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The map label for this gene is hisI [H]

Identifier: 183222650

GI number: 183222650

Start: 3417531

End: 3418139

Strand: Reverse

Name: hisI [H]

Synonym: LEPBI_I3305

Alternate gene names: 183222650

Gene position: 3418139-3417531 (Counterclockwise)

Preceding gene: 183222651

Following gene: 183222649

Centisome position: 94.96

GC content: 36.95

Gene sequence:

>609_bases
ATGATTCAAGTTCCAACTGGAAAAGATATCGTTTTACTTTCAAAACGATCGTATTTATCTCCTGAAGTTTCTCTGCAAAT
TCTTAACTTGGCCCAAACTCAGGATTTTTTAAACAGATTTGATTATACAAAAAAACAATTATATGTGGATTGTGATGAAG
ATACCTTTCTGGAAGTTTCCCCCGAAGAAAGATCATTCGCTAAACAATTGTTATGGGAAAATGGAACACTTAAAGTTTCG
AAGGAAACATTTGATTCGATCTTAGACAGTATGCCACCCTTATCTCCCTTTTTAGCTCAGGATTTGACTGGTAAAGATTT
GATGTTGGCTTGGGGGAAAAAGGAAAGTCTCATCCATGCCATCGAATCTGGGAATGGAACCTATTTCAGTCGATCAAGGA
ATGGAAAGTGGGTAAAGGGAGAAGAGTCAGGGCACTTTCAAAAATTGAAACAGATTTATGTTCACTCCAATCCTTTTTTT
GTCAAATATATCACCGATCAAATTGGTGCCGCCTGCCACACAGGTTATTATTCCTGTTTTTTTAGAGAACTCGGTCAGAA
TGAATCTGTTTCATTCGTCTATTCTAATAAAGTCGGAGAGTCAGTTTGA

Upstream 100 bases:

>100_bases
CTCAAGAATTAAAACAATCATTGAAAATGAAAACGATGGGAACCTTATCTCTGCGTGGCAAAACCAAAACCACTGAAATT
TTAGCAATTGAGGTTCCTTC

Downstream 100 bases:

>100_bases
ATCGAATGATCCTAATCATCATTGCCATTGTTGCTGTTTTATTCATTGTTTACCAATTGAGAAATGTTTCGGGTATGGAC
CAGTCACAACTCAAAGAAAA

Product: putative phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: PRA-CH [H]

Number of amino acids: Translated: 202; Mature: 202

Protein sequence:

>202_residues
MIQVPTGKDIVLLSKRSYLSPEVSLQILNLAQTQDFLNRFDYTKKQLYVDCDEDTFLEVSPEERSFAKQLLWENGTLKVS
KETFDSILDSMPPLSPFLAQDLTGKDLMLAWGKKESLIHAIESGNGTYFSRSRNGKWVKGEESGHFQKLKQIYVHSNPFF
VKYITDQIGAACHTGYYSCFFRELGQNESVSFVYSNKVGESV

Sequences:

>Translated_202_residues
MIQVPTGKDIVLLSKRSYLSPEVSLQILNLAQTQDFLNRFDYTKKQLYVDCDEDTFLEVSPEERSFAKQLLWENGTLKVS
KETFDSILDSMPPLSPFLAQDLTGKDLMLAWGKKESLIHAIESGNGTYFSRSRNGKWVKGEESGHFQKLKQIYVHSNPFF
VKYITDQIGAACHTGYYSCFFRELGQNESVSFVYSNKVGESV
>Mature_202_residues
MIQVPTGKDIVLLSKRSYLSPEVSLQILNLAQTQDFLNRFDYTKKQLYVDCDEDTFLEVSPEERSFAKQLLWENGTLKVS
KETFDSILDSMPPLSPFLAQDLTGKDLMLAWGKKESLIHAIESGNGTYFSRSRNGKWVKGEESGHFQKLKQIYVHSNPFF
VKYITDQIGAACHTGYYSCFFRELGQNESVSFVYSNKVGESV

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6319819, Length=75, Percent_Identity=44, Blast_Score=65, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH [H]

EC number: =3.5.4.19 [H]

Molecular weight: Translated: 23036; Mature: 23036

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQVPTGKDIVLLSKRSYLSPEVSLQILNLAQTQDFLNRFDYTKKQLYVDCDEDTFLEVS
CCCCCCCCCEEEEECCCCCCCCCEEEEHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEC
PEERSFAKQLLWENGTLKVSKETFDSILDSMPPLSPFLAQDLTGKDLMLAWGKKESLIHA
CHHHHHHHHHHHCCCCEEECHHHHHHHHHCCCCCCHHHHHCCCCCEEEEEECCCHHHHHH
IESGNGTYFSRSRNGKWVKGEESGHFQKLKQIYVHSNPFFVKYITDQIGAACHTGYYSCF
HCCCCCEEEEECCCCCEEECCCCCHHHHHHHHHCCCCCEEEEEEHHHHCHHHHHHHHHHH
FRELGQNESVSFVYSNKVGESV
HHHHCCCCCEEEEECCCCCCCC
>Mature Secondary Structure
MIQVPTGKDIVLLSKRSYLSPEVSLQILNLAQTQDFLNRFDYTKKQLYVDCDEDTFLEVS
CCCCCCCCCEEEEECCCCCCCCCEEEEHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEC
PEERSFAKQLLWENGTLKVSKETFDSILDSMPPLSPFLAQDLTGKDLMLAWGKKESLIHA
CHHHHHHHHHHHCCCCEEECHHHHHHHHHCCCCCCHHHHHCCCCCEEEEEECCCHHHHHH
IESGNGTYFSRSRNGKWVKGEESGHFQKLKQIYVHSNPFFVKYITDQIGAACHTGYYSCF
HCCCCCEEEEECCCCCEEECCCCCHHHHHHHHHCCCCCEEEEEEHHHHCHHHHHHHHHHH
FRELGQNESVSFVYSNKVGESV
HHHHCCCCCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA