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The map label for this gene is cobQ

Identifier: 187932798

GI number: 187932798

Start: 2999519

End: 3001024

Strand: Reverse

Name: cobQ

Synonym: CLL_A2917

Alternate gene names: 187932798

Gene position: 3001024-2999519 (Counterclockwise)

Preceding gene: 187933455

Following gene: 187932824

Centisome position: 78.97

GC content: 28.42

Gene sequence:

>1506_bases
ATGAATAAAAAAAATATAATGTTTTTAGGGACAGCATCTTCAGTAGGAAAGAGTACTTTAGTAGCAGCACTATGTCGAGT
ATTAAAAAATGAAGAGTTTAAAGTGGCTCCTTTTAAAGCAATGAATATTTCATTGAATTCCTATGTAACCAAAGATGGAG
CAGAAATGGGAAGAGCCCAAGTCGTACAAGCTGAAGCCTGTAAATTAGAACCTAATGCTTTGATGAATCCAATATTATTA
AAACCAAGTGGAGGCCATACTCAAGTTATAGTAAATGGAAAAGTTTATGATAATATAGAACCTTATAAGTATAAAGAACT
AAACAAAAAGTTAAAAGGTATTGTAAAAGAATCATATGATAAATTAAGCAATAAGTATGAATTAATAGTATTAGAAGGAT
CTGGAGGCTGTGCTGAAATAAATTTAAAAGATAGCGATATAGCTAACATGAATATGGCTGAAAGTGTTGATGCACCAGTT
ATATTAGTAGCTGATATTGATAGAGGTGGAGTTTTTGCATCTATAGTTGGAACTCTTGAATTGTTATCAAAGAATGAGAG
AAGCAGAGTAAAGGGTGTTATAATAAACAAATTTAGAGGTGAAAAACAACATTTTGAAGCTGGAGTAAAACAATTAGAAG
AAATAATAAAAATACCTGTTCTTGGGGTAATGCCATATGAATATTTTGATATTGAAGATGAGGATGCCGTTACAGAAAAA
ATATGTAATAAAGAATCTGAAGATGAGAACAGTATAGATGTAGCAATAATAAGACTTTCTCATATGTCTAATTTTACAGA
TTTTAATGTACTTAGCAGGATAAATGGAGTTAATGTAAGATATGTAGAAAGTACAAAGTATTTAAAAAATCCAGATGTAA
TTATTATACCAGGAACTAAAAATACAATTGAAGATTTAAGAATCTTAAAAGAAAGTAAACTTGCTGATGAGATAATTAAA
TTACATGATAGCGGAACATTAGTATTGGGGATTTGTGGAGGATATCAAATGTTAGGAAAGATACTTCTTGATCAACAAGG
AGTAGAAGGAAATACCTTACAAGAAGAAGGATTAGGTTTACTTGACATAAAGACTAGATTTAATGAAAGAAAAATAACCA
AGCAAGTCGAAGCTCAAGTAGTATCAAATTTAAAAGATATTAATGAAATAGAAAATAAATCATTAGTAGGATATGAAATA
CACAATGGAATAAGTAAAGTTGGAAAAAATGTAAAACCATTCATAAAAGATTCTAAAGGAAAAATCATTGGAGTTTGTGA
TATAGAAGGATCTGTTGCAGGAACTTATTTGCATGGAATTTTTGATTCAGAGGAATTTACTAATGCATTTATTAATGCGT
TAAAGAAGAATAATAACTTTGATTTATTGGAAGATGATGAGCTAAATAAAATATCTGATTATAAAAATGAGCAATATGAA
AAATTAGCAAAAATATTTTCAGAGAATGTAGATGTAGATAAAATAAAAGAAATAATTGGTATTTAA

Upstream 100 bases:

>100_bases
AATAGAAAAGCAAAATTCAGATAACTATGGATATTTAATAATAAAATAAGCAGTTAAAGTATTTTATTAGAAACTGCAAA
AGATGGTTTTGGAGGGTAGT

Downstream 100 bases:

>100_bases
AATTTAATCAAAGTGTTGATATATATAATATCATTTTAACTATTGTATGTATAAACACATATAATTAAAAATTTAACCCA
AATATAAAAGAGCTGTATGA

Product: cobyric acid synthase

Products: ADP; phosphate; adenosylcobyric acid; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 501; Mature: 501

Protein sequence:

>501_residues
MNKKNIMFLGTASSVGKSTLVAALCRVLKNEEFKVAPFKAMNISLNSYVTKDGAEMGRAQVVQAEACKLEPNALMNPILL
KPSGGHTQVIVNGKVYDNIEPYKYKELNKKLKGIVKESYDKLSNKYELIVLEGSGGCAEINLKDSDIANMNMAESVDAPV
ILVADIDRGGVFASIVGTLELLSKNERSRVKGVIINKFRGEKQHFEAGVKQLEEIIKIPVLGVMPYEYFDIEDEDAVTEK
ICNKESEDENSIDVAIIRLSHMSNFTDFNVLSRINGVNVRYVESTKYLKNPDVIIIPGTKNTIEDLRILKESKLADEIIK
LHDSGTLVLGICGGYQMLGKILLDQQGVEGNTLQEEGLGLLDIKTRFNERKITKQVEAQVVSNLKDINEIENKSLVGYEI
HNGISKVGKNVKPFIKDSKGKIIGVCDIEGSVAGTYLHGIFDSEEFTNAFINALKKNNNFDLLEDDELNKISDYKNEQYE
KLAKIFSENVDVDKIKEIIGI

Sequences:

>Translated_501_residues
MNKKNIMFLGTASSVGKSTLVAALCRVLKNEEFKVAPFKAMNISLNSYVTKDGAEMGRAQVVQAEACKLEPNALMNPILL
KPSGGHTQVIVNGKVYDNIEPYKYKELNKKLKGIVKESYDKLSNKYELIVLEGSGGCAEINLKDSDIANMNMAESVDAPV
ILVADIDRGGVFASIVGTLELLSKNERSRVKGVIINKFRGEKQHFEAGVKQLEEIIKIPVLGVMPYEYFDIEDEDAVTEK
ICNKESEDENSIDVAIIRLSHMSNFTDFNVLSRINGVNVRYVESTKYLKNPDVIIIPGTKNTIEDLRILKESKLADEIIK
LHDSGTLVLGICGGYQMLGKILLDQQGVEGNTLQEEGLGLLDIKTRFNERKITKQVEAQVVSNLKDINEIENKSLVGYEI
HNGISKVGKNVKPFIKDSKGKIIGVCDIEGSVAGTYLHGIFDSEEFTNAFINALKKNNNFDLLEDDELNKISDYKNEQYE
KLAKIFSENVDVDKIKEIIGI
>Mature_501_residues
MNKKNIMFLGTASSVGKSTLVAALCRVLKNEEFKVAPFKAMNISLNSYVTKDGAEMGRAQVVQAEACKLEPNALMNPILL
KPSGGHTQVIVNGKVYDNIEPYKYKELNKKLKGIVKESYDKLSNKYELIVLEGSGGCAEINLKDSDIANMNMAESVDAPV
ILVADIDRGGVFASIVGTLELLSKNERSRVKGVIINKFRGEKQHFEAGVKQLEEIIKIPVLGVMPYEYFDIEDEDAVTEK
ICNKESEDENSIDVAIIRLSHMSNFTDFNVLSRINGVNVRYVESTKYLKNPDVIIIPGTKNTIEDLRILKESKLADEIIK
LHDSGTLVLGICGGYQMLGKILLDQQGVEGNTLQEEGLGLLDIKTRFNERKITKQVEAQVVSNLKDINEIENKSLVGYEI
HNGISKVGKNVKPFIKDSKGKIIGVCDIEGSVAGTYLHGIFDSEEFTNAFINALKKNNNFDLLEDDELNKISDYKNEQYE
KLAKIFSENVDVDKIKEIIGI

Specific function: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation

COG id: COG1492

COG function: function code H; Cobyric acid synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GATase cobBQ-type domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COBQ_CLOBB (B2TPE7)

Other databases:

- EMBL:   CP001056
- RefSeq:   YP_001887104.1
- ProteinModelPortal:   B2TPE7
- GeneID:   6293803
- GenomeReviews:   CP001056_GR
- KEGG:   cbk:CLL_A2917
- HOGENOM:   HBG302271
- OMA:   AHTDLNP
- ProtClustDB:   PRK00784
- HAMAP:   MF_00028
- InterPro:   IPR002586
- InterPro:   IPR017929
- InterPro:   IPR004459
- InterPro:   IPR011698
- TIGRFAMs:   TIGR00313

Pfam domain/function: PF01656 CbiA; PF07685 GATase_3

EC number: 6.3.5.10

Molecular weight: Translated: 55680; Mature: 55680

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS51274 GATASE_COBBQ

Important sites: ACT_SITE 332-332 ACT_SITE 438-438

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKKNIMFLGTASSVGKSTLVAALCRVLKNEEFKVAPFKAMNISLNSYVTKDGAEMGRAQ
CCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCEEECCEEEEEEEHHHEECCCCHHCCHHH
VVQAEACKLEPNALMNPILLKPSGGHTQVIVNGKVYDNIEPYKYKELNKKLKGIVKESYD
EEEHHHHCCCCCHHCCCEEECCCCCCEEEEECCEEECCCCCCHHHHHHHHHHHHHHHHHH
KLSNKYELIVLEGSGGCAEINLKDSDIANMNMAESVDAPVILVADIDRGGVFASIVGTLE
HHCCCEEEEEEECCCCEEEEEECCCCCCCCCCHHCCCCCEEEEEECCCCCHHHHHHHHHH
LLSKNERSRVKGVIINKFRGEKQHFEAGVKQLEEIIKIPVLGVMPYEYFDIEDEDAVTEK
HHCCCCHHHHCEEEEECCCCCHHHHHHHHHHHHHHHHCCCEEECCCCEECCCCHHHHHHH
ICNKESEDENSIDVAIIRLSHMSNFTDFNVLSRINGVNVRYVESTKYLKNPDVIIIPGTK
HHCCCCCCCCCEEEEEEEEECCCCCCHHHHHHHCCCCEEEEEECCCCCCCCCEEEECCCC
NTIEDLRILKESKLADEIIKLHDSGTLVLGICGGYQMLGKILLDQQGVEGNTLQEEGLGL
CHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHCCCCCCCCCHHHHCCCE
LDIKTRFNERKITKQVEAQVVSNLKDINEIENKSLVGYEIHNGISKVGKNVKPFIKDSKG
EEEHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHCCCCCCHHCCCCC
KIIGVCDIEGSVAGTYLHGIFDSEEFTNAFINALKKNNNFDLLEDDELNKISDYKNEQYE
CEEEEEECCCCCCHHHEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCHHHHH
KLAKIFSENVDVDKIKEIIGI
HHHHHHHCCCCHHHHHHHHCC
>Mature Secondary Structure
MNKKNIMFLGTASSVGKSTLVAALCRVLKNEEFKVAPFKAMNISLNSYVTKDGAEMGRAQ
CCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCEEECCEEEEEEEHHHEECCCCHHCCHHH
VVQAEACKLEPNALMNPILLKPSGGHTQVIVNGKVYDNIEPYKYKELNKKLKGIVKESYD
EEEHHHHCCCCCHHCCCEEECCCCCCEEEEECCEEECCCCCCHHHHHHHHHHHHHHHHHH
KLSNKYELIVLEGSGGCAEINLKDSDIANMNMAESVDAPVILVADIDRGGVFASIVGTLE
HHCCCEEEEEEECCCCEEEEEECCCCCCCCCCHHCCCCCEEEEEECCCCCHHHHHHHHHH
LLSKNERSRVKGVIINKFRGEKQHFEAGVKQLEEIIKIPVLGVMPYEYFDIEDEDAVTEK
HHCCCCHHHHCEEEEECCCCCHHHHHHHHHHHHHHHHCCCEEECCCCEECCCCHHHHHHH
ICNKESEDENSIDVAIIRLSHMSNFTDFNVLSRINGVNVRYVESTKYLKNPDVIIIPGTK
HHCCCCCCCCCEEEEEEEEECCCCCCHHHHHHHCCCCEEEEEECCCCCCCCCEEEECCCC
NTIEDLRILKESKLADEIIKLHDSGTLVLGICGGYQMLGKILLDQQGVEGNTLQEEGLGL
CHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHCCCCCCCCCHHHHCCCE
LDIKTRFNERKITKQVEAQVVSNLKDINEIENKSLVGYEIHNGISKVGKNVKPFIKDSKG
EEEHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHCCCCCCHHCCCCC
KIIGVCDIEGSVAGTYLHGIFDSEEFTNAFINALKKNNNFDLLEDDELNKISDYKNEQYE
CEEEEEECCCCCCHHHEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCHHHHH
KLAKIFSENVDVDKIKEIIGI
HHHHHHHCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; adenosylcobyrinic acid a,c-diamide; L-glutamine; H2O

Specific reaction: 4 ATP + adenosylcobyrinic acid a,c-diamide + 4 L-glutamine + 4 H2O = 4 ADP + 4 phosphate + adenosylcobyric acid + 4 L-glutamate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA