Click here to switch to the map view.

The map label for this gene is purC [H]

Identifier: 186475230

GI number: 186475230

Start: 525017

End: 525907

Strand: Direct

Name: purC [H]

Synonym: Bphy_0462

Alternate gene names: 186475230

Gene position: 525017-525907 (Clockwise)

Preceding gene: 186475229

Following gene: 186475231

Centisome position: 15.09

GC content: 62.96

Gene sequence:

>891_bases
ATGTCTACCCTCTACGAATCCACGCTCCGCTCGCTGCCGCTGCTCGGCCGCGGCAAGGTCCGCGACAACTACGCGGTGGG
CAACGACCAGTTGCTGATCGTCACGACGGACCGTCTGTCCGCCTTCGACGTCATCATGGGCGAGCCGATTCCGGACAAGG
GTCGCGTGCTGAACCAGATGGCGAACTTCTGGTTCGACAAGCTCAAGCACGTCGTGCCGAACCACTTGACGGGCGTCGCG
CCCGAAACGGTCGTCGCGCCTGACGAAGCCGAGCAGGTGAAAGGCCGCGCCGTGGTCGTCAAGCGCCTCGAGCCGATTCT
CGTCGAAGCCGTGGTGCGCGGTTATCTGGCCGGGAGCGGCTGGAAGGACTATCAGGCCACGGGCGCCGTATGCGGCGTGC
AACTGCCCGAGGGTCTGCAAAACGCGCAGAAGCTGCCCGAGCCGATCTTCACGCCGGCAGCCAAGGCCGAGATGGGCCAC
CACGACGAAAACATCACGTATGAAGAGATGGAACGCCGCATCGGCACCGAGCTGTCGGCAACGATCCGCGACATCTCCAT
CCGTCTGTACAAGGAAGCGGCCGATTACGCGGCAACCCGCGGCATCATCATCGCCGACACGAAGTTCGAATTCGGTCTGG
ACCAGAACGGCAAGCTGTATCTGATGGACGAAGCGCTGACGGCAGACTCGTCGCGCTTCTGGCCGGCGGATCAGTATCAG
GTCGGCACCAATCCGCCGTCCTTCGACAAGCAGTTCGTGCGCGACTGGCTTGAAACGCAGCCGTGGAAGAAAGAGCCGCC
CGCACCGAAGCTGCCCGACGAAGTCGTCACGAAGACGGCCGAAAAGTATCAGGAAGCGCTCGAACGCCTCACGGGACAGA
AGCTCGACTGA

Upstream 100 bases:

>100_bases
GCCAGGTTGTCGTCAGATCGCCGTTCCCGCATGATCCGGGGAACGGCGTTTCCCTTTTGTTCCGGGCGGTTTTTCAGCCC
CATTTTTGCGAATCACGACG

Downstream 100 bases:

>100_bases
GCGCCACGTACACGGAAAGACAACATGAGTGAAGCACACGCGCACAGCGCGCCCGTCGTTGGCGTGCTGATGGGTTCCAG
CTCCGACTGGGAAGTGATGA

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase [H]

Number of amino acids: Translated: 296; Mature: 295

Protein sequence:

>296_residues
MSTLYESTLRSLPLLGRGKVRDNYAVGNDQLLIVTTDRLSAFDVIMGEPIPDKGRVLNQMANFWFDKLKHVVPNHLTGVA
PETVVAPDEAEQVKGRAVVVKRLEPILVEAVVRGYLAGSGWKDYQATGAVCGVQLPEGLQNAQKLPEPIFTPAAKAEMGH
HDENITYEEMERRIGTELSATIRDISIRLYKEAADYAATRGIIIADTKFEFGLDQNGKLYLMDEALTADSSRFWPADQYQ
VGTNPPSFDKQFVRDWLETQPWKKEPPAPKLPDEVVTKTAEKYQEALERLTGQKLD

Sequences:

>Translated_296_residues
MSTLYESTLRSLPLLGRGKVRDNYAVGNDQLLIVTTDRLSAFDVIMGEPIPDKGRVLNQMANFWFDKLKHVVPNHLTGVA
PETVVAPDEAEQVKGRAVVVKRLEPILVEAVVRGYLAGSGWKDYQATGAVCGVQLPEGLQNAQKLPEPIFTPAAKAEMGH
HDENITYEEMERRIGTELSATIRDISIRLYKEAADYAATRGIIIADTKFEFGLDQNGKLYLMDEALTADSSRFWPADQYQ
VGTNPPSFDKQFVRDWLETQPWKKEPPAPKLPDEVVTKTAEKYQEALERLTGQKLD
>Mature_295_residues
STLYESTLRSLPLLGRGKVRDNYAVGNDQLLIVTTDRLSAFDVIMGEPIPDKGRVLNQMANFWFDKLKHVVPNHLTGVAP
ETVVAPDEAEQVKGRAVVVKRLEPILVEAVVRGYLAGSGWKDYQATGAVCGVQLPEGLQNAQKLPEPIFTPAAKAEMGHH
DENITYEEMERRIGTELSATIRDISIRLYKEAADYAATRGIIIADTKFEFGLDQNGKLYLMDEALTADSSRFWPADQYQV
GTNPPSFDKQFVRDWLETQPWKKEPPAPKLPDEVVTKTAEKYQEALERLTGQKLD

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6319326, Length=293, Percent_Identity=45.7337883959044, Blast_Score=266, Evalue=3e-72,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236 [H]

Pfam domain/function: PF01259 SAICAR_synt [H]

EC number: =6.3.2.6 [H]

Molecular weight: Translated: 33117; Mature: 32986

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS01057 SAICAR_SYNTHETASE_1 ; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTLYESTLRSLPLLGRGKVRDNYAVGNDQLLIVTTDRLSAFDVIMGEPIPDKGRVLNQM
CCHHHHHHHHHCCCCCCCCCCCCEEECCCCEEEEECCCCCHHHHHHCCCCCCHHHHHHHH
ANFWFDKLKHVVPNHLTGVAPETVVAPDEAEQVKGRAVVVKRLEPILVEAVVRGYLAGSG
HHHHHHHHHHHHCHHHCCCCCCCEECCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCC
WKDYQATGAVCGVQLPEGLQNAQKLPEPIFTPAAKAEMGHHDENITYEEMERRIGTELSA
CCCHHCCCCEECCCCCHHHHHHHHCCCCCCCCCHHHHCCCCCCCCCHHHHHHHHCCHHHH
TIRDISIRLYKEAADYAATRGIIIADTKFEFGLDQNGKLYLMDEALTADSSRFWPADQYQ
HHHHHHHHHHHHHHHHHHHCCEEEEECCEEECCCCCCCEEEEECCCCCCCCCCCCCCCCC
VGTNPPSFDKQFVRDWLETQPWKKEPPAPKLPDEVVTKTAEKYQEALERLTGQKLD
CCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
STLYESTLRSLPLLGRGKVRDNYAVGNDQLLIVTTDRLSAFDVIMGEPIPDKGRVLNQM
CHHHHHHHHHCCCCCCCCCCCCEEECCCCEEEEECCCCCHHHHHHCCCCCCHHHHHHHH
ANFWFDKLKHVVPNHLTGVAPETVVAPDEAEQVKGRAVVVKRLEPILVEAVVRGYLAGSG
HHHHHHHHHHHHCHHHCCCCCCCEECCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCC
WKDYQATGAVCGVQLPEGLQNAQKLPEPIFTPAAKAEMGHHDENITYEEMERRIGTELSA
CCCHHCCCCEECCCCCHHHHHHHHCCCCCCCCCHHHHCCCCCCCCCHHHHHHHHCCHHHH
TIRDISIRLYKEAADYAATRGIIIADTKFEFGLDQNGKLYLMDEALTADSSRFWPADQYQ
HHHHHHHHHHHHHHHHHHHCCEEEEECCEEECCCCCCCEEEEECCCCCCCCCCCCCCCCC
VGTNPPSFDKQFVRDWLETQPWKKEPPAPKLPDEVVTKTAEKYQEALERLTGQKLD
CCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA