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The map label for this gene is mutL

Identifier: 187734600

GI number: 187734600

Start: 112700

End: 114601

Strand: Direct

Name: mutL

Synonym: Amuc_0086

Alternate gene names: 187734600

Gene position: 112700-114601 (Clockwise)

Preceding gene: 187734599

Following gene: 187734602

Centisome position: 4.23

GC content: 58.94

Gene sequence:

>1902_bases
ATGCCATCCATCCACGTCATGTCTCCCACCCTTGCCAGCCAAGTGGCGGCAGGAGAAGTAGTGGAGCGCCCCGCCTCCGT
TGTGAAGGAACTGGTGGAAAACAGCCTGGATGCAGGAGCCAAATTCGTACGGGTGGAAATACGCCGCGGAGGCGTGGGCA
TGATCAAGGTGACGGACGACGGCAGCGGCATGTCACGGGCAGACGCCGAGCTGTGCACCAAACGGCACGCCACCAGCAAA
CTTTCTTCCCTGGAGGAGCTTTTTGAAATCACACACCTGGGATTCCGCGGAGAGGCTCTGCCCAGCATTGCCAGCGTTTC
CCGCTTCAAACTCTGTACCAGGCAGCAGCAGGATCTGGAAGGCTGGGAAATACGCATTGACGGAGGCCTGGAACACGAAC
CGAGAAGCTCAGGCGTCTCTCCCGGCACCGCCATTGAGGTGGCCGACTTGTTTTACAATACTCCAGCGCGCCGCAAGTTC
CTCAAATCCGCAGAAACGGAAGCTTCCCATGTGGAGCACCAGATACGCCTGCATGCCCTGGCTTATCCCCAAGTACGGTT
TGCCTATAAACGGGACGACCAGCTTGTTTTCGACCTTCCCGCTACAGCGGATCTGCGCGTCCGCATTTCCGCACTGACGG
ATGCTGCCACAGCGGCGGCCCTGATTCCGATAGAAACGACCATCGGCCCCGGTATTTCCATCACGGGATTCCTGCTTCCT
CTTTCCGAAGCCAGACGCACCAGAAAAGGGCAGTACGTCTTTATGAACACGCGCCCCGTGGAGGACCAGCTCATTAACAG
GGCCATTCGGGACGGCTACGGAGGCTTCCCCACCGGACTGCATCCGGCGCTTTTTTTGTATATGGAGGTGGAACCCGCTC
TGGTGGACGTCAATGTGCACCCCGCCAAGAAGGAAGTGAGATTCCGCCGTTCCGCAGACGTGGTAAACACCATTGTGGAA
GCCATAGCCAACACTCTTCAAAAGCATGCCCGGCAGGAAATCCACGCTGCCGCCGCGCCGGAGCCGGAGAGAACTCTTCC
TCCTGCCCATTCTACCACCGCGCCATATGGGGAAATACCCGCCCGTTCCACCAACCCCGGTTCTGCTTTCCCGGCGGCCG
CCAGACCGGCCCCTGCTTCTTCCGCCGCCCAACCGCCGCTTTCCTCCTCTGCCAAACAATCCCATGGGGCTGTCCCTCCC
CCCACCCTCCGGGCCATTCCCCTGAAACAGGTTCCCGCCACCCAGGGAAAACTGGATTTTCACCGTCAGGAGGATGAAGA
GACGGCACGAAACGCCCATGAAAACGCAGCTCTGGAAAGGGATGCCTCCGCCGGATTTTCCTATCTGGGAACACTCCGCC
AGCAATTCGCCCTGTTTGAAACGCCGGAAGGCCTGGTTCTGATGCATCCCAAGGCGGCCCGGGAACGCATCATATTTGAA
CGGCTGCGCGCACGCCGGGAAGCCCCCATGCCGTCCCAGCAGCTTCTGGATCCGGTGGTGCTGGATCTGGACCCGCGGGA
TTTTGCCGTCATCCGGCAGTTCGCCCCGCATTTTGACCAGGCCGGCATGGCCGTTACGCCCTTTGGACAGAATACAATCA
GAATAGAATCCATCCCCGCACTGCTGGAACTGGAAAACGCACGCGCTTTTCTCCTGGAGCTGGTGGACCGTCTCACCCAG
TCCGAATTCAGCCGAAATGCCAAACGCGTGGCTTATGAGACCTTCATTGGGGAATTTGCCAGAAAATCCGCCTGGAGGGA
GCGCATTTCCCCTCACCGGGCCCCTGCCATCCTAAAGGATTTGCTTGCCTGTGAAGTGCCGTACTGCACCCCGGGTGGCA
AACCCACGCTGGTGAATTATTCCGTTCCGGAAATTAAACGTAAATTCGGCCTACAGGCATAA

Upstream 100 bases:

>100_bases
GGTGACGGTTTCTCCCGGCGACCGGGTGGAAATCGTCTCCATCGTCGCCGGCGGCTAGGGTTCCGCTTTCGGGAACAGTC
TTTTCCAATCCGTCATCGCC

Downstream 100 bases:

>100_bases
GGATAAGGGAACCTTGTTTTCCGGAAAACAGGCCGAAACGCTGCAAGATTTTACGGCAAACGGAAAATATGCAGCCAAAG
ACGGATTGACGCCCGCTTCC

Product: DNA mismatch repair protein MutL

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 633; Mature: 632

Protein sequence:

>633_residues
MPSIHVMSPTLASQVAAGEVVERPASVVKELVENSLDAGAKFVRVEIRRGGVGMIKVTDDGSGMSRADAELCTKRHATSK
LSSLEELFEITHLGFRGEALPSIASVSRFKLCTRQQQDLEGWEIRIDGGLEHEPRSSGVSPGTAIEVADLFYNTPARRKF
LKSAETEASHVEHQIRLHALAYPQVRFAYKRDDQLVFDLPATADLRVRISALTDAATAAALIPIETTIGPGISITGFLLP
LSEARRTRKGQYVFMNTRPVEDQLINRAIRDGYGGFPTGLHPALFLYMEVEPALVDVNVHPAKKEVRFRRSADVVNTIVE
AIANTLQKHARQEIHAAAAPEPERTLPPAHSTTAPYGEIPARSTNPGSAFPAAARPAPASSAAQPPLSSSAKQSHGAVPP
PTLRAIPLKQVPATQGKLDFHRQEDEETARNAHENAALERDASAGFSYLGTLRQQFALFETPEGLVLMHPKAARERIIFE
RLRARREAPMPSQQLLDPVVLDLDPRDFAVIRQFAPHFDQAGMAVTPFGQNTIRIESIPALLELENARAFLLELVDRLTQ
SEFSRNAKRVAYETFIGEFARKSAWRERISPHRAPAILKDLLACEVPYCTPGGKPTLVNYSVPEIKRKFGLQA

Sequences:

>Translated_633_residues
MPSIHVMSPTLASQVAAGEVVERPASVVKELVENSLDAGAKFVRVEIRRGGVGMIKVTDDGSGMSRADAELCTKRHATSK
LSSLEELFEITHLGFRGEALPSIASVSRFKLCTRQQQDLEGWEIRIDGGLEHEPRSSGVSPGTAIEVADLFYNTPARRKF
LKSAETEASHVEHQIRLHALAYPQVRFAYKRDDQLVFDLPATADLRVRISALTDAATAAALIPIETTIGPGISITGFLLP
LSEARRTRKGQYVFMNTRPVEDQLINRAIRDGYGGFPTGLHPALFLYMEVEPALVDVNVHPAKKEVRFRRSADVVNTIVE
AIANTLQKHARQEIHAAAAPEPERTLPPAHSTTAPYGEIPARSTNPGSAFPAAARPAPASSAAQPPLSSSAKQSHGAVPP
PTLRAIPLKQVPATQGKLDFHRQEDEETARNAHENAALERDASAGFSYLGTLRQQFALFETPEGLVLMHPKAARERIIFE
RLRARREAPMPSQQLLDPVVLDLDPRDFAVIRQFAPHFDQAGMAVTPFGQNTIRIESIPALLELENARAFLLELVDRLTQ
SEFSRNAKRVAYETFIGEFARKSAWRERISPHRAPAILKDLLACEVPYCTPGGKPTLVNYSVPEIKRKFGLQA
>Mature_632_residues
PSIHVMSPTLASQVAAGEVVERPASVVKELVENSLDAGAKFVRVEIRRGGVGMIKVTDDGSGMSRADAELCTKRHATSKL
SSLEELFEITHLGFRGEALPSIASVSRFKLCTRQQQDLEGWEIRIDGGLEHEPRSSGVSPGTAIEVADLFYNTPARRKFL
KSAETEASHVEHQIRLHALAYPQVRFAYKRDDQLVFDLPATADLRVRISALTDAATAAALIPIETTIGPGISITGFLLPL
SEARRTRKGQYVFMNTRPVEDQLINRAIRDGYGGFPTGLHPALFLYMEVEPALVDVNVHPAKKEVRFRRSADVVNTIVEA
IANTLQKHARQEIHAAAAPEPERTLPPAHSTTAPYGEIPARSTNPGSAFPAAARPAPASSAAQPPLSSSAKQSHGAVPPP
TLRAIPLKQVPATQGKLDFHRQEDEETARNAHENAALERDASAGFSYLGTLRQQFALFETPEGLVLMHPKAARERIIFER
LRARREAPMPSQQLLDPVVLDLDPRDFAVIRQFAPHFDQAGMAVTPFGQNTIRIESIPALLELENARAFLLELVDRLTQS
EFSRNAKRVAYETFIGEFARKSAWRERISPHRAPAILKDLLACEVPYCTPGGKPTLVNYSVPEIKRKFGLQA

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family

Homologues:

Organism=Homo sapiens, GI4557757, Length=473, Percent_Identity=30.0211416490486, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI4505911, Length=321, Percent_Identity=29.9065420560748, Blast_Score=134, Evalue=3e-31,
Organism=Homo sapiens, GI189458898, Length=321, Percent_Identity=29.9065420560748, Blast_Score=133, Evalue=4e-31,
Organism=Homo sapiens, GI189458896, Length=317, Percent_Identity=28.7066246056782, Blast_Score=122, Evalue=1e-27,
Organism=Homo sapiens, GI4505913, Length=323, Percent_Identity=26.0061919504644, Blast_Score=113, Evalue=7e-25,
Organism=Homo sapiens, GI310128478, Length=325, Percent_Identity=26.4615384615385, Blast_Score=112, Evalue=9e-25,
Organism=Homo sapiens, GI91992160, Length=263, Percent_Identity=28.1368821292776, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI91992162, Length=263, Percent_Identity=28.1368821292776, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI263191589, Length=379, Percent_Identity=27.4406332453826, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI310128480, Length=297, Percent_Identity=23.2323232323232, Blast_Score=80, Evalue=6e-15,
Organism=Escherichia coli, GI1790612, Length=576, Percent_Identity=34.375, Blast_Score=248, Evalue=1e-66,
Organism=Caenorhabditis elegans, GI71991825, Length=320, Percent_Identity=30.3125, Blast_Score=155, Evalue=7e-38,
Organism=Caenorhabditis elegans, GI17562796, Length=440, Percent_Identity=24.3181818181818, Blast_Score=127, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6323819, Length=369, Percent_Identity=31.4363143631436, Blast_Score=189, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6324247, Length=365, Percent_Identity=23.8356164383562, Blast_Score=122, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6323063, Length=397, Percent_Identity=24.9370277078086, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6325093, Length=153, Percent_Identity=32.6797385620915, Blast_Score=81, Evalue=5e-16,
Organism=Drosophila melanogaster, GI17136968, Length=629, Percent_Identity=25.2782193958665, Blast_Score=172, Evalue=6e-43,
Organism=Drosophila melanogaster, GI17136970, Length=353, Percent_Identity=26.0623229461756, Blast_Score=125, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTL_AKKM8 (B2ULE2)

Other databases:

- EMBL:   CP001071
- RefSeq:   YP_001876712.1
- ProteinModelPortal:   B2ULE2
- GeneID:   6275009
- GenomeReviews:   CP001071_GR
- KEGG:   amu:Amuc_0086
- HOGENOM:   HBG520262
- OMA:   LYLIDQV
- HAMAP:   MF_00149
- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.565.10
- Gene3D:   G3DSA:3.30.230.10
- PANTHER:   PTHR10073
- SMART:   SM00387
- SMART:   SM00853
- TIGRFAMs:   TIGR00585

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C; SSF55874 ATP_bd_ATPase; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: NA

Molecular weight: Translated: 69555; Mature: 69424

Theoretical pI: Translated: 8.34; Mature: 8.34

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSIHVMSPTLASQVAAGEVVERPASVVKELVENSLDAGAKFVRVEIRRGGVGMIKVTDD
CCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCEEEEEEECC
GSGMSRADAELCTKRHATSKLSSLEELFEITHLGFRGEALPSIASVSRFKLCTRQQQDLE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCC
GWEIRIDGGLEHEPRSSGVSPGTAIEVADLFYNTPARRKFLKSAETEASHVEHQIRLHAL
CEEEEECCCCCCCCCCCCCCCCCCEEHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHEE
AYPQVRFAYKRDDQLVFDLPATADLRVRISALTDAATAAALIPIETTIGPGISITGFLLP
CCCCEEEEEECCCCEEEECCCCCCEEEEEEHHHHHHHHEEEEEEECCCCCCCEEHHEEEE
LSEARRTRKGQYVFMNTRPVEDQLINRAIRDGYGGFPTGLHPALFLYMEVEPALVDVNVH
HHHHHHCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCEEEEEECC
PAKKEVRFRRSADVVNTIVEAIANTLQKHARQEIHAAAAPEPERTLPPAHSTTAPYGEIP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
ARSTNPGSAFPAAARPAPASSAAQPPLSSSAKQSHGAVPPPTLRAIPLKQVPATQGKLDF
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCEECCCCCCCCCCCCCCC
HRQEDEETARNAHENAALERDASAGFSYLGTLRQQFALFETPEGLVLMHPKAARERIIFE
CCCCHHHHHHHHHHHHHHHCCHHCCHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHH
RLRARREAPMPSQQLLDPVVLDLDPRDFAVIRQFAPHFDQAGMAVTPFGQNTIRIESIPA
HHHHHHCCCCCHHHHCCCEEEECCCCHHHHHHHHCCCCCCCCCEEECCCCCEEEEECCCH
LLELENARAFLLELVDRLTQSEFSRNAKRVAYETFIGEFARKSAWRERISPHRAPAILKD
HEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
LLACEVPYCTPGGKPTLVNYSVPEIKRKFGLQA
HHHHCCCCCCCCCCCEEEECCHHHHHHHHCCCC
>Mature Secondary Structure 
PSIHVMSPTLASQVAAGEVVERPASVVKELVENSLDAGAKFVRVEIRRGGVGMIKVTDD
CCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCEEEEEEECC
GSGMSRADAELCTKRHATSKLSSLEELFEITHLGFRGEALPSIASVSRFKLCTRQQQDLE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCC
GWEIRIDGGLEHEPRSSGVSPGTAIEVADLFYNTPARRKFLKSAETEASHVEHQIRLHAL
CEEEEECCCCCCCCCCCCCCCCCCEEHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHEE
AYPQVRFAYKRDDQLVFDLPATADLRVRISALTDAATAAALIPIETTIGPGISITGFLLP
CCCCEEEEEECCCCEEEECCCCCCEEEEEEHHHHHHHHEEEEEEECCCCCCCEEHHEEEE
LSEARRTRKGQYVFMNTRPVEDQLINRAIRDGYGGFPTGLHPALFLYMEVEPALVDVNVH
HHHHHHCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCEEEEEECC
PAKKEVRFRRSADVVNTIVEAIANTLQKHARQEIHAAAAPEPERTLPPAHSTTAPYGEIP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
ARSTNPGSAFPAAARPAPASSAAQPPLSSSAKQSHGAVPPPTLRAIPLKQVPATQGKLDF
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCEECCCCCCCCCCCCCCC
HRQEDEETARNAHENAALERDASAGFSYLGTLRQQFALFETPEGLVLMHPKAARERIIFE
CCCCHHHHHHHHHHHHHHHCCHHCCHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHH
RLRARREAPMPSQQLLDPVVLDLDPRDFAVIRQFAPHFDQAGMAVTPFGQNTIRIESIPA
HHHHHHCCCCCHHHHCCCEEEECCCCHHHHHHHHCCCCCCCCCEEECCCCCEEEEECCCH
LLELENARAFLLELVDRLTQSEFSRNAKRVAYETFIGEFARKSAWRERISPHRAPAILKD
HEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
LLACEVPYCTPGGKPTLVNYSVPEIKRKFGLQA
HHHHCCCCCCCCCCCEEEECCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA