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The map label for this gene is tpiA [H]

Identifier: 187933535

GI number: 187933535

Start: 3168241

End: 3168987

Strand: Reverse

Name: tpiA [H]

Synonym: CLL_A3064

Alternate gene names: 187933535

Gene position: 3168987-3168241 (Counterclockwise)

Preceding gene: 187934425

Following gene: 187935065

Centisome position: 83.39

GC content: 34.0

Gene sequence:

>747_bases
ATGAGAAAAGCAATTATTGCGGGAAACTGGAAAATGAATAAAACTGTTGATGAAGCAGTTAAAGTTGTAGAAGAATTAAA
ACCATTAGTTAAGGATGCTACTTGTGATGTAGTTGTATGTCCTACATTTGTATGTTTAGATGCTGTTAAAAAAGCAACAG
CTGGATCAAATATAAAAGTTGCAGCTCAAAATATGCACTTTGAAGAAAGTGGCGCATTTACAGGAGAAGTTGCTCCAGGA
ATGTTAGAAGCTATGGGAATTGAATATGTTGTTTTAGGACACAGTGAAAGAAGAGAATACTTCAATGAAACTGATGAAGC
AATAAACAAAAAGGTTAAAGCAGCATTTGCTCACAACATTACTCCAATAGTTTGTTGTGGAGAAACTTTAGAACAAAGAG
AAAGCGGAGTTACTAATAACTTTATCGCTTGCCAAATTAAAGTTGATATTGCTGGATTAACTAAAGAACAAGCTGAAAAA
GTTGTTATAGCTTATGAACCAATCTGGGCTATTGGAACTGGTAAAACTGCTACTAAGGAACAAGCTAATGAAACAATATT
AGCAATCAGAAACGTTGTAGTAGAAATGTACGGTAAAGAAGTTGCTGATAAAGTAAGAATTCAATACGGTGGATCAGTTA
AACCAAATACAATCACTGAACAAATGGCTATGTCTGATATAGATGGAGCATTAGTTGGTGGAGCTAGCTTAAAAGCAGAA
GATTTTTCTGGAATAGTTAACTACTAA

Upstream 100 bases:

>100_bases
TAAAACTTCTTAAAGGAGTTTTACCTTACTATGTAGAATTAGTTATTATAGAAATTTAAAACTTTATGTTTTATTATAAT
TTTATTATGAGGTGAAAACG

Downstream 100 bases:

>100_bases
AAATAATAAAAGGCTATGATTTAATCATAGCCTTTTTTGTTTTTAAGAAATTATGTACATTTAAAAATCCTATAATAATT
TATGAAATTTTGTATTCAAA

Product: triosephosphate isomerase

Products: NA

Alternate protein names: TIM; Triose-phosphate isomerase [H]

Number of amino acids: Translated: 248; Mature: 248

Protein sequence:

>248_residues
MRKAIIAGNWKMNKTVDEAVKVVEELKPLVKDATCDVVVCPTFVCLDAVKKATAGSNIKVAAQNMHFEESGAFTGEVAPG
MLEAMGIEYVVLGHSERREYFNETDEAINKKVKAAFAHNITPIVCCGETLEQRESGVTNNFIACQIKVDIAGLTKEQAEK
VVIAYEPIWAIGTGKTATKEQANETILAIRNVVVEMYGKEVADKVRIQYGGSVKPNTITEQMAMSDIDGALVGGASLKAE
DFSGIVNY

Sequences:

>Translated_248_residues
MRKAIIAGNWKMNKTVDEAVKVVEELKPLVKDATCDVVVCPTFVCLDAVKKATAGSNIKVAAQNMHFEESGAFTGEVAPG
MLEAMGIEYVVLGHSERREYFNETDEAINKKVKAAFAHNITPIVCCGETLEQRESGVTNNFIACQIKVDIAGLTKEQAEK
VVIAYEPIWAIGTGKTATKEQANETILAIRNVVVEMYGKEVADKVRIQYGGSVKPNTITEQMAMSDIDGALVGGASLKAE
DFSGIVNY
>Mature_248_residues
MRKAIIAGNWKMNKTVDEAVKVVEELKPLVKDATCDVVVCPTFVCLDAVKKATAGSNIKVAAQNMHFEESGAFTGEVAPG
MLEAMGIEYVVLGHSERREYFNETDEAINKKVKAAFAHNITPIVCCGETLEQRESGVTNNFIACQIKVDIAGLTKEQAEK
VVIAYEPIWAIGTGKTATKEQANETILAIRNVVVEMYGKEVADKVRIQYGGSVKPNTITEQMAMSDIDGALVGGASLKAE
DFSGIVNY

Specific function: Plays an important role in several metabolic pathways. [C]

COG id: COG0149

COG function: function code G; Triosephosphate isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the triosephosphate isomerase family [H]

Homologues:

Organism=Homo sapiens, GI226529917, Length=246, Percent_Identity=44.7154471544715, Blast_Score=184, Evalue=8e-47,
Organism=Homo sapiens, GI4507645, Length=246, Percent_Identity=44.7154471544715, Blast_Score=183, Evalue=1e-46,
Organism=Escherichia coli, GI1790353, Length=247, Percent_Identity=43.3198380566802, Blast_Score=192, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI17536593, Length=248, Percent_Identity=45.5645161290323, Blast_Score=186, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6320255, Length=246, Percent_Identity=37.8048780487805, Blast_Score=166, Evalue=4e-42,
Organism=Drosophila melanogaster, GI28572008, Length=247, Percent_Identity=42.914979757085, Blast_Score=181, Evalue=3e-46,
Organism=Drosophila melanogaster, GI28572006, Length=247, Percent_Identity=42.914979757085, Blast_Score=181, Evalue=3e-46,
Organism=Drosophila melanogaster, GI28572004, Length=247, Percent_Identity=42.1052631578947, Blast_Score=181, Evalue=5e-46,

Paralogues:

None

Copy number: 1120 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR022896
- InterPro:   IPR000652
- InterPro:   IPR020861 [H]

Pfam domain/function: PF00121 TIM [H]

EC number: =5.3.1.1 [H]

Molecular weight: Translated: 26838; Mature: 26838

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS00171 TIM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKAIIAGNWKMNKTVDEAVKVVEELKPLVKDATCDVVVCPTFVCLDAVKKATAGSNIKV
CCCEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEECHHHHHHHHHHHHCCCCCEEE
AAQNMHFEESGAFTGEVAPGMLEAMGIEYVVLGHSERREYFNETDEAINKKVKAAFAHNI
EEECCCCCCCCCCCCCCCCHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCC
TPIVCCGETLEQRESGVTNNFIACQIKVDIAGLTKEQAEKVVIAYEPIWAIGTGKTATKE
CEEEECCHHHHHHHCCCCCCEEEEEEEEEEECCCHHHCCEEEEEECCEEEECCCCCCCHH
QANETILAIRNVVVEMYGKEVADKVRIQYGGSVKPNTITEQMAMSDIDGALVGGASLKAE
HHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHHCCCEEECCCCCCCH
DFSGIVNY
HCCCCCCC
>Mature Secondary Structure
MRKAIIAGNWKMNKTVDEAVKVVEELKPLVKDATCDVVVCPTFVCLDAVKKATAGSNIKV
CCCEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEECHHHHHHHHHHHHCCCCCEEE
AAQNMHFEESGAFTGEVAPGMLEAMGIEYVVLGHSERREYFNETDEAINKKVKAAFAHNI
EEECCCCCCCCCCCCCCCCHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCC
TPIVCCGETLEQRESGVTNNFIACQIKVDIAGLTKEQAEKVVIAYEPIWAIGTGKTATKE
CEEEECCHHHHHHHCCCCCCEEEEEEEEEEECCCHHHCCEEEEEECCEEEECCCCCCCHH
QANETILAIRNVVVEMYGKEVADKVRIQYGGSVKPNTITEQMAMSDIDGALVGGASLKAE
HHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHHCCCEEECCCCCCCH
DFSGIVNY
HCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA