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The map label for this gene is iciA [H]

Identifier: 186476586

GI number: 186476586

Start: 2089819

End: 2090712

Strand: Reverse

Name: iciA [H]

Synonym: Bphy_1829

Alternate gene names: 186476586

Gene position: 2090712-2089819 (Counterclockwise)

Preceding gene: 186476588

Following gene: 186476584

Centisome position: 60.09

GC content: 65.32

Gene sequence:

>894_bases
ATGCTCGACTATGCTCTGCTGGATGCGCTCGCGGCCGTCGTGCGTCACGGCTCGTTCGACCGCGCGGCCGCGGCGCTGAA
TGTGACGCCTTCCGCCGTGTCGCAACGGGTGAAACTGCTTGAAGAACGCGTCGGCAGCGTGCTCGTCAAGCGCGGGCAGC
CCTGCACGGCGACTCGATCGGGAGCGCTGCTGTGCCGGCATACGGAACGGGTGCAATTGCTGGAGGCCGAACTCAACGGG
CGCATGCCCGAACTGCCCGGCGCCTTGCTCGAACCGTGGCCGACATTGCGCGTGGCTGTGAACGACGACAGCGTCGGTAC
CTGGTTCATCGACGCCGTCGCGGACTTCTGCGCGGAGCGCGGCATGCTGCTCGATCTCGTCATCGACGATCAGGACCATA
CCGCGCAGCGGATTCGCGATGGCAGCGTGCAGGGGGCCGTGACGACGCAATCGGAGCCGGTCCAAGGGTGCCGCTCGACG
CGTCTTGGACGCATGCGTTATCTGGCCGTCTGCACGCCCGCGTTCTACGAGCGATATTTCAGCGAGGGCATCAGCCGTGA
CACGCTGCGCCGTGCGCCGTGTGTCGATTTCAATCCGAAAGATCAGCTGCAAACGCGCTTCGTGCGCAAGATCACGCGCG
CCGAAGTCGATGCGCCGACGCACTGGATTCCGCACGTGTCCGGCTTTTTGCGCGCATGTTCGACGGGGCTCGGGTGGGGC
ATGTGCCCCGAACGGATGATCGCCGCGCAACTCGCAAGCGGCGAACTGATCGACATGGCACCGGGCAAGCATCTCGACGT
CGATCTGTACTGGCAGAGCTGGCGGCTGTCGATTGGCTGGCTGGACGAGTTCAGCGCCGCGCTGCGCCAAAGGTCCGCCG
AGTTTCTCGACTGA

Upstream 100 bases:

>100_bases
CATGATGGTTTGAAGAGAAGGATGGATTGGATGGCGAGAGTGTGCCGCGATGGCTACAATAAGAGAAGCTAATTTCCGTA
ACGCCGATTAAGGAACGCTA

Downstream 100 bases:

>100_bases
CGGCTGGCGCCACGCGTTTGACGGCGTGCCAGGTGAATCAGTGCAGCCGGATCACGGGATGCACGCGGCGACGCAGCCAA
TGACTCGCCGTATCAAGCGC

Product: chromosome replication initiation inhibitor protein

Products: NA

Alternate protein names: OriC replication inhibitor [H]

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MLDYALLDALAAVVRHGSFDRAAAALNVTPSAVSQRVKLLEERVGSVLVKRGQPCTATRSGALLCRHTERVQLLEAELNG
RMPELPGALLEPWPTLRVAVNDDSVGTWFIDAVADFCAERGMLLDLVIDDQDHTAQRIRDGSVQGAVTTQSEPVQGCRST
RLGRMRYLAVCTPAFYERYFSEGISRDTLRRAPCVDFNPKDQLQTRFVRKITRAEVDAPTHWIPHVSGFLRACSTGLGWG
MCPERMIAAQLASGELIDMAPGKHLDVDLYWQSWRLSIGWLDEFSAALRQRSAEFLD

Sequences:

>Translated_297_residues
MLDYALLDALAAVVRHGSFDRAAAALNVTPSAVSQRVKLLEERVGSVLVKRGQPCTATRSGALLCRHTERVQLLEAELNG
RMPELPGALLEPWPTLRVAVNDDSVGTWFIDAVADFCAERGMLLDLVIDDQDHTAQRIRDGSVQGAVTTQSEPVQGCRST
RLGRMRYLAVCTPAFYERYFSEGISRDTLRRAPCVDFNPKDQLQTRFVRKITRAEVDAPTHWIPHVSGFLRACSTGLGWG
MCPERMIAAQLASGELIDMAPGKHLDVDLYWQSWRLSIGWLDEFSAALRQRSAEFLD
>Mature_297_residues
MLDYALLDALAAVVRHGSFDRAAAALNVTPSAVSQRVKLLEERVGSVLVKRGQPCTATRSGALLCRHTERVQLLEAELNG
RMPELPGALLEPWPTLRVAVNDDSVGTWFIDAVADFCAERGMLLDLVIDDQDHTAQRIRDGSVQGAVTTQSEPVQGCRST
RLGRMRYLAVCTPAFYERYFSEGISRDTLRRAPCVDFNPKDQLQTRFVRKITRAEVDAPTHWIPHVSGFLRACSTGLGWG
MCPERMIAAQLASGELIDMAPGKHLDVDLYWQSWRLSIGWLDEFSAALRQRSAEFLD

Specific function: Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789283, Length=273, Percent_Identity=36.6300366300366, Blast_Score=160, Evalue=9e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR017685
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33057; Mature: 33057

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDYALLDALAAVVRHGSFDRAAAALNVTPSAVSQRVKLLEERVGSVLVKRGQPCTATRS
CCHHHHHHHHHHHHHCCCCHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
GALLCRHTERVQLLEAELNGRMPELPGALLEPWPTLRVAVNDDSVGTWFIDAVADFCAER
CCEEEECHHHHHHHHHHHCCCCCCCCCHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHCC
GMLLDLVIDDQDHTAQRIRDGSVQGAVTTQSEPVQGCRSTRLGRMRYLAVCTPAFYERYF
CCEEEEEECCCCHHHHHHHCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHH
SEGISRDTLRRAPCVDFNPKDQLQTRFVRKITRAEVDAPTHWIPHVSGFLRACSTGLGWG
HCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCC
MCPERMIAAQLASGELIDMAPGKHLDVDLYWQSWRLSIGWLDEFSAALRQRSAEFLD
CCHHHHHHHHHCCCCEEECCCCCEEEEEEEEECEEEEECCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLDYALLDALAAVVRHGSFDRAAAALNVTPSAVSQRVKLLEERVGSVLVKRGQPCTATRS
CCHHHHHHHHHHHHHCCCCHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
GALLCRHTERVQLLEAELNGRMPELPGALLEPWPTLRVAVNDDSVGTWFIDAVADFCAER
CCEEEECHHHHHHHHHHHCCCCCCCCCHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHCC
GMLLDLVIDDQDHTAQRIRDGSVQGAVTTQSEPVQGCRSTRLGRMRYLAVCTPAFYERYF
CCEEEEEECCCCHHHHHHHCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHH
SEGISRDTLRRAPCVDFNPKDQLQTRFVRKITRAEVDAPTHWIPHVSGFLRACSTGLGWG
HCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCC
MCPERMIAAQLASGELIDMAPGKHLDVDLYWQSWRLSIGWLDEFSAALRQRSAEFLD
CCHHHHHHHHHCCCCEEECCCCCEEEEEEEEECEEEEECCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA