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The map label for this gene is thrC [H]

Identifier: 187928292

GI number: 187928292

Start: 1290748

End: 1292193

Strand: Direct

Name: thrC [H]

Synonym: Rpic_1203

Alternate gene names: 187928292

Gene position: 1290748-1292193 (Clockwise)

Preceding gene: 187928291

Following gene: 187928293

Centisome position: 32.74

GC content: 63.28

Gene sequence:

>1446_bases
ATGCAATACCGATCGACCCGCGGCCACGCAGAGCCGCAAAGCTTCTCCCGCATCCTGCTGGGCGGCCTGGCGCCGGACGG
TGGCCTGTACCTGCCTGAGCAATACCCGCAAGTCAGCGTTGATGAACTGACCCGCTGGCGCGACCTGCCGTACGCCGACC
TCGCGTTCGAAATCCTGCGCAAGTTCGCCACCGACATTCCCGAGGATGACCTGCGCGCACTGACCCGCCGCACCTACACG
CCTGAGGTCTACAGCAACGCGCGCGCCGGCGACAATACCGCCGACATCACGCCGCTGCACAAGCTGGGCGAGGAGGGCGG
CACGTCGCTGTCGCTGCTGTGCCTGTCCAACGGCCCGACGCTGGCCTTCAAGGACATGGCGATGCAGCTGCTGGGCAACC
TGTTCGAATACGCGCTCGACCGTGAACACGCCGAGCTGAACATCCTCGGCGCCACCTCCGGCGACACGGGCAGCGCAGCC
GAATACGCGATGCGCGGCAAGCGCGGCGTGCGTGTATTCATGCTGAGCCCGCATCGCAAGATGAGCGCGTTCCAGACCGC
GCAGATGTTCAGCCTGCAAGACAAGAACATCTTCAACATCGCCATCGAAGGCGTGTTCGACGACGCGCAGGACATCGTCA
AGGCGGTGTCGAACGATCTCGAATACAAGGCACGCCAGAAGATCGGCACGGTCAACTCGATCAACTGGGCGCGCGTCGTC
GCCCAGGTCGTCTACTACTTCAAGGGCTACCTGCTGGCTGCCCCCAAGATTGGCGACAAGGTGTCGTTCTGCGTGCCGTC
GGGCAATTTCGGCAATGTTTGCGCGGGCCACATCGCACGCATGATGGGTTTGCCGATCGACAAGCTGGTTGTGGCCACCA
ACGAGAACGACGTGCTCGACGAATTCTTCCGCACCGGCACGTACCGCGTGCGTTCGGCTGCCCAGACGTATCACACGTCC
AGCCCCAGCATGGACATCAGCAAGGCGTCGAACTTCGAGCGCTTCGTGTTCGACCTGTTGGATCGTGATCCGGCGCGCCT
CGCGCAACTCTTCCGCGACGTGGACGAAAAGGGCGGCTTTTCGATGACGGGCAAGCCGGAGTTCGACCGCATCGCCGAGT
TCGGCTTTGTCTCGGGCCGCAGCTCGCACGAAGACCGCGTCGATACGATCCGCGATGTGTTTGCCACCTACGGCACCATG
ATCGACACCCACACTGCCGATGGCGTGAAAGTGGCGCGCGAGAACCTGACGCCGGGCGTGCCGATGGTGGTGCTGGAAAC
GGCGCTGCCGGCCAAATTTGGCGACACCATTCGCGAAGCGCTGGACCGCGAGCCGGAACGTCCGGCTGGCTACGCCGATA
TCGAATCGCTGCCGCAGCGCTTCGAAGTCATGCCGGCAGACGCTGACCGCATCAAGGTCTATATCGCCCAGCACACCGGT
CTTTAA

Upstream 100 bases:

>100_bases
CGTGAACGCCGCCATCGCCGCCATCGAAGCGTTGCCGACCGTGCTGTCGAAGGTCACGCGCATCCGCATGGAAGAACTGA
ACTAAGCGCAGGACATGAGC

Downstream 100 bases:

>100_bases
AGCGATGAAAGCAGTGCCGGATGACGTGGCCGGAGCAGCGTTCGCGCGCTGCCTGCACGACATCCGCGCCTGCCGCGAGT
GCAAGGGCGCATTGGCGCAC

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 481; Mature: 481

Protein sequence:

>481_residues
MQYRSTRGHAEPQSFSRILLGGLAPDGGLYLPEQYPQVSVDELTRWRDLPYADLAFEILRKFATDIPEDDLRALTRRTYT
PEVYSNARAGDNTADITPLHKLGEEGGTSLSLLCLSNGPTLAFKDMAMQLLGNLFEYALDREHAELNILGATSGDTGSAA
EYAMRGKRGVRVFMLSPHRKMSAFQTAQMFSLQDKNIFNIAIEGVFDDAQDIVKAVSNDLEYKARQKIGTVNSINWARVV
AQVVYYFKGYLLAAPKIGDKVSFCVPSGNFGNVCAGHIARMMGLPIDKLVVATNENDVLDEFFRTGTYRVRSAAQTYHTS
SPSMDISKASNFERFVFDLLDRDPARLAQLFRDVDEKGGFSMTGKPEFDRIAEFGFVSGRSSHEDRVDTIRDVFATYGTM
IDTHTADGVKVARENLTPGVPMVVLETALPAKFGDTIREALDREPERPAGYADIESLPQRFEVMPADADRIKVYIAQHTG
L

Sequences:

>Translated_481_residues
MQYRSTRGHAEPQSFSRILLGGLAPDGGLYLPEQYPQVSVDELTRWRDLPYADLAFEILRKFATDIPEDDLRALTRRTYT
PEVYSNARAGDNTADITPLHKLGEEGGTSLSLLCLSNGPTLAFKDMAMQLLGNLFEYALDREHAELNILGATSGDTGSAA
EYAMRGKRGVRVFMLSPHRKMSAFQTAQMFSLQDKNIFNIAIEGVFDDAQDIVKAVSNDLEYKARQKIGTVNSINWARVV
AQVVYYFKGYLLAAPKIGDKVSFCVPSGNFGNVCAGHIARMMGLPIDKLVVATNENDVLDEFFRTGTYRVRSAAQTYHTS
SPSMDISKASNFERFVFDLLDRDPARLAQLFRDVDEKGGFSMTGKPEFDRIAEFGFVSGRSSHEDRVDTIRDVFATYGTM
IDTHTADGVKVARENLTPGVPMVVLETALPAKFGDTIREALDREPERPAGYADIESLPQRFEVMPADADRIKVYIAQHTG
L
>Mature_481_residues
MQYRSTRGHAEPQSFSRILLGGLAPDGGLYLPEQYPQVSVDELTRWRDLPYADLAFEILRKFATDIPEDDLRALTRRTYT
PEVYSNARAGDNTADITPLHKLGEEGGTSLSLLCLSNGPTLAFKDMAMQLLGNLFEYALDREHAELNILGATSGDTGSAA
EYAMRGKRGVRVFMLSPHRKMSAFQTAQMFSLQDKNIFNIAIEGVFDDAQDIVKAVSNDLEYKARQKIGTVNSINWARVV
AQVVYYFKGYLLAAPKIGDKVSFCVPSGNFGNVCAGHIARMMGLPIDKLVVATNENDVLDEFFRTGTYRVRSAAQTYHTS
SPSMDISKASNFERFVFDLLDRDPARLAQLFRDVDEKGGFSMTGKPEFDRIAEFGFVSGRSSHEDRVDTIRDVFATYGTM
IDTHTADGVKVARENLTPGVPMVVLETALPAKFGDTIREALDREPERPAGYADIESLPQRFEVMPADADRIKVYIAQHTG
L

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI153792148, Length=452, Percent_Identity=32.9646017699115, Blast_Score=206, Evalue=4e-53,
Organism=Homo sapiens, GI149193323, Length=473, Percent_Identity=28.9640591966173, Blast_Score=194, Evalue=2e-49,
Organism=Escherichia coli, GI1786185, Length=481, Percent_Identity=29.1060291060291, Blast_Score=184, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6319901, Length=470, Percent_Identity=39.7872340425532, Blast_Score=310, Evalue=3e-85,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 53423; Mature: 53423

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQYRSTRGHAEPQSFSRILLGGLAPDGGLYLPEQYPQVSVDELTRWRDLPYADLAFEILR
CCCCCCCCCCCHHHHHHHHHHCCCCCCCEECCCCCCCCCHHHHHHHHCCCHHHHHHHHHH
KFATDIPEDDLRALTRRTYTPEVYSNARAGDNTADITPLHKLGEEGGTSLSLLCLSNGPT
HHHHCCCHHHHHHHHHCCCCCHHHCCCCCCCCCCCCCHHHHHHCCCCCEEEEEEECCCCC
LAFKDMAMQLLGNLFEYALDREHAELNILGATSGDTGSAAEYAMRGKRGVRVFMLSPHRK
CHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHCCCCCCEEEEECCCHH
MSAFQTAQMFSLQDKNIFNIAIEGVFDDAQDIVKAVSNDLEYKARQKIGTVNSINWARVV
HHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
AQVVYYFKGYLLAAPKIGDKVSFCVPSGNFGNVCAGHIARMMGLPIDKLVVATNENDVLD
HHHHHHHHHHEEECCCCCCCEEEEECCCCCCCHHHHHHHHHHCCCHHHEEEECCCCHHHH
EFFRTGTYRVRSAAQTYHTSSPSMDISKASNFERFVFDLLDRDPARLAQLFRDVDEKGGF
HHHHCCCHHHHHHHHHHCCCCCCCCHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCC
SMTGKPEFDRIAEFGFVSGRSSHEDRVDTIRDVFATYGTMIDTHTADGVKVARENLTPGV
CCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCC
PMVVLETALPAKFGDTIREALDREPERPAGYADIESLPQRFEVMPADADRIKVYIAQHTG
CHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEEEECCC
L
C
>Mature Secondary Structure
MQYRSTRGHAEPQSFSRILLGGLAPDGGLYLPEQYPQVSVDELTRWRDLPYADLAFEILR
CCCCCCCCCCCHHHHHHHHHHCCCCCCCEECCCCCCCCCHHHHHHHHCCCHHHHHHHHHH
KFATDIPEDDLRALTRRTYTPEVYSNARAGDNTADITPLHKLGEEGGTSLSLLCLSNGPT
HHHHCCCHHHHHHHHHCCCCCHHHCCCCCCCCCCCCCHHHHHHCCCCCEEEEEEECCCCC
LAFKDMAMQLLGNLFEYALDREHAELNILGATSGDTGSAAEYAMRGKRGVRVFMLSPHRK
CHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHCCCCCCEEEEECCCHH
MSAFQTAQMFSLQDKNIFNIAIEGVFDDAQDIVKAVSNDLEYKARQKIGTVNSINWARVV
HHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
AQVVYYFKGYLLAAPKIGDKVSFCVPSGNFGNVCAGHIARMMGLPIDKLVVATNENDVLD
HHHHHHHHHHEEECCCCCCCEEEEECCCCCCCHHHHHHHHHHCCCHHHEEEECCCCHHHH
EFFRTGTYRVRSAAQTYHTSSPSMDISKASNFERFVFDLLDRDPARLAQLFRDVDEKGGF
HHHHCCCHHHHHHHHHHCCCCCCCCHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCC
SMTGKPEFDRIAEFGFVSGRSSHEDRVDTIRDVFATYGTMIDTHTADGVKVARENLTPGV
CCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCC
PMVVLETALPAKFGDTIREALDREPERPAGYADIESLPQRFEVMPADADRIKVYIAQHTG
CHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEEEECCC
L
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8117070 [H]