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The map label for this gene is hmgA [H]

Identifier: 186477184

GI number: 186477184

Start: 2737825

End: 2739147

Strand: Reverse

Name: hmgA [H]

Synonym: Bphy_2435

Alternate gene names: 186477184

Gene position: 2739147-2737825 (Counterclockwise)

Preceding gene: 186477186

Following gene: 186477183

Centisome position: 78.73

GC content: 64.17

Gene sequence:

>1323_bases
ATGGAATCGAGCACACGACGCGAAATCCAGCCGGGCTACCAGTCGGGCTTCGCCAATGAATTCGCCACCGAGGCTTTGCC
CGGCGCGCTGCCGCAAGGCCGCAACTCGCCGCAGCGCGCACCGTACGGCCTGTACGCGGAGCAGTTGTCGGGCACGGCAT
TCACCGCGCCGCGCGGCCATAACCGCCGTTCGTGGCTGTACCGCATCCGCCCGGCGGCCGTGCATCAGCCGTTCACGGCG
CTGCCGTCGCACCGGCTCGTCGCGAATTTCGCCGAGGTGCCGCCGACGCCGCCCAATCAGCTGCGCTGGGATCCGCTGCC
GATGCCGACAGAGCCGACCGATTTCGTCGACGGCTGGGTGACGATGGCGGGCAACGGCTCGGCGGAAGCGATGAGTGGCT
GCGCGATTCACGTATACGCGGCCAATCAGTCGATGCAGGACCGCTTCTTCTACAACGCCGACGGCGAGTTGCTGATCGTG
CCGCAGGCGGGGCGTCTTTCGATCTTCACGGAAATGGGCAAGCTCGATGTCGAGCCGTTCGAGATCGCGGTGATACCGCG
CGGCGTACGCTTTTCGGTATCGCTGCTGGATGGCCGCGCGAGCGGCTACATCTGCGAAAACTTCGGCGCATTGCTGCGCC
TGCCGGACCTCGGGCCGATCGGCTCAAACGGACTGGCGAATCCGCGCGACTTCCTGACGCCGCATGCGGCTTATGAAGAC
CGCGAGGGCGACTTCGAACTGGTCGCGAAGATGAACGGCCATCTGTGGCGCGCGGATATCGGCCACTCGCCGCTCGACGT
GGTTGCGTGGCACGGCAACTACGCGCCGTACAAGTACGATCTGCGCCACTTCAATACGATCGGCTCGATCAGCTATGACC
ATCCGGACCCGTCGATCTTCCTCGTGCTGCAATCGCAAAGCGACACGCCAGGCGTCGATTCGATCGACTTCGTGATCTTC
CCGCCGCGCTGGCTCGCTGCCGAAGACACGTTCCGTCCGCCCTGGTTCCACCGCAATGTCGCGAGCGAGTTCATGGGGCT
TGTGCACGGCGCGTACGACGCGAAGGCAGAAGGCTTCGTGCCCGGCGGCGCGAGCCTGCACAACTGCATGTCGGGCCACG
GCCCGGACGCGGACACGTTCGAGAAGGCGTCGAACATCGACACGAGCAAGCCGAACAAGGTCGACAACACGATGGCCTTC
ATGTTCGAAACGCGCACGCTCATCAAGCCGACCCGCTTCGCATTGGAAACGGCGCAGCTTCAGGCGCATTACTTCGAATG
CTGGCAAGGTCTCGAGAAACATTTCAACCCGGAGCAACGATGA

Upstream 100 bases:

>100_bases
CGGGTTTACGTTAATTTCACTAATCATAATCTGTTTTACTATTCGTAAAAACGTCGGTGGCGATGCGGGAGCGCGCCAAC
GCATTCACGGAGATCACTGC

Downstream 100 bases:

>100_bases
ACGCATCGAGCGATCTTCAGGCGACGCTCGACGCGTCGCGCAAGAGTTGGGTCGAATCGGCGAACGATCCGTCCTGTGAT
TTTTCGATCCAGAATCTGCC

Product: homogentisate 1,2-dioxygenase

Products: NA

Alternate protein names: Homogentisate oxygenase; Homogentisic acid oxidase; Homogentisicase [H]

Number of amino acids: Translated: 440; Mature: 440

Protein sequence:

>440_residues
MESSTRREIQPGYQSGFANEFATEALPGALPQGRNSPQRAPYGLYAEQLSGTAFTAPRGHNRRSWLYRIRPAAVHQPFTA
LPSHRLVANFAEVPPTPPNQLRWDPLPMPTEPTDFVDGWVTMAGNGSAEAMSGCAIHVYAANQSMQDRFFYNADGELLIV
PQAGRLSIFTEMGKLDVEPFEIAVIPRGVRFSVSLLDGRASGYICENFGALLRLPDLGPIGSNGLANPRDFLTPHAAYED
REGDFELVAKMNGHLWRADIGHSPLDVVAWHGNYAPYKYDLRHFNTIGSISYDHPDPSIFLVLQSQSDTPGVDSIDFVIF
PPRWLAAEDTFRPPWFHRNVASEFMGLVHGAYDAKAEGFVPGGASLHNCMSGHGPDADTFEKASNIDTSKPNKVDNTMAF
MFETRTLIKPTRFALETAQLQAHYFECWQGLEKHFNPEQR

Sequences:

>Translated_440_residues
MESSTRREIQPGYQSGFANEFATEALPGALPQGRNSPQRAPYGLYAEQLSGTAFTAPRGHNRRSWLYRIRPAAVHQPFTA
LPSHRLVANFAEVPPTPPNQLRWDPLPMPTEPTDFVDGWVTMAGNGSAEAMSGCAIHVYAANQSMQDRFFYNADGELLIV
PQAGRLSIFTEMGKLDVEPFEIAVIPRGVRFSVSLLDGRASGYICENFGALLRLPDLGPIGSNGLANPRDFLTPHAAYED
REGDFELVAKMNGHLWRADIGHSPLDVVAWHGNYAPYKYDLRHFNTIGSISYDHPDPSIFLVLQSQSDTPGVDSIDFVIF
PPRWLAAEDTFRPPWFHRNVASEFMGLVHGAYDAKAEGFVPGGASLHNCMSGHGPDADTFEKASNIDTSKPNKVDNTMAF
MFETRTLIKPTRFALETAQLQAHYFECWQGLEKHFNPEQR
>Mature_440_residues
MESSTRREIQPGYQSGFANEFATEALPGALPQGRNSPQRAPYGLYAEQLSGTAFTAPRGHNRRSWLYRIRPAAVHQPFTA
LPSHRLVANFAEVPPTPPNQLRWDPLPMPTEPTDFVDGWVTMAGNGSAEAMSGCAIHVYAANQSMQDRFFYNADGELLIV
PQAGRLSIFTEMGKLDVEPFEIAVIPRGVRFSVSLLDGRASGYICENFGALLRLPDLGPIGSNGLANPRDFLTPHAAYED
REGDFELVAKMNGHLWRADIGHSPLDVVAWHGNYAPYKYDLRHFNTIGSISYDHPDPSIFLVLQSQSDTPGVDSIDFVIF
PPRWLAAEDTFRPPWFHRNVASEFMGLVHGAYDAKAEGFVPGGASLHNCMSGHGPDADTFEKASNIDTSKPNKVDNTMAF
MFETRTLIKPTRFALETAQLQAHYFECWQGLEKHFNPEQR

Specific function: Unknown

COG id: COG3508

COG function: function code Q; Homogentisate 1,2-dioxygenase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the homogentisate dioxygenase family [H]

Homologues:

Organism=Homo sapiens, GI115527117, Length=436, Percent_Identity=52.5229357798165, Blast_Score=466, Evalue=1e-131,
Organism=Caenorhabditis elegans, GI17507969, Length=428, Percent_Identity=52.803738317757, Blast_Score=447, Evalue=1e-126,
Organism=Drosophila melanogaster, GI24583650, Length=431, Percent_Identity=51.2761020881671, Blast_Score=427, Evalue=1e-120,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR005708
- InterPro:   IPR022950 [H]

Pfam domain/function: PF04209 HgmA [H]

EC number: =1.13.11.5 [H]

Molecular weight: Translated: 48913; Mature: 48913

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESSTRREIQPGYQSGFANEFATEALPGALPQGRNSPQRAPYGLYAEQLSGTAFTAPRGH
CCCCCCCCCCCCHHHCCHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHCCCCEEECCCCC
NRRSWLYRIRPAAVHQPFTALPSHRLVANFAEVPPTPPNQLRWDPLPMPTEPTDFVDGWV
CCCCEEEEECHHHHCCCHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEE
TMAGNGSAEAMSGCAIHVYAANQSMQDRFFYNADGELLIVPQAGRLSIFTEMGKLDVEPF
EEECCCCCHHHCCCEEEEEECCCCCCCCEEECCCCCEEEEECCCCEEEEECCCCCCCCCE
EIAVIPRGVRFSVSLLDGRASGYICENFGALLRLPDLGPIGSNGLANPRDFLTPHAAYED
EEEEECCCCEEEEEEECCCCCCEEEECCCCEEECCCCCCCCCCCCCCCHHHCCCCCCCCC
REGDFELVAKMNGHLWRADIGHSPLDVVAWHGNYAPYKYDLRHFNTIGSISYDHPDPSIF
CCCCEEEEEECCCCEEEECCCCCCCEEEEECCCCCCEEECHHHHCCCCCCEECCCCCEEE
LVLQSQSDTPGVDSIDFVIFPPRWLAAEDTFRPPWFHRNVASEFMGLVHGAYDAKAEGFV
EEEECCCCCCCCCCEEEEEECCCEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCC
PGGASLHNCMSGHGPDADTFEKASNIDTSKPNKVDNTMAFMFETRTLIKPTRFALETAQL
CCCCHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCCCCEEEEEHHHHHCCCHHHHHHHHHH
QAHYFECWQGLEKHFNPEQR
HHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MESSTRREIQPGYQSGFANEFATEALPGALPQGRNSPQRAPYGLYAEQLSGTAFTAPRGH
CCCCCCCCCCCCHHHCCHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHCCCCEEECCCCC
NRRSWLYRIRPAAVHQPFTALPSHRLVANFAEVPPTPPNQLRWDPLPMPTEPTDFVDGWV
CCCCEEEEECHHHHCCCHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEE
TMAGNGSAEAMSGCAIHVYAANQSMQDRFFYNADGELLIVPQAGRLSIFTEMGKLDVEPF
EEECCCCCHHHCCCEEEEEECCCCCCCCEEECCCCCEEEEECCCCEEEEECCCCCCCCCE
EIAVIPRGVRFSVSLLDGRASGYICENFGALLRLPDLGPIGSNGLANPRDFLTPHAAYED
EEEEECCCCEEEEEEECCCCCCEEEECCCCEEECCCCCCCCCCCCCCCHHHCCCCCCCCC
REGDFELVAKMNGHLWRADIGHSPLDVVAWHGNYAPYKYDLRHFNTIGSISYDHPDPSIF
CCCCEEEEEECCCCEEEECCCCCCCEEEEECCCCCCEEECHHHHCCCCCCEECCCCCEEE
LVLQSQSDTPGVDSIDFVIFPPRWLAAEDTFRPPWFHRNVASEFMGLVHGAYDAKAEGFV
EEEECCCCCCCCCCEEEEEECCCEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCC
PGGASLHNCMSGHGPDADTFEKASNIDTSKPNKVDNTMAFMFETRTLIKPTRFALETAQL
CCCCHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCCCCEEEEEHHHHHCCCHHHHHHHHHH
QAHYFECWQGLEKHFNPEQR
HHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA