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The map label for this gene is hflK [H]

Identifier: 186476171

GI number: 186476171

Start: 1591806

End: 1593203

Strand: Reverse

Name: hflK [H]

Synonym: Bphy_1413

Alternate gene names: 186476171

Gene position: 1593203-1591806 (Counterclockwise)

Preceding gene: 186476172

Following gene: 186476170

Centisome position: 45.79

GC content: 64.74

Gene sequence:

>1398_bases
GTGAACGATTACAACGAGCGGAGTATCTGGCTGCGTGTGCGCGCCATGTTGTCGCTGAACGACCCCCGCTGGGGCCGGGG
TGAAGGCAATGGCGACCGCCAGCGTCTGAACGATTCGAAGCGTCCGCCCAACGGCAAGGACAGCGAAGGTCCGCCCGATC
TCGACGAAATGTGGCGCGACTTCAATCGACGTCTGTCGCGCATGTTCGGCCGCAAGGGCGGGGGCGGCGGTCCGCGTCCG
GACAATGGGCGCGGCGCACGCATCGGCGTGGGCATCATCATCGGCGTGCTGGTCGCCATTTATCTTGGCAGCGGCGTGTT
CGTCGTGCAGGACGGCCAGGCGGCCGCGGTGCTGCGCTTCGGCGAGTTGCGCGGCACGGCCGGCCAGGGCGTGCATTGGC
GCATGCCTTATCCGTTCGAATCCCATGAAATCGTCAACGTCGGCCAGGTGCGCTCAGTGGAAATCGGCCGCAACAACGTC
GTGCGCCTCGCGAACGTGAAAGACGCGTCGATGCTCACGCACGACGCCGATATCGTCGACGTCCGTTTTGCTGTCCAGTA
CCAGATCCGCAAGCCGACCGATTACCTGTTCCGTAGCGCCGATGCCGATCTGAGCGTCACCCAGGCGGCACAGGCGGCTG
TGCGGCAGATCGTCGGTTCGCGCAGTACCAACGACATCCTGTATCGGGATCGCGAGGCGATTCGCATTCAATTGTCGGAA
GCGATCCAGCATTCGTTGGACGAATATCACACGGGTCTCGCCGTGACGGGCGTGACGATCCAGGGCGTGCAACCGCCCGA
CCAGGTGCAGGCCGCCTTCGACGACGCTACGAAGGCACGTCAGGACCGTGAGCGTACCAGGCGCGATGCCGAAGCCTATG
CAAGCGACCTGCTGCCGCGCGCGAAAGCGGAAGGCGAGCGAATGATCGCGGACGCGAAGACGTACAGCGAGCGCGTCGTT
GCGCAAGCGGAAGGCGACGCCGAGCGCTTCAAGGAGGTCTTTGCGCAGTATTCGAAGGCGCCTGCCGTGATCCGCGACCG
GATGTACCTCGAAACCATGCAGCAGATCTTTTCGAACACGACGAAGGTATTCGTCGATAGCAAGTCGGGCAGCAATGTGC
TGTACCTGCCGCTGGACAAGCTCGTCGAGCAGACACGCCAGCGCGCGGCCGAGGCCGCAGCGGCGAATCCGGCGTCGGCA
GCGCAGGCTGTGCCTTCCCCGCAGAACCAGCCAAACGCACCAAGCGCGCAGGGCGCAGCGCAAGGCGGCAATGCGCCGAC
CATCATCACGCAGCCTGCCGCACCCGTCAGCAGCGCAAGTCAGGCGGCAGCCGCGAGCGACGCCTTCCGTTCGCGCGATT
CGTTCCGCAGTCGCGGCCGCGAAGACGATCTGCAATAA

Upstream 100 bases:

>100_bases
TGCAGGCGAAGACTACCGCGACGACCGCAAGATCCCAGACACGGGCGCCGACCCGTTCCAATTGCACTGACCCGCTGTCT
ACTCTGGTGAACGAACACAG

Downstream 100 bases:

>100_bases
GGAGCGCCAAATGAATAAAATCGTTGCGCTCGTCGTGGCCATCGTCATCGTGCTGTTTGCGGCATCGTCGATGGTGTTCG
TTGTCGACCAGCGGCATATG

Product: HflK protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 465; Mature: 465

Protein sequence:

>465_residues
MNDYNERSIWLRVRAMLSLNDPRWGRGEGNGDRQRLNDSKRPPNGKDSEGPPDLDEMWRDFNRRLSRMFGRKGGGGGPRP
DNGRGARIGVGIIIGVLVAIYLGSGVFVVQDGQAAAVLRFGELRGTAGQGVHWRMPYPFESHEIVNVGQVRSVEIGRNNV
VRLANVKDASMLTHDADIVDVRFAVQYQIRKPTDYLFRSADADLSVTQAAQAAVRQIVGSRSTNDILYRDREAIRIQLSE
AIQHSLDEYHTGLAVTGVTIQGVQPPDQVQAAFDDATKARQDRERTRRDAEAYASDLLPRAKAEGERMIADAKTYSERVV
AQAEGDAERFKEVFAQYSKAPAVIRDRMYLETMQQIFSNTTKVFVDSKSGSNVLYLPLDKLVEQTRQRAAEAAAANPASA
AQAVPSPQNQPNAPSAQGAAQGGNAPTIITQPAAPVSSASQAAAASDAFRSRDSFRSRGREDDLQ

Sequences:

>Translated_465_residues
MNDYNERSIWLRVRAMLSLNDPRWGRGEGNGDRQRLNDSKRPPNGKDSEGPPDLDEMWRDFNRRLSRMFGRKGGGGGPRP
DNGRGARIGVGIIIGVLVAIYLGSGVFVVQDGQAAAVLRFGELRGTAGQGVHWRMPYPFESHEIVNVGQVRSVEIGRNNV
VRLANVKDASMLTHDADIVDVRFAVQYQIRKPTDYLFRSADADLSVTQAAQAAVRQIVGSRSTNDILYRDREAIRIQLSE
AIQHSLDEYHTGLAVTGVTIQGVQPPDQVQAAFDDATKARQDRERTRRDAEAYASDLLPRAKAEGERMIADAKTYSERVV
AQAEGDAERFKEVFAQYSKAPAVIRDRMYLETMQQIFSNTTKVFVDSKSGSNVLYLPLDKLVEQTRQRAAEAAAANPASA
AQAVPSPQNQPNAPSAQGAAQGGNAPTIITQPAAPVSSASQAAAASDAFRSRDSFRSRGREDDLQ
>Mature_465_residues
MNDYNERSIWLRVRAMLSLNDPRWGRGEGNGDRQRLNDSKRPPNGKDSEGPPDLDEMWRDFNRRLSRMFGRKGGGGGPRP
DNGRGARIGVGIIIGVLVAIYLGSGVFVVQDGQAAAVLRFGELRGTAGQGVHWRMPYPFESHEIVNVGQVRSVEIGRNNV
VRLANVKDASMLTHDADIVDVRFAVQYQIRKPTDYLFRSADADLSVTQAAQAAVRQIVGSRSTNDILYRDREAIRIQLSE
AIQHSLDEYHTGLAVTGVTIQGVQPPDQVQAAFDDATKARQDRERTRRDAEAYASDLLPRAKAEGERMIADAKTYSERVV
AQAEGDAERFKEVFAQYSKAPAVIRDRMYLETMQQIFSNTTKVFVDSKSGSNVLYLPLDKLVEQTRQRAAEAAAANPASA
AQAVPSPQNQPNAPSAQGAAQGGNAPTIITQPAAPVSSASQAAAASDAFRSRDSFRSRGREDDLQ

Specific function: HflC and HflK could encode or regulate a protease [H]

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflK subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790616, Length=366, Percent_Identity=31.1475409836066, Blast_Score=184, Evalue=1e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001107
- InterPro:   IPR010201
- InterPro:   IPR020980
- InterPro:   IPR001972 [H]

Pfam domain/function: PF01145 Band_7; PF12221 HflK_N [H]

EC number: NA

Molecular weight: Translated: 50951; Mature: 50951

Theoretical pI: Translated: 9.32; Mature: 9.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDYNERSIWLRVRAMLSLNDPRWGRGEGNGDRQRLNDSKRPPNGKDSEGPPDLDEMWRD
CCCCCCHHHEEEEEEHHHCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCHHHHHHH
FNRRLSRMFGRKGGGGGPRPDNGRGARIGVGIIIGVLVAIYLGSGVFVVQDGQAAAVLRF
HHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCEEEEEEE
GELRGTAGQGVHWRMPYPFESHEIVNVGQVRSVEIGRNNVVRLANVKDASMLTHDADIVD
HHHCCCCCCCEEEECCCCCCCCCEEECCCEEEEEECCCCEEEEECCCHHHHHHCCCCEEE
VRFAVQYQIRKPTDYLFRSADADLSVTQAAQAAVRQIVGSRSTNDILYRDREAIRIQLSE
EEEEEEEEECCCHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHCCCHHHHHHHHH
AIQHSLDEYHTGLAVTGVTIQGVQPPDQVQAAFDDATKARQDRERTRRDAEAYASDLLPR
HHHHHHHHHHCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHH
AKAEGERMIADAKTYSERVVAQAEGDAERFKEVFAQYSKAPAVIRDRMYLETMQQIFSNT
HHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCC
TKVFVDSKSGSNVLYLPLDKLVEQTRQRAAEAAAANPASAAQAVPSPQNQPNAPSAQGAA
EEEEEECCCCCEEEEECHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCCCCCC
QGGNAPTIITQPAAPVSSASQAAAASDAFRSRDSFRSRGREDDLQ
CCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MNDYNERSIWLRVRAMLSLNDPRWGRGEGNGDRQRLNDSKRPPNGKDSEGPPDLDEMWRD
CCCCCCHHHEEEEEEHHHCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCHHHHHHH
FNRRLSRMFGRKGGGGGPRPDNGRGARIGVGIIIGVLVAIYLGSGVFVVQDGQAAAVLRF
HHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCEEEEEEE
GELRGTAGQGVHWRMPYPFESHEIVNVGQVRSVEIGRNNVVRLANVKDASMLTHDADIVD
HHHCCCCCCCEEEECCCCCCCCCEEECCCEEEEEECCCCEEEEECCCHHHHHHCCCCEEE
VRFAVQYQIRKPTDYLFRSADADLSVTQAAQAAVRQIVGSRSTNDILYRDREAIRIQLSE
EEEEEEEEECCCHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHCCCHHHHHHHHH
AIQHSLDEYHTGLAVTGVTIQGVQPPDQVQAAFDDATKARQDRERTRRDAEAYASDLLPR
HHHHHHHHHHCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHH
AKAEGERMIADAKTYSERVVAQAEGDAERFKEVFAQYSKAPAVIRDRMYLETMQQIFSNT
HHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCC
TKVFVDSKSGSNVLYLPLDKLVEQTRQRAAEAAAANPASAAQAVPSPQNQPNAPSAQGAA
EEEEEECCCCCEEEEECHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCCCCCC
QGGNAPTIITQPAAPVSSASQAAAASDAFRSRDSFRSRGREDDLQ
CCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]