Click here to switch to the map view.

The map label for this gene is thrB [H]

Identifier: 187935091

GI number: 187935091

Start: 2976154

End: 2977050

Strand: Reverse

Name: thrB [H]

Synonym: CLL_A2897

Alternate gene names: 187935091

Gene position: 2977050-2976154 (Counterclockwise)

Preceding gene: 187933981

Following gene: 187933034

Centisome position: 78.34

GC content: 31.22

Gene sequence:

>897_bases
ATGATTAAAGTTAGAGTGCCAGCTACATCAGCAAATATGGGACCAGGATTTGATTCAATGGGAATGGCAGTGAAAGTATA
TAATGAATTTGCCTTTAGAGAAATAAATAATGGATTAAATTTTAATGGAGTACCAGAAGAATTTTGTAATGAGGATAATA
TAATATATAAGGCTATGAAGTATTGTTTTGATAAGGCAGATTATAAAATTAAGGGGCTTAATATATCTGTATTAAATCAA
GATATACCTATATCAAGAGGACTTGGAAGTAGCTCTAGTTGTATAGTTGGGGGACTAGTTGGAGCTAATGAAATTTTAGG
GGGAAAATTTTCAAAGGATGAACTATTAGAAATGGCTGTTAAAATAGAAGGTCATCCAGATAATGTTGCACCAGCTCTAT
TTGGGGGAATGGTTGTTGCAATAATTGAAAATAATAAGACTGTATACAATAAGATAGAGATTAAAGATAAAGTTAAATTT
ATAACTATAGTACCTGATTTCAGATTATCTACTGAAAAGGCAAGGACGGTTCTTCCAAAACAAATTTCAAGGGCAGATGG
AATTTATAATATTGGGAGAGCAGCACTTATGATTTCTTGCTTTGTTACTGATAGATATGATTTAATAAGAAGTGCTTGTA
ATGATGCACTTCATCAAAATTATAGAAAAGAGTTGATACCTCACTTTGATGACGTTTATAATAAATGTTATGAACTTGGA
GCATTAGGTTGTTATTTGAGTGGTGCAGGACCAACTATTATGGCTATAATCGATAATGGGGCTAATGGCTTTAGCAATAA
TATTAAGCAATATTTAAAAGATAAAGATATTAAATGGGGAGTTTTAGAATTACAAGCAGATAATAAGGGAGCATTTGTAA
TAAAAGGAGATAGTTGA

Upstream 100 bases:

>100_bases
GGCTAATTTATCAGAATATGAAATTTTTCATGATGAAGTTTGGGATAAGTCTGAGATGAAAAAGGCATTACTTTGTTATC
TTGGAATTGAAGGGTAGATT

Downstream 100 bases:

>100_bases
TGAAAGGAAATTACTTAGTTATAGACAAAAGAGTTTTACCCGATGTTTATGAAAAAGTTGTTTTTGCTCAAAAGTTATTG
AAAGATGGCAAGGTTAAAGA

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK [H]

Number of amino acids: Translated: 298; Mature: 298

Protein sequence:

>298_residues
MIKVRVPATSANMGPGFDSMGMAVKVYNEFAFREINNGLNFNGVPEEFCNEDNIIYKAMKYCFDKADYKIKGLNISVLNQ
DIPISRGLGSSSSCIVGGLVGANEILGGKFSKDELLEMAVKIEGHPDNVAPALFGGMVVAIIENNKTVYNKIEIKDKVKF
ITIVPDFRLSTEKARTVLPKQISRADGIYNIGRAALMISCFVTDRYDLIRSACNDALHQNYRKELIPHFDDVYNKCYELG
ALGCYLSGAGPTIMAIIDNGANGFSNNIKQYLKDKDIKWGVLELQADNKGAFVIKGDS

Sequences:

>Translated_298_residues
MIKVRVPATSANMGPGFDSMGMAVKVYNEFAFREINNGLNFNGVPEEFCNEDNIIYKAMKYCFDKADYKIKGLNISVLNQ
DIPISRGLGSSSSCIVGGLVGANEILGGKFSKDELLEMAVKIEGHPDNVAPALFGGMVVAIIENNKTVYNKIEIKDKVKF
ITIVPDFRLSTEKARTVLPKQISRADGIYNIGRAALMISCFVTDRYDLIRSACNDALHQNYRKELIPHFDDVYNKCYELG
ALGCYLSGAGPTIMAIIDNGANGFSNNIKQYLKDKDIKWGVLELQADNKGAFVIKGDS
>Mature_298_residues
MIKVRVPATSANMGPGFDSMGMAVKVYNEFAFREINNGLNFNGVPEEFCNEDNIIYKAMKYCFDKADYKIKGLNISVLNQ
DIPISRGLGSSSSCIVGGLVGANEILGGKFSKDELLEMAVKIEGHPDNVAPALFGGMVVAIIENNKTVYNKIEIKDKVKF
ITIVPDFRLSTEKARTVLPKQISRADGIYNIGRAALMISCFVTDRYDLIRSACNDALHQNYRKELIPHFDDVYNKCYELG
ALGCYLSGAGPTIMAIIDNGANGFSNNIKQYLKDKDIKWGVLELQADNKGAFVIKGDS

Specific function: Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate [H]

COG id: COG0083

COG function: function code E; Homoserine kinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Homoserine kinase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786184, Length=320, Percent_Identity=30.3125, Blast_Score=125, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6321814, Length=348, Percent_Identity=29.3103448275862, Blast_Score=136, Evalue=4e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR000870
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.39 [H]

Molecular weight: Translated: 32809; Mature: 32809

Theoretical pI: Translated: 7.27; Mature: 7.27

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKVRVPATSANMGPGFDSMGMAVKVYNEFAFREINNGLNFNGVPEEFCNEDNIIYKAMK
CEEEEECCCCCCCCCCCCCCCCEEEHHHHHHHHHHCCCCCCCCCCHHHCCCCCHHHHHHH
YCFDKADYKIKGLNISVLNQDIPISRGLGSSSSCIVGGLVGANEILGGKFSKDELLEMAV
HHHCCCCCEEECCEEEEECCCCCCCCCCCCCCCEEEEECCCCHHHCCCCCCHHHHHEEHE
KIEGHPDNVAPALFGGMVVAIIENNKTVYNKIEIKDKVKFITIVPDFRLSTEKARTVLPK
EECCCCCCCCHHHHCCEEEEEEECCCEEEEEEEEECCEEEEEEECCCCCCHHHHHHHHHH
QISRADGIYNIGRAALMISCFVTDRYDLIRSACNDALHQNYRKELIPHFDDVYNKCYELG
HHHHCCCCHHHCHHHHEEEHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHC
ALGCYLSGAGPTIMAIIDNGANGFSNNIKQYLKDKDIKWGVLELQADNKGAFVIKGDS
CCEEEEECCCCEEEEEEECCCCCHHHHHHHHHHCCCCCEEEEEEEECCCCEEEEECCC
>Mature Secondary Structure
MIKVRVPATSANMGPGFDSMGMAVKVYNEFAFREINNGLNFNGVPEEFCNEDNIIYKAMK
CEEEEECCCCCCCCCCCCCCCCEEEHHHHHHHHHHCCCCCCCCCCHHHCCCCCHHHHHHH
YCFDKADYKIKGLNISVLNQDIPISRGLGSSSSCIVGGLVGANEILGGKFSKDELLEMAV
HHHCCCCCEEECCEEEEECCCCCCCCCCCCCCCEEEEECCCCHHHCCCCCCHHHHHEEHE
KIEGHPDNVAPALFGGMVVAIIENNKTVYNKIEIKDKVKFITIVPDFRLSTEKARTVLPK
EECCCCCCCCHHHHCCEEEEEEECCCEEEEEEEEECCEEEEEEECCCCCCHHHHHHHHHH
QISRADGIYNIGRAALMISCFVTDRYDLIRSACNDALHQNYRKELIPHFDDVYNKCYELG
HHHHCCCCHHHCHHHHEEEHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHC
ALGCYLSGAGPTIMAIIDNGANGFSNNIKQYLKDKDIKWGVLELQADNKGAFVIKGDS
CCEEEEECCCCEEEEEEECCCCCHHHHHHHHHHCCCCCEEEEEEEECCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA