Click here to switch to the map view.

The map label for this gene is lpxD

Identifier: 187928377

GI number: 187928377

Start: 1384522

End: 1385595

Strand: Direct

Name: lpxD

Synonym: Rpic_1288

Alternate gene names: 187928377

Gene position: 1384522-1385595 (Clockwise)

Preceding gene: 187928376

Following gene: 187928378

Centisome position: 35.12

GC content: 63.87

Gene sequence:

>1074_bases
ATGTCGTTTTCGCTTGGTGAACTTGCTGCGTCGCTCGGCGCGACCGTCCAGGGTGACGCAGGCCTGATCGTCAAGTCGAT
CGCGCCGCTGGATCAAGCGGGCGCCGATCAGCTCGCTTTTCTCTCCAATCCGCTGTACCTCAATCAGGCTGTGAGTTCCG
GTGCGGGGGCGATCATCGTGTCGCCCCGCGATCTGGAAACGCTCGAAAGCCAGGGCCACGCTGCTGGCCGGAACTGGCTG
ATTGCGGCCAATCCGTATGCTGCGTTTGCGCGCGTTGCCCAGCGCTTTGTTGCGCTGGCCGCGCGCCCCGTTGTACCGGG
CATTCACCGGACTGCCAGCGTGGAAGAGGGCGCCAGGGTGCCGGCATCCTGCTCCATCGGCCCGAACGTCACCATCGAAG
CCGGTGCTGTGCTCGGCGAGCGTGTGCGCATCGCCGGCAACAGCTTTGTTGGCGCCGATGCCCGGATTGGCGACGACACG
TTGCTCTACGCGAACGTTTCGATTTACCACGGCTGCGTTGTTGGCGCGCGCTGCGTTCTGCATAGCGGCGTCGTGATCGG
CGCCGATGGCTTCGGCTTTGCACCCGACTTCGGGCCGCAGGGCGGCGAATGGGTGAAGATTCCGCAGGTTGGCCGGGCCG
TGATTGGTGACGACGTGGAGATCGGCGCAAACACCGCCATCGACCGTGGCGCGATGGCCGATACGGTGGTCGAACAGGGC
TGCAAGATCGACAACCAGGTGCAGATCGCGCACAACGTGCACGTGGGTGCCTATACCGTCATCGCGGGCTGCGCGGCCAT
TTCCGGCAGCACGAAGATCGGGCGCTACTGCATCATCGGCGGTGCGGCCAATTTTGCCGGCCACCTGACCATTGCGGACC
GCGTGACCGTTTCGGGCGGCACATCCATTACCAAATCCATCACCAAGCCCGGTGGCCACTTCACCAGCGTTTTCCCGTTC
ATGCCGCATGGCGACTGGGAGCGTAACGCGGCCATCGTCCGAGGCCTGACGCGCATGCGCGAACGGTTGCAACAACTGGA
ACAGCGGGTCAAAGACCTGCAGCAACAATCATGA

Upstream 100 bases:

>100_bases
CTGATCGTGCAGGAAGCCGTGTACGTGAACCCTCGCATCGACATCACGGACGAGGTGCTCAAGGCGCTGAATTCGCAATC
GGCCAAATGAGGTTGTCCGC

Downstream 100 bases:

>100_bases
CCGAAGCAACGAATGCGACGAGCGCGACCCCCAGCGTCGTCAGCGATTTCAACATCAAGAAGATTCTCGACCTGCTGCCG
CATCGCTACCCGATGCTGCT

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 357; Mature: 356

Protein sequence:

>357_residues
MSFSLGELAASLGATVQGDAGLIVKSIAPLDQAGADQLAFLSNPLYLNQAVSSGAGAIIVSPRDLETLESQGHAAGRNWL
IAANPYAAFARVAQRFVALAARPVVPGIHRTASVEEGARVPASCSIGPNVTIEAGAVLGERVRIAGNSFVGADARIGDDT
LLYANVSIYHGCVVGARCVLHSGVVIGADGFGFAPDFGPQGGEWVKIPQVGRAVIGDDVEIGANTAIDRGAMADTVVEQG
CKIDNQVQIAHNVHVGAYTVIAGCAAISGSTKIGRYCIIGGAANFAGHLTIADRVTVSGGTSITKSITKPGGHFTSVFPF
MPHGDWERNAAIVRGLTRMRERLQQLEQRVKDLQQQS

Sequences:

>Translated_357_residues
MSFSLGELAASLGATVQGDAGLIVKSIAPLDQAGADQLAFLSNPLYLNQAVSSGAGAIIVSPRDLETLESQGHAAGRNWL
IAANPYAAFARVAQRFVALAARPVVPGIHRTASVEEGARVPASCSIGPNVTIEAGAVLGERVRIAGNSFVGADARIGDDT
LLYANVSIYHGCVVGARCVLHSGVVIGADGFGFAPDFGPQGGEWVKIPQVGRAVIGDDVEIGANTAIDRGAMADTVVEQG
CKIDNQVQIAHNVHVGAYTVIAGCAAISGSTKIGRYCIIGGAANFAGHLTIADRVTVSGGTSITKSITKPGGHFTSVFPF
MPHGDWERNAAIVRGLTRMRERLQQLEQRVKDLQQQS
>Mature_356_residues
SFSLGELAASLGATVQGDAGLIVKSIAPLDQAGADQLAFLSNPLYLNQAVSSGAGAIIVSPRDLETLESQGHAAGRNWLI
AANPYAAFARVAQRFVALAARPVVPGIHRTASVEEGARVPASCSIGPNVTIEAGAVLGERVRIAGNSFVGADARIGDDTL
LYANVSIYHGCVVGARCVLHSGVVIGADGFGFAPDFGPQGGEWVKIPQVGRAVIGDDVEIGANTAIDRGAMADTVVEQGC
KIDNQVQIAHNVHVGAYTVIAGCAAISGSTKIGRYCIIGGAANFAGHLTIADRVTVSGGTSITKSITKPGGHFTSVFPFM
PHGDWERNAAIVRGLTRMRERLQQLEQRVKDLQQQS

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily

Homologues:

Organism=Escherichia coli, GI1786376, Length=350, Percent_Identity=41.1428571428571, Blast_Score=265, Evalue=4e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXD_RALPJ (B2UBB1)

Other databases:

- EMBL:   CP001068
- RefSeq:   YP_001898864.1
- ProteinModelPortal:   B2UBB1
- GeneID:   6287035
- GenomeReviews:   CP001068_GR
- KEGG:   rpi:Rpic_1288
- HOGENOM:   HBG469615
- OMA:   CFVGKNT
- ProtClustDB:   PRK00892
- HAMAP:   MF_00523
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573
- TIGRFAMs:   TIGR01853

Pfam domain/function: PF04613 LpxD; SSF51161 Trimer_LpxA_like

EC number: 2.3.1.-

Molecular weight: Translated: 37031; Mature: 36900

Theoretical pI: Translated: 7.00; Mature: 7.00

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFSLGELAASLGATVQGDAGLIVKSIAPLDQAGADQLAFLSNPLYLNQAVSSGAGAIIV
CCCCHHHHHHHHCCEECCCCCEEEEHHCCCCCCCCCHHHHHCCCEEEHHHHCCCCCEEEE
SPRDLETLESQGHAAGRNWLIAANPYAAFARVAQRFVALAARPVVPGIHRTASVEEGARV
CCCCHHHHHHCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
PASCSIGPNVTIEAGAVLGERVRIAGNSFVGADARIGDDTLLYANVSIYHGCVVGARCVL
CCCCCCCCCEEEECCCCCCCEEEEECCCEECCCCCCCCCEEEEEEHHHHHHHHHHHHHHH
HSGVVIGADGFGFAPDFGPQGGEWVKIPQVGRAVIGDDVEIGANTAIDRGAMADTVVEQG
HCCEEEECCCCCCCCCCCCCCCCEEECCCCCHHHHCCCEEECCCCCCCCCHHHHHHHHCC
CKIDNQVQIAHNVHVGAYTVIAGCAAISGSTKIGRYCIIGGAANFAGHLTIADRVTVSGG
CCCCCEEEEEEEEECHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCEEEEEEEEEEECCC
TSITKSITKPGGHFTSVFPFMPHGDWERNAAIVRGLTRMRERLQQLEQRVKDLQQQS
CHHHHHHCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SFSLGELAASLGATVQGDAGLIVKSIAPLDQAGADQLAFLSNPLYLNQAVSSGAGAIIV
CCCHHHHHHHHCCEECCCCCEEEEHHCCCCCCCCCHHHHHCCCEEEHHHHCCCCCEEEE
SPRDLETLESQGHAAGRNWLIAANPYAAFARVAQRFVALAARPVVPGIHRTASVEEGARV
CCCCHHHHHHCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
PASCSIGPNVTIEAGAVLGERVRIAGNSFVGADARIGDDTLLYANVSIYHGCVVGARCVL
CCCCCCCCCEEEECCCCCCCEEEEECCCEECCCCCCCCCEEEEEEHHHHHHHHHHHHHHH
HSGVVIGADGFGFAPDFGPQGGEWVKIPQVGRAVIGDDVEIGANTAIDRGAMADTVVEQG
HCCEEEECCCCCCCCCCCCCCCCEEECCCCCHHHHCCCEEECCCCCCCCCHHHHHHHHCC
CKIDNQVQIAHNVHVGAYTVIAGCAAISGSTKIGRYCIIGGAANFAGHLTIADRVTVSGG
CCCCCEEEEEEEEECHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCEEEEEEEEEEECCC
TSITKSITKPGGHFTSVFPFMPHGDWERNAAIVRGLTRMRERLQQLEQRVKDLQQQS
CHHHHHHCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA