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The map label for this gene is thrC [H]

Identifier: 187933981

GI number: 187933981

Start: 2977054

End: 2978517

Strand: Reverse

Name: thrC [H]

Synonym: CLL_A2898

Alternate gene names: 187933981

Gene position: 2978517-2977054 (Counterclockwise)

Preceding gene: 187932990

Following gene: 187935091

Centisome position: 78.38

GC content: 29.58

Gene sequence:

>1464_bases
ATGAAGTTTAGAAGCACTAGGGGGCTAGAACATGGAGTGGCTTCTGCAATAGCAATAATAAATGGAATTTCTAAAGATGG
AGGACTTTATGTACCTGAAAGTTTTCCTAATATGTATTCATCATTAAAGAGTAAAATGGAATTTAGTTATGAAGAATTAG
CATTTGAAATTATTAATGGATATTTTACTGATATTGATGATGAGGATTTAAAGGAAGCAATTAATGAAGCATATAATAAT
AGGTTTGAAGTTAAGGTACATAATAACTTTTTAGAACTATATCATGGTCCAACTTGTGCATTTAAGGATGCAGCATTGCT
ATTTCTCCCACAGATAATGAAAAGAGCAAAAAAGATTTGCAACAAAGAGGAAGAAATAGTAATATTAGCAGCGACATCAG
GAGATACAGGAAAAGCAGCATTAGAGGGATTCAAAAATATTGATGGATTTAAAGTAGTTGTATACTATCCTAAAAAAGGT
GTAAGTGCTATACAAGAAAGACAAATGATAACTCAACAAGGCAATAATGTTAAAGTTATCGGAATAAACGGCAATTTTGA
TGATGCACAAAGATCTGTGAAAGAAATATTTGGAGACAATGATTTTAAAGATAACCTATTAAAGAAAGGTGTTGCTTTAT
CATCTGCAAATTCTATAAATATAGGTAGGTTAGTTCCACAAATAGTATATTACTTTTATGGGTATTTCAACTTAGTGAAA
AAAGGGGCTATAAAACAAGGTGAAAAAATTAATGTAGTAGTTCCAACAGGAAACTTTGGAAATATATTGGCATCATACTA
TGCTAAACAAATGGGACTTCCTATAGATAAGTTTATCTGTGCTTCAAATGAAAATAAAGTTTTAACAGATTTCTTTAAAA
GTGGCATTTATGATAAGAGACGTGAACTTGTATTAACAGAATCACCATCAATGGATATCTTAGTATCATCTAATCTTGAG
AGATTGTTATTTGAGGCAAGTGGACGAAATCCAGAAGTTATAAATAATCTTATGAATTCATTGAATGAAAATGGTATATA
TGAAATAAATAATGATATGAAAAAATTTATGAAAGATTTTTACGGAGAATATGCTACAACAGAAGAGGTATCTGATGCAA
TAAAAGAAGTTTATAAAAAAGATAGTTACTTGATGGATACTCATACAGCTGTTGGTTATGTTGTTAAAAATAAATATCAA
GCAGAGACTAATGATACTAAAGAAGTATTAATAGCTTCAACTGCTAGTCCGTTCAAATTTCCAAGAAGTATTTGCAAGGC
ATTAAATATTTCAAATGATGGAATTGATGATTTTGAGGTATTAAAAAAGTTATCTGAAATTACAAAAAACAATATACCTG
AGAGTTTGGCTAATTTATCAGAATATGAAATTTTTCATGATGAAGTTTGGGATAAGTCTGAGATGAAAAAGGCATTACTT
TGTTATCTTGGAATTGAAGGGTAG

Upstream 100 bases:

>100_bases
TTGTATTTAAAATAAAAACACTTGTTTTCTGTATAAGGACATGATAATATAGATATTAAGAAAAGGCATGTCTAATTAAA
TAAAAAATTGGGGTGATTCA

Downstream 100 bases:

>100_bases
ATTATGATTAAAGTTAGAGTGCCAGCTACATCAGCAAATATGGGACCAGGATTTGATTCAATGGGAATGGCAGTGAAAGT
ATATAATGAATTTGCCTTTA

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 487; Mature: 487

Protein sequence:

>487_residues
MKFRSTRGLEHGVASAIAIINGISKDGGLYVPESFPNMYSSLKSKMEFSYEELAFEIINGYFTDIDDEDLKEAINEAYNN
RFEVKVHNNFLELYHGPTCAFKDAALLFLPQIMKRAKKICNKEEEIVILAATSGDTGKAALEGFKNIDGFKVVVYYPKKG
VSAIQERQMITQQGNNVKVIGINGNFDDAQRSVKEIFGDNDFKDNLLKKGVALSSANSINIGRLVPQIVYYFYGYFNLVK
KGAIKQGEKINVVVPTGNFGNILASYYAKQMGLPIDKFICASNENKVLTDFFKSGIYDKRRELVLTESPSMDILVSSNLE
RLLFEASGRNPEVINNLMNSLNENGIYEINNDMKKFMKDFYGEYATTEEVSDAIKEVYKKDSYLMDTHTAVGYVVKNKYQ
AETNDTKEVLIASTASPFKFPRSICKALNISNDGIDDFEVLKKLSEITKNNIPESLANLSEYEIFHDEVWDKSEMKKALL
CYLGIEG

Sequences:

>Translated_487_residues
MKFRSTRGLEHGVASAIAIINGISKDGGLYVPESFPNMYSSLKSKMEFSYEELAFEIINGYFTDIDDEDLKEAINEAYNN
RFEVKVHNNFLELYHGPTCAFKDAALLFLPQIMKRAKKICNKEEEIVILAATSGDTGKAALEGFKNIDGFKVVVYYPKKG
VSAIQERQMITQQGNNVKVIGINGNFDDAQRSVKEIFGDNDFKDNLLKKGVALSSANSINIGRLVPQIVYYFYGYFNLVK
KGAIKQGEKINVVVPTGNFGNILASYYAKQMGLPIDKFICASNENKVLTDFFKSGIYDKRRELVLTESPSMDILVSSNLE
RLLFEASGRNPEVINNLMNSLNENGIYEINNDMKKFMKDFYGEYATTEEVSDAIKEVYKKDSYLMDTHTAVGYVVKNKYQ
AETNDTKEVLIASTASPFKFPRSICKALNISNDGIDDFEVLKKLSEITKNNIPESLANLSEYEIFHDEVWDKSEMKKALL
CYLGIEG
>Mature_487_residues
MKFRSTRGLEHGVASAIAIINGISKDGGLYVPESFPNMYSSLKSKMEFSYEELAFEIINGYFTDIDDEDLKEAINEAYNN
RFEVKVHNNFLELYHGPTCAFKDAALLFLPQIMKRAKKICNKEEEIVILAATSGDTGKAALEGFKNIDGFKVVVYYPKKG
VSAIQERQMITQQGNNVKVIGINGNFDDAQRSVKEIFGDNDFKDNLLKKGVALSSANSINIGRLVPQIVYYFYGYFNLVK
KGAIKQGEKINVVVPTGNFGNILASYYAKQMGLPIDKFICASNENKVLTDFFKSGIYDKRRELVLTESPSMDILVSSNLE
RLLFEASGRNPEVINNLMNSLNENGIYEINNDMKKFMKDFYGEYATTEEVSDAIKEVYKKDSYLMDTHTAVGYVVKNKYQ
AETNDTKEVLIASTASPFKFPRSICKALNISNDGIDDFEVLKKLSEITKNNIPESLANLSEYEIFHDEVWDKSEMKKALL
CYLGIEG

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI153792148, Length=435, Percent_Identity=41.8390804597701, Blast_Score=301, Evalue=1e-81,
Organism=Homo sapiens, GI149193323, Length=444, Percent_Identity=29.5045045045045, Blast_Score=190, Evalue=3e-48,
Organism=Escherichia coli, GI1786185, Length=476, Percent_Identity=28.781512605042, Blast_Score=176, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6319901, Length=465, Percent_Identity=37.4193548387097, Blast_Score=279, Evalue=6e-76,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 54856; Mature: 54856

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFRSTRGLEHGVASAIAIINGISKDGGLYVPESFPNMYSSLKSKMEFSYEELAFEIING
CCCCCCCCHHHHHHHHHHHHHCCCCCCCEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHH
YFTDIDDEDLKEAINEAYNNRFEVKVHNNFLELYHGPTCAFKDAALLFLPQIMKRAKKIC
HHCCCCHHHHHHHHHHHHCCEEEEEEECCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
NKEEEIVILAATSGDTGKAALEGFKNIDGFKVVVYYPKKGVSAIQERQMITQQGNNVKVI
CCCCCEEEEEECCCCCCHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCEEEE
GINGNFDDAQRSVKEIFGDNDFKDNLLKKGVALSSANSINIGRLVPQIVYYFYGYFNLVK
EECCCCHHHHHHHHHHHCCCCHHHHHHHCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHH
KGAIKQGEKINVVVPTGNFGNILASYYAKQMGLPIDKFICASNENKVLTDFFKSGIYDKR
HHHCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCHHHHEECCCCCCHHHHHHHCCCCCCC
RELVLTESPSMDILVSSNLERLLFEASGRNPEVINNLMNSLNENGIYEINNDMKKFMKDF
CCEEEECCCCCEEEECCCHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEECHHHHHHHHHH
YGEYATTEEVSDAIKEVYKKDSYLMDTHTAVGYVVKNKYQAETNDTKEVLIASTASPFKF
CCCCCCHHHHHHHHHHHHHCCCEEEECHHHHHHHHHCCCCCCCCCCCEEEEECCCCCHHH
PRSICKALNISNDGIDDFEVLKKLSEITKNNIPESLANLSEYEIFHDEVWDKSEMKKALL
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHH
CYLGIEG
HHCCCCC
>Mature Secondary Structure
MKFRSTRGLEHGVASAIAIINGISKDGGLYVPESFPNMYSSLKSKMEFSYEELAFEIING
CCCCCCCCHHHHHHHHHHHHHCCCCCCCEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHH
YFTDIDDEDLKEAINEAYNNRFEVKVHNNFLELYHGPTCAFKDAALLFLPQIMKRAKKIC
HHCCCCHHHHHHHHHHHHCCEEEEEEECCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
NKEEEIVILAATSGDTGKAALEGFKNIDGFKVVVYYPKKGVSAIQERQMITQQGNNVKVI
CCCCCEEEEEECCCCCCHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCEEEE
GINGNFDDAQRSVKEIFGDNDFKDNLLKKGVALSSANSINIGRLVPQIVYYFYGYFNLVK
EECCCCHHHHHHHHHHHCCCCHHHHHHHCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHH
KGAIKQGEKINVVVPTGNFGNILASYYAKQMGLPIDKFICASNENKVLTDFFKSGIYDKR
HHHCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCHHHHEECCCCCCHHHHHHHCCCCCCC
RELVLTESPSMDILVSSNLERLLFEASGRNPEVINNLMNSLNENGIYEINNDMKKFMKDF
CCEEEECCCCCEEEECCCHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEECHHHHHHHHHH
YGEYATTEEVSDAIKEVYKKDSYLMDTHTAVGYVVKNKYQAETNDTKEVLIASTASPFKF
CCCCCCHHHHHHHHHHHHHCCCEEEECHHHHHHHHHCCCCCCCCCCCEEEEECCCCCHHH
PRSICKALNISNDGIDDFEVLKKLSEITKNNIPESLANLSEYEIFHDEVWDKSEMKKALL
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHH
CYLGIEG
HHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]