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The map label for this gene is parC [H]

Identifier: 186476876

GI number: 186476876

Start: 2383556

End: 2385877

Strand: Reverse

Name: parC [H]

Synonym: Bphy_2123

Alternate gene names: 186476876

Gene position: 2385877-2383556 (Counterclockwise)

Preceding gene: 186476877

Following gene: 186476875

Centisome position: 68.58

GC content: 63.31

Gene sequence:

>2322_bases
ATGGACGACAACACTCCCGATCTGTTTACCGAGCCGGCAGCGCCCGAAGGCGACGTGCTGACGCTCGGCAACTACGCGGA
ACGCGCGTATCTCGACTACGCGGTGAGCGTGGTGAAGGGCCGCGCGCTGCCCGACGTCTGTGATGGCCAGAAGCCCGTGC
AGCGTCGCATTCTGTACGCGATGAACGAGATGGGTCTCGGCGACAACGCAAAGCCGGTGAAGTCGGCGCGTGTGGTCGGC
GATGTGCTGGGTAAATATCACCCGCACGGCGACCAGTCGGCGTACGACGCGCTCGTGCGTCTCGCGCAAGACTTCTCGAT
GCGTTATCCGCTGATCGACGGCCAGGGCAACTTCGGCTCGCGCGACGGCGACGGCGCGGCGGCGATGCGTTACACGGAAG
CGCGCCTCACGCCGATCGCGAAGCTGCTGCTGGACGAAATCGACCAGGGCACGGTCGATTTCATGCCGAACTACGATGGT
TCGTTCGAAGAGCCGAAGCTGCTACCCGCGCGCCTGCCGTTTGTGCTGCTGAACGGCGCGTCGGGCATCGCAGTCGGTCT
CGCGACGGAAATCCCGTCGCACAATCTTCGCGAAGTTGCGGCGGCTGCTGTCGCAATGATCCGCCATCCGAAGATCACGC
ATGCCGAACTGATGCAACTCGTGCCGGGACCGGATTTCCCCGGCGGCGGCCAGATCATCTCCAGCGAAGCGGAAATCTCG
CAGGCGTACGAAACGGGCCGTGGCAGTCTCAAAGTGCGCGCGCGCTGGAAGATCGAAGATCTTGCGCGCGGCCAGTGGCA
ACTCGTCATCACCGAACTGCCGCCTAATACGTCCGGTCAGAAGGTCCTAGAAGAGATCGAGGAGCAGACGAATCCGAAGA
TCAAGCTCGGCAAGAAGTCGCTGACACCGGAACAGTTGCAGACGAAACAGACGCTGCTCGGCCTGCTCGACGCGGTACGC
GACGAGTCGGGCAAGGATGCGCCCGTGCGTCTCGTGTTCGAGCCGAAGTCGAGCCGTATCGATCAAACCGAGTTCGTGAA
CACGTTGCTCGCGCATACGAGCCTCGAATCGAACGCGACGCTGAACCTCGTGATGGTCGGCGCGGATGGACGTCCGCGTC
AGAAGGGCATCGGCGAGATGCTGCACGAGTGGATCGGCTTCCGCTTCACGACAGTCACGCGCCGCTCGCAACATCGTCTG
AACAAGGTCAACGAGAGGATTCACATCCTCGAAGGCCGGATGATCGTCTTTTTGAATATCGACGAGGTCATCCGCATCAT
CCGGGAATCGGAAGAGCCGAAGGCCGCGCTGATTGAAGCGTTCAAGCTGTCCGACCGCCAGGCCGAGGACATTCTCGAAA
TCCGGCTGCGTCAGTTGGCGCGCCTCGAAGCGATCAAGATCGAAAAGGAACTGTCCGAACTGCGCGACGAGAAGGCCAAG
CTCGAAGAACTGCTCGGCAGCGAGCCGGCGATGAAGCGCCTGCTCATCAAGGAAATCGAAGCCGACGCGAAGCAATATGG
CGACGACCGTCGCACGCTGATCCAGCAGGAGAAGCGCGCCACGTTCGAAGCGCGCGTGGTAGACGAACCTGTCACCGTCG
TCGTGTCGCAGAAGGGCTGGGTGCGCGCGCTGAAGGGCCACGGTCTAGACCCGGCGGGCTTCACGTTCAAGGCGGGCGAC
GGTCTCTACGCGGCGTTCCAGTGCCGCACGCCCGACATGCTCATTGCGTGGGGCAGCAAGGGCCGCGTGTATTCCGTCGC
GGTGTCGCAATTGCCGGGCGGGCGCGGCGACGGCGTTCCCGTCACGTCGCTGATCGAGCTCGAATCGGGCACGCATCTGA
TGCATTACTACGCGGCATCGGCGGAGCAGGCGCTGCTGCTGGCATCGTCGAACGGCTTCGGCTTTATCGCGAAGGTCGGC
GACATGGTGAGCCGCGTGAAGGCGGGCAAGGCGTTCATGACGATCGACGAGGGCGCGACGCCGCTCGCGCCGATGCCGAT
GCTGCCCGATGCAACGCAAGTCGCGTGTCTGTCGGGCGGCGGCCGTCTGCTGGTGTTCGGTCTCGACGAGATGAAGACGT
TGTCGGGCGGCGGACGCGGCGTAATCCTGATGGCGCTCGACCCGAACGAAGTGCTCAAGCAGGCGCTGGCGATCAGCAAC
GCGGGTGTCGTGCTGCAAGGCGTGTACCGCAACAAGCCCATGGAAGAAGAGCTGTCCGGCAAGGCGCTCGAACCCAATGT
CGGCAAGCGTGCGCGCAAGGGCCGTGTGCCGGATACGAAGCTGAAAGAGGTGACGTCGCTGCGTCCGGTGTTACCGGGCT
GA

Upstream 100 bases:

>100_bases
CAGCTGGCTCGAAGAGAAGGGCAACCAGGTCGAAGCGGATATCTGAGCGCACGCGTGCATCGTGCGATGCACGCGCGCCC
AACAAGGACACGGAATCTAG

Downstream 100 bases:

>100_bases
CGATGTCAAGCGCCGTGAGCGGGGTCTCTCACGGCGCAACACCACACCTCCCCATGAAAGAAAACAGCGCAGCGAATGAA
CTGCGCATCATGTGGCTGGT

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 773; Mature: 773

Protein sequence:

>773_residues
MDDNTPDLFTEPAAPEGDVLTLGNYAERAYLDYAVSVVKGRALPDVCDGQKPVQRRILYAMNEMGLGDNAKPVKSARVVG
DVLGKYHPHGDQSAYDALVRLAQDFSMRYPLIDGQGNFGSRDGDGAAAMRYTEARLTPIAKLLLDEIDQGTVDFMPNYDG
SFEEPKLLPARLPFVLLNGASGIAVGLATEIPSHNLREVAAAAVAMIRHPKITHAELMQLVPGPDFPGGGQIISSEAEIS
QAYETGRGSLKVRARWKIEDLARGQWQLVITELPPNTSGQKVLEEIEEQTNPKIKLGKKSLTPEQLQTKQTLLGLLDAVR
DESGKDAPVRLVFEPKSSRIDQTEFVNTLLAHTSLESNATLNLVMVGADGRPRQKGIGEMLHEWIGFRFTTVTRRSQHRL
NKVNERIHILEGRMIVFLNIDEVIRIIRESEEPKAALIEAFKLSDRQAEDILEIRLRQLARLEAIKIEKELSELRDEKAK
LEELLGSEPAMKRLLIKEIEADAKQYGDDRRTLIQQEKRATFEARVVDEPVTVVVSQKGWVRALKGHGLDPAGFTFKAGD
GLYAAFQCRTPDMLIAWGSKGRVYSVAVSQLPGGRGDGVPVTSLIELESGTHLMHYYAASAEQALLLASSNGFGFIAKVG
DMVSRVKAGKAFMTIDEGATPLAPMPMLPDATQVACLSGGGRLLVFGLDEMKTLSGGGRGVILMALDPNEVLKQALAISN
AGVVLQGVYRNKPMEEELSGKALEPNVGKRARKGRVPDTKLKEVTSLRPVLPG

Sequences:

>Translated_773_residues
MDDNTPDLFTEPAAPEGDVLTLGNYAERAYLDYAVSVVKGRALPDVCDGQKPVQRRILYAMNEMGLGDNAKPVKSARVVG
DVLGKYHPHGDQSAYDALVRLAQDFSMRYPLIDGQGNFGSRDGDGAAAMRYTEARLTPIAKLLLDEIDQGTVDFMPNYDG
SFEEPKLLPARLPFVLLNGASGIAVGLATEIPSHNLREVAAAAVAMIRHPKITHAELMQLVPGPDFPGGGQIISSEAEIS
QAYETGRGSLKVRARWKIEDLARGQWQLVITELPPNTSGQKVLEEIEEQTNPKIKLGKKSLTPEQLQTKQTLLGLLDAVR
DESGKDAPVRLVFEPKSSRIDQTEFVNTLLAHTSLESNATLNLVMVGADGRPRQKGIGEMLHEWIGFRFTTVTRRSQHRL
NKVNERIHILEGRMIVFLNIDEVIRIIRESEEPKAALIEAFKLSDRQAEDILEIRLRQLARLEAIKIEKELSELRDEKAK
LEELLGSEPAMKRLLIKEIEADAKQYGDDRRTLIQQEKRATFEARVVDEPVTVVVSQKGWVRALKGHGLDPAGFTFKAGD
GLYAAFQCRTPDMLIAWGSKGRVYSVAVSQLPGGRGDGVPVTSLIELESGTHLMHYYAASAEQALLLASSNGFGFIAKVG
DMVSRVKAGKAFMTIDEGATPLAPMPMLPDATQVACLSGGGRLLVFGLDEMKTLSGGGRGVILMALDPNEVLKQALAISN
AGVVLQGVYRNKPMEEELSGKALEPNVGKRARKGRVPDTKLKEVTSLRPVLPG
>Mature_773_residues
MDDNTPDLFTEPAAPEGDVLTLGNYAERAYLDYAVSVVKGRALPDVCDGQKPVQRRILYAMNEMGLGDNAKPVKSARVVG
DVLGKYHPHGDQSAYDALVRLAQDFSMRYPLIDGQGNFGSRDGDGAAAMRYTEARLTPIAKLLLDEIDQGTVDFMPNYDG
SFEEPKLLPARLPFVLLNGASGIAVGLATEIPSHNLREVAAAAVAMIRHPKITHAELMQLVPGPDFPGGGQIISSEAEIS
QAYETGRGSLKVRARWKIEDLARGQWQLVITELPPNTSGQKVLEEIEEQTNPKIKLGKKSLTPEQLQTKQTLLGLLDAVR
DESGKDAPVRLVFEPKSSRIDQTEFVNTLLAHTSLESNATLNLVMVGADGRPRQKGIGEMLHEWIGFRFTTVTRRSQHRL
NKVNERIHILEGRMIVFLNIDEVIRIIRESEEPKAALIEAFKLSDRQAEDILEIRLRQLARLEAIKIEKELSELRDEKAK
LEELLGSEPAMKRLLIKEIEADAKQYGDDRRTLIQQEKRATFEARVVDEPVTVVVSQKGWVRALKGHGLDPAGFTFKAGD
GLYAAFQCRTPDMLIAWGSKGRVYSVAVSQLPGGRGDGVPVTSLIELESGTHLMHYYAASAEQALLLASSNGFGFIAKVG
DMVSRVKAGKAFMTIDEGATPLAPMPMLPDATQVACLSGGGRLLVFGLDEMKTLSGGGRGVILMALDPNEVLKQALAISN
AGVVLQGVYRNKPMEEELSGKALEPNVGKRARKGRVPDTKLKEVTSLRPVLPG

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=254, Percent_Identity=30.7086614173228, Blast_Score=95, Evalue=3e-19,
Organism=Homo sapiens, GI19913406, Length=166, Percent_Identity=33.7349397590361, Blast_Score=88, Evalue=4e-17,
Organism=Escherichia coli, GI1789396, Length=682, Percent_Identity=48.2404692082111, Blast_Score=629, Evalue=0.0,
Organism=Escherichia coli, GI1788562, Length=727, Percent_Identity=35.2132049518569, Blast_Score=393, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI212645845, Length=362, Percent_Identity=29.2817679558011, Blast_Score=94, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17535065, Length=165, Percent_Identity=35.1515151515151, Blast_Score=89, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI212645657, Length=164, Percent_Identity=34.1463414634146, Blast_Score=82, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI115534553, Length=161, Percent_Identity=31.6770186335404, Blast_Score=75, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6324241, Length=332, Percent_Identity=29.2168674698795, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17136538, Length=234, Percent_Identity=28.6324786324786, Blast_Score=91, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760
- InterPro:   IPR005742 [H]

Pfam domain/function: PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 84549; Mature: 84549

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDDNTPDLFTEPAAPEGDVLTLGNYAERAYLDYAVSVVKGRALPDVCDGQKPVQRRILYA
CCCCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
MNEMGLGDNAKPVKSARVVGDVLGKYHPHGDQSAYDALVRLAQDFSMRYPLIDGQGNFGS
HHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEECCCCCCCC
RDGDGAAAMRYTEARLTPIAKLLLDEIDQGTVDFMPNYDGSFEEPKLLPARLPFVLLNGA
CCCCCHHHEEEHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCCEEEEECC
SGIAVGLATEIPSHNLREVAAAAVAMIRHPKITHAELMQLVPGPDFPGGGQIISSEAEIS
CCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCEECCHHHHH
QAYETGRGSLKVRARWKIEDLARGQWQLVITELPPNTSGQKVLEEIEEQTNPKIKLGKKS
HHHHCCCCCEEEEEEECHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCEEECCCC
LTPEQLQTKQTLLGLLDAVRDESGKDAPVRLVFEPKSSRIDQTEFVNTLLAHTSLESNAT
CCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCE
LNLVMVGADGRPRQKGIGEMLHEWIGFRFTTVTRRSQHRLNKVNERIHILEGRMIVFLNI
EEEEEECCCCCCHHHHHHHHHHHHHCEEEEEEHHHHHHHHHHHHHHEEEEECCEEEEEEH
DEVIRIIRESEEPKAALIEAFKLSDRQAEDILEIRLRQLARLEAIKIEKELSELRDEKAK
HHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LEELLGSEPAMKRLLIKEIEADAKQYGDDRRTLIQQEKRATFEARVVDEPVTVVVSQKGW
HHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCEEEEEECCCEEEEEECCCH
VRALKGHGLDPAGFTFKAGDGLYAAFQCRTPDMLIAWGSKGRVYSVAVSQLPGGRGDGVP
HHHHHCCCCCCCCCEEECCCCEEEEEEECCCCEEEEECCCCCEEEEEHHHCCCCCCCCCC
VTSLIELESGTHLMHYYAASAEQALLLASSNGFGFIAKVGDMVSRVKAGKAFMTIDEGAT
EEEEEEECCCCEEEEEECCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEECCCCC
PLAPMPMLPDATQVACLSGGGRLLVFGLDEMKTLSGGGRGVILMALDPNEVLKQALAISN
CCCCCCCCCCCCEEEEECCCCEEEEEECCHHHHHCCCCCEEEEEEECHHHHHHHHHHHCC
AGVVLQGVYRNKPMEEELSGKALEPNVGKRARKGRVPDTKLKEVTSLRPVLPG
CCEEEEEHHCCCCCHHHHCCCCCCCCCCHHHHCCCCCCHHHHHHHHCCCCCCC
>Mature Secondary Structure
MDDNTPDLFTEPAAPEGDVLTLGNYAERAYLDYAVSVVKGRALPDVCDGQKPVQRRILYA
CCCCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
MNEMGLGDNAKPVKSARVVGDVLGKYHPHGDQSAYDALVRLAQDFSMRYPLIDGQGNFGS
HHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEECCCCCCCC
RDGDGAAAMRYTEARLTPIAKLLLDEIDQGTVDFMPNYDGSFEEPKLLPARLPFVLLNGA
CCCCCHHHEEEHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCCEEEEECC
SGIAVGLATEIPSHNLREVAAAAVAMIRHPKITHAELMQLVPGPDFPGGGQIISSEAEIS
CCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCEECCHHHHH
QAYETGRGSLKVRARWKIEDLARGQWQLVITELPPNTSGQKVLEEIEEQTNPKIKLGKKS
HHHHCCCCCEEEEEEECHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCEEECCCC
LTPEQLQTKQTLLGLLDAVRDESGKDAPVRLVFEPKSSRIDQTEFVNTLLAHTSLESNAT
CCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCE
LNLVMVGADGRPRQKGIGEMLHEWIGFRFTTVTRRSQHRLNKVNERIHILEGRMIVFLNI
EEEEEECCCCCCHHHHHHHHHHHHHCEEEEEEHHHHHHHHHHHHHHEEEEECCEEEEEEH
DEVIRIIRESEEPKAALIEAFKLSDRQAEDILEIRLRQLARLEAIKIEKELSELRDEKAK
HHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LEELLGSEPAMKRLLIKEIEADAKQYGDDRRTLIQQEKRATFEARVVDEPVTVVVSQKGW
HHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCEEEEEECCCEEEEEECCCH
VRALKGHGLDPAGFTFKAGDGLYAAFQCRTPDMLIAWGSKGRVYSVAVSQLPGGRGDGVP
HHHHHCCCCCCCCCEEECCCCEEEEEEECCCCEEEEECCCCCEEEEEHHHCCCCCCCCCC
VTSLIELESGTHLMHYYAASAEQALLLASSNGFGFIAKVGDMVSRVKAGKAFMTIDEGAT
EEEEEEECCCCEEEEEECCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEECCCCC
PLAPMPMLPDATQVACLSGGGRLLVFGLDEMKTLSGGGRGVILMALDPNEVLKQALAISN
CCCCCCCCCCCCEEEEECCCCEEEEEECCHHHHHCCCCCEEEEEEECHHHHHHHHHHHCC
AGVVLQGVYRNKPMEEELSGKALEPNVGKRARKGRVPDTKLKEVTSLRPVLPG
CCEEEEEHHCCCCCHHHHCCCCCCCCCCHHHHCCCCCCHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7830580 [H]