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The map label for this gene is lpxB

Identifier: 186476083

GI number: 186476083

Start: 1483799

End: 1484968

Strand: Reverse

Name: lpxB

Synonym: Bphy_1325

Alternate gene names: 186476083

Gene position: 1484968-1483799 (Counterclockwise)

Preceding gene: 186476084

Following gene: 186476082

Centisome position: 42.68

GC content: 64.44

Gene sequence:

>1170_bases
ATGCCGTTGCCTACCAGTCCGCTACGGCTTGCAATGGTGGCCGGCGAGCCGTCGGGCGATCTGCTGGCGGCTTCAATGCT
GGACGGGCTCGCGGCCCGTCTGCCCGACACGACGCAGTATTTCGGCATCGGCGGTCCGCGCATGATCGCGAAGGGCTTCG
ACGCGCATTTTGCGATGGAAAAGCTGTCGGTGCGCGGCTATGTCGAAGCACTGAAGCACGTTCCTGAGATCCTCGGCATC
CGCAACGAACTGAAACGCCAGTTGCTGGCCGAGCCGCCGTCGGCGTTCATCGGCGTCGATGCGCCCGACTTCAATTTCGG
TCTTGAGCATCCGCTGCGCGACGCCGGCATTCCGACCATTCATTTTGTCTGTCCGTCCATCTGGGCATGGCGCGGCGGTC
GCATCAAGAAGATCGTCAAAGCGGTCGATCATATGCTGTGCGTGTTCCCGTTCGAAAAGGCGCTGCTCGAGAAGTCGGGG
GTGACGGCGACCTATGTCGGGCATCCGCTCGCGGACGAGATTCCGCTCGAACCGGATACGGCGGGTGCGCGCCTCGAACT
CGGCTTGCCCGAAAGCGGTCCCGTCATCGCCGTGCTGCCGGGCAGCCGGCGCTCGGAGATCGCGCTGATCGGCCCGACGT
TCTTCGACGCGATGGAACTGATGTTGCAGCGCGAGCCGGGTGTGCGTTTCGTGATGCCGGCCGCGACCCCGGCGCTGCGC
GAACTGCTGAAGCCGCTCGTCGACGCACACGCGAATCTGCCGCTCACGCTGACGGACGGCAACGCGCAGCGGGCGATGAC
GGCCGCCGACGCCATTCTCGTGAAAAGCGGCACGGTCACGCTGGAAGCGGCGCTGCTGAAAAAGCCGATGGTGATCTCTT
ACAAGGTGCCGTGGCTGACGGGTCAGATCATGCGCCGACAGGGCTATCTGCCGTACGTCGGTCTGCCGAACATTCTGGCC
GGGCGTTTTGTCGTACCGGAAATCCTCCAGCATTTCGCGACACCGGAAGCGCTGGCCGACGCCACGCTGACCCAGTTGCG
CGATGACGCGAACCGGCGCACGCTGACGGAAATCTTCACTGAGATGCATCACGTGCTCAAGCAGAACACAGCGCAGCGCG
CGGCCGAAGCCGTCGTCGGCGTGATCGAAGCGCGTCGGGGGCGTCCATGA

Upstream 100 bases:

>100_bases
ATTGCGTGAACTCGCGGCGGCGGGCGGCGACGGCGACGAGCCAGTGCGCGCGCTCGTCGATTTCGTCGAGCAGTCGCAGC
GCGGCATCATCCGCTAACCG

Downstream 100 bases:

>100_bases
ACCGCGCGGCGGGCACGGCCGCGCCGCGCCGCAAGACAGCTGCGAAGGCGTCCGCGCAGGTCGGCCTCGATTTCTCGTCG
CCGGACGACGTGGTTTGCGG

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 389; Mature: 388

Protein sequence:

>389_residues
MPLPTSPLRLAMVAGEPSGDLLAASMLDGLAARLPDTTQYFGIGGPRMIAKGFDAHFAMEKLSVRGYVEALKHVPEILGI
RNELKRQLLAEPPSAFIGVDAPDFNFGLEHPLRDAGIPTIHFVCPSIWAWRGGRIKKIVKAVDHMLCVFPFEKALLEKSG
VTATYVGHPLADEIPLEPDTAGARLELGLPESGPVIAVLPGSRRSEIALIGPTFFDAMELMLQREPGVRFVMPAATPALR
ELLKPLVDAHANLPLTLTDGNAQRAMTAADAILVKSGTVTLEAALLKKPMVISYKVPWLTGQIMRRQGYLPYVGLPNILA
GRFVVPEILQHFATPEALADATLTQLRDDANRRTLTEIFTEMHHVLKQNTAQRAAEAVVGVIEARRGRP

Sequences:

>Translated_389_residues
MPLPTSPLRLAMVAGEPSGDLLAASMLDGLAARLPDTTQYFGIGGPRMIAKGFDAHFAMEKLSVRGYVEALKHVPEILGI
RNELKRQLLAEPPSAFIGVDAPDFNFGLEHPLRDAGIPTIHFVCPSIWAWRGGRIKKIVKAVDHMLCVFPFEKALLEKSG
VTATYVGHPLADEIPLEPDTAGARLELGLPESGPVIAVLPGSRRSEIALIGPTFFDAMELMLQREPGVRFVMPAATPALR
ELLKPLVDAHANLPLTLTDGNAQRAMTAADAILVKSGTVTLEAALLKKPMVISYKVPWLTGQIMRRQGYLPYVGLPNILA
GRFVVPEILQHFATPEALADATLTQLRDDANRRTLTEIFTEMHHVLKQNTAQRAAEAVVGVIEARRGRP
>Mature_388_residues
PLPTSPLRLAMVAGEPSGDLLAASMLDGLAARLPDTTQYFGIGGPRMIAKGFDAHFAMEKLSVRGYVEALKHVPEILGIR
NELKRQLLAEPPSAFIGVDAPDFNFGLEHPLRDAGIPTIHFVCPSIWAWRGGRIKKIVKAVDHMLCVFPFEKALLEKSGV
TATYVGHPLADEIPLEPDTAGARLELGLPESGPVIAVLPGSRRSEIALIGPTFFDAMELMLQREPGVRFVMPAATPALRE
LLKPLVDAHANLPLTLTDGNAQRAMTAADAILVKSGTVTLEAALLKKPMVISYKVPWLTGQIMRRQGYLPYVGLPNILAG
RFVVPEILQHFATPEALADATLTQLRDDANRRTLTEIFTEMHHVLKQNTAQRAAEAVVGVIEARRGRP

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family

Homologues:

Organism=Escherichia coli, GI1786379, Length=374, Percent_Identity=39.8395721925134, Blast_Score=275, Evalue=4e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXB_BURP8 (B2JIB3)

Other databases:

- EMBL:   CP001043
- RefSeq:   YP_001857553.1
- GeneID:   6242816
- GenomeReviews:   CP001043_GR
- KEGG:   bph:Bphy_1325
- HOGENOM:   HBG584837
- OMA:   DFTHRVA
- ProtClustDB:   PRK00025
- HAMAP:   MF_00392
- InterPro:   IPR003835
- TIGRFAMs:   TIGR00215

Pfam domain/function: PF02684 LpxB

EC number: =2.4.1.182

Molecular weight: Translated: 42290; Mature: 42159

Theoretical pI: Translated: 7.79; Mature: 7.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLPTSPLRLAMVAGEPSGDLLAASMLDGLAARLPDTTQYFGIGGPRMIAKGFDAHFAME
CCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCEECCCCHHHHHHCCHHHHHHH
KLSVRGYVEALKHVPEILGIRNELKRQLLAEPPSAFIGVDAPDFNFGLEHPLRDAGIPTI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCHHHCCCCEE
HFVCPSIWAWRGGRIKKIVKAVDHMLCVFPFEKALLEKSGVTATYVGHPLADEIPLEPDT
EEECCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCC
AGARLELGLPESGPVIAVLPGSRRSEIALIGPTFFDAMELMLQREPGVRFVMPAATPALR
CCCEEEECCCCCCCEEEEECCCCCCCEEEECHHHHHHHHHHHHCCCCCEEEECCCCHHHH
ELLKPLVDAHANLPLTLTDGNAQRAMTAADAILVKSGTVTLEAALLKKPMVISYKVPWLT
HHHHHHHHCCCCCCEEEECCCHHHHHHHHHEEEEECCCEEEEHHHHCCCEEEEEECCHHH
GQIMRRQGYLPYVGLPNILAGRFVVPEILQHFATPEALADATLTQLRDDANRRTLTEIFT
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHH
EMHHVLKQNTAQRAAEAVVGVIEARRGRP
HHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
PLPTSPLRLAMVAGEPSGDLLAASMLDGLAARLPDTTQYFGIGGPRMIAKGFDAHFAME
CCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCEECCCCHHHHHHCCHHHHHHH
KLSVRGYVEALKHVPEILGIRNELKRQLLAEPPSAFIGVDAPDFNFGLEHPLRDAGIPTI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCHHHCCCCEE
HFVCPSIWAWRGGRIKKIVKAVDHMLCVFPFEKALLEKSGVTATYVGHPLADEIPLEPDT
EEECCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCC
AGARLELGLPESGPVIAVLPGSRRSEIALIGPTFFDAMELMLQREPGVRFVMPAATPALR
CCCEEEECCCCCCCEEEEECCCCCCCEEEECHHHHHHHHHHHHCCCCCEEEECCCCHHHH
ELLKPLVDAHANLPLTLTDGNAQRAMTAADAILVKSGTVTLEAALLKKPMVISYKVPWLT
HHHHHHHHCCCCCCEEEECCCHHHHHHHHHEEEEECCCEEEEHHHHCCCEEEEEECCHHH
GQIMRRQGYLPYVGLPNILAGRFVVPEILQHFATPEALADATLTQLRDDANRRTLTEIFT
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHH
EMHHVLKQNTAQRAAEAVVGVIEARRGRP
HHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA