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The map label for this gene is ribBA [H]

Identifier: 187734929

GI number: 187734929

Start: 505832

End: 507034

Strand: Direct

Name: ribBA [H]

Synonym: Amuc_0422

Alternate gene names: 187734929

Gene position: 505832-507034 (Clockwise)

Preceding gene: 187734928

Following gene: 187734930

Centisome position: 18.99

GC content: 59.43

Gene sequence:

>1203_bases
ATGGACAATCAACTTCAATTCTGCACCGTTGAAGAAGCCGTGGAAGAAATACGGCAGGGACGGATGATCATCGTTACGGA
CGACCCTGGGCGTGAAAATGAGGCAGACCTGATCATTGCCGCCGAATTCGCTACGCCGGAAGCCATCAACTTCATGGTTA
CCCACGCCAGGGGCCTCGTCTGCGCACCTCTTTCACCGGAACGGGCGGACGCCCTCCAACTCCCGCTCATGACCTCCGTC
AACCGGGAAAACATGTCCACAGCGTTCACCGTCTCCGTGGATGCGGCCCATGACATCACTACGGGCATCAGCGCCGCGGA
ACGCTCCCTCACCATTCGCACGCTGGCGGACCCCAAAGCCACCGTCAACGACTTTGTTCAGCCGGGTCATACATTCCCTC
TCCGCGCCGTTCCCGGCGGAGTGTTGCGCCGCGCCGGCCATACGGAAGCCACCATTGACCTCGTGCGCATGGCAGGCCTT
CAGCCCGCCGGCGTTTGCTGTGAAATCATGAAGGAAGACGGCACCATGGCCCGCATCGGGGATCTGGGGGGATTCCAGAA
AAAACATGGCCTGAAAGCCTGCACCGTAGCCCAGCTTATTGAATACCGCCGGGACAAGGAAAAGCAAATCCGGCTGGTGG
AAACCGTCAACATGCCCACAGACTACGGAGACTTTACCTGCCGCCTTTATGAATCCCAGCTGGACGGAGCTCTTCATCTG
GCCCTGGTTCACGGGGAAATCTCCCCGGACAAGCCCACGCTGGTGCGCGTGCATAGCGAATGCCTGACGGGAGATGTCTT
CGGCTCCCGCCGCTGTGACTGCGGCAGCCAGCTGCACGCCGCCATGCGCCGCATCGCCCAGGAAGGAGGCGTCCTGCTCT
ACCTGCGGCAGGAGGGCCGCGGCATCGGACTGGCGGCAAAACTCAAGGCCTACAAACTTCAGGAACAGGGTCTGGATACC
GTGGAAGCCAACCTCAGGCTCGGCTATCCGGACGACCTGCGCGACTATGGCATCGGAGCGCAAATCCTGCATGACCTGGG
AGCAAACCAGTTGCGCCTGCTTACCAACAACCCGCGGAAAATCGTGGGGCTGGAGGGCTTTGGCATAAAAATCACGGAAC
AGGTTCCTCTCATCATCCCACCCAACGAACAAAACAGCAAATACCTGGCTACCAAAAAATGCAAGCTGGGCCACATCCTG
TAA

Upstream 100 bases:

>100_bases
AGGGACCATGTACCGGGCCGTCGTCCTGTTTTCAACCGCACGGTGGCTCTCAAGGACTCCTGGGCAAAAAAACAAAAATA
ACCTCTCTTCATCCCCTTTT

Downstream 100 bases:

>100_bases
CATTCCACTCCATCCCTTCATGTCCACGGAACTTCCCCGCCGCCAGCGCGCCACGGGCACGCGCGCCAAAATCTGCATCG
TCGCCTCGGAATACAACGAA

Product: 3,4-dihydroxy-2-butanone 4-phosphate synthase

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II [H]

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MDNQLQFCTVEEAVEEIRQGRMIIVTDDPGRENEADLIIAAEFATPEAINFMVTHARGLVCAPLSPERADALQLPLMTSV
NRENMSTAFTVSVDAAHDITTGISAAERSLTIRTLADPKATVNDFVQPGHTFPLRAVPGGVLRRAGHTEATIDLVRMAGL
QPAGVCCEIMKEDGTMARIGDLGGFQKKHGLKACTVAQLIEYRRDKEKQIRLVETVNMPTDYGDFTCRLYESQLDGALHL
ALVHGEISPDKPTLVRVHSECLTGDVFGSRRCDCGSQLHAAMRRIAQEGGVLLYLRQEGRGIGLAAKLKAYKLQEQGLDT
VEANLRLGYPDDLRDYGIGAQILHDLGANQLRLLTNNPRKIVGLEGFGIKITEQVPLIIPPNEQNSKYLATKKCKLGHIL

Sequences:

>Translated_400_residues
MDNQLQFCTVEEAVEEIRQGRMIIVTDDPGRENEADLIIAAEFATPEAINFMVTHARGLVCAPLSPERADALQLPLMTSV
NRENMSTAFTVSVDAAHDITTGISAAERSLTIRTLADPKATVNDFVQPGHTFPLRAVPGGVLRRAGHTEATIDLVRMAGL
QPAGVCCEIMKEDGTMARIGDLGGFQKKHGLKACTVAQLIEYRRDKEKQIRLVETVNMPTDYGDFTCRLYESQLDGALHL
ALVHGEISPDKPTLVRVHSECLTGDVFGSRRCDCGSQLHAAMRRIAQEGGVLLYLRQEGRGIGLAAKLKAYKLQEQGLDT
VEANLRLGYPDDLRDYGIGAQILHDLGANQLRLLTNNPRKIVGLEGFGIKITEQVPLIIPPNEQNSKYLATKKCKLGHIL
>Mature_400_residues
MDNQLQFCTVEEAVEEIRQGRMIIVTDDPGRENEADLIIAAEFATPEAINFMVTHARGLVCAPLSPERADALQLPLMTSV
NRENMSTAFTVSVDAAHDITTGISAAERSLTIRTLADPKATVNDFVQPGHTFPLRAVPGGVLRRAGHTEATIDLVRMAGL
QPAGVCCEIMKEDGTMARIGDLGGFQKKHGLKACTVAQLIEYRRDKEKQIRLVETVNMPTDYGDFTCRLYESQLDGALHL
ALVHGEISPDKPTLVRVHSECLTGDVFGSRRCDCGSQLHAAMRRIAQEGGVLLYLRQEGRGIGLAAKLKAYKLQEQGLDT
VEANLRLGYPDDLRDYGIGAQILHDLGANQLRLLTNNPRKIVGLEGFGIKITEQVPLIIPPNEQNSKYLATKKCKLGHIL

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0108

COG function: function code H; 3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1787533, Length=193, Percent_Identity=53.3678756476684, Blast_Score=199, Evalue=3e-52,
Organism=Escherichia coli, GI1789420, Length=203, Percent_Identity=44.8275862068966, Blast_Score=181, Evalue=7e-47,
Organism=Saccharomyces cerevisiae, GI6320695, Length=206, Percent_Identity=45.1456310679612, Blast_Score=186, Evalue=5e-48,
Organism=Saccharomyces cerevisiae, GI6319438, Length=171, Percent_Identity=47.953216374269, Blast_Score=136, Evalue=5e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12; =3.5.4.25 [H]

Molecular weight: Translated: 43814; Mature: 43814

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00430 TONB_DEPENDENT_REC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDNQLQFCTVEEAVEEIRQGRMIIVTDDPGRENEADLIIAAEFATPEAINFMVTHARGLV
CCCCEEEEEHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEEECCCCCHHEEEEEECCCEE
CAPLSPERADALQLPLMTSVNRENMSTAFTVSVDAAHDITTGISAAERSLTIRTLADPKA
ECCCCCCCCCCEECCHHHCCCCCCCCEEEEEEECCCHHHHHCCHHHHHEEEEEEECCCCH
TVNDFVQPGHTFPLRAVPGGVLRRAGHTEATIDLVRMAGLQPAGVCCEIMKEDGTMARIG
HHHHHCCCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEC
DLGGFQKKHGLKACTVAQLIEYRRDKEKQIRLVETVNMPTDYGDFTCRLYESQLDGALHL
CCCCCHHHCCCCHHHHHHHHHHHCCCHHEEEEEEEECCCCCCCCEEEEEEHHHCCCEEEE
ALVHGEISPDKPTLVRVHSECLTGDVFGSRRCDCGSQLHAAMRRIAQEGGVLLYLRQEGR
EEEECCCCCCCCEEEEEEHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCC
GIGLAAKLKAYKLQEQGLDTVEANLRLGYPDDLRDYGIGAQILHDLGANQLRLLTNNPRK
CCCEEHHHHHHHHHHCCCCEEECCEEECCCCCHHHCCCHHHHHHHCCCCEEEEEECCCCE
IVGLEGFGIKITEQVPLIIPPNEQNSKYLATKKCKLGHIL
EEEECCCCEEEECCCEEEECCCCCCCCEEEECCCCCCCCC
>Mature Secondary Structure
MDNQLQFCTVEEAVEEIRQGRMIIVTDDPGRENEADLIIAAEFATPEAINFMVTHARGLV
CCCCEEEEEHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEEECCCCCHHEEEEEECCCEE
CAPLSPERADALQLPLMTSVNRENMSTAFTVSVDAAHDITTGISAAERSLTIRTLADPKA
ECCCCCCCCCCEECCHHHCCCCCCCCEEEEEEECCCHHHHHCCHHHHHEEEEEEECCCCH
TVNDFVQPGHTFPLRAVPGGVLRRAGHTEATIDLVRMAGLQPAGVCCEIMKEDGTMARIG
HHHHHCCCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEC
DLGGFQKKHGLKACTVAQLIEYRRDKEKQIRLVETVNMPTDYGDFTCRLYESQLDGALHL
CCCCCHHHCCCCHHHHHHHHHHHCCCHHEEEEEEEECCCCCCCCEEEEEEHHHCCCEEEE
ALVHGEISPDKPTLVRVHSECLTGDVFGSRRCDCGSQLHAAMRRIAQEGGVLLYLRQEGR
EEEECCCCCCCCEEEEEEHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCC
GIGLAAKLKAYKLQEQGLDTVEANLRLGYPDDLRDYGIGAQILHDLGANQLRLLTNNPRK
CCCEEHHHHHHHHHHCCCCEEECCEEECCCCCHHHCCCHHHHHHHCCCCEEEEEECCCCE
IVGLEGFGIKITEQVPLIIPPNEQNSKYLATKKCKLGHIL
EEEECCCCEEEECCCEEEECCCCCCCCEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA