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The map label for this gene is pcoA [H]

Identifier: 186476794

GI number: 186476794

Start: 2289840

End: 2291135

Strand: Reverse

Name: pcoA [H]

Synonym: Bphy_2040

Alternate gene names: 186476794

Gene position: 2291135-2289840 (Counterclockwise)

Preceding gene: 186476795

Following gene: 186476793

Centisome position: 65.85

GC content: 60.8

Gene sequence:

>1296_bases
ATGGTCTCACGTCGAAATTTTCTCGGCGGCTCAGGGGCGGCGTTGCTCGGCGCGGCGTTGGTCAGCAAAGCTGGAGCGGC
TGCACTTCCAGAAGCGCCAATCATGCAAAAGACGGCGACGCAGCCACCGCTTGTGCCGCCCAATGGTCGCCCCTATAGGC
CGGTGGCCACGCTTAACGGGTGGACACTGCCCTGGCGGATGAAGAACGGCTGGAAGGAGTTTCACCTTATCGCCGAGCCG
GTCGTTCGCGAAATGGCACCCGGCATGAAGGCGAATCTCTGGGGCTATAACGGCCAGGCACCAGGCCCGACCATCGAGGC
GGTCGAAGGCGACAAGGTCCGCATCTTCGTCACCAACAAACTGCCTGAACACACCACTGTTCACTGGCACGGGATGCTCG
TGCCGTCGGGGATGGACGGCGTGGGCGGTCTCACGCAACCGCACATCCCGCCCGGCAAGACATTCGTCTACGAGTTCCAG
CTCGAAAAGCACGGCACTTTCATGTATCACCCGCATGCCGACGAGATGGTGCAGATGGCCATGGGGATGATGGGCACGTT
CATCGTGCATCCGAAGGACGGCAGCGTCATGCAGGTGGACCGCGACTTCGTGTTCCTGATGTCCGCCTACGACATTGACC
CAGGAAGTTTCACGCCACGCGTCAACGAAATGACGGACTTCAACATGTGGACGTGGAATGCGAGAGTTTTTCCTGGCGTC
GACCCGCTGCCGGTACGCGCAGGAGACCGCGTTCGCATCCGCTTCGGCAATCTCACGATGACCAATCACCCCATTCATCT
TCACGGGTACAGCTTCGAGGTCGCAGGAACCGACGGTGGATGGATTCCGCCTTCCGCTCGCTGGCCGGAAGTGACCGCCG
ACGTTGCGGTCGGTCAGATGCGCGCCATCGAGTTCACGGCAAACCGGCCCGGTGACTGGGCGTTTCACTGCCACAAGTCG
CATCACACGATGAATGCGATGGGGCATCAGGTCCCCAATCTGATTGGCGTGCAGCAGAAAGATCTGGCGAAACGTATCAA
CAGACTTGTGCCGGACTACATGGCGATGGGCAGTTCCGGCGGCTCGATGGGCGAGATGGAGATGCCGCTACCGGACAACA
CGCTACCGATGATGACGGGCACTGGGCCGTTTGGCGCGCTGGAAATGGGCGGCATGTTCACCGTGGTGAAAGTGCGTGAG
GGACTCGGTCGCAACGATTACCGCGACCCGGGCTGGTTCAGACACCCAAAGGGAACCGTTGCGTACGAGTACACGGGTGA
ACTGCCCGATAGCTGA

Upstream 100 bases:

>100_bases
CTACTGCCGCACAGCGGGCACCGGCTCCGAGGCAGGACTCGCCGTTGCCCATTCCAGCGACGCGGCCCGCGTCGCCGATG
AATTCAGAAGGTAAATGAAC

Downstream 100 bases:

>100_bases
TTTCGTCGAAGGCCGGGCATGCACTCCAGCCGGGATTTTTCAATTCAACTGTGGGAGAGAGCGTAATGAAGAACGCGATT
GTTTCGATTGTGATGGGCTG

Product: multicopper oxidase type 3

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MVSRRNFLGGSGAALLGAALVSKAGAAALPEAPIMQKTATQPPLVPPNGRPYRPVATLNGWTLPWRMKNGWKEFHLIAEP
VVREMAPGMKANLWGYNGQAPGPTIEAVEGDKVRIFVTNKLPEHTTVHWHGMLVPSGMDGVGGLTQPHIPPGKTFVYEFQ
LEKHGTFMYHPHADEMVQMAMGMMGTFIVHPKDGSVMQVDRDFVFLMSAYDIDPGSFTPRVNEMTDFNMWTWNARVFPGV
DPLPVRAGDRVRIRFGNLTMTNHPIHLHGYSFEVAGTDGGWIPPSARWPEVTADVAVGQMRAIEFTANRPGDWAFHCHKS
HHTMNAMGHQVPNLIGVQQKDLAKRINRLVPDYMAMGSSGGSMGEMEMPLPDNTLPMMTGTGPFGALEMGGMFTVVKVRE
GLGRNDYRDPGWFRHPKGTVAYEYTGELPDS

Sequences:

>Translated_431_residues
MVSRRNFLGGSGAALLGAALVSKAGAAALPEAPIMQKTATQPPLVPPNGRPYRPVATLNGWTLPWRMKNGWKEFHLIAEP
VVREMAPGMKANLWGYNGQAPGPTIEAVEGDKVRIFVTNKLPEHTTVHWHGMLVPSGMDGVGGLTQPHIPPGKTFVYEFQ
LEKHGTFMYHPHADEMVQMAMGMMGTFIVHPKDGSVMQVDRDFVFLMSAYDIDPGSFTPRVNEMTDFNMWTWNARVFPGV
DPLPVRAGDRVRIRFGNLTMTNHPIHLHGYSFEVAGTDGGWIPPSARWPEVTADVAVGQMRAIEFTANRPGDWAFHCHKS
HHTMNAMGHQVPNLIGVQQKDLAKRINRLVPDYMAMGSSGGSMGEMEMPLPDNTLPMMTGTGPFGALEMGGMFTVVKVRE
GLGRNDYRDPGWFRHPKGTVAYEYTGELPDS
>Mature_431_residues
MVSRRNFLGGSGAALLGAALVSKAGAAALPEAPIMQKTATQPPLVPPNGRPYRPVATLNGWTLPWRMKNGWKEFHLIAEP
VVREMAPGMKANLWGYNGQAPGPTIEAVEGDKVRIFVTNKLPEHTTVHWHGMLVPSGMDGVGGLTQPHIPPGKTFVYEFQ
LEKHGTFMYHPHADEMVQMAMGMMGTFIVHPKDGSVMQVDRDFVFLMSAYDIDPGSFTPRVNEMTDFNMWTWNARVFPGV
DPLPVRAGDRVRIRFGNLTMTNHPIHLHGYSFEVAGTDGGWIPPSARWPEVTADVAVGQMRAIEFTANRPGDWAFHCHKS
HHTMNAMGHQVPNLIGVQQKDLAKRINRLVPDYMAMGSSGGSMGEMEMPLPDNTLPMMTGTGPFGALEMGGMFTVVKVRE
GLGRNDYRDPGWFRHPKGTVAYEYTGELPDS

Specific function: Required for the copper-inducible expression of copper resistance. May have oxidase activity [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family. CopA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=247, Percent_Identity=26.3157894736842, Blast_Score=68, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323703, Length=103, Percent_Identity=42.7184466019417, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6321067, Length=215, Percent_Identity=28.3720930232558, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI18859919, Length=109, Percent_Identity=40.3669724770642, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24650186, Length=95, Percent_Identity=40, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI28574104, Length=108, Percent_Identity=37.037037037037, Blast_Score=66, Evalue=5e-11,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR006376
- InterPro:   IPR002355
- InterPro:   IPR008972
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 47526; Mature: 47526

Theoretical pI: Translated: 7.37; Mature: 7.37

Prosite motif: PS00080 MULTICOPPER_OXIDASE2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
7.0 %Met     (Translated Protein)
7.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
7.0 %Met     (Mature Protein)
7.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSRRNFLGGSGAALLGAALVSKAGAAALPEAPIMQKTATQPPLVPPNGRPYRPVATLNG
CCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCEEEECCC
WTLPWRMKNGWKEFHLIAEPVVREMAPGMKANLWGYNGQAPGPTIEAVEGDKVRIFVTNK
CEEEEEECCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCEEEEECCCEEEEEEECC
LPEHTTVHWHGMLVPSGMDGVGGLTQPHIPPGKTFVYEFQLEKHGTFMYHPHADEMVQMA
CCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCEEEEEEEEECCCEEEECCCHHHHHHHH
MGMMGTFIVHPKDGSVMQVDRDFVFLMSAYDIDPGSFTPRVNEMTDFNMWTWNARVFPGV
HHHHEEEEEECCCCCEEEECCCEEEEEEEEECCCCCCCCCCCCCCCCCEEEECCEECCCC
DPLPVRAGDRVRIRFGNLTMTNHPIHLHGYSFEVAGTDGGWIPPSARWPEVTADVAVGQM
CCCCCCCCCEEEEEECCEEEECCCEEEECEEEEEECCCCCCCCCCCCCCCCCHHHHHCCE
RAIEFTANRPGDWAFHCHKSHHTMNAMGHQVPNLIGVQQKDLAKRINRLVPDYMAMGSSG
EEEEEECCCCCCEEEEEECCCCHHHHHHHHCCHHHCCCHHHHHHHHHHHCCHHHHHCCCC
GSMGEMEMPLPDNTLPMMTGTGPFGALEMGGMFTVVKVREGLGRNDYRDPGWFRHPKGTV
CCCCEEECCCCCCCCCEEECCCCCCCEECCCEEEEEEEHHCCCCCCCCCCCCEECCCCCE
AYEYTGELPDS
EEEECCCCCCC
>Mature Secondary Structure
MVSRRNFLGGSGAALLGAALVSKAGAAALPEAPIMQKTATQPPLVPPNGRPYRPVATLNG
CCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCEEEECCC
WTLPWRMKNGWKEFHLIAEPVVREMAPGMKANLWGYNGQAPGPTIEAVEGDKVRIFVTNK
CEEEEEECCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCEEEEECCCEEEEEEECC
LPEHTTVHWHGMLVPSGMDGVGGLTQPHIPPGKTFVYEFQLEKHGTFMYHPHADEMVQMA
CCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCEEEEEEEEECCCEEEECCCHHHHHHHH
MGMMGTFIVHPKDGSVMQVDRDFVFLMSAYDIDPGSFTPRVNEMTDFNMWTWNARVFPGV
HHHHEEEEEECCCCCEEEECCCEEEEEEEEECCCCCCCCCCCCCCCCCEEEECCEECCCC
DPLPVRAGDRVRIRFGNLTMTNHPIHLHGYSFEVAGTDGGWIPPSARWPEVTADVAVGQM
CCCCCCCCCEEEEEECCEEEECCCEEEECEEEEEECCCCCCCCCCCCCCCCCHHHHHCCE
RAIEFTANRPGDWAFHCHKSHHTMNAMGHQVPNLIGVQQKDLAKRINRLVPDYMAMGSSG
EEEEEECCCCCCEEEEEECCCCHHHHHHHHCCHHHCCCHHHHHHHHHHHCCHHHHHCCCC
GSMGEMEMPLPDNTLPMMTGTGPFGALEMGGMFTVVKVREGLGRNDYRDPGWFRHPKGTV
CCCCEEECCCCCCCCCEEECCCCCCCEECCCEEEEEEEHHCCCCCCCCCCCCEECCCCCE
AYEYTGELPDS
EEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8594334 [H]