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The map label for this gene is uppS [H]

Identifier: 183221972

GI number: 183221972

Start: 2704476

End: 2705189

Strand: Reverse

Name: uppS [H]

Synonym: LEPBI_I2613

Alternate gene names: 183221972

Gene position: 2705189-2704476 (Counterclockwise)

Preceding gene: 183221973

Following gene: 183221971

Centisome position: 75.15

GC content: 40.9

Gene sequence:

>714_bases
ATGAAGTTGCATACGATCCCCGCGCACATTGCTGTCATTATGGACGGAAATGGTAGGTGGGCGGAAAACCAAGGGAAAAA
AAGAACCGAAGGCCATAGAGAAGGGGCAAATGCAATTGATCGCCTCTTGGATGTGGCCTTGGAATATAAAATCCCAAATA
TTTCCCTTTATGCCTTTTCCACAGAAAATTGGAAACGTCCTATCACTGAAATCCAAGCCATCTTTGGTCTGTTAGTTGAG
TTTATTGAAACTCGCCTTGATACCATCCACGCAAAAGGCATTCGTATCCATCACAGTGGTGCCAGGAATAAACTTTCCAA
AACAGTTCTCAAAAAAATCGACCACGCAATGGCCGTGACCAAAAAAAACAAAAAACTGACTGCTAACTTTTGTTTGAACT
ATGGTGGGCATGAAGAAATTTTGAGTAATTTTTCACGTGTGATGGCGGCACGTAAGGCCAAAAAAGAAACTTTGGACAAA
CCCATTTCCCCCAAAGAATTTGAAAAATATTTGTATACATCCCCTTTGCCACCCGTAGATTTATTGATCAGAACTGCGGG
CGAACAAAGGATTTCTAACTTTCTATTATGGCAAAGTGCATATGCAGAAATGTATTTTACGAGTACACTTTGGCCTGACT
TTGGAAGGACCTCACTCGAGGAAGCTCTTCTTTTTTTTGATTCCCGAAAACGTAAATTTGGTGGTTTGTTATGA

Upstream 100 bases:

>100_bases
CCACCAAGACAAAATCCAAAAAATTACGGATTCTTATATTGCCAAATTGGGAGATTTAGAAAAGGAAAAAGAAAAAGAGA
TCACAACTCTTTAATTTCCT

Downstream 100 bases:

>100_bases
GTGAAACGACACTCCGTATTTTGTCTGCAATTGTACTCACTTTTGTATATGTATTCATGATCTTTCATAGTTCCTGGTAC
TACTTGGAATTTTATACCTT

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MKLHTIPAHIAVIMDGNGRWAENQGKKRTEGHREGANAIDRLLDVALEYKIPNISLYAFSTENWKRPITEIQAIFGLLVE
FIETRLDTIHAKGIRIHHSGARNKLSKTVLKKIDHAMAVTKKNKKLTANFCLNYGGHEEILSNFSRVMAARKAKKETLDK
PISPKEFEKYLYTSPLPPVDLLIRTAGEQRISNFLLWQSAYAEMYFTSTLWPDFGRTSLEEALLFFDSRKRKFGGLL

Sequences:

>Translated_237_residues
MKLHTIPAHIAVIMDGNGRWAENQGKKRTEGHREGANAIDRLLDVALEYKIPNISLYAFSTENWKRPITEIQAIFGLLVE
FIETRLDTIHAKGIRIHHSGARNKLSKTVLKKIDHAMAVTKKNKKLTANFCLNYGGHEEILSNFSRVMAARKAKKETLDK
PISPKEFEKYLYTSPLPPVDLLIRTAGEQRISNFLLWQSAYAEMYFTSTLWPDFGRTSLEEALLFFDSRKRKFGGLL
>Mature_237_residues
MKLHTIPAHIAVIMDGNGRWAENQGKKRTEGHREGANAIDRLLDVALEYKIPNISLYAFSTENWKRPITEIQAIFGLLVE
FIETRLDTIHAKGIRIHHSGARNKLSKTVLKKIDHAMAVTKKNKKLTANFCLNYGGHEEILSNFSRVMAARKAKKETLDK
PISPKEFEKYLYTSPLPPVDLLIRTAGEQRISNFLLWQSAYAEMYFTSTLWPDFGRTSLEEALLFFDSRKRKFGGLL

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=231, Percent_Identity=35.9307359307359, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI45580742, Length=231, Percent_Identity=35.9307359307359, Blast_Score=127, Evalue=1e-29,
Organism=Escherichia coli, GI1786371, Length=227, Percent_Identity=41.4096916299559, Blast_Score=191, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI71993029, Length=228, Percent_Identity=32.4561403508772, Blast_Score=108, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6319474, Length=232, Percent_Identity=34.051724137931, Blast_Score=131, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6323748, Length=224, Percent_Identity=29.0178571428571, Blast_Score=87, Evalue=3e-18,
Organism=Drosophila melanogaster, GI18857969, Length=210, Percent_Identity=33.8095238095238, Blast_Score=128, Evalue=4e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 27105; Mature: 27105

Theoretical pI: Translated: 10.25; Mature: 10.25

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLHTIPAHIAVIMDGNGRWAENQGKKRTEGHREGANAIDRLLDVALEYKIPNISLYAFS
CCCEEECEEEEEEECCCCCCCCCCCCCHHCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEC
TENWKRPITEIQAIFGLLVEFIETRLDTIHAKGIRIHHSGARNKLSKTVLKKIDHAMAVT
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHH
KKNKKLTANFCLNYGGHEEILSNFSRVMAARKAKKETLDKPISPKEFEKYLYTSPLPPVD
HCCCEEEEEHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHH
LLIRTAGEQRISNFLLWQSAYAEMYFTSTLWPDFGRTSLEEALLFFDSRKRKFGGLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKLHTIPAHIAVIMDGNGRWAENQGKKRTEGHREGANAIDRLLDVALEYKIPNISLYAFS
CCCEEECEEEEEEECCCCCCCCCCCCCHHCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEC
TENWKRPITEIQAIFGLLVEFIETRLDTIHAKGIRIHHSGARNKLSKTVLKKIDHAMAVT
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHH
KKNKKLTANFCLNYGGHEEILSNFSRVMAARKAKKETLDKPISPKEFEKYLYTSPLPPVD
HCCCEEEEEHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHH
LLIRTAGEQRISNFLLWQSAYAEMYFTSTLWPDFGRTSLEEALLFFDSRKRKFGGLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA