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The map label for this gene is dacC [H]

Identifier: 186474981

GI number: 186474981

Start: 234977

End: 236206

Strand: Direct

Name: dacC [H]

Synonym: Bphy_0212

Alternate gene names: 186474981

Gene position: 234977-236206 (Clockwise)

Preceding gene: 186474980

Following gene: 186474982

Centisome position: 6.75

GC content: 62.44

Gene sequence:

>1230_bases
ATGCGCTTTTCGAACTCCGGCTCCATCAGCCTTTCCAGCTTCGCTTCTTTCGTTCCGCGATCCGCCGCCAGCAAGTTTGC
GTTGGGTTTCGCGCTGCCGGCAGCACTCGTCGCGAGCACCGCGTTCGCGCAGGTGCCGCCGCCGGGCGTGAACGCACGCT
CGTGGGTGCTCGTCGATGCAACCAGCAACCAGGTGCTCGCATCGGGCAATCCGGACGAGCGCGTGGAACCGGCTTCGCTG
ACCAAGCTGATGACGGCGTATCTGACGTTCGAAGCGCTCGCGTCGAAGAAGATCACGATGGACCAGTCCATCAATCCCAG
CGAGGCCGTGCGCCGCGTGAGGAACGACGAGTCGCGCATGTTCATCGAGGCGAACAAGCCCGTCACCGTGCACGACCTCG
TGTACGGCATGATCATCCAGTCGGGCAACGACGCCGCCATCGCGCTCGCCGAACTGGTCGGCGGCAGCGAAGCGCAGTTC
GTCAACATGATGAACGCGGAAGCGCAAAAGCTCGGCATGAAGAACACGCATTTCGCCGACGTGAACGGCATGCCCGATCC
GCAGCACTACACGACGGCAGGCGACCTCGCCATTCTGTCGGCGCGCCTGATTCGCGACTATCCGGACTACTACAACATCT
TTTCCGTGAAGGAATTCACGTATAACAAGATCAAGCAGCCGAACCGCAACCGTCTGCTGTGGATCGACCCGACCGTCGAC
GGCCTGAAGACGGGCCACACGCAAGCGGCCGGATACTGTCTGATCGCGAGCGCGAAGCGTTCGTTGCCCGGCGTGCCGGA
TGCGTCGCGCCGTCTGGTGACAGTGATGATGGGCGAGCAGAAGGAACACGACCGCGTGCAAGACAGCCTGAAGATGCTGA
ACTACGGCTACTCTGCGTACGACGCGGTGCGCCTGTACAAGGCCAATCAGGTCGTCGAGACGCCGCGCGTCTACAAGGGC
TCGCAGGACACCGTGAAGCTCGGCGTGACCACCGATCAATACATCACGCTGCCGAAGGGCATGGCCGACAAGGCCAAGCC
GCAGATCGAACACGCCGATCCGTTGATCGCACCGATTGCGCAGGGCCAGCAGGTCGGCACGGTGAAGTTTGTCGCCGATG
GCAAGACGCTCGCGCAGGTGCCGCTGGTCGCGCTGCAGGGTGTGCCGCAGGCGGGCATCGTCGGCCGCGTGTGGGATTCG
ATGATGCTGATGTTCAACAAGAAGAAGTAA

Upstream 100 bases:

>100_bases
ATCGCATGCGTGCGGCGGCGCCTGCCAGTCGGGCATCACGCGAATCATCCGAACTGCGCATCCTTTGCGCGCTCAGCCCA
TTTCTGCCCGAATCGACCCT

Downstream 100 bases:

>100_bases
GCCGTAGACAAGTCGAAAAGCAAGAAGATCTGCGGCTTGCTTTTGCGCCGCGCGCATTCATATAGGGTGATTGCGTGCGG
TGAGTAAAGGAGTCGAGGAT

Product: Serine-type D-Ala-D-Ala carboxypeptidase

Products: NA

Alternate protein names: DD-carboxypeptidase; DD-peptidase; Penicillin-binding protein 6; PBP-6 [H]

Number of amino acids: Translated: 409; Mature: 409

Protein sequence:

>409_residues
MRFSNSGSISLSSFASFVPRSAASKFALGFALPAALVASTAFAQVPPPGVNARSWVLVDATSNQVLASGNPDERVEPASL
TKLMTAYLTFEALASKKITMDQSINPSEAVRRVRNDESRMFIEANKPVTVHDLVYGMIIQSGNDAAIALAELVGGSEAQF
VNMMNAEAQKLGMKNTHFADVNGMPDPQHYTTAGDLAILSARLIRDYPDYYNIFSVKEFTYNKIKQPNRNRLLWIDPTVD
GLKTGHTQAAGYCLIASAKRSLPGVPDASRRLVTVMMGEQKEHDRVQDSLKMLNYGYSAYDAVRLYKANQVVETPRVYKG
SQDTVKLGVTTDQYITLPKGMADKAKPQIEHADPLIAPIAQGQQVGTVKFVADGKTLAQVPLVALQGVPQAGIVGRVWDS
MMLMFNKKK

Sequences:

>Translated_409_residues
MRFSNSGSISLSSFASFVPRSAASKFALGFALPAALVASTAFAQVPPPGVNARSWVLVDATSNQVLASGNPDERVEPASL
TKLMTAYLTFEALASKKITMDQSINPSEAVRRVRNDESRMFIEANKPVTVHDLVYGMIIQSGNDAAIALAELVGGSEAQF
VNMMNAEAQKLGMKNTHFADVNGMPDPQHYTTAGDLAILSARLIRDYPDYYNIFSVKEFTYNKIKQPNRNRLLWIDPTVD
GLKTGHTQAAGYCLIASAKRSLPGVPDASRRLVTVMMGEQKEHDRVQDSLKMLNYGYSAYDAVRLYKANQVVETPRVYKG
SQDTVKLGVTTDQYITLPKGMADKAKPQIEHADPLIAPIAQGQQVGTVKFVADGKTLAQVPLVALQGVPQAGIVGRVWDS
MMLMFNKKK
>Mature_409_residues
MRFSNSGSISLSSFASFVPRSAASKFALGFALPAALVASTAFAQVPPPGVNARSWVLVDATSNQVLASGNPDERVEPASL
TKLMTAYLTFEALASKKITMDQSINPSEAVRRVRNDESRMFIEANKPVTVHDLVYGMIIQSGNDAAIALAELVGGSEAQF
VNMMNAEAQKLGMKNTHFADVNGMPDPQHYTTAGDLAILSARLIRDYPDYYNIFSVKEFTYNKIKQPNRNRLLWIDPTVD
GLKTGHTQAAGYCLIASAKRSLPGVPDASRRLVTVMMGEQKEHDRVQDSLKMLNYGYSAYDAVRLYKANQVVETPRVYKG
SQDTVKLGVTTDQYITLPKGMADKAKPQIEHADPLIAPIAQGQQVGTVKFVADGKTLAQVPLVALQGVPQAGIVGRVWDS
MMLMFNKKK

Specific function: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors [H]

COG id: COG1686

COG function: function code M; D-alanyl-D-alanine carboxypeptidase

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein. Note=N-terminal lies in the periplasmic space [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S11 family [H]

Homologues:

Organism=Escherichia coli, GI1787062, Length=381, Percent_Identity=41.7322834645669, Blast_Score=296, Evalue=1e-81,
Organism=Escherichia coli, GI1786851, Length=365, Percent_Identity=39.1780821917808, Blast_Score=260, Evalue=1e-70,
Organism=Escherichia coli, GI87082022, Length=386, Percent_Identity=38.60103626943, Blast_Score=254, Evalue=1e-68,
Organism=Escherichia coli, GI87082054, Length=254, Percent_Identity=30.3149606299213, Blast_Score=79, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR015956
- InterPro:   IPR018044
- InterPro:   IPR012907
- InterPro:   IPR001967 [H]

Pfam domain/function: PF07943 PBP5_C; PF00768 Peptidase_S11 [H]

EC number: =3.4.16.4 [H]

Molecular weight: Translated: 44580; Mature: 44580

Theoretical pI: Translated: 9.63; Mature: 9.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFSNSGSISLSSFASFVPRSAASKFALGFALPAALVASTAFAQVPPPGVNARSWVLVDA
CCCCCCCCEEHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEC
TSNQVLASGNPDERVEPASLTKLMTAYLTFEALASKKITMDQSINPSEAVRRVRNDESRM
CCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEECCCCCCHHHHHHHHHCCCCEE
FIEANKPVTVHDLVYGMIIQSGNDAAIALAELVGGSEAQFVNMMNAEAQKLGMKNTHFAD
EEECCCCEEHHHHHEEHHEECCCCHHEEHHHHHCCCHHHHHHHHHHHHHHCCCCCCEEEE
VNGMPDPQHYTTAGDLAILSARLIRDYPDYYNIFSVKEFTYNKIKQPNRNRLLWIDPTVD
CCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHCEEEEHHHHHHHHCCCCCCEEEEECCCCC
GLKTGHTQAAGYCLIASAKRSLPGVPDASRRLVTVMMGEQKEHDRVQDSLKMLNYGYSAY
CHHCCCCCCCCEEEEEECHHCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHCCCCHH
DAVRLYKANQVVETPRVYKGSQDTVKLGVTTDQYITLPKGMADKAKPQIEHADPLIAPIA
HHEEEEECCCHHCCCCCCCCCCCEEEEECCCCCEEECCCCCCCCCCCCCCCCCCCHHHHC
QGQQVGTVKFVADGKTLAQVPLVALQGVPQAGIVGRVWDSMMLMFNKKK
CCCCCCEEEEEECCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRFSNSGSISLSSFASFVPRSAASKFALGFALPAALVASTAFAQVPPPGVNARSWVLVDA
CCCCCCCCEEHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEC
TSNQVLASGNPDERVEPASLTKLMTAYLTFEALASKKITMDQSINPSEAVRRVRNDESRM
CCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEECCCCCCHHHHHHHHHCCCCEE
FIEANKPVTVHDLVYGMIIQSGNDAAIALAELVGGSEAQFVNMMNAEAQKLGMKNTHFAD
EEECCCCEEHHHHHEEHHEECCCCHHEEHHHHHCCCHHHHHHHHHHHHHHCCCCCCEEEE
VNGMPDPQHYTTAGDLAILSARLIRDYPDYYNIFSVKEFTYNKIKQPNRNRLLWIDPTVD
CCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHCEEEEHHHHHHHHCCCCCCEEEEECCCCC
GLKTGHTQAAGYCLIASAKRSLPGVPDASRRLVTVMMGEQKEHDRVQDSLKMLNYGYSAY
CHHCCCCCCCCEEEEEECHHCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHCCCCHH
DAVRLYKANQVVETPRVYKGSQDTVKLGVTTDQYITLPKGMADKAKPQIEHADPLIAPIA
HHEEEEECCCHHCCCCCCCCCCCEEEEECCCCCEEECCCCCCCCCCCCCCCCCCCHHHHC
QGQQVGTVKFVADGKTLAQVPLVALQGVPQAGIVGRVWDSMMLMFNKKK
CCCCCCEEEEEECCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3279397; 8905232; 9278503; 7042389 [H]