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The map label for this gene is fkpB [H]

Identifier: 183222083

GI number: 183222083

Start: 2818811

End: 2819239

Strand: Direct

Name: fkpB [H]

Synonym: LEPBI_I2725

Alternate gene names: 183222083

Gene position: 2818811-2819239 (Clockwise)

Preceding gene: 183222081

Following gene: 183222084

Centisome position: 78.31

GC content: 44.06

Gene sequence:

>429_bases
TTGGCAAAGTTTCGGCCTTTGGTTAGCCTTTCGATTAGAATGAAGTCTTGGATCCCCCTATCTCTCTCTTTTTTAATGTT
TTTGAGTCTCCCCCTTTCCCCTGCGGAAAAAGATTTCCAAATCATTGACCTCGTCGTTGGCAAAGGAGATGAAGCCTTCT
CTGGTTCCTATGTCACCGTCCATTATGTGGGAAAATTAAAAAACGGAACCAAATTTGATAGTTCACGCGATCGCAACCGC
CCTTTTGAATTCAACTTGGGAGCAGGAGAAGTGGTGAAGGGTTGGGACAAAGGCATCAAAGGGATGCGAGTGGGTGGCAA
ACGGAAACTCATCATCCCACCAGAGCTTGGGTATGGCAGTAAAAAAGTAGGAAACATCCCACCTGACTCCACTCTCATCT
TTGAAGTGGAATTATTAAAAATATACTAA

Upstream 100 bases:

>100_bases
TTTCGGAAAATAAAGCCTTCTAATTCCTTACAATAAAAAACCAATTCATGAAACATGGGTTCACCATAATTTGAGAACTG
AACTCGGCTAGTTTTTTTCA

Downstream 100 bases:

>100_bases
TCCACTATATTCGAAATTTGGAATCCAAGGAAGGCCCTGGTCACTAGGGAAATTCCTTGACAATTATTAGAATCCTTCTA
CCGTAAACCCTCTATGGAAA

Product: FKBP-type peptidyl-prolyl cis-trans isomerase SlyD

Products: NA

Alternate protein names: Peptidyl-prolyl cis-trans isomerase; PPIase; Rotamase [H]

Number of amino acids: Translated: 142; Mature: 141

Protein sequence:

>142_residues
MAKFRPLVSLSIRMKSWIPLSLSFLMFLSLPLSPAEKDFQIIDLVVGKGDEAFSGSYVTVHYVGKLKNGTKFDSSRDRNR
PFEFNLGAGEVVKGWDKGIKGMRVGGKRKLIIPPELGYGSKKVGNIPPDSTLIFEVELLKIY

Sequences:

>Translated_142_residues
MAKFRPLVSLSIRMKSWIPLSLSFLMFLSLPLSPAEKDFQIIDLVVGKGDEAFSGSYVTVHYVGKLKNGTKFDSSRDRNR
PFEFNLGAGEVVKGWDKGIKGMRVGGKRKLIIPPELGYGSKKVGNIPPDSTLIFEVELLKIY
>Mature_141_residues
AKFRPLVSLSIRMKSWIPLSLSFLMFLSLPLSPAEKDFQIIDLVVGKGDEAFSGSYVTVHYVGKLKNGTKFDSSRDRNRP
FEFNLGAGEVVKGWDKGIKGMRVGGKRKLIIPPELGYGSKKVGNIPPDSTLIFEVELLKIY

Specific function: PPIases accelerate the folding of proteins [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Cytoplasm And Periplasmic Protein [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI206725530, Length=88, Percent_Identity=57.9545454545455, Blast_Score=105, Evalue=2e-23,
Organism=Homo sapiens, GI17149844, Length=88, Percent_Identity=57.9545454545455, Blast_Score=105, Evalue=2e-23,
Organism=Homo sapiens, GI17149842, Length=88, Percent_Identity=57.9545454545455, Blast_Score=105, Evalue=2e-23,
Organism=Homo sapiens, GI17149836, Length=88, Percent_Identity=53.4090909090909, Blast_Score=100, Evalue=4e-22,
Organism=Homo sapiens, GI4503725, Length=88, Percent_Identity=53.4090909090909, Blast_Score=100, Evalue=4e-22,
Organism=Homo sapiens, GI224809329, Length=109, Percent_Identity=48.6238532110092, Blast_Score=98, Evalue=2e-21,
Organism=Homo sapiens, GI224809327, Length=109, Percent_Identity=48.6238532110092, Blast_Score=98, Evalue=2e-21,
Organism=Homo sapiens, GI4758384, Length=109, Percent_Identity=48.6238532110092, Blast_Score=98, Evalue=2e-21,
Organism=Homo sapiens, GI4758380, Length=88, Percent_Identity=51.1363636363636, Blast_Score=97, Evalue=7e-21,
Organism=Homo sapiens, GI8923659, Length=90, Percent_Identity=55.5555555555556, Blast_Score=95, Evalue=2e-20,
Organism=Homo sapiens, GI224809331, Length=109, Percent_Identity=48.6238532110092, Blast_Score=94, Evalue=3e-20,
Organism=Homo sapiens, GI192448443, Length=93, Percent_Identity=47.3118279569892, Blast_Score=88, Evalue=2e-18,
Organism=Homo sapiens, GI4503729, Length=87, Percent_Identity=51.7241379310345, Blast_Score=88, Evalue=2e-18,
Organism=Homo sapiens, GI33469985, Length=89, Percent_Identity=42.6966292134831, Blast_Score=87, Evalue=4e-18,
Organism=Homo sapiens, GI206725547, Length=91, Percent_Identity=47.2527472527472, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI31317231, Length=92, Percent_Identity=46.7391304347826, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI150010552, Length=105, Percent_Identity=39.0476190476191, Blast_Score=75, Evalue=2e-14,
Organism=Homo sapiens, GI4503727, Length=109, Percent_Identity=37.6146788990826, Blast_Score=70, Evalue=7e-13,
Organism=Escherichia coli, GI87082390, Length=100, Percent_Identity=48, Blast_Score=80, Evalue=4e-17,
Organism=Escherichia coli, GI1789745, Length=103, Percent_Identity=44.6601941747573, Blast_Score=78, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71993519, Length=89, Percent_Identity=56.1797752808989, Blast_Score=100, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17540882, Length=134, Percent_Identity=41.7910447761194, Blast_Score=97, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17561782, Length=109, Percent_Identity=46.7889908256881, Blast_Score=93, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17561778, Length=104, Percent_Identity=41.3461538461538, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71993555, Length=65, Percent_Identity=55.3846153846154, Blast_Score=77, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17561780, Length=103, Percent_Identity=38.8349514563107, Blast_Score=67, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17506169, Length=95, Percent_Identity=38.9473684210526, Blast_Score=66, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17506167, Length=89, Percent_Identity=40.4494382022472, Blast_Score=66, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6324194, Length=89, Percent_Identity=55.0561797752809, Blast_Score=100, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6323482, Length=101, Percent_Identity=48.5148514851485, Blast_Score=97, Evalue=8e-22,
Organism=Saccharomyces cerevisiae, GI6320727, Length=93, Percent_Identity=52.6881720430108, Blast_Score=96, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6323566, Length=101, Percent_Identity=46.5346534653465, Blast_Score=95, Evalue=4e-21,
Organism=Drosophila melanogaster, GI281363946, Length=90, Percent_Identity=58.8888888888889, Blast_Score=113, Evalue=4e-26,
Organism=Drosophila melanogaster, GI17352457, Length=90, Percent_Identity=58.8888888888889, Blast_Score=113, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24655568, Length=104, Percent_Identity=52.8846153846154, Blast_Score=112, Evalue=7e-26,
Organism=Drosophila melanogaster, GI24647110, Length=118, Percent_Identity=46.6101694915254, Blast_Score=108, Evalue=1e-24,
Organism=Drosophila melanogaster, GI21356629, Length=93, Percent_Identity=53.763440860215, Blast_Score=95, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24583150, Length=95, Percent_Identity=48.4210526315789, Blast_Score=92, Evalue=1e-19,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179 [H]

Pfam domain/function: PF00254 FKBP_C [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 15822; Mature: 15691

Theoretical pI: Translated: 10.40; Mature: 10.40

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKFRPLVSLSIRMKSWIPLSLSFLMFLSLPLSPAEKDFQIIDLVVGKGDEAFSGSYVTV
CCCCCCEEEEEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCCCCCCCEEEE
HYVGKLKNGTKFDSSRDRNRPFEFNLGAGEVVKGWDKGIKGMRVGGKRKLIIPPELGYGS
EEEEECCCCCCCCCCCCCCCCEEEECCCCHHHHHHHCCCCCEEECCCEEEEECCCCCCCC
KKVGNIPPDSTLIFEVELLKIY
CCCCCCCCCCEEEEEEEEEEEC
>Mature Secondary Structure 
AKFRPLVSLSIRMKSWIPLSLSFLMFLSLPLSPAEKDFQIIDLVVGKGDEAFSGSYVTV
CCCCCEEEEEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCCCCCCCEEEE
HYVGKLKNGTKFDSSRDRNRPFEFNLGAGEVVKGWDKGIKGMRVGGKRKLIIPPELGYGS
EEEEECCCCCCCCCCCCCCCCEEEECCCCHHHHHHHCCCCCEEECCCEEEEECCCCCCCC
KKVGNIPPDSTLIFEVELLKIY
CCCCCCCCCCEEEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]