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The map label for this gene is kynU [H]

Identifier: 187927805

GI number: 187927805

Start: 745092

End: 746345

Strand: Reverse

Name: kynU [H]

Synonym: Rpic_0709

Alternate gene names: 187927805

Gene position: 746345-745092 (Counterclockwise)

Preceding gene: 187927806

Following gene: 187927804

Centisome position: 18.93

GC content: 65.47

Gene sequence:

>1254_bases
ATGACCATCACCCGCAACTCCTGCCTCGAACGCGACGCGGCCGATCCGATCGCCACGCTGCGCGACGCCTTTGCACTGCC
CGACGGCGTGATTTACCTCGACGGCAACTCGCTGGGCGCCCGCCCGAAAACTGCGCTTGCCCGCGCGCAGGAAGTCGTCG
CCAACGAATGGGGCGACGGCCTCATCCGCAGCTGGAACCAGGCAGGCTGGTTTGAACTGCCGCGCCGCCTGGGCAACAAG
CTGGCGCCGCTGATTGGTGCGCGTGAAGATGAAGTCGTCGTCACCGACACCACATCGATCAACCTGTTCAAGGTGCTGGC
CGCCGCGATTCGCGTGCAGCGCGAAGACGCGCCAGGCCGCAAGATCATCGTGTCGGAAACGCACAATTTTCCGACCGATC
TGTACATCGCTGAAGGACTGGCCGACCTGCTGCGCGACGGCTACAAACTGCGCCTGATAGACTCGCCGGAAGAACTGGAA
GGCGCGCTGGGCGACGACGTCGCCGTCACCATGCTGACGCATGTGAACTACAAGAGCGGCCACATGTACGACATGGCGGC
CGTCTCGGCGCTGGCGCACAAGCACGGCGCGCTGGCCATCTGGGATCTGGCGCATTCGGCGGGCGCTGTGCCCGTTGACC
TGCACGCAGGCGGCGCGGATTACGCCATCGGCTGTACCTACAAATACCTCAACGGCGGCCCCGGCTCGCCAGCCTTCGTG
TGGGTGGCACCGGCGTTGCGCGAGCGCTTCTGGCAGCCGCTATCGGGCTGGTGGGGGCACGCGCGGCCGTTCGCGATGGA
GTCGCGCTACGACGCCGATGCCGGCATCGGCCGCTTCCTGTGCGGCACACAACCGATCACGTCGATGGCGATGGTGGAAT
GCGGGCTCGACATCTTCGCGCAGACGTCGATGGCCGCGCTGCGTGCCAAGTCGCTCGCGCTCACCGACCTCTTCATCACG
CTGGTGGAAACCCGCTGCGCTGGCTTTCCGCTCACGCTCGTCACGCCGCGCGAGCACGCCGTACGCGGCAGCCACGTCAG
CTACGAACACCCCAACGGCTATGCCGTGGTGCAGGCGCTGATTGCGCGAGGTGTGATCGGCGACTACCGCGAGCCGCGCA
TCATGCGCTTCGGTTTCACGCCGCTCTACACGAGCTATGCCGATGTGTGGGATGCCGTGGAAATTCTGCGCGATGTGCTG
GAAACCGGCGCATGGCAATCGGCCCAATTCAACGAACGTACGCTGGTGACCTGA

Upstream 100 bases:

>100_bases
TCGCCACCCTCGATGCCAGCCCGGTTCGCGCCGTGCTGCGCAGCCTGCCCTGATCGATACAACGACAGAACACAAACCGC
TTTTTCGCTCCCGTAATCAC

Downstream 100 bases:

>100_bases
GATGTCGAACCCGAATCAACCCGCAGCATCGGGCTGCCCCATGCAAGCCGCCCAGGGCGAGGGCTGGCACGACGCACAGC
TCGATTTCTCGAAGTCGATG

Product: kynureninase

Products: NA

Alternate protein names: L-kynurenine hydrolase [H]

Number of amino acids: Translated: 417; Mature: 416

Protein sequence:

>417_residues
MTITRNSCLERDAADPIATLRDAFALPDGVIYLDGNSLGARPKTALARAQEVVANEWGDGLIRSWNQAGWFELPRRLGNK
LAPLIGAREDEVVVTDTTSINLFKVLAAAIRVQREDAPGRKIIVSETHNFPTDLYIAEGLADLLRDGYKLRLIDSPEELE
GALGDDVAVTMLTHVNYKSGHMYDMAAVSALAHKHGALAIWDLAHSAGAVPVDLHAGGADYAIGCTYKYLNGGPGSPAFV
WVAPALRERFWQPLSGWWGHARPFAMESRYDADAGIGRFLCGTQPITSMAMVECGLDIFAQTSMAALRAKSLALTDLFIT
LVETRCAGFPLTLVTPREHAVRGSHVSYEHPNGYAVVQALIARGVIGDYREPRIMRFGFTPLYTSYADVWDAVEILRDVL
ETGAWQSAQFNERTLVT

Sequences:

>Translated_417_residues
MTITRNSCLERDAADPIATLRDAFALPDGVIYLDGNSLGARPKTALARAQEVVANEWGDGLIRSWNQAGWFELPRRLGNK
LAPLIGAREDEVVVTDTTSINLFKVLAAAIRVQREDAPGRKIIVSETHNFPTDLYIAEGLADLLRDGYKLRLIDSPEELE
GALGDDVAVTMLTHVNYKSGHMYDMAAVSALAHKHGALAIWDLAHSAGAVPVDLHAGGADYAIGCTYKYLNGGPGSPAFV
WVAPALRERFWQPLSGWWGHARPFAMESRYDADAGIGRFLCGTQPITSMAMVECGLDIFAQTSMAALRAKSLALTDLFIT
LVETRCAGFPLTLVTPREHAVRGSHVSYEHPNGYAVVQALIARGVIGDYREPRIMRFGFTPLYTSYADVWDAVEILRDVL
ETGAWQSAQFNERTLVT
>Mature_416_residues
TITRNSCLERDAADPIATLRDAFALPDGVIYLDGNSLGARPKTALARAQEVVANEWGDGLIRSWNQAGWFELPRRLGNKL
APLIGAREDEVVVTDTTSINLFKVLAAAIRVQREDAPGRKIIVSETHNFPTDLYIAEGLADLLRDGYKLRLIDSPEELEG
ALGDDVAVTMLTHVNYKSGHMYDMAAVSALAHKHGALAIWDLAHSAGAVPVDLHAGGADYAIGCTYKYLNGGPGSPAFVW
VAPALRERFWQPLSGWWGHARPFAMESRYDADAGIGRFLCGTQPITSMAMVECGLDIFAQTSMAALRAKSLALTDLFITL
VETRCAGFPLTLVTPREHAVRGSHVSYEHPNGYAVVQALIARGVIGDYREPRIMRFGFTPLYTSYADVWDAVEILRDVLE
TGAWQSAQFNERTLVT

Specific function: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively [H]

COG id: COG3844

COG function: function code E; Kynureninase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kynureninase family [H]

Homologues:

Organism=Homo sapiens, GI4504937, Length=442, Percent_Identity=26.4705882352941, Blast_Score=149, Evalue=5e-36,
Organism=Homo sapiens, GI74101437, Length=255, Percent_Identity=25.8823529411765, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17550466, Length=429, Percent_Identity=27.039627039627, Blast_Score=152, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6323261, Length=461, Percent_Identity=27.9826464208243, Blast_Score=150, Evalue=3e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR010111
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =3.7.1.3 [H]

Molecular weight: Translated: 45617; Mature: 45486

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: PS00630 IMP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTITRNSCLERDAADPIATLRDAFALPDGVIYLDGNSLGARPKTALARAQEVVANEWGDG
CCCCCCHHHCCCCCCHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHCCCH
LIRSWNQAGWFELPRRLGNKLAPLIGAREDEVVVTDTTSINLFKVLAAAIRVQREDAPGR
HHHCCCCCCHHHHHHHHCHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHCCCCCCC
KIIVSETHNFPTDLYIAEGLADLLRDGYKLRLIDSPEELEGALGDDVAVTMLTHVNYKSG
EEEEECCCCCCCHHHHHHHHHHHHHCCEEEEEECCHHHHHHCCCCCCEEEHHHHCCCCCC
HMYDMAAVSALAHKHGALAIWDLAHSAGAVPVDLHAGGADYAIGCTYKYLNGGPGSPAFV
CCHHHHHHHHHHHCCCCEEEEEHHHCCCCCEEEEECCCCCEEEEEEEEECCCCCCCCEEE
WVAPALRERFWQPLSGWWGHARPFAMESRYDADAGIGRFLCGTQPITSMAMVECGLDIFA
EECHHHHHHHHCHHHCCCCCCCCCEECCCCCCCCCCCHHHCCCCCHHHHHHHHHCHHHHH
QTSMAALRAKSLALTDLFITLVETRCAGFPLTLVTPREHAVRGSHVSYEHPNGYAVVQAL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHCCCCCCCCCCCCCHHHHHHH
IARGVIGDYREPRIMRFGFTPLYTSYADVWDAVEILRDVLETGAWQSAQFNERTLVT
HHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TITRNSCLERDAADPIATLRDAFALPDGVIYLDGNSLGARPKTALARAQEVVANEWGDG
CCCCCHHHCCCCCCHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHCCCH
LIRSWNQAGWFELPRRLGNKLAPLIGAREDEVVVTDTTSINLFKVLAAAIRVQREDAPGR
HHHCCCCCCHHHHHHHHCHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHCCCCCCC
KIIVSETHNFPTDLYIAEGLADLLRDGYKLRLIDSPEELEGALGDDVAVTMLTHVNYKSG
EEEEECCCCCCCHHHHHHHHHHHHHCCEEEEEECCHHHHHHCCCCCCEEEHHHHCCCCCC
HMYDMAAVSALAHKHGALAIWDLAHSAGAVPVDLHAGGADYAIGCTYKYLNGGPGSPAFV
CCHHHHHHHHHHHCCCCEEEEEHHHCCCCCEEEEECCCCCEEEEEEEEECCCCCCCCEEE
WVAPALRERFWQPLSGWWGHARPFAMESRYDADAGIGRFLCGTQPITSMAMVECGLDIFA
EECHHHHHHHHCHHHCCCCCCCCCEECCCCCCCCCCCHHHCCCCCHHHHHHHHHCHHHHH
QTSMAALRAKSLALTDLFITLVETRCAGFPLTLVTPREHAVRGSHVSYEHPNGYAVVQAL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHCCCCCCCCCCCCCHHHHHHH
IARGVIGDYREPRIMRFGFTPLYTSYADVWDAVEILRDVLETGAWQSAQFNERTLVT
HHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA