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The map label for this gene is parE [H]

Identifier: 186476877

GI number: 186476877

Start: 2385932

End: 2387917

Strand: Reverse

Name: parE [H]

Synonym: Bphy_2124

Alternate gene names: 186476877

Gene position: 2387917-2385932 (Counterclockwise)

Preceding gene: 186476878

Following gene: 186476876

Centisome position: 68.63

GC content: 63.29

Gene sequence:

>1986_bases
ATGTCAACGAAAAAGCCAAACGCCGCGTATAGCGAAGCATCGATCAAGGTGCTCAAAGGCCTGGAGCCGGTCAAGCAGCG
GCCCGGCATGTACACGCGCACCGAAAATCCGCTGCACATCATTCAGGAAGTCATCGACAACGCATCCGACGAAGCGCTCG
GCGGCTACGGCCGTCAGATCACCGTCACGCTGCACGCCGATCATTCCGTTTCAGTCGAAGACGACGGCCGTGGTATTCCG
TTCGGCATGCACCCCGAAGAGCGCGTCCCCGTCGTCGAAATCGTTTTCACGCGCCTGCACGCCGGCGGCAAGTTCGACAA
GGCGGCGGGCGGCGCCTACACGTTCTCGGGCGGCCTGCACGGCGTCGGCGTATCGGTGACCAACGCGCTGTCCACGCGCC
TGGATGTCACCGTCTGGCGCGACGGCAAGGTCGCCGAGCTGAGCTTCTCGCACGGCGACGTCATCAAGCCGCTGCAGGTG
CGCGCCGCGACGAAGGCCGACAAGAAGTCGGGCACGCGCGTCACGGCGTGGGCCGATCCGAAATACTTCGATTCGCCGAA
TCTGCCGCTCGGCGAACTGCAACGCCTGCTGCGTTCGAAAGCCGTGCTGCTGCCGGGCGTGGAAGTCGTTCTCATCAACG
AAAAGACAGGCGAGCGCCAAAGCTGGAAATACGAAGACGGCCTGCGTGGCTATCTGATGGAAGGCATGGCGGGCAGCGAC
CTGCTGATCCCGCTGTTCGAAGGGGAACGCTACGCGGAAAGTTCGCGCTCGAACGAAGAAACCTTTGCCGAAGGCGAAGG
CGCGGCGTGGGTCGTCGCGTGGAGCGAGGAAGGACCGCTCACGCGCGAATCCTACGTCAATCTGATTCCGACTCCCGCGG
GCGGCACGCATGAAGCGGGTCTGCGCGACGGTCTCTTCCAGGCCGTGAAGAGCTTTGTCGAACTGCACAACCTGCAGCCC
AAGGGCGTGAAGCTGCTCGCGGAAGACGTGTTCGCGCGCGTCTCGTTCGTGCTCTCCGCGAAGGTGCTCGACCCGCAGTT
CCAGGGGCAAATCAAGGAGCGTCTGAATAGCCGCGATGCCGTCAAGCTGGTGTCCTCGTTCGCGCGCCCCGCGCTGGAAC
TGTGGCTCAACCAGCACGTCGAGCACGGCAAGAAGCTCGCCGACCTCGTCATCAAGCAGGCGCAGGCGCGCACGCGCGCC
GGCCAGAAGGTCGAAAAGCGCAAGAGCTCGGGTGTGGCCGTGCTGCCAGGCAAACTGACGGATTGCGAATCGACCGAAAT
CGGCCGCAACGAACTGTTCCTCGTCGAGGGCGATTCAGCAGGCGGTTCCGCGAAGATGGGCCGTGACAAGGAGTACCAGG
CCATCCTGCCGTTGCGCGGCAAGGTGCTGAACACCTGGGAAACCGAGCGGGATCGTCTCTTCGCGAATAACGAAGTGCAC
GATATTTCCGTAGCGATCGGCGTCGATCCGCATAACCCGGACGACACCGTCGATCTGTCCAATCTGCGCTACGGCAAGAT
CTGTATCTTGTCCGATGCGGACGTCGACGGTTCGCATATCCAGGTGCTATTGCTGACGCTGTTCTTCAAGCACTTCCCGC
AACTGATCGAGCGCGGTCACGTGCATGTCGCGCGTCCGCCGCTGTTCCGCGTCGATGCGCCCGCGCGCGGCAAGAAGCCG
GCGCAGAAGCTGTACGCGCTCGACGAAGGCGAACTCGAAGCGATTCTCGACAAGCTGCGCAAGGACGGCGTGCGCGAATC
GCAATGGTCGATCAGCCGCTTCAAGGGGCTCGGTGAAATGAGCGCCGAGCAGCTGTGGGACACGACGATGAACCCGGACA
CGCGGCGCCTGTCGCCCGTTGCCCTCGGCGAACTCGACTTCGACGCGACGGTCACGCGCATGACGATGCTGATGGGCAAG
GGCGAAGCGGCGTCGCGCCGCAGCTGGCTCGAAGAGAAGGGCAACCAGGTCGAAGCGGATATCTGA

Upstream 100 bases:

>100_bases
CGTTGTTTCGTTTCGCTTTTTTTTGAAAACTCGACGCATTGTCCACGCACCTGTCCGCAAGACATGTGGACAACGATGAA
CCGACGGACCCGAGCAAGCC

Downstream 100 bases:

>100_bases
GCGCACGCGTGCATCGTGCGATGCACGCGCGCCCAACAAGGACACGGAATCTAGATGGACGACAACACTCCCGATCTGTT
TACCGAGCCGGCAGCGCCCG

Product: DNA topoisomerase IV subunit B

Products: NA

Alternate protein names: Topoisomerase IV subunit B [H]

Number of amino acids: Translated: 661; Mature: 660

Protein sequence:

>661_residues
MSTKKPNAAYSEASIKVLKGLEPVKQRPGMYTRTENPLHIIQEVIDNASDEALGGYGRQITVTLHADHSVSVEDDGRGIP
FGMHPEERVPVVEIVFTRLHAGGKFDKAAGGAYTFSGGLHGVGVSVTNALSTRLDVTVWRDGKVAELSFSHGDVIKPLQV
RAATKADKKSGTRVTAWADPKYFDSPNLPLGELQRLLRSKAVLLPGVEVVLINEKTGERQSWKYEDGLRGYLMEGMAGSD
LLIPLFEGERYAESSRSNEETFAEGEGAAWVVAWSEEGPLTRESYVNLIPTPAGGTHEAGLRDGLFQAVKSFVELHNLQP
KGVKLLAEDVFARVSFVLSAKVLDPQFQGQIKERLNSRDAVKLVSSFARPALELWLNQHVEHGKKLADLVIKQAQARTRA
GQKVEKRKSSGVAVLPGKLTDCESTEIGRNELFLVEGDSAGGSAKMGRDKEYQAILPLRGKVLNTWETERDRLFANNEVH
DISVAIGVDPHNPDDTVDLSNLRYGKICILSDADVDGSHIQVLLLTLFFKHFPQLIERGHVHVARPPLFRVDAPARGKKP
AQKLYALDEGELEAILDKLRKDGVRESQWSISRFKGLGEMSAEQLWDTTMNPDTRRLSPVALGELDFDATVTRMTMLMGK
GEAASRRSWLEEKGNQVEADI

Sequences:

>Translated_661_residues
MSTKKPNAAYSEASIKVLKGLEPVKQRPGMYTRTENPLHIIQEVIDNASDEALGGYGRQITVTLHADHSVSVEDDGRGIP
FGMHPEERVPVVEIVFTRLHAGGKFDKAAGGAYTFSGGLHGVGVSVTNALSTRLDVTVWRDGKVAELSFSHGDVIKPLQV
RAATKADKKSGTRVTAWADPKYFDSPNLPLGELQRLLRSKAVLLPGVEVVLINEKTGERQSWKYEDGLRGYLMEGMAGSD
LLIPLFEGERYAESSRSNEETFAEGEGAAWVVAWSEEGPLTRESYVNLIPTPAGGTHEAGLRDGLFQAVKSFVELHNLQP
KGVKLLAEDVFARVSFVLSAKVLDPQFQGQIKERLNSRDAVKLVSSFARPALELWLNQHVEHGKKLADLVIKQAQARTRA
GQKVEKRKSSGVAVLPGKLTDCESTEIGRNELFLVEGDSAGGSAKMGRDKEYQAILPLRGKVLNTWETERDRLFANNEVH
DISVAIGVDPHNPDDTVDLSNLRYGKICILSDADVDGSHIQVLLLTLFFKHFPQLIERGHVHVARPPLFRVDAPARGKKP
AQKLYALDEGELEAILDKLRKDGVRESQWSISRFKGLGEMSAEQLWDTTMNPDTRRLSPVALGELDFDATVTRMTMLMGK
GEAASRRSWLEEKGNQVEADI
>Mature_660_residues
STKKPNAAYSEASIKVLKGLEPVKQRPGMYTRTENPLHIIQEVIDNASDEALGGYGRQITVTLHADHSVSVEDDGRGIPF
GMHPEERVPVVEIVFTRLHAGGKFDKAAGGAYTFSGGLHGVGVSVTNALSTRLDVTVWRDGKVAELSFSHGDVIKPLQVR
AATKADKKSGTRVTAWADPKYFDSPNLPLGELQRLLRSKAVLLPGVEVVLINEKTGERQSWKYEDGLRGYLMEGMAGSDL
LIPLFEGERYAESSRSNEETFAEGEGAAWVVAWSEEGPLTRESYVNLIPTPAGGTHEAGLRDGLFQAVKSFVELHNLQPK
GVKLLAEDVFARVSFVLSAKVLDPQFQGQIKERLNSRDAVKLVSSFARPALELWLNQHVEHGKKLADLVIKQAQARTRAG
QKVEKRKSSGVAVLPGKLTDCESTEIGRNELFLVEGDSAGGSAKMGRDKEYQAILPLRGKVLNTWETERDRLFANNEVHD
ISVAIGVDPHNPDDTVDLSNLRYGKICILSDADVDGSHIQVLLLTLFFKHFPQLIERGHVHVARPPLFRVDAPARGKKPA
QKLYALDEGELEAILDKLRKDGVRESQWSISRFKGLGEMSAEQLWDTTMNPDTRRLSPVALGELDFDATVTRMTMLMGKG
EAASRRSWLEEKGNQVEADI

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type II topoisomerase family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=648, Percent_Identity=24.8456790123457, Blast_Score=128, Evalue=2e-29,
Organism=Homo sapiens, GI19913406, Length=660, Percent_Identity=24.2424242424242, Blast_Score=123, Evalue=5e-28,
Organism=Escherichia coli, GI1789408, Length=654, Percent_Identity=49.6941896024465, Blast_Score=629, Evalue=0.0,
Organism=Escherichia coli, GI48994957, Length=644, Percent_Identity=36.8012422360248, Blast_Score=360, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17535065, Length=646, Percent_Identity=23.9938080495356, Blast_Score=111, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI212645845, Length=608, Percent_Identity=23.1907894736842, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI212645657, Length=213, Percent_Identity=29.5774647887324, Blast_Score=76, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6324241, Length=655, Percent_Identity=25.6488549618321, Blast_Score=130, Evalue=5e-31,
Organism=Drosophila melanogaster, GI17136538, Length=658, Percent_Identity=25.531914893617, Blast_Score=125, Evalue=8e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522
- InterPro:   IPR005737 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c [H]

EC number: 5.99.1.-

Molecular weight: Translated: 72819; Mature: 72687

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTKKPNAAYSEASIKVLKGLEPVKQRPGMYTRTENPLHIIQEVIDNASDEALGGYGRQI
CCCCCCCCCHHHHHHHHHHCCCHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCEE
TVTLHADHSVSVEDDGRGIPFGMHPEERVPVVEIVFTRLHAGGKFDKAAGGAYTFSGGLH
EEEEECCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEECCCCC
GVGVSVTNALSTRLDVTVWRDGKVAELSFSHGDVIKPLQVRAATKADKKSGTRVTAWADP
CCCHHHHHHHHCCEEEEEECCCCEEEEECCCCCCCCCHHHHHHHCCCCCCCCEEEEECCC
KYFDSPNLPLGELQRLLRSKAVLLPGVEVVLINEKTGERQSWKYEDGLRGYLMEGMAGSD
CCCCCCCCCHHHHHHHHHHCCEECCCEEEEEEECCCCCCCCCCCCCCCHHHHHCCCCCCC
LLIPLFEGERYAESSRSNEETFAEGEGAAWVVAWSEEGPLTRESYVNLIPTPAGGTHEAG
EEEEEECCCHHHHHCCCCCHHHHCCCCCEEEEEECCCCCCCHHHCCEEEECCCCCCCCCH
LRDGLFQAVKSFVELHNLQPKGVKLLAEDVFARVSFVLSAKVLDPQFQGQIKERLNSRDA
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHH
VKLVSSFARPALELWLNQHVEHGKKLADLVIKQAQARTRAGQKVEKRKSSGVAVLPGKLT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCC
DCESTEIGRNELFLVEGDSAGGSAKMGRDKEYQAILPLRGKVLNTWETERDRLFANNEVH
CCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCEEECCCCCEEECCCCCCHHHEECCCCEE
DISVAIGVDPHNPDDTVDLSNLRYGKICILSDADVDGSHIQVLLLTLFFKHFPQLIERGH
EEEEEEECCCCCCCCCEECCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCC
VHVARPPLFRVDAPARGKKPAQKLYALDEGELEAILDKLRKDGVRESQWSISRFKGLGEM
EEEECCCCEEECCCCCCCCHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCH
SAEQLWDTTMNPDTRRLSPVALGELDFDATVTRMTMLMGKGEAASRRSWLEEKGNQVEAD
HHHHHHCCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCEEECC
I
C
>Mature Secondary Structure 
STKKPNAAYSEASIKVLKGLEPVKQRPGMYTRTENPLHIIQEVIDNASDEALGGYGRQI
CCCCCCCCHHHHHHHHHHCCCHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCEE
TVTLHADHSVSVEDDGRGIPFGMHPEERVPVVEIVFTRLHAGGKFDKAAGGAYTFSGGLH
EEEEECCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEECCCCC
GVGVSVTNALSTRLDVTVWRDGKVAELSFSHGDVIKPLQVRAATKADKKSGTRVTAWADP
CCCHHHHHHHHCCEEEEEECCCCEEEEECCCCCCCCCHHHHHHHCCCCCCCCEEEEECCC
KYFDSPNLPLGELQRLLRSKAVLLPGVEVVLINEKTGERQSWKYEDGLRGYLMEGMAGSD
CCCCCCCCCHHHHHHHHHHCCEECCCEEEEEEECCCCCCCCCCCCCCCHHHHHCCCCCCC
LLIPLFEGERYAESSRSNEETFAEGEGAAWVVAWSEEGPLTRESYVNLIPTPAGGTHEAG
EEEEEECCCHHHHHCCCCCHHHHCCCCCEEEEEECCCCCCCHHHCCEEEECCCCCCCCCH
LRDGLFQAVKSFVELHNLQPKGVKLLAEDVFARVSFVLSAKVLDPQFQGQIKERLNSRDA
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHH
VKLVSSFARPALELWLNQHVEHGKKLADLVIKQAQARTRAGQKVEKRKSSGVAVLPGKLT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCC
DCESTEIGRNELFLVEGDSAGGSAKMGRDKEYQAILPLRGKVLNTWETERDRLFANNEVH
CCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCEEECCCCCEEECCCCCCHHHEECCCCEE
DISVAIGVDPHNPDDTVDLSNLRYGKICILSDADVDGSHIQVLLLTLFFKHFPQLIERGH
EEEEEEECCCCCCCCCEECCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCC
VHVARPPLFRVDAPARGKKPAQKLYALDEGELEAILDKLRKDGVRESQWSISRFKGLGEM
EEEECCCCEEECCCCCCCCHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCH
SAEQLWDTTMNPDTRRLSPVALGELDFDATVTRMTMLMGKGEAASRRSWLEEKGNQVEAD
HHHHHHCCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCEEECC
I
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2170028; 8388096; 9278503; 8227000; 8980775 [H]