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The map label for this gene is 187935213

Identifier: 187935213

GI number: 187935213

Start: 2988985

End: 2989659

Strand: Reverse

Name: 187935213

Synonym: CLL_A2908

Alternate gene names: NA

Gene position: 2989659-2988985 (Counterclockwise)

Preceding gene: 187935430

Following gene: 187933878

Centisome position: 78.67

GC content: 23.56

Gene sequence:

>675_bases
ATGTTTAAGGATAATAAAGAGCATATTTATGACGAAGAAATAGATTATTCTTTTATTTCACTACTTTCTAATAAAATAAA
TATTGGTGTTATTGGTGGCGGCAGAGCTGGGTTTATAAAGATTAAACATTTTTTAAAAACAGGCTGCTATGTTGAAGTTA
TTTCAAAAGATTTTTGTGAAGAAGTAATAAGTTTATGTGAAGAATTTAAGGGAAGATTAATTTTAATAAAAAGTGAATTT
AATTATGAGTTTTTAGAAAATAAGCATTTAATTCTAATAACAACAGACGATAGAGAAATTAACGATGATATAAAAAGATA
TTGTGATAGAAATTATAAAATATACATAGAATCTTCAAATTTTAAGAACGGTATGGGTGTTATACCTGTTCAAAGAAATC
TTAAGAATATAACTTTTGCATTAAACACAAAAGGGGGAAACCCTAAAGGTTCAGTAATGCTTGCAAATAAAGTTCAAGAT
TTATTAGAGGATTATGATGATTTTATAGCATTAACAACTAAGATTAGAAATAAAGCTATAAAAATTTCAAAATATAAAAA
AGAGATAATAAATTTTATTTCTTGTGATGATTTTAAGTTTTTCTATGATAATCATAAAGAGGGATTAGTATTAAAACTCT
ATTTTGAAGAAGAAATATTAAATAAGTTAATATAG

Upstream 100 bases:

>100_bases
TTGATTTAGCGAATAGAATGATAAAGAGCACATCTGACTATTATATGAATAGAGCTATAGATATAATGAAAGAAGAAACT
TTAAAGGGAAGTGAAGAGGA

Downstream 100 bases:

>100_bases
ATTATATTTAAATCAAAAAATTTCACTAGATAAAGGAGCAGTAAAAAATAATGAATGAATTAATAATAGCAACTAGAAAA
AGTAAGTTGGCTCAAGTTCA

Product: precorrin-2 dehydrogenase

Products: sirohydrochlorin; NADH; H+

Alternate protein names: Siroheme Synthase

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MFKDNKEHIYDEEIDYSFISLLSNKINIGVIGGGRAGFIKIKHFLKTGCYVEVISKDFCEEVISLCEEFKGRLILIKSEF
NYEFLENKHLILITTDDREINDDIKRYCDRNYKIYIESSNFKNGMGVIPVQRNLKNITFALNTKGGNPKGSVMLANKVQD
LLEDYDDFIALTTKIRNKAIKISKYKKEIINFISCDDFKFFYDNHKEGLVLKLYFEEEILNKLI

Sequences:

>Translated_224_residues
MFKDNKEHIYDEEIDYSFISLLSNKINIGVIGGGRAGFIKIKHFLKTGCYVEVISKDFCEEVISLCEEFKGRLILIKSEF
NYEFLENKHLILITTDDREINDDIKRYCDRNYKIYIESSNFKNGMGVIPVQRNLKNITFALNTKGGNPKGSVMLANKVQD
LLEDYDDFIALTTKIRNKAIKISKYKKEIINFISCDDFKFFYDNHKEGLVLKLYFEEEILNKLI
>Mature_224_residues
MFKDNKEHIYDEEIDYSFISLLSNKINIGVIGGGRAGFIKIKHFLKTGCYVEVISKDFCEEVISLCEEFKGRLILIKSEF
NYEFLENKHLILITTDDREINDDIKRYCDRNYKIYIESSNFKNGMGVIPVQRNLKNITFALNTKGGNPKGSVMLANKVQD
LLEDYDDFIALTTKIRNKAIKISKYKKEIINFISCDDFKFFYDNHKEGLVLKLYFEEEILNKLI

Specific function: Unknown

COG id: COG1648

COG function: function code H; Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 1.3.1.76; 4.99.1.4

Molecular weight: Translated: 26179; Mature: 26179

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKDNKEHIYDEEIDYSFISLLSNKINIGVIGGGRAGFIKIKHFLKTGCYVEVISKDFCE
CCCCCCCCCCCCCCCHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHCCCEEEHHHHHHHH
EVISLCEEFKGRLILIKSEFNYEFLENKHLILITTDDREINDDIKRYCDRNYKIYIESSN
HHHHHHHHCCCCEEEEEECCCCHHHCCCEEEEEEECCCCCHHHHHHHHCCCCEEEEECCC
FKNGMGVIPVQRNLKNITFALNTKGGNPKGSVMLANKVQDLLEDYDDFIALTTKIRNKAI
CCCCCEEEEECCCCCEEEEEEECCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHEE
KISKYKKEIINFISCDDFKFFYDNHKEGLVLKLYFEEEILNKLI
EHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEEEHHHHHHHCC
>Mature Secondary Structure
MFKDNKEHIYDEEIDYSFISLLSNKINIGVIGGGRAGFIKIKHFLKTGCYVEVISKDFCE
CCCCCCCCCCCCCCCHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHCCCEEEHHHHHHHH
EVISLCEEFKGRLILIKSEFNYEFLENKHLILITTDDREINDDIKRYCDRNYKIYIESSN
HHHHHHHHCCCCEEEEEECCCCHHHCCCEEEEEEECCCCCHHHHHHHHCCCCEEEEECCC
FKNGMGVIPVQRNLKNITFALNTKGGNPKGSVMLANKVQDLLEDYDDFIALTTKIRNKAI
CCCCCEEEEECCCCCEEEEEEECCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHEE
KISKYKKEIINFISCDDFKFFYDNHKEGLVLKLYFEEEILNKLI
EHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEEEHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Precorrin 2; NAD+

Specific reaction: precorrin-2 + NAD+ = sirohydrochlorin + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA