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The map label for this gene is kynA

Identifier: 187927804

GI number: 187927804

Start: 744215

End: 745051

Strand: Reverse

Name: kynA

Synonym: Rpic_0708

Alternate gene names: 187927804

Gene position: 745051-744215 (Counterclockwise)

Preceding gene: 187927805

Following gene: 187927802

Centisome position: 18.9

GC content: 61.53

Gene sequence:

>837_bases
ATGCAAGCCGCCCAGGGCGAGGGCTGGCACGACGCACAGCTCGATTTCTCGAAGTCGATGAGCTATGGCGACTACCTCGC
GCTCGACCAGATCCTGAACGCGCAGCACCCGCGCTCGCCGGATCACAACGAGATGCTCTTCATCGTTCAGCATCAGACCA
CCGAGCTGTGGATGAAGCTGATGCTGCACGAGTTGCGCGCCGCGCGGGATTGCGTGCGCAATGACAACCTGCCGCCTGCG
TTCAAGATGCTGGCGCGCGTGTCGCGCATCATGGATCAGCTGGTGCAGGCGTGGAACGTGCTCGCCACTATGACGCCGCC
GGAGTACTCGGCCATGCGTCCGCACCTCGGGCAATCGTCAGGCTTTCAGTCGTATCAGTACCGCGAGATCGAGTTCATCC
TCGGCAACAAGAACGCGGCGATGCTCAAGCCGCACGCGCATCGCACCGAGCATTACGAACAGGTCAAGGCTGCGTTGGAA
ACGCCGTCGCTGTACGACGAGGCGGTGCGTTACATGGCGCGTCACGGCTTTGCATTCGACGCAGATTGCATCGAGCGTGA
CTGGTCGCGTCCCGTGACTTACAACGCCTCGGTGGAAGCGGCGTGGCTGGAGGTCTATCGAGACCCGACGCACCACTGGG
AGCTGTACGAGCTGGCTGAGAAGTTCGTCGATCTGGAAGATGCGTTCCGGCAATGGCGCTTCCGGCATGTGACCACGGTC
GAGCGCGTGATTGGCTTCAAGCGTGGCACGGGCGGCACCGAGGGCGTCGGTTACCTGCGGAAGATGCTGGATGTGGTGTT
GTTTCCGGAGCTTTGGAAGTTGCGGACTGATCTTTGA

Upstream 100 bases:

>100_bases
GTGCTGGAAACCGGCGCATGGCAATCGGCCCAATTCAACGAACGTACGCTGGTGACCTGAGATGTCGAACCCGAATCAAC
CCGCAGCATCGGGCTGCCCC

Downstream 100 bases:

>100_bases
TCGACCCGACTCAGGCGGGCTCGGCGACTTGGCCGAGCCTTGCCGCGAACTCTCGCAGCGCGGGGGCCAGTTCGTCGCGG
ATGCGCTCTGCATCGGCGGA

Product: tryptophan 2,3-dioxygenase

Products: NA

Alternate protein names: TDO; Tryptamin 2,3-dioxygenase; Tryptophan oxygenase; TO; TRPO; Tryptophan pyrrolase; Tryptophanase

Number of amino acids: Translated: 278; Mature: 278

Protein sequence:

>278_residues
MQAAQGEGWHDAQLDFSKSMSYGDYLALDQILNAQHPRSPDHNEMLFIVQHQTTELWMKLMLHELRAARDCVRNDNLPPA
FKMLARVSRIMDQLVQAWNVLATMTPPEYSAMRPHLGQSSGFQSYQYREIEFILGNKNAAMLKPHAHRTEHYEQVKAALE
TPSLYDEAVRYMARHGFAFDADCIERDWSRPVTYNASVEAAWLEVYRDPTHHWELYELAEKFVDLEDAFRQWRFRHVTTV
ERVIGFKRGTGGTEGVGYLRKMLDVVLFPELWKLRTDL

Sequences:

>Translated_278_residues
MQAAQGEGWHDAQLDFSKSMSYGDYLALDQILNAQHPRSPDHNEMLFIVQHQTTELWMKLMLHELRAARDCVRNDNLPPA
FKMLARVSRIMDQLVQAWNVLATMTPPEYSAMRPHLGQSSGFQSYQYREIEFILGNKNAAMLKPHAHRTEHYEQVKAALE
TPSLYDEAVRYMARHGFAFDADCIERDWSRPVTYNASVEAAWLEVYRDPTHHWELYELAEKFVDLEDAFRQWRFRHVTTV
ERVIGFKRGTGGTEGVGYLRKMLDVVLFPELWKLRTDL
>Mature_278_residues
MQAAQGEGWHDAQLDFSKSMSYGDYLALDQILNAQHPRSPDHNEMLFIVQHQTTELWMKLMLHELRAARDCVRNDNLPPA
FKMLARVSRIMDQLVQAWNVLATMTPPEYSAMRPHLGQSSGFQSYQYREIEFILGNKNAAMLKPHAHRTEHYEQVKAALE
TPSLYDEAVRYMARHGFAFDADCIERDWSRPVTYNASVEAAWLEVYRDPTHHWELYELAEKFVDLEDAFRQWRFRHVTTV
ERVIGFKRGTGGTEGVGYLRKMLDVVLFPELWKLRTDL

Specific function: Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring

COG id: COG3483

COG function: function code E; Tryptophan 2,3-dioxygenase (vermilion)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tryptophan 2,3-dioxygenase family

Homologues:

Organism=Homo sapiens, GI5032165, Length=338, Percent_Identity=28.1065088757396, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI32564651, Length=159, Percent_Identity=32.0754716981132, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17552370, Length=159, Percent_Identity=32.0754716981132, Blast_Score=77, Evalue=7e-15,
Organism=Drosophila melanogaster, GI17530891, Length=350, Percent_Identity=26.2857142857143, Blast_Score=106, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): T23O_RALPJ (B2U7J7)

Other databases:

- EMBL:   CP001068
- RefSeq:   YP_001898291.1
- ProteinModelPortal:   B2U7J7
- GeneID:   6288350
- GenomeReviews:   CP001068_GR
- KEGG:   rpi:Rpic_0708
- HOGENOM:   HBG647485
- OMA:   HWELYEL
- ProtClustDB:   CLSK896672
- InterPro:   IPR017485
- InterPro:   IPR004981
- PANTHER:   PTHR10138
- TIGRFAMs:   TIGR03036

Pfam domain/function: PF03301 Trp_dioxygenase

EC number: =1.13.11.11

Molecular weight: Translated: 32492; Mature: 32492

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: NA

Important sites: BINDING 109-109 BINDING 113-113 BINDING 120-120 BINDING 250-250

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQAAQGEGWHDAQLDFSKSMSYGDYLALDQILNAQHPRSPDHNEMLFIVQHQTTELWMKL
CCCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHCCCCCCCCCCCCEEEEEECCHHHHHHHH
MLHELRAARDCVRNDNLPPAFKMLARVSRIMDQLVQAWNVLATMTPPEYSAMRPHLGQSS
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCC
GFQSYQYREIEFILGNKNAAMLKPHAHRTEHYEQVKAALETPSLYDEAVRYMARHGFAFD
CCCCCCEEEEEEEECCCCCEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCC
ADCIERDWSRPVTYNASVEAAWLEVYRDPTHHWELYELAEKFVDLEDAFRQWRFRHVTTV
HHHHHHHCCCCEEECCCHHHHHHHHHCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHH
ERVIGFKRGTGGTEGVGYLRKMLDVVLFPELWKLRTDL
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQAAQGEGWHDAQLDFSKSMSYGDYLALDQILNAQHPRSPDHNEMLFIVQHQTTELWMKL
CCCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHCCCCCCCCCCCCEEEEEECCHHHHHHHH
MLHELRAARDCVRNDNLPPAFKMLARVSRIMDQLVQAWNVLATMTPPEYSAMRPHLGQSS
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCC
GFQSYQYREIEFILGNKNAAMLKPHAHRTEHYEQVKAALETPSLYDEAVRYMARHGFAFD
CCCCCCEEEEEEEECCCCCEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCC
ADCIERDWSRPVTYNASVEAAWLEVYRDPTHHWELYELAEKFVDLEDAFRQWRFRHVTTV
HHHHHHHCCCCEEECCCHHHHHHHHHCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHH
ERVIGFKRGTGGTEGVGYLRKMLDVVLFPELWKLRTDL
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA