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The map label for this gene is xasA [C]

Identifier: 187734553

GI number: 187734553

Start: 51964

End: 53448

Strand: Direct

Name: xasA [C]

Synonym: Amuc_0037

Alternate gene names: 187734553

Gene position: 51964-53448 (Clockwise)

Preceding gene: 187734550

Following gene: 187734554

Centisome position: 1.95

GC content: 55.08

Gene sequence:

>1485_bases
ATGGGAGTATTCACTCTCGCCATGATCAACGTTTCCGCCATTGTCAGCCTGCGCGGCATGCCTGCGGAAAGCACTTACGG
ACTGAGTTCCGTTTTTTATTACATTTTCGCCGCGGTATTCTTTCTGGTGCCTGTTTCCCTGGTCGCCGCGGAGCTTACTA
CCGGATGGCCCCAAAAGGGCGGCGTTTACCGCTGGGTAGGCGAGGCATTCGGGAAAAAATGGGGGTTCCTGGCCATCTGG
CTGCAATGGATTGAGAGTACCATCTGGTTCCCTACCGTTCTGACATTCGCCGCCGTTTCCCTGGCTTTCATGGGGCCCGG
ACAAAGATGGGATGAAGCGCTTGCCGCCAATAAATGGTATGTTCTCATCGTGGTGCTGTGCGTGTACTGGGCGGCCACCC
TGCTTAATCTGCGCGGCATGAAGACTTCCGCAGGCGTCACCAAATGGGGAACCATCATCGGAACCATTATTCCCGGAGCC
ATCCTGATCCTGCTGGGCCTGGGCTATTGGGCCGGCGGCAACCCGATCCTGCTGGATATGAGCTGGGACAAGCTGGTGCC
GGACATGAGCAATTTCAACAACCTCGTTCTGGCAGCCAGCATCTTCCTGTTTTACGCGGGGATGGAAATGTCCGCCGTGC
ATGTGAAGGATGTGAATAATCCCGGACGCAATTATCCGCTGGCCATTCTGATTTCCGCCATCATTACGGTGCTTATTTTC
GTTCTAGGCACGCTGGCCATCGGCTTCATCATTCCCAATTCCCAGATTAATCTGGTGCAGAGCCTGCTGATTACTTATGA
CAGCTATTTCAGCTTCTTCGGCCTCGGCTGGATGAACTGGATTCTGGCGCTTGCGCTGGCCGTCGGCGTTCTGGCCCAGG
TAACCGCATGGGTGGGAGGCCCCTCAAAAGGCCTGTACCAAGTGGGCCTGGCCGGCAACCTTCCGCCTGTCATGCAGAAG
CGGAACAAGAACAACGTCCAGATGGGCATCCTTTTTATCCAGGGGGGAATCGTCACCCTGCTTTCCATCATGTTTGTGAT
CATGCCTTCCGTGCAATCCGCCTACCAGATTATTTCCCAGCTGACCATCATTCTGTACCTCATCATGTACATGCTGATGT
TCGCGTCAGGCATTTACCTGCGCTACCGGGAACCGAATACGCCCCGTACTTTCCGCATTCCCGGCGGCAGAACCTTCGGC
ATGTGGATTGTCGGAGGGCTCGGCTTCCTGGCCAGCCTGGCGGCTTTCCTGGTGAGCTTCATCCCGCCTAACCAAATTAC
CGTAGGCAGCAGTACCATGTACATTCTCCTTCTGGTGGTGGGTACCTTCATTTTCGCGGGTATTCCCTTTATCATCCATG
CCATGGCCAAACCCTCCTGGAAACGGCCGGTGGATCCCGAAGACGCCTTTGAACCCTTCGGATGGGAGAAAAACAATGAT
TCCCATTCCGCAGCAACCCCTAGCCATTCCATATCCCATGAGTGA

Upstream 100 bases:

>100_bases
AACCCGGAATAAACCAATGAATAATACGACTCAACCAGGGGCTGCTCCAACAGGCCCCGCAACAACCAATAACGCTCCGG
CGGTAAAATCCGTCCTCCGC

Downstream 100 bases:

>100_bases
CATTCCTTCCAATGAACAGATCCGGACGGCCCTGGATAACGCATACGCCTACGCCAAAACCGTCCAGGGAGGCAAAAACG
CCTCGTACATTCCCGCCCTG

Product: amino acid permease-associated region

Products: L-glutamate [Cytoplasm]; 4-aminobutyrate [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 494; Mature: 493

Protein sequence:

>494_residues
MGVFTLAMINVSAIVSLRGMPAESTYGLSSVFYYIFAAVFFLVPVSLVAAELTTGWPQKGGVYRWVGEAFGKKWGFLAIW
LQWIESTIWFPTVLTFAAVSLAFMGPGQRWDEALAANKWYVLIVVLCVYWAATLLNLRGMKTSAGVTKWGTIIGTIIPGA
ILILLGLGYWAGGNPILLDMSWDKLVPDMSNFNNLVLAASIFLFYAGMEMSAVHVKDVNNPGRNYPLAILISAIITVLIF
VLGTLAIGFIIPNSQINLVQSLLITYDSYFSFFGLGWMNWILALALAVGVLAQVTAWVGGPSKGLYQVGLAGNLPPVMQK
RNKNNVQMGILFIQGGIVTLLSIMFVIMPSVQSAYQIISQLTIILYLIMYMLMFASGIYLRYREPNTPRTFRIPGGRTFG
MWIVGGLGFLASLAAFLVSFIPPNQITVGSSTMYILLLVVGTFIFAGIPFIIHAMAKPSWKRPVDPEDAFEPFGWEKNND
SHSAATPSHSISHE

Sequences:

>Translated_494_residues
MGVFTLAMINVSAIVSLRGMPAESTYGLSSVFYYIFAAVFFLVPVSLVAAELTTGWPQKGGVYRWVGEAFGKKWGFLAIW
LQWIESTIWFPTVLTFAAVSLAFMGPGQRWDEALAANKWYVLIVVLCVYWAATLLNLRGMKTSAGVTKWGTIIGTIIPGA
ILILLGLGYWAGGNPILLDMSWDKLVPDMSNFNNLVLAASIFLFYAGMEMSAVHVKDVNNPGRNYPLAILISAIITVLIF
VLGTLAIGFIIPNSQINLVQSLLITYDSYFSFFGLGWMNWILALALAVGVLAQVTAWVGGPSKGLYQVGLAGNLPPVMQK
RNKNNVQMGILFIQGGIVTLLSIMFVIMPSVQSAYQIISQLTIILYLIMYMLMFASGIYLRYREPNTPRTFRIPGGRTFG
MWIVGGLGFLASLAAFLVSFIPPNQITVGSSTMYILLLVVGTFIFAGIPFIIHAMAKPSWKRPVDPEDAFEPFGWEKNND
SHSAATPSHSISHE
>Mature_493_residues
GVFTLAMINVSAIVSLRGMPAESTYGLSSVFYYIFAAVFFLVPVSLVAAELTTGWPQKGGVYRWVGEAFGKKWGFLAIWL
QWIESTIWFPTVLTFAAVSLAFMGPGQRWDEALAANKWYVLIVVLCVYWAATLLNLRGMKTSAGVTKWGTIIGTIIPGAI
LILLGLGYWAGGNPILLDMSWDKLVPDMSNFNNLVLAASIFLFYAGMEMSAVHVKDVNNPGRNYPLAILISAIITVLIFV
LGTLAIGFIIPNSQINLVQSLLITYDSYFSFFGLGWMNWILALALAVGVLAQVTAWVGGPSKGLYQVGLAGNLPPVMQKR
NKNNVQMGILFIQGGIVTLLSIMFVIMPSVQSAYQIISQLTIILYLIMYMLMFASGIYLRYREPNTPRTFRIPGGRTFGM
WIVGGLGFLASLAAFLVSFIPPNQITVGSSTMYILLLVVGTFIFAGIPFIIHAMAKPSWKRPVDPEDAFEPFGWEKNNDS
HSAATPSHSISHE

Specific function: Probable Amino Acid Transporter. Involved In Extreme Acid Resistance. [C]

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Homo sapiens, GI115648063, Length=403, Percent_Identity=24.5657568238213, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI115648022, Length=403, Percent_Identity=24.5657568238213, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI186910308, Length=358, Percent_Identity=24.3016759776536, Blast_Score=70, Evalue=7e-12,
Organism=Homo sapiens, GI186910306, Length=358, Percent_Identity=24.3016759776536, Blast_Score=70, Evalue=7e-12,
Organism=Homo sapiens, GI186910304, Length=358, Percent_Identity=24.3016759776536, Blast_Score=70, Evalue=7e-12,
Organism=Escherichia coli, GI1787768, Length=493, Percent_Identity=31.8458417849899, Blast_Score=235, Evalue=5e-63,
Organism=Escherichia coli, GI48994921, Length=450, Percent_Identity=22.2222222222222, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI87081798, Length=458, Percent_Identity=21.3973799126638, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI2367353, Length=349, Percent_Identity=23.4957020057307, Blast_Score=62, Evalue=8e-11,
Organism=Drosophila melanogaster, GI221331183, Length=364, Percent_Identity=23.9010989010989, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17647653, Length=364, Percent_Identity=23.9010989010989, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24664379, Length=364, Percent_Identity=23.9010989010989, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 54196; Mature: 54065

Theoretical pI: Translated: 9.49; Mature: 9.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVFTLAMINVSAIVSLRGMPAESTYGLSSVFYYIFAAVFFLVPVSLVAAELTTGWPQKG
CCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
GVYRWVGEAFGKKWGFLAIWLQWIESTIWFPTVLTFAAVSLAFMGPGQRWDEALAANKWY
CCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHH
VLIVVLCVYWAATLLNLRGMKTSAGVTKWGTIIGTIIPGAILILLGLGYWAGGNPILLDM
HHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEC
SWDKLVPDMSNFNNLVLAASIFLFYAGMEMSAVHVKDVNNPGRNYPLAILISAIITVLIF
CHHHHCCCHHCCCHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHH
VLGTLAIGFIIPNSQINLVQSLLITYDSYFSFFGLGWMNWILALALAVGVLAQVTAWVGG
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PSKGLYQVGLAGNLPPVMQKRNKNNVQMGILFIQGGIVTLLSIMFVIMPSVQSAYQIISQ
CCCCEEEECCCCCCCHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
LTIILYLIMYMLMFASGIYLRYREPNTPRTFRIPGGRTFGMWIVGGLGFLASLAAFLVSF
HHHHHHHHHHHHHHCCCCEEEEECCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
IPPNQITVGSSTMYILLLVVGTFIFAGIPFIIHAMAKPSWKRPVDPEDAFEPFGWEKNND
CCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCCCCCCCCCCC
SHSAATPSHSISHE
CCCCCCCCCCCCCC
>Mature Secondary Structure 
GVFTLAMINVSAIVSLRGMPAESTYGLSSVFYYIFAAVFFLVPVSLVAAELTTGWPQKG
CCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
GVYRWVGEAFGKKWGFLAIWLQWIESTIWFPTVLTFAAVSLAFMGPGQRWDEALAANKWY
CCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHH
VLIVVLCVYWAATLLNLRGMKTSAGVTKWGTIIGTIIPGAILILLGLGYWAGGNPILLDM
HHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEC
SWDKLVPDMSNFNNLVLAASIFLFYAGMEMSAVHVKDVNNPGRNYPLAILISAIITVLIF
CHHHHCCCHHCCCHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHH
VLGTLAIGFIIPNSQINLVQSLLITYDSYFSFFGLGWMNWILALALAVGVLAQVTAWVGG
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PSKGLYQVGLAGNLPPVMQKRNKNNVQMGILFIQGGIVTLLSIMFVIMPSVQSAYQIISQ
CCCCEEEECCCCCCCHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
LTIILYLIMYMLMFASGIYLRYREPNTPRTFRIPGGRTFGMWIVGGLGFLASLAAFLVSF
HHHHHHHHHHHHHHCCCCEEEEECCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
IPPNQITVGSSTMYILLLVVGTFIFAGIPFIIHAMAKPSWKRPVDPEDAFEPFGWEKNND
CCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCCCCCCCCCCC
SHSAATPSHSISHE
CCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-aminobutyrate [Cytoplasm]; L-glutamate [Periplasm] [C]

Specific reaction: 4-aminobutyrate [Cytoplasm] + L-glutamate [Periplasm] = L-glutamate [Cytoplasm] + 4-aminobutyrate [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8366052 [H]