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The map label for this gene is fchA [H]

Identifier: 187935273

GI number: 187935273

Start: 2538281

End: 2538931

Strand: Reverse

Name: fchA [H]

Synonym: CLL_A2454

Alternate gene names: 187935273

Gene position: 2538931-2538281 (Counterclockwise)

Preceding gene: 187933839

Following gene: 187933242

Centisome position: 66.81

GC content: 28.88

Gene sequence:

>651_bases
ATGGAATTTTATAAACAAACAATAAAAGAATTTATTGGGGATGTAGAAAGTGATAAGGCATCACCAGGTGGTGGAAGTGT
AGCAGGATTATTAGGGGCATTATCAGGGGCATTGAACTCAATGGTGTATTCTTTAACTGTTGGCAAAAAAAAGTACCAAG
AATTAGATGAACAAACTAAAGCTATGATAGATAATTTTAGAGAACAATCTAAAGAGTTTGCATATAGAAGCTTAGAATTA
ATGGAAGAAGATCGAAATGGATTTTTGAAGTTAATGGAATGCTATAAACTTCCTAAAGATACAGATGAGGAAAAATGTAA
TAGAAATAATGCTATAAAAGAAGGTACAAAAGAAGCTATGTTACCACCATTAAAATTAGCCAGAGAATCTTTTGAGTTTT
ACAAAAATCTAGATGTTATGAGCCAATATGGTAACAAAATGCTTTTATCAGACTTAGGCATGTCAGCAATATTACTACAC
TGTACTATAGAAAGTGCAATAATGAATGTCAAAGTTAACTTAAATGGATTAAGAGATGATAAAATATTCTTTAATGAAAT
AAAAGAAGAATTAGATGATTTATTTAATAAATCTAAACACAAAAAAGAAGAGATTGTAGCACAAGTAAATTCAGTTATAT
TTCAAGAATAA

Upstream 100 bases:

>100_bases
AATAAGTTTTATATCCATTATGTTTTGGATATATCTTGGGTATACAATATCTATATTAGATAATAGAAATATAAGCAATA
ATAACTAGGGGGATTTTAAA

Downstream 100 bases:

>100_bases
TAATTTGCAATTAAATCTATGTTTATATATGCAATAGGAAAAATGGCATTGTAATTGGATTTTGAGAATAGTTAAGTGAG
AGTAAAAATTTTATATTTTA

Product: methenyltetrahydrofolate cyclohydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 216; Mature: 216

Protein sequence:

>216_residues
MEFYKQTIKEFIGDVESDKASPGGGSVAGLLGALSGALNSMVYSLTVGKKKYQELDEQTKAMIDNFREQSKEFAYRSLEL
MEEDRNGFLKLMECYKLPKDTDEEKCNRNNAIKEGTKEAMLPPLKLARESFEFYKNLDVMSQYGNKMLLSDLGMSAILLH
CTIESAIMNVKVNLNGLRDDKIFFNEIKEELDDLFNKSKHKKEEIVAQVNSVIFQE

Sequences:

>Translated_216_residues
MEFYKQTIKEFIGDVESDKASPGGGSVAGLLGALSGALNSMVYSLTVGKKKYQELDEQTKAMIDNFREQSKEFAYRSLEL
MEEDRNGFLKLMECYKLPKDTDEEKCNRNNAIKEGTKEAMLPPLKLARESFEFYKNLDVMSQYGNKMLLSDLGMSAILLH
CTIESAIMNVKVNLNGLRDDKIFFNEIKEELDDLFNKSKHKKEEIVAQVNSVIFQE
>Mature_216_residues
MEFYKQTIKEFIGDVESDKASPGGGSVAGLLGALSGALNSMVYSLTVGKKKYQELDEQTKAMIDNFREQSKEFAYRSLEL
MEEDRNGFLKLMECYKLPKDTDEEKCNRNNAIKEGTKEAMLPPLKLARESFEFYKNLDVMSQYGNKMLLSDLGMSAILLH
CTIESAIMNVKVNLNGLRDDKIFFNEIKEELDDLFNKSKHKKEEIVAQVNSVIFQE

Specific function: Required for both C1 and C2 metabolism [H]

COG id: COG3404

COG function: function code E; Methenyl tetrahydrofolate cyclohydrolase

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cyclodeaminase/cyclohydrolase family [H]

Homologues:

Organism=Homo sapiens, GI46255035, Length=162, Percent_Identity=31.4814814814815, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI11140815, Length=162, Percent_Identity=31.4814814814815, Blast_Score=86, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007044 [H]

Pfam domain/function: PF04961 FTCD_C [H]

EC number: =3.5.4.9 [H]

Molecular weight: Translated: 24626; Mature: 24626

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFYKQTIKEFIGDVESDKASPGGGSVAGLLGALSGALNSMVYSLTVGKKKYQELDEQTK
CCHHHHHHHHHHCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AMIDNFREQSKEFAYRSLELMEEDRNGFLKLMECYKLPKDTDEEKCNRNNAIKEGTKEAM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCHHHHCHHHHC
LPPLKLARESFEFYKNLDVMSQYGNKMLLSDLGMSAILLHCTIESAIMNVKVNLNGLRDD
CCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCHHHHHHHHHHHHHHHHEEEECCCCCCH
KIFFNEIKEELDDLFNKSKHKKEEIVAQVNSVIFQE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEFYKQTIKEFIGDVESDKASPGGGSVAGLLGALSGALNSMVYSLTVGKKKYQELDEQTK
CCHHHHHHHHHHCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AMIDNFREQSKEFAYRSLELMEEDRNGFLKLMECYKLPKDTDEEKCNRNNAIKEGTKEAM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCHHHHCHHHHC
LPPLKLARESFEFYKNLDVMSQYGNKMLLSDLGMSAILLHCTIESAIMNVKVNLNGLRDD
CCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCHHHHHHHHHHHHHHHHEEEECCCCCCH
KIFFNEIKEELDDLFNKSKHKKEEIVAQVNSVIFQE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7961516; 10215859 [H]