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The map label for this gene is thiL [H]

Identifier: 187735098

GI number: 187735098

Start: 701509

End: 702405

Strand: Direct

Name: thiL [H]

Synonym: Amuc_0592

Alternate gene names: 187735098

Gene position: 701509-702405 (Clockwise)

Preceding gene: 187735097

Following gene: 187735100

Centisome position: 26.33

GC content: 65.44

Gene sequence:

>897_bases
ATGGAACCTGAGCCCAGCATCCGGCAGATGGGAGAGGATGCGCTGGTAGCCCGCCTCCTTCCCCTGATGCCTTCCAATCC
GTCCCTGGAGACGGGGCCGGGAGACGATTGCGCCATAATCCGGGGGTCAGGAAACCGTCAGCTGCTCCTGAAAACGGACT
GCGTGGTGGAAGGCATGCATTTCCTGCCCGGAACGGACCCGGAACTGATCGGGAGGAAGGCGCTGGCACGGGCCGTTTCA
GACATAGGGGCCATGGGCGGCACGCCCCTTCACGCACTGGTGACCCTGTTCGTGCACGCAGACCGCCCCATCTCCCAAGT
GGAAGGAATTTACCGCGGCATGGGGCGGCTGGCACGGCAGTTCGGCATCAGCATCGCCGGGGGGGAAAGCTCCGGCCTGC
CCGCGGACGGGCTCATCATCAACGTGGCGCTGACCGGAGAAGTGGAGGCAGGCAAAGCCGTACTGCGCAGCACGGCGCGG
GCGGGGGATCTGATTGCCGTAACGGGAACGCTCGGCGGCAGCTTCCCCACCGGCCACCATCTTTCCTTCACGCCGCGTGT
CAGGGAAGGAGGCATCCTGGCCGCCTCCGGCGTAGCCACCTCCATGATGGATCTTTCCGACGGGCTGGGAACCGACCTCC
CCCGGCTGGCGGCCGCCTCCGGGCTTGGGTTCCGTATTCATGAAGAGCTTCTTCCCGTGCGCCCGGGGTTTACTGCGGCC
CAGGCTGTAGGGGATGGGGAGGATTACGAATTGCTGGTGACCTTCCGTCCCGGCGACCGAGAACGGGCGGCACGACTGGC
CGCGGAGCATTTTCCGGAAACGCCTCTCACCGTCATCGGGGAAATGACTGCGGAAACGGCCTCCGCCCTTCCCCCAGGTT
ACAGGCACTTCAGCTAG

Upstream 100 bases:

>100_bases
TACGAATACACGGGCAGCATCTGGACGCCCATCATCGCCCATTGCATTTTCAACACCGCCACTCTCATCAACATTCTGTA
TCCCGGCATCCTTCTTCCGT

Downstream 100 bases:

>100_bases
CCCGTTAAGAACCGGGGGCAGAGCCACGCAAAACGCCTGCGGAATTATTCCGCCGCCTTTTCCTCCTCTTTCTCCCGCTG
CATGTAAGGCAGGAGCTGTT

Product: thiamine-monophosphate kinase

Products: NA

Alternate protein names: Thiamine-phosphate kinase [H]

Number of amino acids: Translated: 298; Mature: 298

Protein sequence:

>298_residues
MEPEPSIRQMGEDALVARLLPLMPSNPSLETGPGDDCAIIRGSGNRQLLLKTDCVVEGMHFLPGTDPELIGRKALARAVS
DIGAMGGTPLHALVTLFVHADRPISQVEGIYRGMGRLARQFGISIAGGESSGLPADGLIINVALTGEVEAGKAVLRSTAR
AGDLIAVTGTLGGSFPTGHHLSFTPRVREGGILAASGVATSMMDLSDGLGTDLPRLAAASGLGFRIHEELLPVRPGFTAA
QAVGDGEDYELLVTFRPGDRERAARLAAEHFPETPLTVIGEMTAETASALPPGYRHFS

Sequences:

>Translated_298_residues
MEPEPSIRQMGEDALVARLLPLMPSNPSLETGPGDDCAIIRGSGNRQLLLKTDCVVEGMHFLPGTDPELIGRKALARAVS
DIGAMGGTPLHALVTLFVHADRPISQVEGIYRGMGRLARQFGISIAGGESSGLPADGLIINVALTGEVEAGKAVLRSTAR
AGDLIAVTGTLGGSFPTGHHLSFTPRVREGGILAASGVATSMMDLSDGLGTDLPRLAAASGLGFRIHEELLPVRPGFTAA
QAVGDGEDYELLVTFRPGDRERAARLAAEHFPETPLTVIGEMTAETASALPPGYRHFS
>Mature_298_residues
MEPEPSIRQMGEDALVARLLPLMPSNPSLETGPGDDCAIIRGSGNRQLLLKTDCVVEGMHFLPGTDPELIGRKALARAVS
DIGAMGGTPLHALVTLFVHADRPISQVEGIYRGMGRLARQFGISIAGGESSGLPADGLIINVALTGEVEAGKAVLRSTAR
AGDLIAVTGTLGGSFPTGHHLSFTPRVREGGILAASGVATSMMDLSDGLGTDLPRLAAASGLGFRIHEELLPVRPGFTAA
QAVGDGEDYELLVTFRPGDRERAARLAAEHFPETPLTVIGEMTAETASALPPGYRHFS

Specific function: Thiamine biosynthesis. [C]

COG id: COG0611

COG function: function code H; Thiamine monophosphate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiamine-monophosphate kinase family [H]

Homologues:

Organism=Escherichia coli, GI1786619, Length=329, Percent_Identity=33.434650455927, Blast_Score=122, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR016188
- InterPro:   IPR006283 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =2.7.4.16 [H]

Molecular weight: Translated: 31089; Mature: 31089

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEPEPSIRQMGEDALVARLLPLMPSNPSLETGPGDDCAIIRGSGNRQLLLKTDCVVEGMH
CCCCCHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCEEEEEECHHHHCHH
FLPGTDPELIGRKALARAVSDIGAMGGTPLHALVTLFVHADRPISQVEGIYRGMGRLARQ
CCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
FGISIAGGESSGLPADGLIINVALTGEVEAGKAVLRSTARAGDLIAVTGTLGGSFPTGHH
HCCEEECCCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCC
LSFTPRVREGGILAASGVATSMMDLSDGLGTDLPRLAAASGLGFRIHEELLPVRPGFTAA
EEECCCCCCCCEEEECCHHHHHHHHHCCCCCCHHHHHHHCCCCEEEHHHHCCCCCCCHHH
QAVGDGEDYELLVTFRPGDRERAARLAAEHFPETPLTVIGEMTAETASALPPGYRHFS
HHCCCCCCEEEEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MEPEPSIRQMGEDALVARLLPLMPSNPSLETGPGDDCAIIRGSGNRQLLLKTDCVVEGMH
CCCCCHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCEEEEEECHHHHCHH
FLPGTDPELIGRKALARAVSDIGAMGGTPLHALVTLFVHADRPISQVEGIYRGMGRLARQ
CCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
FGISIAGGESSGLPADGLIINVALTGEVEAGKAVLRSTARAGDLIAVTGTLGGSFPTGHH
HCCEEECCCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCC
LSFTPRVREGGILAASGVATSMMDLSDGLGTDLPRLAAASGLGFRIHEELLPVRPGFTAA
EEECCCCCCCCEEEECCHHHHHHHHHCCCCCCHHHHHHHCCCCEEEHHHHCCCCCCCHHH
QAVGDGEDYELLVTFRPGDRERAARLAAEHFPETPLTVIGEMTAETASALPPGYRHFS
HHCCCCCCEEEEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9202461; 9384377; 8419296 [H]