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The map label for this gene is lpxA

Identifier: 186476084

GI number: 186476084

Start: 1484972

End: 1485760

Strand: Reverse

Name: lpxA

Synonym: Bphy_1326

Alternate gene names: 186476084

Gene position: 1485760-1484972 (Counterclockwise)

Preceding gene: 186476085

Following gene: 186476083

Centisome position: 42.7

GC content: 63.62

Gene sequence:

>789_bases
ATGAGCAGGATTCATCCCACTGCGATCATCGAGTCGGGCGCTCAGCTCGACGAATCCGTCGAAATCGGACCGTACGCCAT
CGTCGGCGCGAACGTCACCATCGGGGCGCGTACGACCATCGGTTCGCATAGCGTGATCGAGGGCCACACGACGATCGGCG
AAGACAACCGCATCGGCCATTACGCGTCGGTCGGCGGCCGTCCGCAGGACATGAAGTACCGCGACGAGCCGACGAAGCTC
GTCATCGGCAGTCGCAACACGATCCGCGAATTCACGACAATCCACACGGGCACCGTGCAGGACAAGGGCATCACCACGCT
CGGCGACGACAACTGGATCATGGCCTACGTGCATATCGGGCACGACTGCCAGATCGGTAGCAACGTGATCCTGTCGAGCA
ATGCGCAGATGGCGGGCCATGTGATCGTCGGCGATCACGCAATCGTAGGCGGAATGTCGGGCGTGCACCAGTTCGTGCGC
ATCGGCGCGCATTCGATGCTGGGCGGCGCATCGGCGCTCGTGCAAGACATTCCGCCGTTCGTGATCGCGGCGGGCAACAA
GGCCGAGCCTCACGGTATCAATGTCGAAGGGTTGCGCCGCCGCGGCTTTTCGGCGGACGCGATTTCGGCGCTGCGTTCGG
CCTACCGTCTGCTGTACAAGAACGGTCTGTCGCTCGAAGACGCGAAGGTGCAATTGCGTGAACTCGCGGCGGCGGGCGGC
GACGGCGACGAGCCAGTGCGCGCGCTCGTCGATTTCGTCGAGCAGTCGCAGCGCGGCATCATCCGCTAA

Upstream 100 bases:

>100_bases
CGGAGCGGTCGCCATCACGCTTTCACAGGTGACCGCGTCGGCGCGCCGGGTGATGCGACAGCGTTTATCCGCGCGAGCAA
CGCAATTCAAGCGAGGGCGC

Downstream 100 bases:

>100_bases
CCGATGCCGTTGCCTACCAGTCCGCTACGGCTTGCAATGGTGGCCGGCGAGCCGTCGGGCGATCTGCTGGCGGCTTCAAT
GCTGGACGGGCTCGCGGCCC

Product: UDP-N-acetylglucosamine acyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine acyltransferase

Number of amino acids: Translated: 262; Mature: 261

Protein sequence:

>262_residues
MSRIHPTAIIESGAQLDESVEIGPYAIVGANVTIGARTTIGSHSVIEGHTTIGEDNRIGHYASVGGRPQDMKYRDEPTKL
VIGSRNTIREFTTIHTGTVQDKGITTLGDDNWIMAYVHIGHDCQIGSNVILSSNAQMAGHVIVGDHAIVGGMSGVHQFVR
IGAHSMLGGASALVQDIPPFVIAAGNKAEPHGINVEGLRRRGFSADAISALRSAYRLLYKNGLSLEDAKVQLRELAAAGG
DGDEPVRALVDFVEQSQRGIIR

Sequences:

>Translated_262_residues
MSRIHPTAIIESGAQLDESVEIGPYAIVGANVTIGARTTIGSHSVIEGHTTIGEDNRIGHYASVGGRPQDMKYRDEPTKL
VIGSRNTIREFTTIHTGTVQDKGITTLGDDNWIMAYVHIGHDCQIGSNVILSSNAQMAGHVIVGDHAIVGGMSGVHQFVR
IGAHSMLGGASALVQDIPPFVIAAGNKAEPHGINVEGLRRRGFSADAISALRSAYRLLYKNGLSLEDAKVQLRELAAAGG
DGDEPVRALVDFVEQSQRGIIR
>Mature_261_residues
SRIHPTAIIESGAQLDESVEIGPYAIVGANVTIGARTTIGSHSVIEGHTTIGEDNRIGHYASVGGRPQDMKYRDEPTKLV
IGSRNTIREFTTIHTGTVQDKGITTLGDDNWIMAYVHIGHDCQIGSNVILSSNAQMAGHVIVGDHAIVGGMSGVHQFVRI
GAHSMLGGASALVQDIPPFVIAAGNKAEPHGINVEGLRRRGFSADAISALRSAYRLLYKNGLSLEDAKVQLRELAAAGGD
GDEPVRALVDFVEQSQRGIIR

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG1043

COG function: function code M; Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxA subfamily

Homologues:

Organism=Escherichia coli, GI1786378, Length=259, Percent_Identity=52.5096525096525, Blast_Score=283, Evalue=9e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXA_BURP8 (B2JIB4)

Other databases:

- EMBL:   CP001043
- RefSeq:   YP_001857554.1
- ProteinModelPortal:   B2JIB4
- SMR:   B2JIB4
- GeneID:   6242817
- GenomeReviews:   CP001043_GR
- KEGG:   bph:Bphy_1326
- HOGENOM:   HBG659295
- OMA:   DLKYQGE
- ProtClustDB:   PRK05289
- GO:   GO:0005737
- HAMAP:   MF_00387
- InterPro:   IPR001451
- InterPro:   IPR010137
- InterPro:   IPR011004
- PIRSF:   PIRSF000456
- TIGRFAMs:   TIGR01852

Pfam domain/function: PF00132 Hexapep; SSF51161 Trimer_LpxA_like

EC number: =2.3.1.129

Molecular weight: Translated: 27847; Mature: 27716

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRIHPTAIIESGAQLDESVEIGPYAIVGANVTIGARTTIGSHSVIEGHTTIGEDNRIGH
CCCCCCHHHHHCCCCCCCCCCCCCEEEEECCEEEECEEECCCCCEEECCCCCCCCCCCCC
YASVGGRPQDMKYRDEPTKLVIGSRNTIREFTTIHTGTVQDKGITTLGDDNWIMAYVHIG
CCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHEEECCCCCCCCCEEECCCCEEEEEEEEC
HDCQIGSNVILSSNAQMAGHVIVGDHAIVGGMSGVHQFVRIGAHSMLGGASALVQDIPPF
CCCCCCCEEEEECCCCEEEEEEECCCCEECCHHHHHHHHHHHHHHHHCHHHHHHHHCCCE
VIAAGNKAEPHGINVEGLRRRGFSADAISALRSAYRLLYKNGLSLEDAKVQLRELAAAGG
EEECCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCC
DGDEPVRALVDFVEQSQRGIIR
CCCHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SRIHPTAIIESGAQLDESVEIGPYAIVGANVTIGARTTIGSHSVIEGHTTIGEDNRIGH
CCCCCHHHHHCCCCCCCCCCCCCEEEEECCEEEECEEECCCCCEEECCCCCCCCCCCCC
YASVGGRPQDMKYRDEPTKLVIGSRNTIREFTTIHTGTVQDKGITTLGDDNWIMAYVHIG
CCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHEEECCCCCCCCCEEECCCCEEEEEEEEC
HDCQIGSNVILSSNAQMAGHVIVGDHAIVGGMSGVHQFVRIGAHSMLGGASALVQDIPPF
CCCCCCCEEEEECCCCEEEEEEECCCCEECCHHHHHHHHHHHHHHHHCHHHHHHHHCCCE
VIAAGNKAEPHGINVEGLRRRGFSADAISALRSAYRLLYKNGLSLEDAKVQLRELAAAGG
EEECCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCC
DGDEPVRALVDFVEQSQRGIIR
CCCHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA