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The map label for this gene is mntH [H]

Identifier: 186476039

GI number: 186476039

Start: 1436736

End: 1438082

Strand: Direct

Name: mntH [H]

Synonym: Bphy_1280

Alternate gene names: 186476039

Gene position: 1436736-1438082 (Clockwise)

Preceding gene: 186476034

Following gene: 186476040

Centisome position: 41.3

GC content: 66.96

Gene sequence:

>1347_bases
ATGGCGCTTGCCCACGCGGATAGAGTCTTCCGCCGTCGGAAAGCGATGAACACGAACCCGTTCACATTGACTGCCGTCCG
CCGCAAGCGCCGCCGCGGTGCGGGGTCGCCGCGTTCCCGGAACCCGCTGTCGTTCGTCGGCGCGGGCGCGCTCGTCGCGG
TCGGCTATATGGATCCTGGCAACTGGGCGACGGCGCTCGCCGGCGGCGCAAGCTACGGCTACGCGCTGCTGAGCGTCGTG
ATCGCATCGAGCCTGATGGCGATGCTGCTGCAGTGGGTGTCATCGCGTCTGGGCGTCGTGACGGGCCTCGACCTCGCGCA
GCACTGCCGCGAACATACAGGCCGTCGCACGACGGTGATGCTCTGGGTGACCAGCGAGATCGCGATCGTCGCCTGCGATG
TCGCCGAGGTGGTCGGCAGCGCCGTGGCGCTGCAACTGCTGGTCGGCGTGTCGCTAACGGCGGGCGTGCTGATCTCGGCC
GTCGGCACTTTCGCGATGCTCGCATTGCAACAGCACGGCCGTCGGACGCTGGAAACGGCCGTCGTCGCTTTCATCCTGTT
CGTCGGCTTGTGCTTCGTGATCGAACTGGCGCTGGCGCGGCCGGACTGGCGCGCGGCCCTGACGGGCGCGGCCCCGAGCG
CTCAACTGCTGCGCAATGCAGGGATGGTTTGGCTCGCGGCAGGCATTCTGGGCGCGACCGTCATGCCGCACAACCTCTAC
CTGCATTCCGCGCTCGTTAAAATTCACGCATGCCCGGCCAGCGATGCCGGCATCGACGATGCGCTGCGCGGCGTCAACTT
CGGCACCTTCAGCGCGCTTTCATTGGCATTCGTCATTAATGCGGCCTTGTTGATCGTGTCGGCGGCCGTGTTTCATACGA
GCGGCTACCGCAACGTGACAGACCTCGCGGACGCGCACCGCCTGATCGCACCCATCGTCGGCTCGCACTGGGCAGCCATT
CTGTTCGCGGCAGCGTTGCTCGCATGCGGACTGAGCGCAACCGTCACGGGCACACTGGCAGGTCAAGCCGTAATGGAAGG
CTTCCTGGAGATCCGGCTGCCGCGCTGGCAGCGCGCGTTGCTCACGCGCTCCCTCGCGATCGGACCGGCGCTCGTGGCAG
TCGGTCTGTTCGGACCGAACGGCTCGGCGCAACTGCTGGTCGCAAGCCAGGTTGTACTGAGCCTCCAGTTGCCGCTCGCG
GTCGTCCCGTTGATCCGCTTTTCGTCGGATGCGCGGCTGATGCGTGGCTGGCGCGTGCGCGGCGTGCCGCTCGCGCTGGC
GTGGGCATGTGCGGCCGGCATCATCGCGCTAAATGGCGCACTCATCTGGGAAACGGCGATGGGTTGA

Upstream 100 bases:

>100_bases
AGCGGACTGCATCCTGCCGGAAACGGGTCGCCCAACGTCACTATAGACTGTCAAATATGTCCGGTCAGCGAACGCCGCGC
GATGTACCCGAGTGCATGGC

Downstream 100 bases:

>100_bases
CAGCATTGCGCGATGAACTGCAACGTATTCGTCCGCAACAAACAGAGCACCGGAAGCCCATTTCGCTTTTCGTTTACCAT
AGCGGACCGCACGCATTTAC

Product: Mn2+/Fe2+ transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 448; Mature: 447

Protein sequence:

>448_residues
MALAHADRVFRRRKAMNTNPFTLTAVRRKRRRGAGSPRSRNPLSFVGAGALVAVGYMDPGNWATALAGGASYGYALLSVV
IASSLMAMLLQWVSSRLGVVTGLDLAQHCREHTGRRTTVMLWVTSEIAIVACDVAEVVGSAVALQLLVGVSLTAGVLISA
VGTFAMLALQQHGRRTLETAVVAFILFVGLCFVIELALARPDWRAALTGAAPSAQLLRNAGMVWLAAGILGATVMPHNLY
LHSALVKIHACPASDAGIDDALRGVNFGTFSALSLAFVINAALLIVSAAVFHTSGYRNVTDLADAHRLIAPIVGSHWAAI
LFAAALLACGLSATVTGTLAGQAVMEGFLEIRLPRWQRALLTRSLAIGPALVAVGLFGPNGSAQLLVASQVVLSLQLPLA
VVPLIRFSSDARLMRGWRVRGVPLALAWACAAGIIALNGALIWETAMG

Sequences:

>Translated_448_residues
MALAHADRVFRRRKAMNTNPFTLTAVRRKRRRGAGSPRSRNPLSFVGAGALVAVGYMDPGNWATALAGGASYGYALLSVV
IASSLMAMLLQWVSSRLGVVTGLDLAQHCREHTGRRTTVMLWVTSEIAIVACDVAEVVGSAVALQLLVGVSLTAGVLISA
VGTFAMLALQQHGRRTLETAVVAFILFVGLCFVIELALARPDWRAALTGAAPSAQLLRNAGMVWLAAGILGATVMPHNLY
LHSALVKIHACPASDAGIDDALRGVNFGTFSALSLAFVINAALLIVSAAVFHTSGYRNVTDLADAHRLIAPIVGSHWAAI
LFAAALLACGLSATVTGTLAGQAVMEGFLEIRLPRWQRALLTRSLAIGPALVAVGLFGPNGSAQLLVASQVVLSLQLPLA
VVPLIRFSSDARLMRGWRVRGVPLALAWACAAGIIALNGALIWETAMG
>Mature_447_residues
ALAHADRVFRRRKAMNTNPFTLTAVRRKRRRGAGSPRSRNPLSFVGAGALVAVGYMDPGNWATALAGGASYGYALLSVVI
ASSLMAMLLQWVSSRLGVVTGLDLAQHCREHTGRRTTVMLWVTSEIAIVACDVAEVVGSAVALQLLVGVSLTAGVLISAV
GTFAMLALQQHGRRTLETAVVAFILFVGLCFVIELALARPDWRAALTGAAPSAQLLRNAGMVWLAAGILGATVMPHNLYL
HSALVKIHACPASDAGIDDALRGVNFGTFSALSLAFVINAALLIVSAAVFHTSGYRNVTDLADAHRLIAPIVGSHWAAIL
FAAALLACGLSATVTGTLAGQAVMEGFLEIRLPRWQRALLTRSLAIGPALVAVGLFGPNGSAQLLVASQVVLSLQLPLAV
VPLIRFSSDARLMRGWRVRGVPLALAWACAAGIIALNGALIWETAMG

Specific function: H(+)-stimulated, highly selective, manganese uptake system [H]

COG id: COG1914

COG function: function code P; Mn2+ and Fe2+ transporters of the NRAMP family

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NRAMP family [H]

Homologues:

Organism=Homo sapiens, GI109255241, Length=410, Percent_Identity=35.8536585365854, Blast_Score=190, Evalue=3e-48,
Organism=Homo sapiens, GI295293167, Length=414, Percent_Identity=35.7487922705314, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI295293178, Length=418, Percent_Identity=35.6459330143541, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI295293175, Length=418, Percent_Identity=35.6459330143541, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI295293173, Length=418, Percent_Identity=35.6459330143541, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI10835169, Length=418, Percent_Identity=35.6459330143541, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI295293171, Length=414, Percent_Identity=35.7487922705314, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI295293169, Length=414, Percent_Identity=35.7487922705314, Blast_Score=186, Evalue=3e-47,
Organism=Escherichia coli, GI1788736, Length=430, Percent_Identity=37.906976744186, Blast_Score=258, Evalue=5e-70,
Organism=Caenorhabditis elegans, GI17569473, Length=374, Percent_Identity=36.3636363636364, Blast_Score=205, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI193210616, Length=429, Percent_Identity=32.8671328671329, Blast_Score=199, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI71999499, Length=437, Percent_Identity=31.5789473684211, Blast_Score=184, Evalue=6e-47,
Organism=Caenorhabditis elegans, GI71993856, Length=206, Percent_Identity=38.3495145631068, Blast_Score=135, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6323062, Length=399, Percent_Identity=37.844611528822, Blast_Score=234, Evalue=3e-62,
Organism=Saccharomyces cerevisiae, GI6324450, Length=449, Percent_Identity=33.8530066815145, Blast_Score=221, Evalue=3e-58,
Organism=Saccharomyces cerevisiae, GI6321841, Length=453, Percent_Identity=34.6578366445916, Blast_Score=214, Evalue=3e-56,
Organism=Drosophila melanogaster, GI45553443, Length=408, Percent_Identity=33.0882352941176, Blast_Score=196, Evalue=2e-50,
Organism=Drosophila melanogaster, GI24648607, Length=408, Percent_Identity=33.0882352941176, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI281362176, Length=408, Percent_Identity=33.0882352941176, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI24648609, Length=408, Percent_Identity=33.0882352941176, Blast_Score=196, Evalue=3e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023056
- InterPro:   IPR001046 [H]

Pfam domain/function: PF01566 Nramp [H]

EC number: NA

Molecular weight: Translated: 46941; Mature: 46810

Theoretical pI: Translated: 11.32; Mature: 11.32

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALAHADRVFRRRKAMNTNPFTLTAVRRKRRRGAGSPRSRNPLSFVGAGALVAVGYMDPG
CCCCHHHHHHHHHHHCCCCCEEHHHHHHHHHCCCCCCCCCCCCHHCCCCCEEEEEECCCC
NWATALAGGASYGYALLSVVIASSLMAMLLQWVSSRLGVVTGLDLAQHCREHTGRRTTVM
CHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCEEEE
LWVTSEIAIVACDVAEVVGSAVALQLLVGVSLTAGVLISAVGTFAMLALQQHGRRTLETA
EEEECCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHH
VVAFILFVGLCFVIELALARPDWRAALTGAAPSAQLLRNAGMVWLAAGILGATVMPHNLY
HHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCHHHHHHHCCHHHHHHHHHHHHCCCCHHH
LHSALVKIHACPASDAGIDDALRGVNFGTFSALSLAFVINAALLIVSAAVFHTSGYRNVT
HHHHHHHEEECCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
DLADAHRLIAPIVGSHWAAILFAAALLACGLSATVTGTLAGQAVMEGFLEIRLPRWQRAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHH
LTRSLAIGPALVAVGLFGPNGSAQLLVASQVVLSLQLPLAVVPLIRFSSDARLMRGWRVR
HHHHHHHCHHHHEEEEECCCCCCEEEHHHHHHHHHHCHHHHHHHHHCCCCHHHHHCCCCC
GVPLALAWACAAGIIALNGALIWETAMG
CCHHHHHHHHHHHHHHHCCEEEEEECCC
>Mature Secondary Structure 
ALAHADRVFRRRKAMNTNPFTLTAVRRKRRRGAGSPRSRNPLSFVGAGALVAVGYMDPG
CCCHHHHHHHHHHHCCCCCEEHHHHHHHHHCCCCCCCCCCCCHHCCCCCEEEEEECCCC
NWATALAGGASYGYALLSVVIASSLMAMLLQWVSSRLGVVTGLDLAQHCREHTGRRTTVM
CHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCEEEE
LWVTSEIAIVACDVAEVVGSAVALQLLVGVSLTAGVLISAVGTFAMLALQQHGRRTLETA
EEEECCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHH
VVAFILFVGLCFVIELALARPDWRAALTGAAPSAQLLRNAGMVWLAAGILGATVMPHNLY
HHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCHHHHHHHCCHHHHHHHHHHHHCCCCHHH
LHSALVKIHACPASDAGIDDALRGVNFGTFSALSLAFVINAALLIVSAAVFHTSGYRNVT
HHHHHHHEEECCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
DLADAHRLIAPIVGSHWAAILFAAALLACGLSATVTGTLAGQAVMEGFLEIRLPRWQRAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHH
LTRSLAIGPALVAVGLFGPNGSAQLLVASQVVLSLQLPLAVVPLIRFSSDARLMRGWRVR
HHHHHHHCHHHHEEEEECCCCCCEEEHHHHHHHHHHCHHHHHHHHHCCCCHHHHHCCCCC
GVPLALAWACAAGIIALNGALIWETAMG
CCHHHHHHHHHHHHHHHCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]