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The map label for this gene is nuoM [H]

Identifier: 183220696

GI number: 183220696

Start: 1359699

End: 1361438

Strand: Direct

Name: nuoM [H]

Synonym: LEPBI_I1306

Alternate gene names: 183220696

Gene position: 1359699-1361438 (Clockwise)

Preceding gene: 183220695

Following gene: 183220697

Centisome position: 37.77

GC content: 39.83

Gene sequence:

>1740_bases
GTGCCGGATCAAATTTTATCCATCATTATCTTTTTACCAATTGTTTCCACATTTCTCATCGTAATCCAAAAACGCGTGGG
GGCTGTGGTCGTGATCTCGGCTCTGTCTTCTGCCTTTACGACAATTTTGTCTCTTGGTTTATTCTTCTTTTATGATGCTT
CCAAAGCAGGATTACAATTTGTCCATTGGATTCCGGATTGGATTCTTTCTGGCAAACTCAGCGTAGATTACCATGTGGGA
CTTGATGGAGTATCGCTCCTTTTATTTGCTCTCACCACCTTTATGTTTTTTCTTTCGAGTATTGCCTCTTGGTCCAATAT
TCCTAAAAAAATCAAAGAATTCCATATCTGTTTGCTTGTCCTAGAAACGGCGGTTCTCGGTGTTTTTGCGTCTGGGAATC
TTGTCTTATTTTATGTGTTTTGGGAACTCATGGTACTTCCCATGGTCCTCATGATTGGAATTTGGGGTGGAGAAGAAAGA
ACAAAAGCCGCACTCAAATACTTTCTATTTTCCATGGCTGGTTCTTTGTTTATGTTAGGTGGAATCCTGACTTTGTATTT
CAAAACAGGGAAAACATCCATTGAGTCATTATCAACCGCAAGCCTTGCTTTGTATTCGGAACCCTTACAATGGTTTTTGT
TTTTTAGCTTTTTTCTTGCCTTTGCGATCAAAATCCCACTTTTTCCTTTCCACACTTGGATGCCGGATGTCCATACCCAA
GCACCTACTGTTGGTTCGGTGGACCTTGCTGGTGTTTTATTAAAAATTGGTGCTTATGGATTCATTCGATTTTGTATCCC
ATTTTTTCCCGAACAAAGTTTACTCTCTCAAAATGGAATCCAGATCCTTGCCGTGATTGGGATTGTGTATGGGTCTATGG
CTGCCCTTGTCCAAACTGATATCAAACGGATCATTGCGTATAGTTCTTTGTCTCACCTTGGGTTTTGTATCCTTGGGATT
TTTTCTTTTACCACAGAAGGAGTTGTGGGAGGGATGTTACAAATGGTTTCCCATGGAATTTCCACTGGTATGATCTTTCT
TATGATCGGGATGATTTATGAACGTGCCCACACAAGAAACATTTCCGAATTTGGTGGCCTAGCAGGGCAGATGCCAGTGT
TTTCTACCTTCTTTTTAATCGCCGTACTTTCTTCCATCGGACTTCCTGGAACGAATGGGTTTGTTGGTGAGTTTCTGATT
CTCATCGGTGCCATCAAATCCAATGTTTGGCTTGGTGGGATTGCAGCCACGGGTGTTGTTCTTGGTGCCTTATATCTATT
ATGGTTTGTAAAACGATTCCTATTTGGGGTCAGTAAAACAATCCAAGCAAAACCTTATAAAGACTTAAGTTTTCGTGAAA
TTGGAATTTTAAGTCCACTCGTAGTGTTGATTTTTTGGATTGGATTGTATCCAAAACCTTTCCTTTCCATATTAAATTCC
TCTTCGAATGTGTTTTTGAATTCCGCATCGGTTGTGACCATTGAAGAAAGAAAACACATCCAAAAAGATTTTTTAAGCCA
AAACGACCAGAGGTTATTTCCTGATTATCTCAGTTTGGGAATGGAACCGAAGTCCTATGAAGAACGATTAGGCAAATTCC
AATCAAAATTTGTCCTACCAAATTTTGGTTCCGCACAGTTGCCTCTTCCCAAAGTGGAAGAGGATTTAGAGAATTTAGAA
AATTCCATCGAGTCAGATTTTGATTTGGAATTAGAACCGAACGAGAAAAAAGGAAACTAA

Upstream 100 bases:

>100_bases
CTCCGTCGATTACAATCCGGGTTCATTGGTGATTATGCGTTGTATGTTGTCCTTGGTACATTTTGTATCTTGGCCTATCT
TTTGACAAGGGGGGTGTAAG

Downstream 100 bases:

>100_bases
CAAATGTCATATACTCCTTCCTCGAATGACTTAATAGCGATTTCACCCATGCTCATATTGTGTGGGGTAGCTTTACTTTC
CCTAGTTGTCCAATTTTTAA

Product: NADH-quinone oxidoreductase subunit M

Products: NA

Alternate protein names: NADH dehydrogenase I subunit M; NDH-1 subunit M [H]

Number of amino acids: Translated: 579; Mature: 578

Protein sequence:

>579_residues
MPDQILSIIIFLPIVSTFLIVIQKRVGAVVVISALSSAFTTILSLGLFFFYDASKAGLQFVHWIPDWILSGKLSVDYHVG
LDGVSLLLFALTTFMFFLSSIASWSNIPKKIKEFHICLLVLETAVLGVFASGNLVLFYVFWELMVLPMVLMIGIWGGEER
TKAALKYFLFSMAGSLFMLGGILTLYFKTGKTSIESLSTASLALYSEPLQWFLFFSFFLAFAIKIPLFPFHTWMPDVHTQ
APTVGSVDLAGVLLKIGAYGFIRFCIPFFPEQSLLSQNGIQILAVIGIVYGSMAALVQTDIKRIIAYSSLSHLGFCILGI
FSFTTEGVVGGMLQMVSHGISTGMIFLMIGMIYERAHTRNISEFGGLAGQMPVFSTFFLIAVLSSIGLPGTNGFVGEFLI
LIGAIKSNVWLGGIAATGVVLGALYLLWFVKRFLFGVSKTIQAKPYKDLSFREIGILSPLVVLIFWIGLYPKPFLSILNS
SSNVFLNSASVVTIEERKHIQKDFLSQNDQRLFPDYLSLGMEPKSYEERLGKFQSKFVLPNFGSAQLPLPKVEEDLENLE
NSIESDFDLELEPNEKKGN

Sequences:

>Translated_579_residues
MPDQILSIIIFLPIVSTFLIVIQKRVGAVVVISALSSAFTTILSLGLFFFYDASKAGLQFVHWIPDWILSGKLSVDYHVG
LDGVSLLLFALTTFMFFLSSIASWSNIPKKIKEFHICLLVLETAVLGVFASGNLVLFYVFWELMVLPMVLMIGIWGGEER
TKAALKYFLFSMAGSLFMLGGILTLYFKTGKTSIESLSTASLALYSEPLQWFLFFSFFLAFAIKIPLFPFHTWMPDVHTQ
APTVGSVDLAGVLLKIGAYGFIRFCIPFFPEQSLLSQNGIQILAVIGIVYGSMAALVQTDIKRIIAYSSLSHLGFCILGI
FSFTTEGVVGGMLQMVSHGISTGMIFLMIGMIYERAHTRNISEFGGLAGQMPVFSTFFLIAVLSSIGLPGTNGFVGEFLI
LIGAIKSNVWLGGIAATGVVLGALYLLWFVKRFLFGVSKTIQAKPYKDLSFREIGILSPLVVLIFWIGLYPKPFLSILNS
SSNVFLNSASVVTIEERKHIQKDFLSQNDQRLFPDYLSLGMEPKSYEERLGKFQSKFVLPNFGSAQLPLPKVEEDLENLE
NSIESDFDLELEPNEKKGN
>Mature_578_residues
PDQILSIIIFLPIVSTFLIVIQKRVGAVVVISALSSAFTTILSLGLFFFYDASKAGLQFVHWIPDWILSGKLSVDYHVGL
DGVSLLLFALTTFMFFLSSIASWSNIPKKIKEFHICLLVLETAVLGVFASGNLVLFYVFWELMVLPMVLMIGIWGGEERT
KAALKYFLFSMAGSLFMLGGILTLYFKTGKTSIESLSTASLALYSEPLQWFLFFSFFLAFAIKIPLFPFHTWMPDVHTQA
PTVGSVDLAGVLLKIGAYGFIRFCIPFFPEQSLLSQNGIQILAVIGIVYGSMAALVQTDIKRIIAYSSLSHLGFCILGIF
SFTTEGVVGGMLQMVSHGISTGMIFLMIGMIYERAHTRNISEFGGLAGQMPVFSTFFLIAVLSSIGLPGTNGFVGEFLIL
IGAIKSNVWLGGIAATGVVLGALYLLWFVKRFLFGVSKTIQAKPYKDLSFREIGILSPLVVLIFWIGLYPKPFLSILNSS
SNVFLNSASVVTIEERKHIQKDFLSQNDQRLFPDYLSLGMEPKSYEERLGKFQSKFVLPNFGSAQLPLPKVEEDLENLEN
SIESDFDLELEPNEKKGN

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cyto

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=327, Percent_Identity=29.3577981651376, Blast_Score=152, Evalue=9e-37,
Organism=Homo sapiens, GI251831117, Length=327, Percent_Identity=25.6880733944954, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI1788613, Length=513, Percent_Identity=37.037037037037, Blast_Score=295, Evalue=6e-81,
Organism=Escherichia coli, GI1788827, Length=279, Percent_Identity=28.3154121863799, Blast_Score=121, Evalue=1e-28,
Organism=Escherichia coli, GI1788831, Length=517, Percent_Identity=25.7253384912959, Blast_Score=115, Evalue=6e-27,
Organism=Escherichia coli, GI145693160, Length=386, Percent_Identity=27.4611398963731, Blast_Score=115, Evalue=1e-26,
Organism=Escherichia coli, GI1788614, Length=420, Percent_Identity=26.9047619047619, Blast_Score=99, Evalue=8e-22,
Organism=Escherichia coli, GI1788829, Length=331, Percent_Identity=26.2839879154079, Blast_Score=89, Evalue=9e-19,
Organism=Escherichia coli, GI2367154, Length=352, Percent_Identity=26.4204545454545, Blast_Score=85, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 64112; Mature: 63980

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCCCCCCHHHHHHHHHHHHHCCCCCEEECCCCCCCC
>Mature Secondary Structure 
PDQILSIIIFLPIVSTFLIVIQKRVGAVVVISALSSAFTTILSLGLFFFYDASKAGLQF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH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CCCCCCCCCCHHHHHHHHHHHHHCCCCCEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA