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The map label for this gene is cyaA [H]

Identifier: 183222651

GI number: 183222651

Start: 3418136

End: 3419434

Strand: Reverse

Name: cyaA [H]

Synonym: LEPBI_I3306

Alternate gene names: 183222651

Gene position: 3419434-3418136 (Counterclockwise)

Preceding gene: 183222652

Following gene: 183222650

Centisome position: 94.99

GC content: 38.57

Gene sequence:

>1299_bases
ATGGCAACAAAGTCAGAACAAATATTAAGGGAGAAAGAAATCCAAGGGATTAAGTTTAGTCTCTATGGAAAGATGATTGT
TTTTTCCTTATTGACCATCGGTACTTTCTTTGTTGCTCAGACTTTGTTTGAATTATTTACAATCGCCTCAATTTCCTTAG
CGCTTAATATCGTGTTGTATATATTTTCCAAATTTTTAAAAAAGGGAAAGTATGTATCCTTTGTTGGACTATTTTGTGTA
GCGATTGATTTGGTCATCATCACTGTGTTGCCTTTTATTTGGTACAATGCAGTGGGGGGTGAATCACAAGTACCAAGAAC
CTATCTCATCAAAACCTATGTTCATTTTATCATCGCAGGCACTCTTGTGATCAATGCGTTCAGTATCCAACCCATTTATC
CAATGATGTATGCGTTAGGTGTTGTGATCAGTCAGGCAGGCATTTTAGTGTATGCCCAACAAGACCCTCGTTTTGTGAGT
ACTGAAAATTTCAAAGAGGCAATCATCGGTCCTGCAGCCCATGTGAATAATTACATCATGTCAATGGGGATCATTGGAGT
ACTTGGATTTTTTTTGGCATACCTTACCTACCGCGTTAGGCGGACAGTGCTTATGGCTGTTACCAATGAAGTGAAGATGA
CACAACTCACTCGTTATTTTTCACCAAATGTTGTGGAAGAAATGGACCAAGCGGATGAGGATTTTTTTAAACCTGGTGGC
AAGGAATCTACAGTTGCAGTTCTATTTTGTGATATAGCCAATTTTACACAGATTTCGGAAACTTTGGGGCCAGCCAAAAC
CATGTCTCTTTTGTCTGAATACCATAGTTTTATGTTGGACATTGTTTTCCAAAACCATGGAACACTCGATAAATTCATAG
GGGATGGAATGATGGTAACCTTTGGTACTCCAACCGCTTCCAAAGAAGATGCCACAAATTCCGTAAAAGCAGGAATTGCT
ATGTTACAGGCATTAGCTGAGTGGAACAAAAAAAGGGAAACCAATGAAGAGAAGGCAATTTCCATTCGCATCGGAATCCA
TTATGGACCTGTGATCGTTGGAAATGTGGGGATCGAAAAACGTTTAGAATACACAGTGATTGGTGATACAGTGAATGCTG
CCAGCCGATTGGAAACACTTGGCAAAGAATTAAAACGAAATTTTTTGATTTCTAAGGAATTATACGATCACATCTCTCAA
GAATTAAAACAATCATTGAAAATGAAAACGATGGGAACCTTATCTCTGCGTGGCAAAACCAAAACCACTGAAATTTTAGC
AATTGAGGTTCCTTCATGA

Upstream 100 bases:

>100_bases
TTTATCAGAAGCGATGTTACTTGCGTCAGGAAAGGACAAAACATTATCCTTGTTTGTTCCTGACCGCGATGCAAGTCCTG
GTGACCTTTTGAAATAAACA

Downstream 100 bases:

>100_bases
TTCAAGTTCCAACTGGAAAAGATATCGTTTTACTTTCAAAACGATCGTATTTATCTCCTGAAGTTTCTCTGCAAATTCTT
AACTTGGCCCAAACTCAGGA

Product: putative adenylate cyclase

Products: NA

Alternate protein names: ATP pyrophosphate-lyase 1; Adenylyl cyclase 1; AC 1 [H]

Number of amino acids: Translated: 432; Mature: 431

Protein sequence:

>432_residues
MATKSEQILREKEIQGIKFSLYGKMIVFSLLTIGTFFVAQTLFELFTIASISLALNIVLYIFSKFLKKGKYVSFVGLFCV
AIDLVIITVLPFIWYNAVGGESQVPRTYLIKTYVHFIIAGTLVINAFSIQPIYPMMYALGVVISQAGILVYAQQDPRFVS
TENFKEAIIGPAAHVNNYIMSMGIIGVLGFFLAYLTYRVRRTVLMAVTNEVKMTQLTRYFSPNVVEEMDQADEDFFKPGG
KESTVAVLFCDIANFTQISETLGPAKTMSLLSEYHSFMLDIVFQNHGTLDKFIGDGMMVTFGTPTASKEDATNSVKAGIA
MLQALAEWNKKRETNEEKAISIRIGIHYGPVIVGNVGIEKRLEYTVIGDTVNAASRLETLGKELKRNFLISKELYDHISQ
ELKQSLKMKTMGTLSLRGKTKTTEILAIEVPS

Sequences:

>Translated_432_residues
MATKSEQILREKEIQGIKFSLYGKMIVFSLLTIGTFFVAQTLFELFTIASISLALNIVLYIFSKFLKKGKYVSFVGLFCV
AIDLVIITVLPFIWYNAVGGESQVPRTYLIKTYVHFIIAGTLVINAFSIQPIYPMMYALGVVISQAGILVYAQQDPRFVS
TENFKEAIIGPAAHVNNYIMSMGIIGVLGFFLAYLTYRVRRTVLMAVTNEVKMTQLTRYFSPNVVEEMDQADEDFFKPGG
KESTVAVLFCDIANFTQISETLGPAKTMSLLSEYHSFMLDIVFQNHGTLDKFIGDGMMVTFGTPTASKEDATNSVKAGIA
MLQALAEWNKKRETNEEKAISIRIGIHYGPVIVGNVGIEKRLEYTVIGDTVNAASRLETLGKELKRNFLISKELYDHISQ
ELKQSLKMKTMGTLSLRGKTKTTEILAIEVPS
>Mature_431_residues
ATKSEQILREKEIQGIKFSLYGKMIVFSLLTIGTFFVAQTLFELFTIASISLALNIVLYIFSKFLKKGKYVSFVGLFCVA
IDLVIITVLPFIWYNAVGGESQVPRTYLIKTYVHFIIAGTLVINAFSIQPIYPMMYALGVVISQAGILVYAQQDPRFVST
ENFKEAIIGPAAHVNNYIMSMGIIGVLGFFLAYLTYRVRRTVLMAVTNEVKMTQLTRYFSPNVVEEMDQADEDFFKPGGK
ESTVAVLFCDIANFTQISETLGPAKTMSLLSEYHSFMLDIVFQNHGTLDKFIGDGMMVTFGTPTASKEDATNSVKAGIAM
LQALAEWNKKRETNEEKAISIRIGIHYGPVIVGNVGIEKRLEYTVIGDTVNAASRLETLGKELKRNFLISKELYDHISQE
LKQSLKMKTMGTLSLRGKTKTTEILAIEVPS

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate cyclase domain [H]

Homologues:

Organism=Homo sapiens, GI167830411, Length=187, Percent_Identity=31.5508021390374, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI4580422, Length=187, Percent_Identity=29.4117647058824, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI134152694, Length=221, Percent_Identity=28.5067873303167, Blast_Score=73, Evalue=6e-13,
Organism=Homo sapiens, GI148536830, Length=254, Percent_Identity=23.6220472440945, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI4557255, Length=141, Percent_Identity=29.7872340425532, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI4504217, Length=171, Percent_Identity=29.8245614035088, Blast_Score=68, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71989822, Length=184, Percent_Identity=29.8913043478261, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI71989805, Length=188, Percent_Identity=29.7872340425532, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17534657, Length=170, Percent_Identity=31.1764705882353, Blast_Score=75, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17534649, Length=170, Percent_Identity=30.5882352941176, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI212645052, Length=176, Percent_Identity=28.9772727272727, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17534653, Length=170, Percent_Identity=30, Blast_Score=72, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17534651, Length=170, Percent_Identity=30.5882352941176, Blast_Score=72, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17534665, Length=180, Percent_Identity=28.3333333333333, Blast_Score=72, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI71982300, Length=195, Percent_Identity=29.7435897435897, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17561804, Length=142, Percent_Identity=28.8732394366197, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17534659, Length=181, Percent_Identity=29.2817679558011, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17508769, Length=157, Percent_Identity=29.9363057324841, Blast_Score=69, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17568383, Length=148, Percent_Identity=33.1081081081081, Blast_Score=68, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI71990146, Length=143, Percent_Identity=32.1678321678322, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI193207841, Length=178, Percent_Identity=28.6516853932584, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI212645647, Length=139, Percent_Identity=30.2158273381295, Blast_Score=65, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17561794, Length=185, Percent_Identity=29.7297297297297, Blast_Score=65, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI17561802, Length=139, Percent_Identity=30.9352517985612, Blast_Score=65, Evalue=9e-11,
Organism=Drosophila melanogaster, GI62484477, Length=180, Percent_Identity=28.8888888888889, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI62484298, Length=180, Percent_Identity=28.8888888888889, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI116008008, Length=180, Percent_Identity=28.8888888888889, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24583978, Length=180, Percent_Identity=30, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24663843, Length=187, Percent_Identity=31.5508021390374, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24663839, Length=187, Percent_Identity=31.5508021390374, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI161076872, Length=145, Percent_Identity=28.9655172413793, Blast_Score=72, Evalue=9e-13,
Organism=Drosophila melanogaster, GI28574512, Length=145, Percent_Identity=28.9655172413793, Blast_Score=72, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24667100, Length=203, Percent_Identity=26.1083743842365, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI221330468, Length=192, Percent_Identity=29.1666666666667, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI221330470, Length=192, Percent_Identity=29.1666666666667, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI85725044, Length=202, Percent_Identity=28.2178217821782, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI281366459, Length=184, Percent_Identity=28.2608695652174, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI281366457, Length=184, Percent_Identity=28.2608695652174, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI281366455, Length=184, Percent_Identity=28.2608695652174, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI56292422, Length=184, Percent_Identity=28.2608695652174, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI56292424, Length=184, Percent_Identity=28.2608695652174, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24666940, Length=184, Percent_Identity=28.2608695652174, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI161078020, Length=177, Percent_Identity=28.2485875706215, Blast_Score=66, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054 [H]

Pfam domain/function: PF00211 Guanylate_cyc [H]

EC number: =4.6.1.1 [H]

Molecular weight: Translated: 48188; Mature: 48057

Theoretical pI: Translated: 8.80; Mature: 8.80

Prosite motif: PS50125 GUANYLATE_CYCLASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCEEEEEEECCC
>Mature Secondary Structure 
ATKSEQILREKEIQGIKFSLYGKMIVFSLLTIGTFFVAQTLFELFTIASISLALNIVLY
CCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IFSKFLKKGKYVSFVGLFCVAIDLVIITVLPFIWYNAVGGESQVPRTYLIKTYVHFIIAG
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
TLVINAFSIQPIYPMMYALGVVISQAGILVYAQQDPRFVSTENFKEAIIGPAAHVNNYIM
HHHHHHCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHCCCHHHHHHHHH
SMGIIGVLGFFLAYLTYRVRRTVLMAVTNEVKMTQLTRYFSPNVVEEMDQADEDFFKPGG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCHHHHHHHHCCHHHHCCCC
KESTVAVLFCDIANFTQISETLGPAKTMSLLSEYHSFMLDIVFQNHGTLDKFIGDGMMVT
CCCEEEEEEECHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCEEEE
FGTPTASKEDATNSVKAGIAMLQALAEWNKKRETNEEKAISIRIGIHYGPVIVGNVGIEK
ECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEECCEEEECCCHHH
RLEYTVIGDTVNAASRLETLGKELKRNFLISKELYDHISQELKQSLKMKTMGTLSLRGKT
CEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCC
KTTEILAIEVPS
CCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9523018; 8418825 [H]