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The map label for this gene is hemD [H]

Identifier: 187934684

GI number: 187934684

Start: 2986372

End: 2987847

Strand: Reverse

Name: hemD [H]

Synonym: CLL_A2906

Alternate gene names: 187934684

Gene position: 2987847-2986372 (Counterclockwise)

Preceding gene: 187933878

Following gene: 187935456

Centisome position: 78.62

GC content: 30.49

Gene sequence:

>1476_bases
ATGAATAAAGTATATATTATAGGTACAGGACCTGGAGACGAAGAATTATTAACCGTAAAAGCTGTCAACAAATTAAAAGA
GTGTACAGCAGTTTTATATGATAGATTGGTTTCAAATAATATTTTAAATTATTTAAGCGATTCTTGTGAAATTTATTATT
GTGGAAAAGAACCAGGAGCACATTATAAAACACAAGAAGAAATAAATGAAATGCTAGTAAAATTAGCAAAAGAAGACCAT
GTAGTAGGAAGAGTTAAAGGCGGAGACCCATATGTTTTTGGAAGAGGAGGAGAAGAGGTATTGGCGCTTAAGGAAGAAAA
TATTCCTTTTGAAGTAATACCAGGAGTAACTTCTCCAATAGCAGTATTAAATTATGCAGGTATTCCAATAACTCATAGGG
GAATAGCTCAAAGTTTTCATGTTGTAACTGGAATGTCAGCAAAACATATTAAGTCTAATTTCAAAGCCTTAGCTATGGAA
GAAGGAACTTTAGTATTTATGATGGGATTAAGCAACTTAGAAAACATAGTACATGAACTTGTGTTAAATGGAAAAGATAT
TTCTACACCTTGTGGCGTTGTTATGAGAGGAACTTCAAGTAAGCAAAAGAAGGTAGTTGGAACTTTAGAAAATATATGTG
AAAAAGTAGAAGAAGCTAAATTGCAATCACCATGTATAATTGTTATCGGTGAAGTGGTTAATTTAAATGAAGACTTAGCT
TGGTATGAACATAAACCTTTGTTTGGGAAAAATATTTGTGTAACTAGATCTCAAAAACAAGCAGCTACTTTAAAACAAAA
GTTAAGAGATATGGGTGCTGAAGTTACGGCTTTAAGTGCTATAGAAATAGAAAGTACAGCTAGTAATTTAGATAGCTATA
TGGGTGATTTAGAAAATTATGATCATATAGTATTTACCTCTGTGAATTCAGTTGATATATTCTTTGATTATTTAATAGAA
AATAAATATGATATAAGAAAATTACAAGCTAAAGTATCAGCTATAGGTAAAGCAACATGGCAAGCTCTTGAAAGAAGAGG
TATAATATGTTTTGTGAAAGCTAGAGAATTTATAGGTGCTGGATTAATAAAAGTATTAAAACCACATGTTAAAGAAAATG
AAAAGGTACTTATTCCATGTTCATCATTAGCAAAATCAGATATAGCAGATGAATTATCTAATGTAGGTGCTAATGTAGAT
AGAGTATTTATTTATGATACAGTAAAAGGAAGAGTAAGAAATAAAAGAGCATTTGATGAAGTAGATATAGTATTTTTTAC
AAGCCCATCAACTGTATATAATATGATAGATATGGTTGGATTAGATGCTATTAAAGAAAAACAAGTTATAGCAATAGGCA
CTAGAACTAATAAACCACTTGAAGAACTAGGCATAAAGGCATATATTTGCAAGGAGCATTCACAAGACGGATTCTTAAAT
GAAATTGAATCATTTGTAAAAGATATGGAGGCGTAA

Upstream 100 bases:

>100_bases
AACATTCATTTAAGATATATGTTGAAAATTTAACTGAAAGGTGGCTTAGAATTAATAAGACTGTTATGTAAAGTACATAA
TACCTTATTAAAAATCGATT

Downstream 100 bases:

>100_bases
TTATGATAAAAAGAGGCAGAAGATTAAGAGCAACATCTGCTATTAGAGATATGATAAGAGAGACTACACTAAATACTAAG
GATTTTATATATCCTATATT

Product: uroporphyrinogen III synthase/methyltransferase

Products: NA

Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Uroporphyrinogen-III synthase; UROS; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthase [H]

Number of amino acids: Translated: 491; Mature: 491

Protein sequence:

>491_residues
MNKVYIIGTGPGDEELLTVKAVNKLKECTAVLYDRLVSNNILNYLSDSCEIYYCGKEPGAHYKTQEEINEMLVKLAKEDH
VVGRVKGGDPYVFGRGGEEVLALKEENIPFEVIPGVTSPIAVLNYAGIPITHRGIAQSFHVVTGMSAKHIKSNFKALAME
EGTLVFMMGLSNLENIVHELVLNGKDISTPCGVVMRGTSSKQKKVVGTLENICEKVEEAKLQSPCIIVIGEVVNLNEDLA
WYEHKPLFGKNICVTRSQKQAATLKQKLRDMGAEVTALSAIEIESTASNLDSYMGDLENYDHIVFTSVNSVDIFFDYLIE
NKYDIRKLQAKVSAIGKATWQALERRGIICFVKAREFIGAGLIKVLKPHVKENEKVLIPCSSLAKSDIADELSNVGANVD
RVFIYDTVKGRVRNKRAFDEVDIVFFTSPSTVYNMIDMVGLDAIKEKQVIAIGTRTNKPLEELGIKAYICKEHSQDGFLN
EIESFVKDMEA

Sequences:

>Translated_491_residues
MNKVYIIGTGPGDEELLTVKAVNKLKECTAVLYDRLVSNNILNYLSDSCEIYYCGKEPGAHYKTQEEINEMLVKLAKEDH
VVGRVKGGDPYVFGRGGEEVLALKEENIPFEVIPGVTSPIAVLNYAGIPITHRGIAQSFHVVTGMSAKHIKSNFKALAME
EGTLVFMMGLSNLENIVHELVLNGKDISTPCGVVMRGTSSKQKKVVGTLENICEKVEEAKLQSPCIIVIGEVVNLNEDLA
WYEHKPLFGKNICVTRSQKQAATLKQKLRDMGAEVTALSAIEIESTASNLDSYMGDLENYDHIVFTSVNSVDIFFDYLIE
NKYDIRKLQAKVSAIGKATWQALERRGIICFVKAREFIGAGLIKVLKPHVKENEKVLIPCSSLAKSDIADELSNVGANVD
RVFIYDTVKGRVRNKRAFDEVDIVFFTSPSTVYNMIDMVGLDAIKEKQVIAIGTRTNKPLEELGIKAYICKEHSQDGFLN
EIESFVKDMEA
>Mature_491_residues
MNKVYIIGTGPGDEELLTVKAVNKLKECTAVLYDRLVSNNILNYLSDSCEIYYCGKEPGAHYKTQEEINEMLVKLAKEDH
VVGRVKGGDPYVFGRGGEEVLALKEENIPFEVIPGVTSPIAVLNYAGIPITHRGIAQSFHVVTGMSAKHIKSNFKALAME
EGTLVFMMGLSNLENIVHELVLNGKDISTPCGVVMRGTSSKQKKVVGTLENICEKVEEAKLQSPCIIVIGEVVNLNEDLA
WYEHKPLFGKNICVTRSQKQAATLKQKLRDMGAEVTALSAIEIESTASNLDSYMGDLENYDHIVFTSVNSVDIFFDYLIE
NKYDIRKLQAKVSAIGKATWQALERRGIICFVKAREFIGAGLIKVLKPHVKENEKVLIPCSSLAKSDIADELSNVGANVD
RVFIYDTVKGRVRNKRAFDEVDIVFFTSPSTVYNMIDMVGLDAIKEKQVIAIGTRTNKPLEELGIKAYICKEHSQDGFLN
EIESFVKDMEA

Specific function: May catalyze sequential reactions to synthesize uroporphyrinogen III from hydroxymethylbilane (HMB) and then precorrin-2, which are intermediate compounds in both vitamin B12 and siroheme biosyntheses [H]

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=247, Percent_Identity=39.6761133603239, Blast_Score=195, Evalue=6e-51,
Organism=Saccharomyces cerevisiae, GI6322922, Length=234, Percent_Identity=32.0512820512821, Blast_Score=125, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR003754
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR003043 [H]

Pfam domain/function: PF02602 HEM4; PF00590 TP_methylase [H]

EC number: =2.1.1.107; =4.2.1.75 [H]

Molecular weight: Translated: 54457; Mature: 54457

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: PS00839 SUMT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKVYIIGTGPGDEELLTVKAVNKLKECTAVLYDRLVSNNILNYLSDSCEIYYCGKEPGA
CCEEEEEECCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCC
HYKTQEEINEMLVKLAKEDHVVGRVKGGDPYVFGRGGEEVLALKEENIPFEVIPGVTSPI
CCCCHHHHHHHHHHHHHCCCEEEEEECCCCEEECCCCCEEEEEECCCCCEEEECCCCCHH
AVLNYAGIPITHRGIAQSFHVVTGMSAKHIKSNFKALAMEEGTLVFMMGLSNLENIVHEL
HHHCCCCCCEECHHHHHHHHHHCCCCHHHHHCCCCEEEECCCCEEEEECHHHHHHHHHHH
VLNGKDISTPCGVVMRGTSSKQKKVVGTLENICEKVEEAKLQSPCIIVIGEVVNLNEDLA
HCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECEECCCCCCH
WYEHKPLFGKNICVTRSQKQAATLKQKLRDMGAEVTALSAIEIESTASNLDSYMGDLENY
HHCCCCCCCCCEEEECCHHHHHHHHHHHHHCCCCEEEEEEEEEHHHHHHHHHHHHHHCCC
DHIVFTSVNSVDIFFDYLIENKYDIRKLQAKVSAIGKATWQALERRGIICFVKAREFIGA
CEEEEEECCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHH
GLIKVLKPHVKENEKVLIPCSSLAKSDIADELSNVGANVDRVFIYDTVKGRVRNKRAFDE
HHHHHHCHHCCCCCEEEEECHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHCCCCCCCC
VDIVFFTSPSTVYNMIDMVGLDAIKEKQVIAIGTRTNKPLEELGIKAYICKEHSQDGFLN
EEEEEEECCHHHHHHHHHHCCHHHCCCCEEEEECCCCCCHHHHCCEEEEECCCCCCCCHH
EIESFVKDMEA
HHHHHHHHHCC
>Mature Secondary Structure
MNKVYIIGTGPGDEELLTVKAVNKLKECTAVLYDRLVSNNILNYLSDSCEIYYCGKEPGA
CCEEEEEECCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCC
HYKTQEEINEMLVKLAKEDHVVGRVKGGDPYVFGRGGEEVLALKEENIPFEVIPGVTSPI
CCCCHHHHHHHHHHHHHCCCEEEEEECCCCEEECCCCCEEEEEECCCCCEEEECCCCCHH
AVLNYAGIPITHRGIAQSFHVVTGMSAKHIKSNFKALAMEEGTLVFMMGLSNLENIVHEL
HHHCCCCCCEECHHHHHHHHHHCCCCHHHHHCCCCEEEECCCCEEEEECHHHHHHHHHHH
VLNGKDISTPCGVVMRGTSSKQKKVVGTLENICEKVEEAKLQSPCIIVIGEVVNLNEDLA
HCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECEECCCCCCH
WYEHKPLFGKNICVTRSQKQAATLKQKLRDMGAEVTALSAIEIESTASNLDSYMGDLENY
HHCCCCCCCCCEEEECCHHHHHHHHHHHHHCCCCEEEEEEEEEHHHHHHHHHHHHHHCCC
DHIVFTSVNSVDIFFDYLIENKYDIRKLQAKVSAIGKATWQALERRGIICFVKAREFIGA
CEEEEEECCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHH
GLIKVLKPHVKENEKVLIPCSSLAKSDIADELSNVGANVDRVFIYDTVKGRVRNKRAFDE
HHHHHHCHHCCCCCEEEEECHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHCCCCCCCC
VDIVFFTSPSTVYNMIDMVGLDAIKEKQVIAIGTRTNKPLEELGIKAYICKEHSQDGFLN
EEEEEEECCHHHHHHHHHHCCHHHCCCCEEEEECCCCCCHHHHCCEEEEECCCCCCCCHH
EIESFVKDMEA
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7665501 [H]