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The map label for this gene is degP [H]

Identifier: 187918643

GI number: 187918643

Start: 840710

End: 842350

Strand: Direct

Name: degP [H]

Synonym: BH0790A

Alternate gene names: 187918643

Gene position: 840710-842350 (Clockwise)

Preceding gene: 187918642

Following gene: 187918644

Centisome position: 91.15

GC content: 30.77

Gene sequence:

>1641_bases
TTGATGCATAGAAAAATTTTTATTATTTTTATGTTAATTTTTTCATGCAGTACAATAAAAGACATAGATGACAAACGAAT
TTATTATATCCCATCTGAAAGCATAAATAAGCATATTGAAAAAAATAATTTTGAGATTGCTCTTTCAAGTTATTACAATC
TAAAAAATAGTGGTTTTAAAATGGATCAAGGTATTCTAGACTTAAGAGATAAAGCTTTGTCTGGCATTCAAAATGAATAC
TTTAAGTTTTGTAAGGAAAAAGATTATGAGAGCGCACTCTTTAAGCTTGAGACTTTAAATTTGTTTGGTATCATGCTTCA
TGAGAGTAGAGAACAATTGATTTTAAAGCATCTTGAGAGTTTAAAGCGCAAGGACCCGATGCTTGCAAGTTTTTTTGCAA
AATATTATTCATTTGATAATACTTTTGATTCTTTGAAAAAATTTGTCATTAATAAAAAATCTCCCTCAAGAAATGTCTTG
CTTGATACGGCTGTTTTAACAGTTTGGGTGGATATGGGAACTAAAATTGTAAATGGCCATAGGTTGCCAAATATTGCCGT
GGGTTCTGCTTTTGTTGTTGATAATCTTAAGGGGTATGCTTTAACTAATTATCATGTAATTAGTTCTCAGGTTGATAATG
ATTACAAAGGAGTTTCCAATCTTTATGTCAGACTTCCAAGAGGCAAGGGCGAAAAACTGCCTGCAAAAGTAATTTCTTAT
TCAAAGAAAATGGATCTTGCTTTAATTAAGGTCTCTTTTAAATTAGAGCATCAATTTAATTTAAATTATTCTTCGAATAT
TAATATTGGAGATAGAATTTATGCTATGGGTTCTCCTATGGGATTTGAGAAGACTATTACTTCAGGAATAATTTCTGGAA
AGAATAGAAACTTGTTATCTGTGGGTGATTCTTATCAAATTGATGCTGCTATTAATCAGGGAAATTCTGGTGGGCCTGTG
GTAAATGAAGGTGGCGAATTTGTTGGACTTACATTTGCTGGAATTTTACATTCACAAGGTCTTAATTTCGTTATACCTTC
AAAATGGGTTTTAAAGGTCTTGCCATTTATGTATGAAGGTGGAATTTTGAGAAATAAATGGTTGGGATTTACTTTTTCTG
AAAGTTTGAAAAATTTGGAAATATCATATATAGCTCCTAATTCTCCTGCAGATATTGGTGGGTTGAGGAGTGGAGATTCT
ATTCTTAGTGTTAATTCCTTGAAATTTGATAGCTTAAGAGAGCTTCAATACTATATTTTGCAAAGGAGATCTATGGTGAG
AATTAGGTATAGAAGAGATAATAAAGAGTATGAGAGTTATTTGTATCCACAAGACCGACCAGAAGATATTATTGAAAGTA
TTGTAGAGAGTGATTCTTTTAAAAATTTGATGGGAGCTTTTTTGGGATTAAATTTGAATTTGATTTCTGGGAGAGAGTAT
AGAGTTGCTAAGGTATTTTCAAATGGTCTTGGTGATGAACTTAATTTTAGGGCAAATGATGAAATTTTTGTTTATTCTTT
TAACTATCTTATGGATAAGAGATTATTTGTCTTATTGCTTTATGTTAAAAGATTGTTTTCAGGATATTTAGGAGCTCCTT
TGCAGCTTGTTATTCCCTTTGATTCTCTTATTTTTGTATAA

Upstream 100 bases:

>100_bases
TATGTTGAAATTTATGACAAAGGGGTTTTAAAAGTTAAGAGAGTTATTTTAGATGATAGTTTTGATATCTATCATAACGT
TAATTAGCTTTTGAGAATTA

Downstream 100 bases:

>100_bases
AAAATTATTTAGTATGTTTGGAGTTGATTTTAATGAGCTTTTATTTGAAATTAGTTAGTGGAGATACTGAGTCCAAACTT
GATAATATTGTTTCTATTAG

Product: protease HhoB

Products: NA

Alternate protein names: Antigen htrA [H]

Number of amino acids: Translated: 546; Mature: 546

Protein sequence:

>546_residues
MMHRKIFIIFMLIFSCSTIKDIDDKRIYYIPSESINKHIEKNNFEIALSSYYNLKNSGFKMDQGILDLRDKALSGIQNEY
FKFCKEKDYESALFKLETLNLFGIMLHESREQLILKHLESLKRKDPMLASFFAKYYSFDNTFDSLKKFVINKKSPSRNVL
LDTAVLTVWVDMGTKIVNGHRLPNIAVGSAFVVDNLKGYALTNYHVISSQVDNDYKGVSNLYVRLPRGKGEKLPAKVISY
SKKMDLALIKVSFKLEHQFNLNYSSNINIGDRIYAMGSPMGFEKTITSGIISGKNRNLLSVGDSYQIDAAINQGNSGGPV
VNEGGEFVGLTFAGILHSQGLNFVIPSKWVLKVLPFMYEGGILRNKWLGFTFSESLKNLEISYIAPNSPADIGGLRSGDS
ILSVNSLKFDSLRELQYYILQRRSMVRIRYRRDNKEYESYLYPQDRPEDIIESIVESDSFKNLMGAFLGLNLNLISGREY
RVAKVFSNGLGDELNFRANDEIFVYSFNYLMDKRLFVLLLYVKRLFSGYLGAPLQLVIPFDSLIFV

Sequences:

>Translated_546_residues
MMHRKIFIIFMLIFSCSTIKDIDDKRIYYIPSESINKHIEKNNFEIALSSYYNLKNSGFKMDQGILDLRDKALSGIQNEY
FKFCKEKDYESALFKLETLNLFGIMLHESREQLILKHLESLKRKDPMLASFFAKYYSFDNTFDSLKKFVINKKSPSRNVL
LDTAVLTVWVDMGTKIVNGHRLPNIAVGSAFVVDNLKGYALTNYHVISSQVDNDYKGVSNLYVRLPRGKGEKLPAKVISY
SKKMDLALIKVSFKLEHQFNLNYSSNINIGDRIYAMGSPMGFEKTITSGIISGKNRNLLSVGDSYQIDAAINQGNSGGPV
VNEGGEFVGLTFAGILHSQGLNFVIPSKWVLKVLPFMYEGGILRNKWLGFTFSESLKNLEISYIAPNSPADIGGLRSGDS
ILSVNSLKFDSLRELQYYILQRRSMVRIRYRRDNKEYESYLYPQDRPEDIIESIVESDSFKNLMGAFLGLNLNLISGREY
RVAKVFSNGLGDELNFRANDEIFVYSFNYLMDKRLFVLLLYVKRLFSGYLGAPLQLVIPFDSLIFV
>Mature_546_residues
MMHRKIFIIFMLIFSCSTIKDIDDKRIYYIPSESINKHIEKNNFEIALSSYYNLKNSGFKMDQGILDLRDKALSGIQNEY
FKFCKEKDYESALFKLETLNLFGIMLHESREQLILKHLESLKRKDPMLASFFAKYYSFDNTFDSLKKFVINKKSPSRNVL
LDTAVLTVWVDMGTKIVNGHRLPNIAVGSAFVVDNLKGYALTNYHVISSQVDNDYKGVSNLYVRLPRGKGEKLPAKVISY
SKKMDLALIKVSFKLEHQFNLNYSSNINIGDRIYAMGSPMGFEKTITSGIISGKNRNLLSVGDSYQIDAAINQGNSGGPV
VNEGGEFVGLTFAGILHSQGLNFVIPSKWVLKVLPFMYEGGILRNKWLGFTFSESLKNLEISYIAPNSPADIGGLRSGDS
ILSVNSLKFDSLRELQYYILQRRSMVRIRYRRDNKEYESYLYPQDRPEDIIESIVESDSFKNLMGAFLGLNLNLISGREY
RVAKVFSNGLGDELNFRANDEIFVYSFNYLMDKRLFVLLLYVKRLFSGYLGAPLQLVIPFDSLIFV

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI22129776, Length=293, Percent_Identity=29.3515358361775, Blast_Score=108, Evalue=2e-23,
Organism=Homo sapiens, GI4506141, Length=322, Percent_Identity=27.639751552795, Blast_Score=106, Evalue=7e-23,
Organism=Homo sapiens, GI24308541, Length=287, Percent_Identity=29.9651567944251, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI7019477, Length=300, Percent_Identity=28.3333333333333, Blast_Score=84, Evalue=4e-16,
Organism=Escherichia coli, GI1786356, Length=305, Percent_Identity=31.4754098360656, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI1789629, Length=275, Percent_Identity=29.0909090909091, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI1789630, Length=361, Percent_Identity=25.207756232687, Blast_Score=84, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24646839, Length=292, Percent_Identity=25.6849315068493, Blast_Score=85, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 62332; Mature: 62332

Theoretical pI: Translated: 9.53; Mature: 9.53

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMHRKIFIIFMLIFSCSTIKDIDDKRIYYIPSESINKHIEKNNFEIALSSYYNLKNSGFK
CCCHHHHHHHHHHHCCCHHCCCCCCEEEECCCHHHHHHHCCCCEEEEEEEEECCCCCCCC
MDQGILDLRDKALSGIQNEYFKFCKEKDYESALFKLETLNLFGIMLHESREQLILKHLES
CCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHEEEHHHEEEEEECCCHHHHHHHHHHH
LKRKDPMLASFFAKYYSFDNTFDSLKKFVINKKSPSRNVLLDTAVLTVWVDMGTKIVNGH
HHHCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHCCCEEECCC
RLPNIAVGSAFVVDNLKGYALTNYHVISSQVDNDYKGVSNLYVRLPRGKGEKLPAKVISY
CCCCEECCCEEEECCCCCEEEEEEEEEECCCCCCCCCCCEEEEECCCCCCCCCCHHHHHH
SKKMDLALIKVSFKLEHQFNLNYSSNINIGDRIYAMGSPMGFEKTITSGIISGKNRNLLS
CCCCCEEEEEEEEEEEEEEECCCCCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCCCEEE
VGDSYQIDAAINQGNSGGPVVNEGGEFVGLTFAGILHSQGLNFVIPSKWVLKVLPFMYEG
CCCCEEEEEEECCCCCCCCEECCCCCEEEHHHHHHHHHCCCCEECCCHHHHHHHHHHHCC
GILRNKWLGFTFSESLKNLEISYIAPNSPADIGGLRSGDSILSVNSLKFDSLRELQYYIL
CEEECCCCCCCHHHHHCCEEEEEECCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHH
QRRSMVRIRYRRDNKEYESYLYPQDRPEDIIESIVESDSFKNLMGAFLGLNLNLISGREY
HHCCEEEEEEECCCCHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHCCCEEEECCCCE
RVAKVFSNGLGDELNFRANDEIFVYSFNYLMDKRLFVLLLYVKRLFSGYLGAPLQLVIPF
EHHHHHHCCCCCCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEC
DSLIFV
HHHHCC
>Mature Secondary Structure
MMHRKIFIIFMLIFSCSTIKDIDDKRIYYIPSESINKHIEKNNFEIALSSYYNLKNSGFK
CCCHHHHHHHHHHHCCCHHCCCCCCEEEECCCHHHHHHHCCCCEEEEEEEEECCCCCCCC
MDQGILDLRDKALSGIQNEYFKFCKEKDYESALFKLETLNLFGIMLHESREQLILKHLES
CCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHEEEHHHEEEEEECCCHHHHHHHHHHH
LKRKDPMLASFFAKYYSFDNTFDSLKKFVINKKSPSRNVLLDTAVLTVWVDMGTKIVNGH
HHHCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHCCCEEECCC
RLPNIAVGSAFVVDNLKGYALTNYHVISSQVDNDYKGVSNLYVRLPRGKGEKLPAKVISY
CCCCEECCCEEEECCCCCEEEEEEEEEECCCCCCCCCCCEEEEECCCCCCCCCCHHHHHH
SKKMDLALIKVSFKLEHQFNLNYSSNINIGDRIYAMGSPMGFEKTITSGIISGKNRNLLS
CCCCCEEEEEEEEEEEEEEECCCCCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCCCEEE
VGDSYQIDAAINQGNSGGPVVNEGGEFVGLTFAGILHSQGLNFVIPSKWVLKVLPFMYEG
CCCCEEEEEEECCCCCCCCEECCCCCEEEHHHHHHHHHCCCCEECCCHHHHHHHHHHHCC
GILRNKWLGFTFSESLKNLEISYIAPNSPADIGGLRSGDSILSVNSLKFDSLRELQYYIL
CEEECCCCCCCHHHHHCCEEEEEECCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHH
QRRSMVRIRYRRDNKEYESYLYPQDRPEDIIESIVESDSFKNLMGAFLGLNLNLISGREY
HHCCEEEEEEECCCCHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHCCCEEEECCCCE
RVAKVFSNGLGDELNFRANDEIFVYSFNYLMDKRLFVLLLYVKRLFSGYLGAPLQLVIPF
EHHHHHHCCCCCCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEC
DSLIFV
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8027347 [H]