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The map label for this gene is cbbA [H]

Identifier: 186475229

GI number: 186475229

Start: 523822

End: 524886

Strand: Direct

Name: cbbA [H]

Synonym: Bphy_0461

Alternate gene names: 186475229

Gene position: 523822-524886 (Clockwise)

Preceding gene: 186475228

Following gene: 186475230

Centisome position: 15.06

GC content: 61.41

Gene sequence:

>1065_bases
ATGCCTCTCGTATCAATGCGTCAACTGCTGGACCATGCCGCCGAAAACGGTTATGGCCTTCCGGCATTCAACGTGAACAA
CCTGGAGCAGGTGCAGGCCATCATGGCGGCGGCGGATCAGGTCAATGCGCCCGTGATCATGCAGGCTTCGGCAGGCGCGC
GTAAGTATGCGGGCGAGCCGTTCCTGCGCCATCTGATCGAAGCGGCTATCGAGTCCTATCCGCACATTCCCGTCGTGATG
CACCAGGACCACGGCCAGTCGCCGGCAGTCTGCATGGCCGCGATCCGCAGCGGCTTCACGAGCGTAATGATGGACGGCTC
GCTGGAAGCCGACGGCAAGACGGTGGCGTCGTACGAGTACAACGTCGATGTGTCGCGCAAGGTCGTCGAGGCGGCGCATT
CGATCGGCGTGACGGTTGAAGCGGAACTGGGTGTGCTCGGTTCGCTGGAAACGATGAAGGGCGACAAGGAAGACGGCCAC
GGCGCGGAAGGCACGATGACGCGCGAGCAGCTGCTGACCGACGTCGAACAGGCAGCGGACTTCGTGAAGCTCACGCAGTG
CGACGCACTCGCCATTGCAATCGGCACGTCGCATGGCGCGTACAAATTCTCGAAGAAGCCGACGGGCGATATCCTGTCGA
TCCAGCGTATCCGCGAGATTCACGAGCGTATTCCGAACACGCACCTGGTGATGCACGGCTCGTCATCGGTGCCGCAGGAA
CTGCTCGCTGAAATCCGCGAATTCGGCGGCGACATGAAGGAAACCTACGGCGTGCCCGTCGAGGAAATCCAGATCGGCAT
CAAGCATGGCGTGCGCAAGATCAACATCGACACCGATCTGCGTCTTGCCATCACGGGCGCGATTCGCCGCTACCTGGCGG
AAAATCCGTCGAAGTTCGATCCGCGCGACTACCTGAAGCCGGCTCGCGAAGCCGCGAAGAAGGTCTGCGTGGATCGTTAT
CTGGCGTTCGGTTGCGAAGGCCAGGCGTCGAAGATCAAGCCGGTCTCGCTGGACAAGATCGCTGAGAAGTACAAGGCGGG
CGAGCTCGCGCAGGTCGTTCGCTAA

Upstream 100 bases:

>100_bases
GCATGCGCGCGGGACACGGTCTGCTTCACGATAAAATTGCACGAAATTGCACAAAAAGATGCCGTCGGCACAGATTTCGT
TTCAATCTATGGAGTAATCA

Downstream 100 bases:

>100_bases
GCAGTTGTTGCGCACGCACCTGGCCATCCGGCCAGGTTGTCGTCAGATCGCCGTTCCCGCATGATCCGGGGAACGGCGTT
TCCCTTTTGTTCCGGGCGGT

Product: fructose-1,6-bisphosphate aldolase

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase [H]

Number of amino acids: Translated: 354; Mature: 353

Protein sequence:

>354_residues
MPLVSMRQLLDHAAENGYGLPAFNVNNLEQVQAIMAAADQVNAPVIMQASAGARKYAGEPFLRHLIEAAIESYPHIPVVM
HQDHGQSPAVCMAAIRSGFTSVMMDGSLEADGKTVASYEYNVDVSRKVVEAAHSIGVTVEAELGVLGSLETMKGDKEDGH
GAEGTMTREQLLTDVEQAADFVKLTQCDALAIAIGTSHGAYKFSKKPTGDILSIQRIREIHERIPNTHLVMHGSSSVPQE
LLAEIREFGGDMKETYGVPVEEIQIGIKHGVRKINIDTDLRLAITGAIRRYLAENPSKFDPRDYLKPAREAAKKVCVDRY
LAFGCEGQASKIKPVSLDKIAEKYKAGELAQVVR

Sequences:

>Translated_354_residues
MPLVSMRQLLDHAAENGYGLPAFNVNNLEQVQAIMAAADQVNAPVIMQASAGARKYAGEPFLRHLIEAAIESYPHIPVVM
HQDHGQSPAVCMAAIRSGFTSVMMDGSLEADGKTVASYEYNVDVSRKVVEAAHSIGVTVEAELGVLGSLETMKGDKEDGH
GAEGTMTREQLLTDVEQAADFVKLTQCDALAIAIGTSHGAYKFSKKPTGDILSIQRIREIHERIPNTHLVMHGSSSVPQE
LLAEIREFGGDMKETYGVPVEEIQIGIKHGVRKINIDTDLRLAITGAIRRYLAENPSKFDPRDYLKPAREAAKKVCVDRY
LAFGCEGQASKIKPVSLDKIAEKYKAGELAQVVR
>Mature_353_residues
PLVSMRQLLDHAAENGYGLPAFNVNNLEQVQAIMAAADQVNAPVIMQASAGARKYAGEPFLRHLIEAAIESYPHIPVVMH
QDHGQSPAVCMAAIRSGFTSVMMDGSLEADGKTVASYEYNVDVSRKVVEAAHSIGVTVEAELGVLGSLETMKGDKEDGHG
AEGTMTREQLLTDVEQAADFVKLTQCDALAIAIGTSHGAYKFSKKPTGDILSIQRIREIHERIPNTHLVMHGSSSVPQEL
LAEIREFGGDMKETYGVPVEEIQIGIKHGVRKINIDTDLRLAITGAIRRYLAENPSKFDPRDYLKPAREAAKKVCVDRYL
AFGCEGQASKIKPVSLDKIAEKYKAGELAQVVR

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI87082041, Length=329, Percent_Identity=34.6504559270517, Blast_Score=172, Evalue=3e-44,
Organism=Escherichia coli, GI1789526, Length=331, Percent_Identity=33.8368580060423, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI1788072, Length=329, Percent_Identity=29.1793313069909, Blast_Score=118, Evalue=6e-28,
Organism=Escherichia coli, GI1789293, Length=354, Percent_Identity=24.5762711864407, Blast_Score=81, Evalue=9e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006412
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 38536; Mature: 38404

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS00602 ALDOLASE_CLASS_II_1 ; PS00806 ALDOLASE_CLASS_II_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLVSMRQLLDHAAENGYGLPAFNVNNLEQVQAIMAAADQVNAPVIMQASAGARKYAGEP
CCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCHHCCCCH
FLRHLIEAAIESYPHIPVVMHQDHGQSPAVCMAAIRSGFTSVMMDGSLEADGKTVASYEY
HHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHCHHHHHCCCCCCCCCCEEEEEEE
NVDVSRKVVEAAHSIGVTVEAELGVLGSLETMKGDKEDGHGAEGTMTREQLLTDVEQAAD
CCCHHHHHHHHHHHCCCEEEECCCCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHH
FVKLTQCDALAIAIGTSHGAYKFSKKPTGDILSIQRIREIHERIPNTHLVMHGSSSVPQE
HHHHHCCCEEEEEEECCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCHHH
LLAEIREFGGDMKETYGVPVEEIQIGIKHGVRKINIDTDLRLAITGAIRRYLAENPSKFD
HHHHHHHHCCCHHHHHCCCHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHCCCCCCC
PRDYLKPAREAAKKVCVDRYLAFGCEGQASKIKPVSLDKIAEKYKAGELAQVVR
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCHHHHHCC
>Mature Secondary Structure 
PLVSMRQLLDHAAENGYGLPAFNVNNLEQVQAIMAAADQVNAPVIMQASAGARKYAGEP
CHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCHHCCCCH
FLRHLIEAAIESYPHIPVVMHQDHGQSPAVCMAAIRSGFTSVMMDGSLEADGKTVASYEY
HHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHCHHHHHCCCCCCCCCCEEEEEEE
NVDVSRKVVEAAHSIGVTVEAELGVLGSLETMKGDKEDGHGAEGTMTREQLLTDVEQAAD
CCCHHHHHHHHHHHCCCEEEECCCCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHH
FVKLTQCDALAIAIGTSHGAYKFSKKPTGDILSIQRIREIHERIPNTHLVMHGSSSVPQE
HHHHHCCCEEEEEEECCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCHHH
LLAEIREFGGDMKETYGVPVEEIQIGIKHGVRKINIDTDLRLAITGAIRRYLAENPSKFD
HHHHHHHHCCCHHHHHCCCHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHCCCCCCC
PRDYLKPAREAAKKVCVDRYLAFGCEGQASKIKPVSLDKIAEKYKAGELAQVVR
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8550527 [H]