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The map label for this gene is 186477183

Identifier: 186477183

GI number: 186477183

Start: 2736518

End: 2737828

Strand: Reverse

Name: 186477183

Synonym: Bphy_2434

Alternate gene names: NA

Gene position: 2737828-2736518 (Counterclockwise)

Preceding gene: 186477184

Following gene: 186477179

Centisome position: 78.69

GC content: 64.61

Gene sequence:

>1311_bases
ATGAACGCATCGAGCGATCTTCAGGCGACGCTCGACGCGTCGCGCAAGAGTTGGGTCGAATCGGCGAACGATCCGTCCTG
TGATTTTTCGATCCAGAATCTGCCGTTCGGCATCTTCAGCGATGGACTCAACGCAACCCGCCGTGCCGGCGTCGCGCTCG
GCGACTGCATCGTCGATCTGGCGGCGCTCGAAAGCGCGGGGCTGTTGACGGTGCCGTCCTCGGGCGCAGGCGACAGCGTG
TTCGTGCGCGACGCGCTCAACGATTTCATCGCGCTCGGCCGCGATGCGTGGCGCAGCGTGCGCATCCAGTTGAGCAAGCT
GCTGTCGCGCGATAATCCGGTGCTGCGCGACGACGCCGAACTGCGCAGCCGCGCGCTGATCCGCCAAGGCGACGCAGCGC
TGCATCTGCCCGTGCAGATTCCGGGCTACACGGACTTCTATTCGTCGAAGGAACACGCCACCAATGTCGGCTCGATGTTC
CGCGATCCGAAGAACGCGCTGCTGCCGAACTGGCTGGAAATCCCAATCGGGTATAACGGGCGGGCGTCGTCGGTGGTGGT
GAGCGGCACGCCCGTGCGCCGTCCCAACGGCCAGTTGAAGCTGCCCGATCAGGAACGGCCGGTGTTCGGCGCGTGCCGCA
AGCTCGATATCGAGCTGGAGACGGGCTTTATCGTCGGACGCGGCAATGCGCTCGGCGAGCCGATCCCCTGCGAACAGGCG
GAAGACCACATTTTCGGCATGGTGCTGCTGAACGACTGGAGCGCTCGCGACATCCAGCAATGGGAATACGTGCCGCTCGG
GCCGTTCAATTCCAAAGGCTTCGCGACTACGATCTCGCCGTGGATCGTCACGCTCGACGCGCTCGAACCGTTCCGCGTCG
CGCAACCCGTGCAGGATCCGCAGCCGCTCGACTATCTGCGCCAGGGCGGCGAGCATGGCTTCGATATCTCGCTTGAAGTG
CTGCTGAAGCCGAAGGGCGCGAAGGAAGCGACGACGATCTCGCGCACCAACTTCCGTCACATGTACTGGACGATGGCGCA
GCAGCTTGCGCATCACACGGTATCGGGCTGCAATACGCGCGTCGGCGATCTGATGGGTTCGGGCACGATCAGCGGGCCGA
CGGGCGATTCGTTCGGCAGCCTGCTCGAACTGACGTGGAACGGGAAGAATCCGCTGCAACTGCCTGACGGCAGCACGCGC
GCCTTCATTGAGGACGGCGACGAACTCACGCTCGCCGGATGGTGCCAGGGCGACGGCTATCGCGTCGGCTTTGGCACGTG
CGTCGGCGAGATCGTGCCGGCGCAGCGCTGA

Upstream 100 bases:

>100_bases
TCATCAAGCCGACCCGCTTCGCATTGGAAACGGCGCAGCTTCAGGCGCATTACTTCGAATGCTGGCAAGGTCTCGAGAAA
CATTTCAACCCGGAGCAACG

Downstream 100 bases:

>100_bases
ATCGCCCGCGAAATCAGGACGCGGCGCGCGCCACGCCGCGTCTTTTTTCCCACAGCATCGCCGCGAGAAACGCCAACGCG
CTCGCGAGCACGACGCCGAT

Product: fumarylacetoacetase

Products: acetoacetate; fumarate

Alternate protein names: Fumarylacetoacetate Hydrolase; Hydroxylase; Fumarylacetoacetate Hydrolase Family Protein; 2-Hydroxyhepta-2 4-Diene-1 7-Dioate Isomerase; Fumarylacetoacetate Hydrolase Domain-Containing; Fumarylacetoacetase Hydrolase; LOW QUALITY PROTEIN Fumarylacetoacetase

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MNASSDLQATLDASRKSWVESANDPSCDFSIQNLPFGIFSDGLNATRRAGVALGDCIVDLAALESAGLLTVPSSGAGDSV
FVRDALNDFIALGRDAWRSVRIQLSKLLSRDNPVLRDDAELRSRALIRQGDAALHLPVQIPGYTDFYSSKEHATNVGSMF
RDPKNALLPNWLEIPIGYNGRASSVVVSGTPVRRPNGQLKLPDQERPVFGACRKLDIELETGFIVGRGNALGEPIPCEQA
EDHIFGMVLLNDWSARDIQQWEYVPLGPFNSKGFATTISPWIVTLDALEPFRVAQPVQDPQPLDYLRQGGEHGFDISLEV
LLKPKGAKEATTISRTNFRHMYWTMAQQLAHHTVSGCNTRVGDLMGSGTISGPTGDSFGSLLELTWNGKNPLQLPDGSTR
AFIEDGDELTLAGWCQGDGYRVGFGTCVGEIVPAQR

Sequences:

>Translated_436_residues
MNASSDLQATLDASRKSWVESANDPSCDFSIQNLPFGIFSDGLNATRRAGVALGDCIVDLAALESAGLLTVPSSGAGDSV
FVRDALNDFIALGRDAWRSVRIQLSKLLSRDNPVLRDDAELRSRALIRQGDAALHLPVQIPGYTDFYSSKEHATNVGSMF
RDPKNALLPNWLEIPIGYNGRASSVVVSGTPVRRPNGQLKLPDQERPVFGACRKLDIELETGFIVGRGNALGEPIPCEQA
EDHIFGMVLLNDWSARDIQQWEYVPLGPFNSKGFATTISPWIVTLDALEPFRVAQPVQDPQPLDYLRQGGEHGFDISLEV
LLKPKGAKEATTISRTNFRHMYWTMAQQLAHHTVSGCNTRVGDLMGSGTISGPTGDSFGSLLELTWNGKNPLQLPDGSTR
AFIEDGDELTLAGWCQGDGYRVGFGTCVGEIVPAQR
>Mature_436_residues
MNASSDLQATLDASRKSWVESANDPSCDFSIQNLPFGIFSDGLNATRRAGVALGDCIVDLAALESAGLLTVPSSGAGDSV
FVRDALNDFIALGRDAWRSVRIQLSKLLSRDNPVLRDDAELRSRALIRQGDAALHLPVQIPGYTDFYSSKEHATNVGSMF
RDPKNALLPNWLEIPIGYNGRASSVVVSGTPVRRPNGQLKLPDQERPVFGACRKLDIELETGFIVGRGNALGEPIPCEQA
EDHIFGMVLLNDWSARDIQQWEYVPLGPFNSKGFATTISPWIVTLDALEPFRVAQPVQDPQPLDYLRQGGEHGFDISLEV
LLKPKGAKEATTISRTNFRHMYWTMAQQLAHHTVSGCNTRVGDLMGSGTISGPTGDSFGSLLELTWNGKNPLQLPDGSTR
AFIEDGDELTLAGWCQGDGYRVGFGTCVGEIVPAQR

Specific function: Unknown

COG id: COG0179

COG function: function code Q; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557587, Length=418, Percent_Identity=57.177033492823, Blast_Score=503, Evalue=1e-142,
Organism=Caenorhabditis elegans, GI17568863, Length=411, Percent_Identity=54.9878345498783, Blast_Score=463, Evalue=1e-130,
Organism=Drosophila melanogaster, GI24657182, Length=412, Percent_Identity=52.6699029126214, Blast_Score=435, Evalue=1e-122,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 3.7.1.2

Molecular weight: Translated: 47411; Mature: 47411

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNASSDLQATLDASRKSWVESANDPSCDFSIQNLPFGIFSDGLNATRRAGVALGDCIVDL
CCCCCCHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCHHHCCCCHHHHCCCCHHHHHHHH
AALESAGLLTVPSSGAGDSVFVRDALNDFIALGRDAWRSVRIQLSKLLSRDNPVLRDDAE
HHHCCCCEEECCCCCCCCCEEHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCCCHH
LRSRALIRQGDAALHLPVQIPGYTDFYSSKEHATNVGSMFRDPKNALLPNWLEIPIGYNG
HHHHHHHHCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCHHCCCCEEEECCCCCC
RASSVVVSGTPVRRPNGQLKLPDQERPVFGACRKLDIELETGFIVGRGNALGEPIPCEQA
CCCEEEEECCCCCCCCCCEECCCCCCCHHHHHEEEEEEEECCEEEECCCCCCCCCCCCCC
EDHIFGMVLLNDWSARDIQQWEYVPLGPFNSKGFATTISPWIVTLDALEPFRVAQPVQDP
CCCEEEEEEECCCCCCCCCCCCEEECCCCCCCCCEEECCCEEEEEECCCCHHHHCCCCCC
QPLDYLRQGGEHGFDISLEVLLKPKGAKEATTISRTNFRHMYWTMAQQLAHHTVSGCNTR
CCHHHHHCCCCCCCCEEEEEEECCCCCCCHHEEECCCCHHHHHHHHHHHHHHHHHCCCCH
VGDLMGSGTISGPTGDSFGSLLELTWNGKNPLQLPDGSTRAFIEDGDELTLAGWCQGDGY
HHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEEECCCEEEEEEEECCCCE
RVGFGTCVGEIVPAQR
EEEHHHHHHHHCCCCC
>Mature Secondary Structure
MNASSDLQATLDASRKSWVESANDPSCDFSIQNLPFGIFSDGLNATRRAGVALGDCIVDL
CCCCCCHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCHHHCCCCHHHHCCCCHHHHHHHH
AALESAGLLTVPSSGAGDSVFVRDALNDFIALGRDAWRSVRIQLSKLLSRDNPVLRDDAE
HHHCCCCEEECCCCCCCCCEEHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCCCHH
LRSRALIRQGDAALHLPVQIPGYTDFYSSKEHATNVGSMFRDPKNALLPNWLEIPIGYNG
HHHHHHHHCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCHHCCCCEEEECCCCCC
RASSVVVSGTPVRRPNGQLKLPDQERPVFGACRKLDIELETGFIVGRGNALGEPIPCEQA
CCCEEEEECCCCCCCCCCEECCCCCCCHHHHHEEEEEEEECCEEEECCCCCCCCCCCCCC
EDHIFGMVLLNDWSARDIQQWEYVPLGPFNSKGFATTISPWIVTLDALEPFRVAQPVQDP
CCCEEEEEEECCCCCCCCCCCCEEECCCCCCCCCEEECCCEEEEEECCCCHHHHCCCCCC
QPLDYLRQGGEHGFDISLEVLLKPKGAKEATTISRTNFRHMYWTMAQQLAHHTVSGCNTR
CCHHHHHCCCCCCCCEEEEEEECCCCCCCHHEEECCCCHHHHHHHHHHHHHHHHHCCCCH
VGDLMGSGTISGPTGDSFGSLLELTWNGKNPLQLPDGSTRAFIEDGDELTLAGWCQGDGY
HHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEEECCCEEEEEEEECCCCE
RVGFGTCVGEIVPAQR
EEEHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-fumarylacetoacetate; H2O

Specific reaction: 4-fumarylacetoacetate + H2O = acetoacetate + fumarate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA