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The map label for this gene is hom [H]

Identifier: 187928291

GI number: 187928291

Start: 1289413

End: 1290732

Strand: Direct

Name: hom [H]

Synonym: Rpic_1202

Alternate gene names: 187928291

Gene position: 1289413-1290732 (Clockwise)

Preceding gene: 187928290

Following gene: 187928292

Centisome position: 32.7

GC content: 63.79

Gene sequence:

>1320_bases
ATGAATCCCATCAAGATCGGCCTGCTCGGGCTCGGTACCGTCGGTGGCGGTACCCTCAAGGTTCTGCAACGGAACCAGGA
AGAAATCCGCCGTCGCGCGGGTCGCGGCATTGAAGTCGCCATGATTGCCGTGCGCAATCTCGACCGGGCCCGTGCCATCG
TGCAGGAGGCCGGTGCGACCGTGCCGGTGGTGAACGACCCGTTTGCGATTGTGGATTCGCCCGAGATCGATATCGTCGTG
GAGCTGATCGGCGGCTATGACCTGACGCGCGAGCTGGTGCTGCGCGCCATCGCCAACGGCAAGCACGTTGTCACCGCCAA
CAAGGCGCTGCTGGCCGTGCATGGCAACGAAATCTTCAAGGCCGCGCAGGACAAGGGCGTGATGGTGGCATTCGAAGCCG
CCGTGGCCGGTGGCATCCCCATCATCAAGGCGCTGCGCGAAGGTCTGACGGCCAACCGCATCGAGTGGATCGCGGGCATC
ATCAACGGCACCACGAATTTCATCCTGTCCGAGATGCGTGACAAGGGTCTGGATTTCGATACGGTGCTCAAGGAAGCCCA
GCGCCTGGGCTACGCTGAAGCCGATCCGACGTTCGACATCGAAGGTTTTGACGCCGCGCACAAGCTCACGCTCATGAGCG
CCATCGCCTTTGGCGTGCCGGTGCAGTTCGAGCGCGCATATGTGGAAGGCATCACCAAGCTGGAAGCCGTCGACATCCGC
TACGCCGAAGAACTGGGCTACCGCATCAAGCTGCTGGGCATCACGCGCCGTGTCGAGGCGGGCATCGAGCTGCGCGTGCA
TCCGACGCTGGTGCCGACCAAGCGCCTGATCGCCAACGTCGAAGGCGCGATGAATGCCGTGGTCGTCAACGGCGATGCCG
TGGGCCCGACGCTGTACTACGGCAAGGGTGCCGGTGCTGAGCCGACCGCTTCGGCCGTGGTCGCCGATCTGGTGGACGTG
ACGCGCCTGCATACGGCTGACCCCGAGCACCGCGTGCCGCATCTGGCGTTCCAGCCGGACGCGCTGTCCGACACGCCGGT
ACTGCCGATCGACGAAGTGCGTTCGAGTTACTACCTGCGCATGCGCGTGGCGGATGAAACCGGCGTGCTGGCCGACATCA
CGCGCATCCTAGCCGAGGGCGGCATCTCCATCGACGCGATGCTGCAGAAGGAATCGCGCGAAGGCGAGCCGCAGACCGAC
ATCATCATGCTGTCGCATGTGACGGTGGAAAAACGCGTGAACGCCGCCATCGCCGCCATCGAAGCGTTGCCGACCGTGCT
GTCGAAGGTCACGCGCATCCGCATGGAAGAACTGAACTAA

Upstream 100 bases:

>100_bases
AACATCGGTCTTCCGCCAGATCAGTAATTGCGGGGCAGACCGAGGTGTCTGCCCTGTGTTTTTTTGCCTTTCGCTTTTTC
GTTTCTTTACGACACGTCTC

Downstream 100 bases:

>100_bases
GCGCAGGACATGAGCATGCAATACCGATCGACCCGCGGCCACGCAGAGCCGCAAAGCTTCTCCCGCATCCTGCTGGGCGG
CCTGGCGCCGGACGGTGGCC

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 439; Mature: 439

Protein sequence:

>439_residues
MNPIKIGLLGLGTVGGGTLKVLQRNQEEIRRRAGRGIEVAMIAVRNLDRARAIVQEAGATVPVVNDPFAIVDSPEIDIVV
ELIGGYDLTRELVLRAIANGKHVVTANKALLAVHGNEIFKAAQDKGVMVAFEAAVAGGIPIIKALREGLTANRIEWIAGI
INGTTNFILSEMRDKGLDFDTVLKEAQRLGYAEADPTFDIEGFDAAHKLTLMSAIAFGVPVQFERAYVEGITKLEAVDIR
YAEELGYRIKLLGITRRVEAGIELRVHPTLVPTKRLIANVEGAMNAVVVNGDAVGPTLYYGKGAGAEPTASAVVADLVDV
TRLHTADPEHRVPHLAFQPDALSDTPVLPIDEVRSSYYLRMRVADETGVLADITRILAEGGISIDAMLQKESREGEPQTD
IIMLSHVTVEKRVNAAIAAIEALPTVLSKVTRIRMEELN

Sequences:

>Translated_439_residues
MNPIKIGLLGLGTVGGGTLKVLQRNQEEIRRRAGRGIEVAMIAVRNLDRARAIVQEAGATVPVVNDPFAIVDSPEIDIVV
ELIGGYDLTRELVLRAIANGKHVVTANKALLAVHGNEIFKAAQDKGVMVAFEAAVAGGIPIIKALREGLTANRIEWIAGI
INGTTNFILSEMRDKGLDFDTVLKEAQRLGYAEADPTFDIEGFDAAHKLTLMSAIAFGVPVQFERAYVEGITKLEAVDIR
YAEELGYRIKLLGITRRVEAGIELRVHPTLVPTKRLIANVEGAMNAVVVNGDAVGPTLYYGKGAGAEPTASAVVADLVDV
TRLHTADPEHRVPHLAFQPDALSDTPVLPIDEVRSSYYLRMRVADETGVLADITRILAEGGISIDAMLQKESREGEPQTD
IIMLSHVTVEKRVNAAIAAIEALPTVLSKVTRIRMEELN
>Mature_439_residues
MNPIKIGLLGLGTVGGGTLKVLQRNQEEIRRRAGRGIEVAMIAVRNLDRARAIVQEAGATVPVVNDPFAIVDSPEIDIVV
ELIGGYDLTRELVLRAIANGKHVVTANKALLAVHGNEIFKAAQDKGVMVAFEAAVAGGIPIIKALREGLTANRIEWIAGI
INGTTNFILSEMRDKGLDFDTVLKEAQRLGYAEADPTFDIEGFDAAHKLTLMSAIAFGVPVQFERAYVEGITKLEAVDIR
YAEELGYRIKLLGITRRVEAGIELRVHPTLVPTKRLIANVEGAMNAVVVNGDAVGPTLYYGKGAGAEPTASAVVADLVDV
TRLHTADPEHRVPHLAFQPDALSDTPVLPIDEVRSSYYLRMRVADETGVLADITRILAEGGISIDAMLQKESREGEPQTD
IIMLSHVTVEKRVNAAIAAIEALPTVLSKVTRIRMEELN

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1790376, Length=357, Percent_Identity=23.5294117647059, Blast_Score=62, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6322599, Length=140, Percent_Identity=33.5714285714286, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 47405; Mature: 47405

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: PS01042 HOMOSER_DHGENASE ; PS00318 HMG_COA_REDUCTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPIKIGLLGLGTVGGGTLKVLQRNQEEIRRRAGRGIEVAMIAVRNLDRARAIVQEAGAT
CCCEEEEEEEECCCCCCHHHHHHCCHHHHHHHHCCCCEEEEEEHHCCHHHHHHHHHCCCC
VPVVNDPFAIVDSPEIDIVVELIGGYDLTRELVLRAIANGKHVVTANKALLAVHGNEIFK
CEEECCCEEEECCCCCEEEEEECCCCCHHHHHHHHHHCCCCEEEEECCEEEEEECCHHHH
AAQDKGVMVAFEAAVAGGIPIIKALREGLTANRIEWIAGIINGTTNFILSEMRDKGLDFD
HHCCCCEEEEEECHHHCCCHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCHH
TVLKEAQRLGYAEADPTFDIEGFDAAHKLTLMSAIAFGVPVQFERAYVEGITKLEAVDIR
HHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
YAEELGYRIKLLGITRRVEAGIELRVHPTLVPTKRLIANVEGAMNAVVVNGDAVGPTLYY
HHHHCCCEEEEEEEEEHHCCCEEEEEECCCCCHHHHHHHHCCCCEEEEEECCCCCCEEEE
GKGAGAEPTASAVVADLVDVTRLHTADPEHRVPHLAFQPDALSDTPVLPIDEVRSSYYLR
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCCCCCHHHHCCCEEEE
MRVADETGVLADITRILAEGGISIDAMLQKESREGEPQTDIIMLSHVTVEKRVNAAIAAI
EEECCCCCHHHHHHHHHHHCCCCEEHHHHHHCCCCCCCCCEEEEEEEEHHHHHHHHHHHH
EALPTVLSKVTRIRMEELN
HHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNPIKIGLLGLGTVGGGTLKVLQRNQEEIRRRAGRGIEVAMIAVRNLDRARAIVQEAGAT
CCCEEEEEEEECCCCCCHHHHHHCCHHHHHHHHCCCCEEEEEEHHCCHHHHHHHHHCCCC
VPVVNDPFAIVDSPEIDIVVELIGGYDLTRELVLRAIANGKHVVTANKALLAVHGNEIFK
CEEECCCEEEECCCCCEEEEEECCCCCHHHHHHHHHHCCCCEEEEECCEEEEEECCHHHH
AAQDKGVMVAFEAAVAGGIPIIKALREGLTANRIEWIAGIINGTTNFILSEMRDKGLDFD
HHCCCCEEEEEECHHHCCCHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCHH
TVLKEAQRLGYAEADPTFDIEGFDAAHKLTLMSAIAFGVPVQFERAYVEGITKLEAVDIR
HHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
YAEELGYRIKLLGITRRVEAGIELRVHPTLVPTKRLIANVEGAMNAVVVNGDAVGPTLYY
HHHHCCCEEEEEEEEEHHCCCEEEEEECCCCCHHHHHHHHCCCCEEEEEECCCCCCEEEE
GKGAGAEPTASAVVADLVDVTRLHTADPEHRVPHLAFQPDALSDTPVLPIDEVRSSYYLR
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCCCCCHHHHCCCEEEE
MRVADETGVLADITRILAEGGISIDAMLQKESREGEPQTDIIMLSHVTVEKRVNAAIAAI
EEECCCCCHHHHHHHHHHHCCCCEEHHHHHHCCCCCCCCCEEEEEEEEHHHHHHHHHHHH
EALPTVLSKVTRIRMEELN
HHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]