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The map label for this gene is patB [H]

Identifier: 187736580

GI number: 187736580

Start: 2555426

End: 2556628

Strand: Direct

Name: patB [H]

Synonym: Amuc_2102

Alternate gene names: 187736580

Gene position: 2555426-2556628 (Clockwise)

Preceding gene: 187736579

Following gene: 187736581

Centisome position: 95.92

GC content: 58.35

Gene sequence:

>1203_bases
ATGCAGTACGATTTTGACGAAGTAATTGAGCGACGCGGCACCGGAGCCCTGAAATATGAAGCGCTGCTTCCCCGCTGGGG
CCGGGACGACCTGATTCCCCTGTGGGTGGCGGACATGGACTTCAGGACGCCCCCCTTCATCATGGAAGCTATCCGCCGCC
GCTGCGAGCACGAAATCCTGGGATATACCGTCAAGCCCCGCGCTTTCTTTGAAGCCATCAGGGACTGGGTGGACCGACGC
CACGGGTGGAAGGTGAACGCCTCGGAAATAGGCTTCGCTCCGGGCATTGTTCCCGGCATTTCCAGCGCCATCCAATGCTT
TACGGAACCGGGGGACAAAATCATGATCCAGCCTCCGGTGTACCACCCCTTTGCCATGATCATCCGGGAAAACGGCCGGG
AAATCGTCAACAATCCCCTCATTCTGGAAAACGGCCGCTACCGCATGGACTTCAACCACATGCAGGAAGCCGTGCGTGGC
TGCCGCATGTTCATCCTGTGCAATCCCCACAACCCCGGAGGCCGCGTATGGAGTCCGGAGGAATTGCGCCGCGTGGCTGA
AATCTGTACGGCAAACGGCACGCTGGTCGTTTCTGATGAAATCCATGCGGATCTGACCCTTCCCGGCCACAGGCACACCG
TATTCGCCACTGTTTCCGAACAGGCCCGCATGAACTCCGTCACCTACATGGCGCCCAGCAAGACCTTCAACGTGCCCGGC
CTGGGCAGTTCCTACGTGATTTGCCAGAATCCGGACCTGTTCGCGAAATACCAGGACTTTGTCAGCGGCAGGGAGCTTGC
GGAAGGGCACGTTTTCGCGTACGACGGGCTCATCAGCGCCTATTCAGGCCCGGAAGGGGAGGAATGGCTGGCCCAGGCGC
TGGACTACATTCAGGAAAACATCCGCTTCATTGACGCGGAACTGCGCCGCCGCATGCCAAAAATTAAAACCATCATGCCG
GATGCCTCCTACCTAGTATTTCTGGACTGCCGGGAAATGAACCTTTCCCAGAAGGAACTGGTGGAATTTTTTGTGGACGG
AGCGCGCCTGGCTCTCAACGACGGTTCCATCTTCGGCAAGGAAGGGGAAGGCTTCATGCGCCTGAACGCGGGCTGTCCCC
GCTCCATCCTGGAACGGGCGCTCAGCCAGCTGGAGGAAGCCTATGAAAACCGCGGCTTCCGGCAACAACAATCACAAAAT
TAA

Upstream 100 bases:

>100_bases
GCCGTCGTCATTACCGGGGAAACGGCCAAATACGGCAACATCATCCTGAAAAAAGGCGTTACCCCTCTTTCCTGACCATT
GGCCGCCAGACAAACCTTCC

Downstream 100 bases:

>100_bases
AGACACGCATCACGCTCCCCGGCAATGGAATTCATTTCCGGAACCATGTATTGGGGAAATTTTCCCGGAGACATCCAGCC
CCGCCGTATTTTCTCCTGTT

Product: aminotransferase class I and II

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MQYDFDEVIERRGTGALKYEALLPRWGRDDLIPLWVADMDFRTPPFIMEAIRRRCEHEILGYTVKPRAFFEAIRDWVDRR
HGWKVNASEIGFAPGIVPGISSAIQCFTEPGDKIMIQPPVYHPFAMIIRENGREIVNNPLILENGRYRMDFNHMQEAVRG
CRMFILCNPHNPGGRVWSPEELRRVAEICTANGTLVVSDEIHADLTLPGHRHTVFATVSEQARMNSVTYMAPSKTFNVPG
LGSSYVICQNPDLFAKYQDFVSGRELAEGHVFAYDGLISAYSGPEGEEWLAQALDYIQENIRFIDAELRRRMPKIKTIMP
DASYLVFLDCREMNLSQKELVEFFVDGARLALNDGSIFGKEGEGFMRLNAGCPRSILERALSQLEEAYENRGFRQQQSQN

Sequences:

>Translated_400_residues
MQYDFDEVIERRGTGALKYEALLPRWGRDDLIPLWVADMDFRTPPFIMEAIRRRCEHEILGYTVKPRAFFEAIRDWVDRR
HGWKVNASEIGFAPGIVPGISSAIQCFTEPGDKIMIQPPVYHPFAMIIRENGREIVNNPLILENGRYRMDFNHMQEAVRG
CRMFILCNPHNPGGRVWSPEELRRVAEICTANGTLVVSDEIHADLTLPGHRHTVFATVSEQARMNSVTYMAPSKTFNVPG
LGSSYVICQNPDLFAKYQDFVSGRELAEGHVFAYDGLISAYSGPEGEEWLAQALDYIQENIRFIDAELRRRMPKIKTIMP
DASYLVFLDCREMNLSQKELVEFFVDGARLALNDGSIFGKEGEGFMRLNAGCPRSILERALSQLEEAYENRGFRQQQSQN
>Mature_400_residues
MQYDFDEVIERRGTGALKYEALLPRWGRDDLIPLWVADMDFRTPPFIMEAIRRRCEHEILGYTVKPRAFFEAIRDWVDRR
HGWKVNASEIGFAPGIVPGISSAIQCFTEPGDKIMIQPPVYHPFAMIIRENGREIVNNPLILENGRYRMDFNHMQEAVRG
CRMFILCNPHNPGGRVWSPEELRRVAEICTANGTLVVSDEIHADLTLPGHRHTVFATVSEQARMNSVTYMAPSKTFNVPG
LGSSYVICQNPDLFAKYQDFVSGRELAEGHVFAYDGLISAYSGPEGEEWLAQALDYIQENIRFIDAELRRRMPKIKTIMP
DASYLVFLDCREMNLSQKELVEFFVDGARLALNDGSIFGKEGEGFMRLNAGCPRSILERALSQLEEAYENRGFRQQQSQN

Specific function: Catalyzes the transformation of cystathionine to homocysteine. Also exhibits cysteine desulfhydrase activity in vitro, producing sulfide from cysteine [H]

COG id: COG1168

COG function: function code E; Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787909, Length=389, Percent_Identity=31.3624678663239, Blast_Score=233, Evalue=2e-62,
Organism=Escherichia coli, GI1786816, Length=218, Percent_Identity=23.394495412844, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322401, Length=185, Percent_Identity=24.3243243243243, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 45711; Mature: 45711

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQYDFDEVIERRGTGALKYEALLPRWGRDDLIPLWVADMDFRTPPFIMEAIRRRCEHEIL
CCCCHHHHHHHCCCCCEEEHHHCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHH
GYTVKPRAFFEAIRDWVDRRHGWKVNASEIGFAPGIVPGISSAIQCFTEPGDKIMIQPPV
CEEECHHHHHHHHHHHHHHCCCCEECHHHCCCCCCCHHHHHHHHHHHCCCCCEEEEECCC
YHPFAMIIRENGREIVNNPLILENGRYRMDFNHMQEAVRGCRMFILCNPHNPGGRVWSPE
CCHHHHEEHHCCHHHHCCCEEEECCCEEECHHHHHHHHHHCEEEEEECCCCCCCCCCCHH
ELRRVAEICTANGTLVVSDEIHADLTLPGHRHTVFATVSEQARMNSVTYMAPSKTFNVPG
HHHHHHHHHCCCCEEEEECCCCEEEECCCCCEEEEEEECHHHHHCCEEEECCCCCCCCCC
LGSSYVICQNPDLFAKYQDFVSGRELAEGHVFAYDGLISAYSGPEGEEWLAQALDYIQEN
CCCCEEEECCCCHHHHHHHHHCCHHHHCCCEEEECCCHHHCCCCCHHHHHHHHHHHHHHH
IRFIDAELRRRMPKIKTIMPDASYLVFLDCREMNLSQKELVEFFVDGARLALNDGSIFGK
HHHHHHHHHHCCCHHHEECCCCCEEEEEECCCCCCCHHHHHHHHHCCCEEEEECCCEECC
EGEGFMRLNAGCPRSILERALSQLEEAYENRGFRQQQSQN
CCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCCHHHCCC
>Mature Secondary Structure
MQYDFDEVIERRGTGALKYEALLPRWGRDDLIPLWVADMDFRTPPFIMEAIRRRCEHEIL
CCCCHHHHHHHCCCCCEEEHHHCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHH
GYTVKPRAFFEAIRDWVDRRHGWKVNASEIGFAPGIVPGISSAIQCFTEPGDKIMIQPPV
CEEECHHHHHHHHHHHHHHCCCCEECHHHCCCCCCCHHHHHHHHHHHCCCCCEEEEECCC
YHPFAMIIRENGREIVNNPLILENGRYRMDFNHMQEAVRGCRMFILCNPHNPGGRVWSPE
CCHHHHEEHHCCHHHHCCCEEEECCCEEECHHHHHHHHHHCEEEEEECCCCCCCCCCCHH
ELRRVAEICTANGTLVVSDEIHADLTLPGHRHTVFATVSEQARMNSVTYMAPSKTFNVPG
HHHHHHHHHCCCCEEEEECCCCEEEECCCCCEEEEEEECHHHHHCCEEEECCCCCCCCCC
LGSSYVICQNPDLFAKYQDFVSGRELAEGHVFAYDGLISAYSGPEGEEWLAQALDYIQEN
CCCCEEEECCCCHHHHHHHHHCCHHHHCCCEEEECCCHHHCCCCCHHHHHHHHHHHHHHH
IRFIDAELRRRMPKIKTIMPDASYLVFLDCREMNLSQKELVEFFVDGARLALNDGSIFGK
HHHHHHHHHHCCCHHHEECCCCCEEEEEECCCCCCCHHHHHHHHHCCCEEEEECCCEECC
EGEGFMRLNAGCPRSILERALSQLEEAYENRGFRQQQSQN
CCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8497199; 9274030; 9384377 [H]