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The map label for this gene is tmk

Identifier: 187928511

GI number: 187928511

Start: 1514501

End: 1515118

Strand: Reverse

Name: tmk

Synonym: Rpic_1425

Alternate gene names: 187928511

Gene position: 1515118-1514501 (Counterclockwise)

Preceding gene: 187928512

Following gene: 187928510

Centisome position: 38.43

GC content: 65.05

Gene sequence:

>618_bases
ATGACCGGCAAGTTCATCACATTCGAAGGGATCGACGGCGCGGGCAAGAGCACGCACCTGGCGTGGTTTGCACAGCAACT
GCAGGCGAAGCTCGCGCCCCTGGGCAAAAAGGTGGTCGTCACCCGCGAGCCCGGCGGCACGCCGCTGGGCGAGCGACTGC
GCGAAGTGTTGCTGCACGAACGCATGCACCTGGAAACCGAAGCGCTGCTGATGTTCGCGAGCCGCCGCGAGCACATTGCC
GAGGTGATTCAGCCCGCGCTGGACGCCGGCGATTGGGTCATCTCGGACCGCTTCACCGATGCCACGTTCGCCTATCAGGG
CGGGGGCAGGGGCCTGGCAATCGACCGGCTGGAAGCGCTGGAGCACTGGGTACAGCAGGGCCTGCAGCCGACCAAGACCA
TCCTCTTCGATCTGGCGCCTGAAATTGCCGCCGCGCGCCTGGCCGATGCCCGCACGCCGGACAAGTTCGAGGCCGAATCA
GCGCAGTTCTTCCTGCGCACGCGCGCCGAATACCTGCGCCGCGCGGCAGCCGAACCGGATCGATTTGTCGTGCTCAACGC
CAACCGCGAGCGCAGTGATATCCAGAAAGACTTGGAGAATCTGCTTGCAACGCTCTGA

Upstream 100 bases:

>100_bases
ACGCGCTGTATTTCGTGGCGCGCGGCGACGGCAGCAGCCAGTTTTCGACCAACCTGACGGACCACAACCGGGCCGTCAAC
AAATATCAGCGCGGCCAACC

Downstream 100 bases:

>100_bases
TTTTGCAGGCAATTTCGGATACGGAAATAATGGTTCCACGGCAAGTTTTCGCATCAATAATCTGACGCAACCCATTGATT
CATGATGCTTTATCCTTGGC

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 205; Mature: 204

Protein sequence:

>205_residues
MTGKFITFEGIDGAGKSTHLAWFAQQLQAKLAPLGKKVVVTREPGGTPLGERLREVLLHERMHLETEALLMFASRREHIA
EVIQPALDAGDWVISDRFTDATFAYQGGGRGLAIDRLEALEHWVQQGLQPTKTILFDLAPEIAAARLADARTPDKFEAES
AQFFLRTRAEYLRRAAAEPDRFVVLNANRERSDIQKDLENLLATL

Sequences:

>Translated_205_residues
MTGKFITFEGIDGAGKSTHLAWFAQQLQAKLAPLGKKVVVTREPGGTPLGERLREVLLHERMHLETEALLMFASRREHIA
EVIQPALDAGDWVISDRFTDATFAYQGGGRGLAIDRLEALEHWVQQGLQPTKTILFDLAPEIAAARLADARTPDKFEAES
AQFFLRTRAEYLRRAAAEPDRFVVLNANRERSDIQKDLENLLATL
>Mature_204_residues
TGKFITFEGIDGAGKSTHLAWFAQQLQAKLAPLGKKVVVTREPGGTPLGERLREVLLHERMHLETEALLMFASRREHIAE
VIQPALDAGDWVISDRFTDATFAYQGGGRGLAIDRLEALEHWVQQGLQPTKTILFDLAPEIAAARLADARTPDKFEAESA
QFFLRTRAEYLRRAAAEPDRFVVLNANRERSDIQKDLENLLATL

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Escherichia coli, GI1787340, Length=185, Percent_Identity=40, Blast_Score=117, Evalue=7e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_RALPJ (B2UBZ3)

Other databases:

- EMBL:   CP001068
- RefSeq:   YP_001898998.1
- ProteinModelPortal:   B2UBZ3
- SMR:   B2UBZ3
- GeneID:   6289303
- GenomeReviews:   CP001068_GR
- KEGG:   rpi:Rpic_1425
- HOGENOM:   HBG626009
- OMA:   LFITLEG
- ProtClustDB:   PRK00698
- HAMAP:   MF_00165
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 22935; Mature: 22804

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGKFITFEGIDGAGKSTHLAWFAQQLQAKLAPLGKKVVVTREPGGTPLGERLREVLLHE
CCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHH
RMHLETEALLMFASRREHIAEVIQPALDAGDWVISDRFTDATFAYQGGGRGLAIDRLEAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCEEEECCCCCCHHHHHHHHH
EHWVQQGLQPTKTILFDLAPEIAAARLADARTPDKFEAESAQFFLRTRAEYLRRAAAEPD
HHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
RFVVLNANRERSDIQKDLENLLATL
CEEEEECCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TGKFITFEGIDGAGKSTHLAWFAQQLQAKLAPLGKKVVVTREPGGTPLGERLREVLLHE
CCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHH
RMHLETEALLMFASRREHIAEVIQPALDAGDWVISDRFTDATFAYQGGGRGLAIDRLEAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCEEEECCCCCCHHHHHHHHH
EHWVQQGLQPTKTILFDLAPEIAAARLADARTPDKFEAESAQFFLRTRAEYLRRAAAEPD
HHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
RFVVLNANRERSDIQKDLENLLATL
CEEEEECCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA