Click here to switch to the map view.

The map label for this gene is cobD [H]

Identifier: 187933455

GI number: 187933455

Start: 3001264

End: 3002340

Strand: Reverse

Name: cobD [H]

Synonym: CLL_A2918

Alternate gene names: 187933455

Gene position: 3002340-3001264 (Counterclockwise)

Preceding gene: 187934156

Following gene: 187932798

Centisome position: 79.0

GC content: 24.14

Gene sequence:

>1077_bases
ATGGCTAATACAGGACATGGTGGAAATATAAAAGAGATAGCAAGAAAAAAAGGAATTGATTACAATAATATAATAGATTT
TTCATCAAATATTAATCCTTTAGGTATGTCAAGTAAAGTAAAGAGAGCTATAATAGATTCAATGGAGGAAATAAAAAAAT
ATCCAGATATAAGCTATATGGAATTAAAAAAATCAATATCTGAATATGAAAATATTAATGAATCTTATTTAATGTTAGGA
AATGGTGCAGCAGAAGTATTATTTAATATAGTTAAAGCATTAAAGCCTAAAAAAGTATTAATACCTGTACCAACTTTTTC
AGAATATAAAGAAGCTGTAGAATGTGTAAATTCAAAAGTTGAACTATATAAAATGAGTGAAAATAATTCTTTTAAAATAT
GTGAGGATATTTTAGATAAAATTACAGAAGAAATTGACTTAATTTTTATATGTAACCCTAATAATCCAACAGGAGTATTA
ACAAATAGAGAATTATTAATGAAAATTTTAATAAAGTCTAAAGAAAATAATAGTACAGTTTTAATTGATGAGTCTTTTAT
GGATTTTATAACAGAAGATATTTCAATGGTTAATACTGTAGAAACTTTTGATAATTTAATTATACTAAAGTCGCTTACTA
AATTTTTTGCAATGCCAGGATTGAGAATAGGGTATGGGGTATGTTCAAACAAAGATTTTATAAGTGAGGTTTATAAGATA
ACTCCAGCTTGGAATATAAATATACTGGCTGATGTAGCAACTAGAGTTTCTTTGCACGATAAAAATTACATGAGAAAAAC
AATACAATATATGGAAAAAGAAAAAGCTTTCCTATATAATAGTCTAAAGACATTTAAAAACTTAAATGTATATGAACCTA
GTGTGAATTTTATATTTTTTAAAAGTAATTTAGATATTAATTTAAAATCAGAACTATTAAAATACAATGTTTTAATAAGA
AGTTGTAGTAACTATGATGGGTTAAATGAGTATTATTATAGAGTAGCAGTAAAAAGTAGGGAAGATAATACTAAGTTAAT
TTGTTGCATAAAAAATATACTTGGTGATAACGAATAG

Upstream 100 bases:

>100_bases
GAGGTTTTGGATGTGGACAAAACGTCAAAAGTACTTTACTGTAGTGCTATTTTATCATACATATTATCAATTATATTAAT
TTTTATTGGAGGACATATCT

Downstream 100 bases:

>100_bases
AATTTAAAAATAAATCTAAAGACAAAGAGGTAAGGGTGGAAAATTTAAAGTTTGTAAATTTATATAGTGGCAAAAATGGA
CAATATCATAAATTCGTATA

Product: threonine-phosphate decarboxylase

Products: NA

Alternate protein names: L-threonine-O-3-phosphate decarboxylase [H]

Number of amino acids: Translated: 358; Mature: 357

Protein sequence:

>358_residues
MANTGHGGNIKEIARKKGIDYNNIIDFSSNINPLGMSSKVKRAIIDSMEEIKKYPDISYMELKKSISEYENINESYLMLG
NGAAEVLFNIVKALKPKKVLIPVPTFSEYKEAVECVNSKVELYKMSENNSFKICEDILDKITEEIDLIFICNPNNPTGVL
TNRELLMKILIKSKENNSTVLIDESFMDFITEDISMVNTVETFDNLIILKSLTKFFAMPGLRIGYGVCSNKDFISEVYKI
TPAWNINILADVATRVSLHDKNYMRKTIQYMEKEKAFLYNSLKTFKNLNVYEPSVNFIFFKSNLDINLKSELLKYNVLIR
SCSNYDGLNEYYYRVAVKSREDNTKLICCIKNILGDNE

Sequences:

>Translated_358_residues
MANTGHGGNIKEIARKKGIDYNNIIDFSSNINPLGMSSKVKRAIIDSMEEIKKYPDISYMELKKSISEYENINESYLMLG
NGAAEVLFNIVKALKPKKVLIPVPTFSEYKEAVECVNSKVELYKMSENNSFKICEDILDKITEEIDLIFICNPNNPTGVL
TNRELLMKILIKSKENNSTVLIDESFMDFITEDISMVNTVETFDNLIILKSLTKFFAMPGLRIGYGVCSNKDFISEVYKI
TPAWNINILADVATRVSLHDKNYMRKTIQYMEKEKAFLYNSLKTFKNLNVYEPSVNFIFFKSNLDINLKSELLKYNVLIR
SCSNYDGLNEYYYRVAVKSREDNTKLICCIKNILGDNE
>Mature_357_residues
ANTGHGGNIKEIARKKGIDYNNIIDFSSNINPLGMSSKVKRAIIDSMEEIKKYPDISYMELKKSISEYENINESYLMLGN
GAAEVLFNIVKALKPKKVLIPVPTFSEYKEAVECVNSKVELYKMSENNSFKICEDILDKITEEIDLIFICNPNNPTGVLT
NRELLMKILIKSKENNSTVLIDESFMDFITEDISMVNTVETFDNLIILKSLTKFFAMPGLRIGYGVCSNKDFISEVYKIT
PAWNINILADVATRVSLHDKNYMRKTIQYMEKEKAFLYNSLKTFKNLNVYEPSVNFIFFKSNLDINLKSELLKYNVLIRS
CSNYDGLNEYYYRVAVKSREDNTKLICCIKNILGDNE

Specific function: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1- amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin [H]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=307, Percent_Identity=22.1498371335505, Blast_Score=95, Evalue=8e-21,
Organism=Escherichia coli, GI1788627, Length=154, Percent_Identity=29.8701298701299, Blast_Score=73, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6322075, Length=339, Percent_Identity=26.8436578171091, Blast_Score=86, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005860
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.1.1.81 [H]

Molecular weight: Translated: 41089; Mature: 40958

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANTGHGGNIKEIARKKGIDYNNIIDFSSNINPLGMSSKVKRAIIDSMEEIKKYPDISYM
CCCCCCCCCHHHHHHHCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHH
ELKKSISEYENINESYLMLGNGAAEVLFNIVKALKPKKVLIPVPTFSEYKEAVECVNSKV
HHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCCCE
ELYKMSENNSFKICEDILDKITEEIDLIFICNPNNPTGVLTNRELLMKILIKSKENNSTV
EEEEECCCCCHHHHHHHHHHHHHHEEEEEEECCCCCCEEEECHHHHHHHHHHCCCCCCEE
LIDESFMDFITEDISMVNTVETFDNLIILKSLTKFFAMPGLRIGYGVCSNKDFISEVYKI
EEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHC
TPAWNINILADVATRVSLHDKNYMRKTIQYMEKEKAFLYNSLKTFKNLNVYEPSVNFIFF
CCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCEEEE
KSNLDINLKSELLKYNVLIRSCSNYDGLNEYYYRVAVKSREDNTKLICCIKNILGDNE
ECCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCEEEEEEHHHHCCCC
>Mature Secondary Structure 
ANTGHGGNIKEIARKKGIDYNNIIDFSSNINPLGMSSKVKRAIIDSMEEIKKYPDISYM
CCCCCCCCHHHHHHHCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHH
ELKKSISEYENINESYLMLGNGAAEVLFNIVKALKPKKVLIPVPTFSEYKEAVECVNSKV
HHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCCCE
ELYKMSENNSFKICEDILDKITEEIDLIFICNPNNPTGVLTNRELLMKILIKSKENNSTV
EEEEECCCCCHHHHHHHHHHHHHHEEEEEEECCCCCCEEEECHHHHHHHHHHCCCCCCEE
LIDESFMDFITEDISMVNTVETFDNLIILKSLTKFFAMPGLRIGYGVCSNKDFISEVYKI
EEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHC
TPAWNINILADVATRVSLHDKNYMRKTIQYMEKEKAFLYNSLKTFKNLNVYEPSVNFIFF
CCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCEEEE
KSNLDINLKSELLKYNVLIRSCSNYDGLNEYYYRVAVKSREDNTKLICCIKNILGDNE
ECCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCEEEEEEHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]