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The map label for this gene is purE [H]

Identifier: 187734628

GI number: 187734628

Start: 141829

End: 142239

Strand: Reverse

Name: purE [H]

Synonym: Amuc_0114

Alternate gene names: 187734628

Gene position: 142239-141829 (Counterclockwise)

Preceding gene: 187734629

Following gene: 187734627

Centisome position: 5.34

GC content: 60.58

Gene sequence:

>411_bases
ATGAAAGTCATCGTCATCTACGGCAGCCCGAATGATAAGCCCTTTATGGAACCGGCCCGCGAGTATTTTGCTCAGGAGAA
TGTTCCTTATGAAGAAACCGTTCTGTCCGCCCACCGCGACCTTCCGGAGCTGATCAGGTTCCTGGGGGATTTGGAAGCCA
GCGGAGAAAAAGCGGTTATCCTGGCTGTGGCCGGCCTGTCCGCCGCCCTTCCCGGCGTGGTGGTGATGAGCTGTTCCCTC
CCGGTTATCGGCGTGCCGGTCCCCGGAGGCCCCCTGAACGGCATTGACGCCCTGCTGGCGATTGCCCAGTGTCCCGGCGG
CGTGCCCTGCACTACGGTTGGCTTGCATAAGAAAACCCCCGTCAATGCCGCCATGGCCGCCCACCGCATTTTAAAACTGG
CGGGGCTGTAA

Upstream 100 bases:

>100_bases
CCATTTCCACCCGGGGCCTTCCTTTTTTTGCAGGTTAAGTCTTGCCAGGGCAGGGGGCTTGGGGGCATAATCTGCAAGTT
TCACAACCGCACACACAGCC

Downstream 100 bases:

>100_bases
CGTGAACTTTTTCCCCCATCCGGCAAATGACTCCTCCTTCACAGGAAATCGTATTGGACGGTCCGGGAATTTCCCGTGCG
CTTGAGCGCATGGCCCACGG

Product: 1-(5-phosphoribosyl)-5-amino-4-imidazole- carboxylate (AIR) carboxylase

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 136; Mature: 136

Protein sequence:

>136_residues
MKVIVIYGSPNDKPFMEPAREYFAQENVPYEETVLSAHRDLPELIRFLGDLEASGEKAVILAVAGLSAALPGVVVMSCSL
PVIGVPVPGGPLNGIDALLAIAQCPGGVPCTTVGLHKKTPVNAAMAAHRILKLAGL

Sequences:

>Translated_136_residues
MKVIVIYGSPNDKPFMEPAREYFAQENVPYEETVLSAHRDLPELIRFLGDLEASGEKAVILAVAGLSAALPGVVVMSCSL
PVIGVPVPGGPLNGIDALLAIAQCPGGVPCTTVGLHKKTPVNAAMAAHRILKLAGL
>Mature_136_residues
MKVIVIYGSPNDKPFMEPAREYFAQENVPYEETVLSAHRDLPELIRFLGDLEASGEKAVILAVAGLSAALPGVVVMSCSL
PVIGVPVPGGPLNGIDALLAIAQCPGGVPCTTVGLHKKTPVNAAMAAHRILKLAGL

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=112, Percent_Identity=40.1785714285714, Blast_Score=79, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6324702, Length=127, Percent_Identity=42.5196850393701, Blast_Score=82, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 14137; Mature: 14137

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVIVIYGSPNDKPFMEPAREYFAQENVPYEETVLSAHRDLPELIRFLGDLEASGEKAVI
CEEEEEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHCCCCCCCCEEE
LAVAGLSAALPGVVVMSCSLPVIGVPVPGGPLNGIDALLAIAQCPGGVPCTTVGLHKKTP
EEECCHHHHCCCEEEEECCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEECCCCCCC
VNAAMAAHRILKLAGL
HHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKVIVIYGSPNDKPFMEPAREYFAQENVPYEETVLSAHRDLPELIRFLGDLEASGEKAVI
CEEEEEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHCCCCCCCCEEE
LAVAGLSAALPGVVVMSCSLPVIGVPVPGGPLNGIDALLAIAQCPGGVPCTTVGLHKKTP
EEECCHHHHCCCEEEEECCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEECCCCCCC
VNAAMAAHRILKLAGL
HHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9311113; 11427726 [H]