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The map label for this gene is yeaE [H]

Identifier: 187929086

GI number: 187929086

Start: 2113897

End: 2114730

Strand: Reverse

Name: yeaE [H]

Synonym: Rpic_2007

Alternate gene names: 187929086

Gene position: 2114730-2113897 (Counterclockwise)

Preceding gene: 187929087

Following gene: 187929083

Centisome position: 53.64

GC content: 66.55

Gene sequence:

>834_bases
ATGAAACACGTCACTCTGCCCAACGGCGAACGCGTCCCTGCACTCGGCATGGGCACCTGGAACATGGGCGACGACCGCGC
CACGCGCGCCGAAGAAATCGCCACGCTGCGCCTGGGCCTCGACCTGGGTTTGCGCCTGATCGACACCGCCGAGATGTACG
GCGAAGGCCTCTCTGAATCGCTGATTGGCGAGGCCATTGCCGGGCGGCGCGATGAAGTCTTTCTGGTGAGCAAGGTCTAT
CCGCACAACGCCAGTCGGCGCGGCATTGCTGCGGCGTGCGAGCGCAGCCTGCGCCGCCTCGGCACCGACCGCCTCGATCT
GTACCTGCTGCACTGGCGCGGCGATGTGCCGTTCGACGACACGCTGGAAGGCCTGCAGGCCCTGCAGCGCGAGGGCAAGA
TCCGCCAGTACGGCGTGAGCAATCTCGACCTCTCCGACATGCAGGAATGGTGGGACGTGCCCGGCGGCGATCAGATTGCC
GTCAACCAGCTGCTCTACAACCTCAGCCGGCGCGGCATCGAATGGGATGTGTTGCCCTGGCTGCGCGAGCGCCGTGTGCC
GGTGATGGCCTATTCGCCCATCGAGCAGGCGCGGCTCATTCGGCATCCGAAGCTGGTGCGCTTCGCGCAGGCGTGCGGCA
TGACGCCGGCACAGGTGGCGCTGGCGTGGCTGCTGGCGCGCGACGACATCATCGCGATTCCCAAGACCGGCCATCGTGAC
CGGCTGCGCGAAAACATCGGCGCGTTATCGCACACGCTCACGGCTGAGCAGCTTGCGATGCTGGACAGCATCTTCCCGCC
GCCCAAGGGGCCGAGCGCGCTGGAGATGCTGTAA

Upstream 100 bases:

>100_bases
AGGCGCGCTAGCGCGTATTTTCTGACCGGACCGGCGCAGCCTTACCGATGCGCCGCGTCTCTTGTAGATTCATGTTTTGC
CTCCGATCGGAAAGCACGAC

Downstream 100 bases:

>100_bases
CCGCTCAGCGCGACTTCGCCAGGTAGCGCGCGTGATCGACGTAGCCCATCAGGTAGACGCGGGCTTTGTCGCGTGTGTCT
TTGGTGACGCGGTCGGCTGC

Product: aldo/keto reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 277; Mature: 277

Protein sequence:

>277_residues
MKHVTLPNGERVPALGMGTWNMGDDRATRAEEIATLRLGLDLGLRLIDTAEMYGEGLSESLIGEAIAGRRDEVFLVSKVY
PHNASRRGIAAACERSLRRLGTDRLDLYLLHWRGDVPFDDTLEGLQALQREGKIRQYGVSNLDLSDMQEWWDVPGGDQIA
VNQLLYNLSRRGIEWDVLPWLRERRVPVMAYSPIEQARLIRHPKLVRFAQACGMTPAQVALAWLLARDDIIAIPKTGHRD
RLRENIGALSHTLTAEQLAMLDSIFPPPKGPSALEML

Sequences:

>Translated_277_residues
MKHVTLPNGERVPALGMGTWNMGDDRATRAEEIATLRLGLDLGLRLIDTAEMYGEGLSESLIGEAIAGRRDEVFLVSKVY
PHNASRRGIAAACERSLRRLGTDRLDLYLLHWRGDVPFDDTLEGLQALQREGKIRQYGVSNLDLSDMQEWWDVPGGDQIA
VNQLLYNLSRRGIEWDVLPWLRERRVPVMAYSPIEQARLIRHPKLVRFAQACGMTPAQVALAWLLARDDIIAIPKTGHRD
RLRENIGALSHTLTAEQLAMLDSIFPPPKGPSALEML
>Mature_277_residues
MKHVTLPNGERVPALGMGTWNMGDDRATRAEEIATLRLGLDLGLRLIDTAEMYGEGLSESLIGEAIAGRRDEVFLVSKVY
PHNASRRGIAAACERSLRRLGTDRLDLYLLHWRGDVPFDDTLEGLQALQREGKIRQYGVSNLDLSDMQEWWDVPGGDQIA
VNQLLYNLSRRGIEWDVLPWLRERRVPVMAYSPIEQARLIRHPKLVRFAQACGMTPAQVALAWLLARDDIIAIPKTGHRD
RLRENIGALSHTLTAEQLAMLDSIFPPPKGPSALEML

Specific function: Unknown

COG id: COG0656

COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI24497577, Length=309, Percent_Identity=27.5080906148867, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI5174391, Length=309, Percent_Identity=27.5080906148867, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI223468663, Length=303, Percent_Identity=25.7425742574257, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI24497585, Length=305, Percent_Identity=26.5573770491803, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI310109922, Length=282, Percent_Identity=25.886524822695, Blast_Score=92, Evalue=3e-19,
Organism=Homo sapiens, GI5453543, Length=302, Percent_Identity=25.4966887417219, Blast_Score=91, Evalue=8e-19,
Organism=Homo sapiens, GI310109920, Length=302, Percent_Identity=25.4966887417219, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI45446745, Length=302, Percent_Identity=25.1655629139073, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI4503285, Length=302, Percent_Identity=25.1655629139073, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI24497583, Length=304, Percent_Identity=25.3289473684211, Blast_Score=88, Evalue=7e-18,
Organism=Homo sapiens, GI4502049, Length=295, Percent_Identity=27.1186440677966, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI291291012, Length=271, Percent_Identity=25.0922509225092, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1788081, Length=281, Percent_Identity=48.7544483985765, Blast_Score=289, Evalue=1e-79,
Organism=Escherichia coli, GI1786400, Length=251, Percent_Identity=29.4820717131474, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI87081735, Length=306, Percent_Identity=30.718954248366, Blast_Score=111, Evalue=6e-26,
Organism=Escherichia coli, GI87082198, Length=265, Percent_Identity=29.0566037735849, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1788070, Length=298, Percent_Identity=28.8590604026846, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1787674, Length=257, Percent_Identity=29.1828793774319, Blast_Score=91, Evalue=8e-20,
Organism=Escherichia coli, GI1789375, Length=315, Percent_Identity=27.6190476190476, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI1789199, Length=354, Percent_Identity=28.5310734463277, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI48994888, Length=287, Percent_Identity=26.1324041811847, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17537077, Length=305, Percent_Identity=26.2295081967213, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17537075, Length=305, Percent_Identity=25.9016393442623, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17564128, Length=306, Percent_Identity=26.4705882352941, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71998625, Length=273, Percent_Identity=24.9084249084249, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17561298, Length=283, Percent_Identity=27.9151943462898, Blast_Score=91, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17566692, Length=302, Percent_Identity=25.8278145695364, Blast_Score=87, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17550248, Length=304, Percent_Identity=25.3289473684211, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17552492, Length=273, Percent_Identity=25.2747252747253, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17561300, Length=268, Percent_Identity=23.134328358209, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17538386, Length=283, Percent_Identity=24.7349823321555, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6320576, Length=284, Percent_Identity=28.169014084507, Blast_Score=100, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6324694, Length=302, Percent_Identity=25.8278145695364, Blast_Score=100, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6322556, Length=278, Percent_Identity=25.1798561151079, Blast_Score=84, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6325169, Length=342, Percent_Identity=23.6842105263158, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320079, Length=289, Percent_Identity=25.6055363321799, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI45553081, Length=298, Percent_Identity=27.8523489932886, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24663317, Length=301, Percent_Identity=26.9102990033223, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24644950, Length=313, Percent_Identity=29.7124600638978, Blast_Score=104, Evalue=5e-23,
Organism=Drosophila melanogaster, GI221378297, Length=333, Percent_Identity=28.2282282282282, Blast_Score=98, Evalue=6e-21,
Organism=Drosophila melanogaster, GI24662789, Length=284, Percent_Identity=27.112676056338, Blast_Score=88, Evalue=7e-18,
Organism=Drosophila melanogaster, GI281366140, Length=260, Percent_Identity=26.5384615384615, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24657054, Length=296, Percent_Identity=25, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI20129731, Length=301, Percent_Identity=24.2524916943522, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24662781, Length=292, Percent_Identity=24.6575342465753, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24662785, Length=291, Percent_Identity=24.0549828178694, Blast_Score=68, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: NA

Molecular weight: Translated: 31105; Mature: 31105

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHVTLPNGERVPALGMGTWNMGDDRATRAEEIATLRLGLDLGLRLIDTAEMYGEGLSES
CCCCCCCCCCCCCEECCCCCCCCCCHHHHHHHHHHHHCCHHHCHHHHHHHHHHHCCHHHH
LIGEAIAGRRDEVFLVSKVYPHNASRRGIAAACERSLRRLGTDRLDLYLLHWRGDVPFDD
HHHHHHCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHH
TLEGLQALQREGKIRQYGVSNLDLSDMQEWWDVPGGDQIAVNQLLYNLSRRGIEWDVLPW
HHHHHHHHHHCCCHHHCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHH
LRERRVPVMAYSPIEQARLIRHPKLVRFAQACGMTPAQVALAWLLARDDIIAIPKTGHRD
HHHCCCCEEEECCHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHCCCEEECCCCCCHH
RLRENIGALSHTLTAEQLAMLDSIFPPPKGPSALEML
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCC
>Mature Secondary Structure
MKHVTLPNGERVPALGMGTWNMGDDRATRAEEIATLRLGLDLGLRLIDTAEMYGEGLSES
CCCCCCCCCCCCCEECCCCCCCCCCHHHHHHHHHHHHCCHHHCHHHHHHHHHHHCCHHHH
LIGEAIAGRRDEVFLVSKVYPHNASRRGIAAACERSLRRLGTDRLDLYLLHWRGDVPFDD
HHHHHHCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHH
TLEGLQALQREGKIRQYGVSNLDLSDMQEWWDVPGGDQIAVNQLLYNLSRRGIEWDVLPW
HHHHHHHHHHCCCHHHCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHH
LRERRVPVMAYSPIEQARLIRHPKLVRFAQACGMTPAQVALAWLLARDDIIAIPKTGHRD
HHHCCCCEEEECCHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHCCCEEECCCCCCHH
RLRENIGALSHTLTAEQLAMLDSIFPPPKGPSALEML
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503 [H]