183

Theoretical pI: Translated: 9.59; Mature: 9.59

Prosite motif: PS00519 HTH_ASNC_1 ; PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKSETKLQERPDASAASARHALDRTDRAILRALQRDASISNVALAAKVNLSPPACLRRV
CCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHH
ERLKELGLIKGIVALLDPRALDLGSLVMIGVVLDRSTPESFTAFEKAVQKVPGCLECHVV
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEEEE
TGEFDYFMLVRTKDNEGYNRLHAEQLLYLPGVRQIRTFMVLKQVLSTTELPVA
ECCCEEEEEEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKKSETKLQERPDASAASARHALDRTDRAILRALQRDASISNVALAAKVNLSPPACLRRV
CCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHH
ERLKELGLIKGIVALLDPRALDLGSLVMIGVVLDRSTPESFTAFEKAVQKVPGCLECHVV
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEEEE
TGEFDYFMLVRTKDNEGYNRLHAEQLLYLPGVRQIRTFMVLKQVLSTTELPVA
ECCCEEEEEEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]