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The map label for this gene is sdhA [H]

Identifier: 183221084

GI number: 183221084

Start: 1770059

End: 1771984

Strand: Direct

Name: sdhA [H]

Synonym: LEPBI_I1698

Alternate gene names: 183221084

Gene position: 1770059-1771984 (Clockwise)

Preceding gene: 183221083

Following gene: 183221085

Centisome position: 49.17

GC content: 45.48

Gene sequence:

>1926_bases
ATGAAATTAGATTCAAAAATACCATCAGGCCCATTGGAACAAAAATGGGACAAACACAAACAAGACATCAAATTAGTGAA
CCCCGCAAACAAACGGAAATACAAAGTCATCATTGTCGGAACAGGTTTAGCGGGAGCATCCGCTGCTGCCACTCTTTCCG
AACTTGGTTACCAAGTGTCTGTATTTTGTTTCCAAGATAGTCCTAGACGTGCGCACTCGATTGCTGCCCAAGGTGGGATC
AATGCGGCTAAGAACTACCAAAACGATGGAGATTCCGTTTACAGATTGTTTTATGACACTGTAAAAGGTGGTGATTTCCG
TGCCAGAGAAGCAAACGTTTACCGATTAGCACAAGTTTCCACAAACATCATTGACCAGTGTGTGGCACAAGGGGTTCCGT
TTGCACGTGAATACGGTGGAACACTCGCCAATCGTTCGTTTGGTGGTGCGCAAGTGTCTCGTACTTTTTATGCAAAAGGT
CAAACAGGTCAACAGTTACTCCTTGGTGCCTACTCTGCCCTAGAAAAACAAATCTCTCGTGGTGCTGTCAAAATGTATCC
TAGAACAGAGATGTTGGAGTTAGTCCTTGTGGATGGCCATGCGAAAGGGATTGTAGTCCGTGACCTAGTCACAGGAGAAA
TTTCTTCCCATGCAGGTGATGCAGTGATTTTGGCATCTGGTGGTTACGGAAACGTATTTTATCTTTCCACAAACGCGAAA
GGATCGAATGTAACGGCAACTTACCGTGCTTACAAAAAAGGCGCTGCGTTTGCAAACCCATGTTATACGCAAATCCACCC
TACTTGTATCCCACAATCTGGTGACTACCAATCGAAACTTACCCTAATGTCGGAATCTCTCCGAAATGACGGACGAGTTT
GGGTGCCAAAGAAAAAAGATGACCTTCGCCCTCCTCATCAAATCCCTGAGGAAGAAAGAGATTATTACCTAGAAAGAAAG
TATCCTTCTTACGGAAACCTTGCCCCTCGTGACATCTCGTCTCGTTCTGCAAAAGAAGCCTGTGACAATGGCCTCGGTGT
GGGACCAAAAGTGGGAGACAAACGTCTTGGTGTGTATTTGGACTTTTCGGATTCCATCAAACGATTGGGAGAACCAGTCG
TCGCAGACCGTTACGACAACCTCTTCCAGATGTACGAACGAATCACTGGCGAAAACCCATACAAAGTGCCAATGCGGATC
TACCCTGCCGTTCACTATACAATGGGTGGGCTTTGGGTCGATTATAACCTCATGTCAAACATCCCTGGTCTCCATGTCCT
TGGGGAAGCCAACTTCTCTGACCATGGTGCGAACCGCCTCGGTGCCTCTGCCCTCATGCAAGGCCTTGCGGATGGTTATT
TTGTCATCCCTTACACAATTGGTGATTATTTTGCCAAAGAAGGAGCCAAAAATATTTCCACAGACCGCCCTGAATTCAAA
GAAGCAGAAGCCCGTGTTCGTGAAATGACAAACAAATTCTTAACGATCAATGGGAATAAAACTCCAGATGATTTCCATAG
AGCGCTTGGAAAAATCATGTGGGACCAATGTGGTATGGCGCGTAACGAAAAAGGCCTAAAAGACGCTTTGAAAAAAATCC
CTGAACTCAGAGAAGAATTTTGGAAAAACGTAAAAGTTGCGGGCAAAGGGGAAGAACTGAACCAAGAGTTAGAGAAAGCA
GGCCGTGTTGCCGACTTCTTAGAGTTTGGCGAACTCATGTGCCTTGATGCCCTTACAAGAGAAGAATCTTGTGGTGGTCA
CTTCCGAGAAGAACACCAAACAGAAGATGGCGAAGCAAAACGTAACGATGATAAATTCTGCCACGTATCCGCTTGGGAAT
ACCAAGGAGAAGGAAAAACTCCGGTAGAACACCGAGAAAAACTCGAATACGAAAACATCCACTTAGCCGTAAGGAGCTAC
AAATAA

Upstream 100 bases:

>100_bases
GATTTCCACAGGACTTGGTCTACTTGTCTTCATTGGAAATTGTTCCATGCCACTCTCGATTTTACTCGGGTATGTGCGTT
AAGGGGATTTAGGAGAGAAT

Downstream 100 bases:

>100_bases
TGGATACAATGAAGTTACACCTGAAAGTTTGGAGACAAAAAGACAAAAACGACAAAGGTCGTATGGTGAGTTACGAAGCA
AACAACGTAAGCGAACATAT

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 641; Mature: 641

Protein sequence:

>641_residues
MKLDSKIPSGPLEQKWDKHKQDIKLVNPANKRKYKVIIVGTGLAGASAAATLSELGYQVSVFCFQDSPRRAHSIAAQGGI
NAAKNYQNDGDSVYRLFYDTVKGGDFRAREANVYRLAQVSTNIIDQCVAQGVPFAREYGGTLANRSFGGAQVSRTFYAKG
QTGQQLLLGAYSALEKQISRGAVKMYPRTEMLELVLVDGHAKGIVVRDLVTGEISSHAGDAVILASGGYGNVFYLSTNAK
GSNVTATYRAYKKGAAFANPCYTQIHPTCIPQSGDYQSKLTLMSESLRNDGRVWVPKKKDDLRPPHQIPEEERDYYLERK
YPSYGNLAPRDISSRSAKEACDNGLGVGPKVGDKRLGVYLDFSDSIKRLGEPVVADRYDNLFQMYERITGENPYKVPMRI
YPAVHYTMGGLWVDYNLMSNIPGLHVLGEANFSDHGANRLGASALMQGLADGYFVIPYTIGDYFAKEGAKNISTDRPEFK
EAEARVREMTNKFLTINGNKTPDDFHRALGKIMWDQCGMARNEKGLKDALKKIPELREEFWKNVKVAGKGEELNQELEKA
GRVADFLEFGELMCLDALTREESCGGHFREEHQTEDGEAKRNDDKFCHVSAWEYQGEGKTPVEHREKLEYENIHLAVRSY
K

Sequences:

>Translated_641_residues
MKLDSKIPSGPLEQKWDKHKQDIKLVNPANKRKYKVIIVGTGLAGASAAATLSELGYQVSVFCFQDSPRRAHSIAAQGGI
NAAKNYQNDGDSVYRLFYDTVKGGDFRAREANVYRLAQVSTNIIDQCVAQGVPFAREYGGTLANRSFGGAQVSRTFYAKG
QTGQQLLLGAYSALEKQISRGAVKMYPRTEMLELVLVDGHAKGIVVRDLVTGEISSHAGDAVILASGGYGNVFYLSTNAK
GSNVTATYRAYKKGAAFANPCYTQIHPTCIPQSGDYQSKLTLMSESLRNDGRVWVPKKKDDLRPPHQIPEEERDYYLERK
YPSYGNLAPRDISSRSAKEACDNGLGVGPKVGDKRLGVYLDFSDSIKRLGEPVVADRYDNLFQMYERITGENPYKVPMRI
YPAVHYTMGGLWVDYNLMSNIPGLHVLGEANFSDHGANRLGASALMQGLADGYFVIPYTIGDYFAKEGAKNISTDRPEFK
EAEARVREMTNKFLTINGNKTPDDFHRALGKIMWDQCGMARNEKGLKDALKKIPELREEFWKNVKVAGKGEELNQELEKA
GRVADFLEFGELMCLDALTREESCGGHFREEHQTEDGEAKRNDDKFCHVSAWEYQGEGKTPVEHREKLEYENIHLAVRSY
K
>Mature_641_residues
MKLDSKIPSGPLEQKWDKHKQDIKLVNPANKRKYKVIIVGTGLAGASAAATLSELGYQVSVFCFQDSPRRAHSIAAQGGI
NAAKNYQNDGDSVYRLFYDTVKGGDFRAREANVYRLAQVSTNIIDQCVAQGVPFAREYGGTLANRSFGGAQVSRTFYAKG
QTGQQLLLGAYSALEKQISRGAVKMYPRTEMLELVLVDGHAKGIVVRDLVTGEISSHAGDAVILASGGYGNVFYLSTNAK
GSNVTATYRAYKKGAAFANPCYTQIHPTCIPQSGDYQSKLTLMSESLRNDGRVWVPKKKDDLRPPHQIPEEERDYYLERK
YPSYGNLAPRDISSRSAKEACDNGLGVGPKVGDKRLGVYLDFSDSIKRLGEPVVADRYDNLFQMYERITGENPYKVPMRI
YPAVHYTMGGLWVDYNLMSNIPGLHVLGEANFSDHGANRLGASALMQGLADGYFVIPYTIGDYFAKEGAKNISTDRPEFK
EAEARVREMTNKFLTINGNKTPDDFHRALGKIMWDQCGMARNEKGLKDALKKIPELREEFWKNVKVAGKGEELNQELEKA
GRVADFLEFGELMCLDALTREESCGGHFREEHQTEDGEAKRNDDKFCHVSAWEYQGEGKTPVEHREKLEYENIHLAVRSY
K

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=627, Percent_Identity=24.4019138755981, Blast_Score=149, Evalue=7e-36,
Organism=Escherichia coli, GI1790597, Length=576, Percent_Identity=27.0833333333333, Blast_Score=194, Evalue=1e-50,
Organism=Escherichia coli, GI1786942, Length=597, Percent_Identity=25.6281407035176, Blast_Score=133, Evalue=4e-32,
Organism=Escherichia coli, GI1788928, Length=595, Percent_Identity=26.7226890756303, Blast_Score=130, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17505833, Length=568, Percent_Identity=26.9366197183099, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17550100, Length=563, Percent_Identity=28.0639431616341, Blast_Score=157, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6322701, Length=618, Percent_Identity=26.2135922330097, Blast_Score=172, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6322416, Length=627, Percent_Identity=26.1562998405104, Blast_Score=157, Evalue=6e-39,
Organism=Drosophila melanogaster, GI17137288, Length=652, Percent_Identity=27.3006134969325, Blast_Score=179, Evalue=8e-45,
Organism=Drosophila melanogaster, GI24655642, Length=652, Percent_Identity=27.3006134969325, Blast_Score=179, Evalue=8e-45,
Organism=Drosophila melanogaster, GI24655647, Length=652, Percent_Identity=27.3006134969325, Blast_Score=179, Evalue=8e-45,
Organism=Drosophila melanogaster, GI24663005, Length=587, Percent_Identity=25.8943781942078, Blast_Score=147, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011280 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 71486; Mature: 71486

Theoretical pI: Translated: 8.12; Mature: 8.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLDSKIPSGPLEQKWDKHKQDIKLVNPANKRKYKVIIVGTGLAGASAAATLSELGYQVS
CCCCCCCCCCCHHHHHHHHHCCEEEECCCCCCEEEEEEEECCCCCCHHHHHHHHCCCEEE
VFCFQDSPRRAHSIAAQGGINAAKNYQNDGDSVYRLFYDTVKGGDFRAREANVYRLAQVS
EEEECCCCHHHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEHHHHHH
TNIIDQCVAQGVPFAREYGGTLANRSFGGAQVSRTFYAKGQTGQQLLLGAYSALEKQISR
HHHHHHHHHCCCCCHHHHCCCCCCCCCCCCHHEEEEEECCCCCHHHHHHHHHHHHHHHHC
GAVKMYPRTEMLELVLVDGHAKGIVVRDLVTGEISSHAGDAVILASGGYGNVFYLSTNAK
CCEEECCCHHEEEEEEECCCCCCEEEEEEHHCCHHCCCCCEEEEEECCCCCEEEEEECCC
GSNVTATYRAYKKGAAFANPCYTQIHPTCIPQSGDYQSKLTLMSESLRNDGRVWVPKKKD
CCCEEEEHHHHHCCCCCCCCCHHCCCCEECCCCCCHHHHHHHHHHHHCCCCEEECCCCCC
DLRPPHQIPEEERDYYLERKYPSYGNLAPRDISSRSAKEACDNGLGVGPKVGDKRLGVYL
CCCCCCCCCCHHHHHEECCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCEEEEE
DFSDSIKRLGEPVVADRYDNLFQMYERITGENPYKVPMRIYPAVHYTMGGLWVDYNLMSN
ECHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCEEECCCEEEEEHHHHC
IPGLHVLGEANFSDHGANRLGASALMQGLADGYFVIPYTIGDYFAKEGAKNISTDRPEFK
CCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCEEEEEEEHHHHHHHCCCCCCCCCCCHHH
EAEARVREMTNKFLTINGNKTPDDFHRALGKIMWDQCGMARNEKGLKDALKKIPELREEF
HHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
WKNVKVAGKGEELNQELEKAGRVADFLEFGELMCLDALTREESCGGHFREEHQTEDGEAK
HCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCCC
RNDDKFCHVSAWEYQGEGKTPVEHREKLEYENIHLAVRSYK
CCCCCEEEEEEEEECCCCCCCHHHHHHCCCCEEEEEEEECC
>Mature Secondary Structure
MKLDSKIPSGPLEQKWDKHKQDIKLVNPANKRKYKVIIVGTGLAGASAAATLSELGYQVS
CCCCCCCCCCCHHHHHHHHHCCEEEECCCCCCEEEEEEEECCCCCCHHHHHHHHCCCEEE
VFCFQDSPRRAHSIAAQGGINAAKNYQNDGDSVYRLFYDTVKGGDFRAREANVYRLAQVS
EEEECCCCHHHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEHHHHHH
TNIIDQCVAQGVPFAREYGGTLANRSFGGAQVSRTFYAKGQTGQQLLLGAYSALEKQISR
HHHHHHHHHCCCCCHHHHCCCCCCCCCCCCHHEEEEEECCCCCHHHHHHHHHHHHHHHHC
GAVKMYPRTEMLELVLVDGHAKGIVVRDLVTGEISSHAGDAVILASGGYGNVFYLSTNAK
CCEEECCCHHEEEEEEECCCCCCEEEEEEHHCCHHCCCCCEEEEEECCCCCEEEEEECCC
GSNVTATYRAYKKGAAFANPCYTQIHPTCIPQSGDYQSKLTLMSESLRNDGRVWVPKKKD
CCCEEEEHHHHHCCCCCCCCCHHCCCCEECCCCCCHHHHHHHHHHHHCCCCEEECCCCCC
DLRPPHQIPEEERDYYLERKYPSYGNLAPRDISSRSAKEACDNGLGVGPKVGDKRLGVYL
CCCCCCCCCCHHHHHEECCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCEEEEE
DFSDSIKRLGEPVVADRYDNLFQMYERITGENPYKVPMRIYPAVHYTMGGLWVDYNLMSN
ECHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCEEECCCEEEEEHHHHC
IPGLHVLGEANFSDHGANRLGASALMQGLADGYFVIPYTIGDYFAKEGAKNISTDRPEFK
CCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCEEEEEEEHHHHHHHCCCCCCCCCCCHHH
EAEARVREMTNKFLTINGNKTPDDFHRALGKIMWDQCGMARNEKGLKDALKKIPELREEF
HHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
WKNVKVAGKGEELNQELEKAGRVADFLEFGELMCLDALTREESCGGHFREEHQTEDGEAK
HCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCCC
RNDDKFCHVSAWEYQGEGKTPVEHREKLEYENIHLAVRSYK
CCCCCEEEEEEEEECCCCCCCHHHHHHCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3027051; 8969504; 9384377; 3086287; 3021212 [H]