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The map label for this gene is hemC [H]

Identifier: 187933878

GI number: 187933878

Start: 2988062

End: 2988934

Strand: Reverse

Name: hemC [H]

Synonym: CLL_A2907

Alternate gene names: 187933878

Gene position: 2988934-2988062 (Counterclockwise)

Preceding gene: 187935213

Following gene: 187934684

Centisome position: 78.65

GC content: 29.32

Gene sequence:

>873_bases
ATGAATGAATTAATAATAGCAACTAGAAAAAGTAAGTTGGCTCAAGTTCAAACTGAAATAATTATGGGAAAATTGAAATC
AAAATTTAATATAGATAGTAAAAAATTACTTATAGTAACTGAGGGTGACAGAAAGTTAGATGTTTCATTAAATAAAATAG
GTGGTAAGGGACTTTTTGTTAAGGATATAGAACTTGCTCTTTTAAATAAGGAAGCTCATGCTGCAGTTCATAGTATGAAA
GATGTTCCTTTTGAAGTTAGTAGTGAATTTGAAATTACAGCTATAACAGGAAGAGAAGATATAAGGGATGTATTTATTTC
AAATGGAGATATCTCATTTAAAGATATTAAAAAAGGCGCTAAAGTAGGAACAAGTAGTATAAGAAGAGCAGCACAACTAA
AACTTCTAAGAAGTGATTTAGAGATAGTACCTATAAGAGGCAATGTTCAAACTAGATTAAAGAAAATGGAAGAACAAAAT
TTAGATGGAATCGTGCTAGCAGCAGCAGGTCTTAAAAGACTTGGTGATGAAAATTTAATAACAGATTATTTTGATCCAAA
AGAATTTTTACCAGCAGTTTCTCAAGGGGCACTTGGAATTGAGTGTTTAAAAGATGGTGATGCCAATAAATATTTTGAAG
CTTTAATAGATGCAGAAGCAACTTTAACTGTGGAAGCTGAAAGAAGTTTTATGAAAGAATTACAAGGAGATTGTCATAGC
CTTATTGGAGCTTATTCTGAAATTCAAGGTGATGATTTATATATGATTGGAATATATGATATAGGTGGAAAAATAGTTAA
AAAAGATATTTTAGGATGCAAAACTAATAATATTGAATTAGGAAAGAAATTAGCACAAAAAATATTAGGATAA

Upstream 100 bases:

>100_bases
TAGTATTAAAACTCTATTTTGAAGAAGAAATATTAAATAAGTTAATATAGATTATATTTAAATCAAAAAATTTCACTAGA
TAAAGGAGCAGTAAAAAATA

Downstream 100 bases:

>100_bases
TGTTGTTTAAGTATGATATGGATATTTTAATATAAAGCTAATATAGAGGAAACTTAATTTTAAGAATTATGAAAAATAAA
TTCCAATGATACAGTGTTTT

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 290; Mature: 290

Protein sequence:

>290_residues
MNELIIATRKSKLAQVQTEIIMGKLKSKFNIDSKKLLIVTEGDRKLDVSLNKIGGKGLFVKDIELALLNKEAHAAVHSMK
DVPFEVSSEFEITAITGREDIRDVFISNGDISFKDIKKGAKVGTSSIRRAAQLKLLRSDLEIVPIRGNVQTRLKKMEEQN
LDGIVLAAAGLKRLGDENLITDYFDPKEFLPAVSQGALGIECLKDGDANKYFEALIDAEATLTVEAERSFMKELQGDCHS
LIGAYSEIQGDDLYMIGIYDIGGKIVKKDILGCKTNNIELGKKLAQKILG

Sequences:

>Translated_290_residues
MNELIIATRKSKLAQVQTEIIMGKLKSKFNIDSKKLLIVTEGDRKLDVSLNKIGGKGLFVKDIELALLNKEAHAAVHSMK
DVPFEVSSEFEITAITGREDIRDVFISNGDISFKDIKKGAKVGTSSIRRAAQLKLLRSDLEIVPIRGNVQTRLKKMEEQN
LDGIVLAAAGLKRLGDENLITDYFDPKEFLPAVSQGALGIECLKDGDANKYFEALIDAEATLTVEAERSFMKELQGDCHS
LIGAYSEIQGDDLYMIGIYDIGGKIVKKDILGCKTNNIELGKKLAQKILG
>Mature_290_residues
MNELIIATRKSKLAQVQTEIIMGKLKSKFNIDSKKLLIVTEGDRKLDVSLNKIGGKGLFVKDIELALLNKEAHAAVHSMK
DVPFEVSSEFEITAITGREDIRDVFISNGDISFKDIKKGAKVGTSSIRRAAQLKLLRSDLEIVPIRGNVQTRLKKMEEQN
LDGIVLAAAGLKRLGDENLITDYFDPKEFLPAVSQGALGIECLKDGDANKYFEALIDAEATLTVEAERSFMKELQGDCHS
LIGAYSEIQGDDLYMIGIYDIGGKIVKKDILGCKTNNIELGKKLAQKILG

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI20149500, Length=270, Percent_Identity=37.4074074074074, Blast_Score=172, Evalue=5e-43,
Organism=Homo sapiens, GI66933009, Length=270, Percent_Identity=37.4074074074074, Blast_Score=172, Evalue=5e-43,
Organism=Escherichia coli, GI48994974, Length=293, Percent_Identity=43.3447098976109, Blast_Score=208, Evalue=4e-55,
Organism=Saccharomyces cerevisiae, GI6319996, Length=307, Percent_Identity=35.1791530944625, Blast_Score=145, Evalue=1e-35,
Organism=Drosophila melanogaster, GI20130425, Length=296, Percent_Identity=35.8108108108108, Blast_Score=169, Evalue=2e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 31914; Mature: 31914

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNELIIATRKSKLAQVQTEIIMGKLKSKFNIDSKKLLIVTEGDRKLDVSLNKIGGKGLFV
CCCEEEEECHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEEEEECCCCCEEEE
KDIELALLNKEAHAAVHSMKDVPFEVSSEFEITAITGREDIRDVFISNGDISFKDIKKGA
EEEEEEEECCHHHHHHHHHHCCCEECCCCEEEEEECCCHHHHHHHHCCCCCCHHHHHCCH
KVGTSSIRRAAQLKLLRSDLEIVPIRGNVQTRLKKMEEQNLDGIVLAAAGLKRLGDENLI
HCCHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHCCCCEEEEEEHHHHHCCCCCCE
TDYFDPKEFLPAVSQGALGIECLKDGDANKYFEALIDAEATLTVEAERSFMKELQGDCHS
ECCCCHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHH
LIGAYSEIQGDDLYMIGIYDIGGKIVKKDILGCKTNNIELGKKLAQKILG
HHHHHHHCCCCCEEEEEEEECCCHHHHHHHHCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MNELIIATRKSKLAQVQTEIIMGKLKSKFNIDSKKLLIVTEGDRKLDVSLNKIGGKGLFV
CCCEEEEECHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEEEEECCCCCEEEE
KDIELALLNKEAHAAVHSMKDVPFEVSSEFEITAITGREDIRDVFISNGDISFKDIKKGA
EEEEEEEECCHHHHHHHHHHCCCEECCCCEEEEEECCCHHHHHHHHCCCCCCHHHHHCCH
KVGTSSIRRAAQLKLLRSDLEIVPIRGNVQTRLKKMEEQNLDGIVLAAAGLKRLGDENLI
HCCHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHCCCCEEEEEEHHHHHCCCCCCE
TDYFDPKEFLPAVSQGALGIECLKDGDANKYFEALIDAEATLTVEAERSFMKELQGDCHS
ECCCCHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHH
LIGAYSEIQGDDLYMIGIYDIGGKIVKKDILGCKTNNIELGKKLAQKILG
HHHHHHHCCCCCEEEEEEEECCCHHHHHHHHCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA