Click here to switch to the map view.

The map label for this gene is nuoL [H]

Identifier: 183220695

GI number: 183220695

Start: 1357769

End: 1359697

Strand: Direct

Name: nuoL [H]

Synonym: LEPBI_I1305

Alternate gene names: 183220695

Gene position: 1357769-1359697 (Clockwise)

Preceding gene: 183220694

Following gene: 183220696

Centisome position: 37.72

GC content: 39.76

Gene sequence:

>1929_bases
ATGTTAGATTTATTTCCAATTGTTGTCCTACTCCCACTCCTTGGTTTTTTACATAATGGCCTATTAAAGGACAAAATCCC
ACATCGTTTTGCAGGTGCGATCGGAACGTTAGCAGTATTCATTCCTTTTCTCATCACCTTAGGTGCGTTTAACGAATTTA
ATCCAATGGAAAGAACGGCTCCTCATTTGGTCTCTGTCTTTGATTGGATTGTGATTGGAAATTTTAAGTCTTCATTTGGA
TACCAAATTGACCAACTTTCATTGTATATGACACTTATCATCACAGGCATTGGGTCACTCATCCATTTGTATTCGATGGG
GTACATGAAAGGGAATAAAGGTTACAACAGATTTTTTGCATATTTAAATCTTTTTATCTTTTGTATGTTAAACCTAGTGC
TAAGCGACAACTTAGTTTTAACCTTCCTTGGATGGGAAGGTGTAGGACTTGCTTCTTATTTACTCATTGGGTTTGATTAT
GATAAAGTTTCCGCGGCCGAAGCGGGGATGAAAGCCTTTATCCTCAATCGAATTGGAGATGTGGGTTTTATCTTAGGGAC
TGGATTTCTTTTTTGGTTAGGTGGAAGTTTAGAATACCTAACTTTACAAACCAATTTGAGTGGGCATTCGAATCTTTCTG
AGTATGCCAACATCATTGCCCTCTTTTTCTTTATTGCCGCTATGGGGAAATCAGCTCAAATTCCACTTTATGTTTGGTTA
CCCGATGCGATGGCAGGTCCTACGCCCGTATCAGCTCTCATCCATGCGGCAACCATGGTGACGGCAGGGGTTTTTCTCAT
TGTCCGGCTCAATTTTGTGTTTTACCTCGCACCCGAGACTTCTTTTTTCATCGCTTGCATTGGAGCTTTAACAGCACTTT
TTGCTGCGACCATTGGTATCCTACAAAACGATATCAAAAAGATCCTTGCATACTCCACCGTATCACAGTTAGGTTTTATG
TTCCTTGCAATGGGTAGCATGAGTTATGTGGCGGGACTTTTTCACTTGATGACGCATGCGTTTTTCAAAGCCTTACTTTT
CCTGGGAGCAGGTTCTGTGATCCATGCCCTTCATCATGAACAAAACATCAAACACATGGGGAAATTATTCGGAAAAATCA
AAATCACTTCGATCACGTTTTTACTAGGAACTTTGGCGATTGCTGGATTTTTTCCCTTTTCTGGATTTTTTTCAAAAGAC
TTAATTTTGGAAAAAGCATACACATACGGGGCCTATGGTTCTATCCTTTGGACCATGGGAGTGGTTGCCGCTTTTTTTAC
TTCGTTTTATATGTTCCGGCTCGTGTTTGTTGTGTTTTTCGGAAAAGACAATACAGACTCACACCACAAAATCCATGAAT
CTCCTTGGACCATGACCTTACCTCTCATGATCCTTGCCATCGGTGCTGTTTTCGCTGGTTTTTTACAAACCCCACATTTC
TTTTTGCAGATTGATACTTTGGAACGTTATTTTGCTCCTGTGTTAACAAGTGGATACCAACTGGCAATAGGGAAGGGAAC
ACTTGCCAAACACATTGAGTTATCTCATAACATTGAATTTTCACTCGCAATGTTTTCTGTCATCATCGCAAGTATCGGAT
TTCTATTGGCATACTTTTTATACCAACGAAATCAAAATCCTATCCTCGAAGAACATACAGGTTTTCGAAAGATCCTATTT
CATAAATACTACATTGATGAAATCTATGAAGTTCTTTTTGTGAAGCCCTTCGTGTTTGTTTCCAAAGCCATTGCCTATTA
TTTTGATACCAAAATCCTCGATCGTTTTTTTATCGGGATTGGTGGAAGTTTTGGCGTGATTGCAAATGGACTCCGTCGAT
TACAATCCGGGTTCATTGGTGATTATGCGTTGTATGTTGTCCTTGGTACATTTTGTATCTTGGCCTATCTTTTGACAAGG
GGGGTGTAA

Upstream 100 bases:

>100_bases
GCTGCGGAAGCGGCGGTGGGTCTTGCACTCGTCATCGCTATTTTCCGGCATAAAAAATCCACAAACGTGGATGAACTCCA
ATCGATGAAATGGTAATCCT

Downstream 100 bases:

>100_bases
GGTGCCGGATCAAATTTTATCCATCATTATCTTTTTACCAATTGTTTCCACATTTCTCATCGTAATCCAAAAACGCGTGG
GGGCTGTGGTCGTGATCTCG

Product: NADH-quinone oxidoreductase subunit L

Products: NA

Alternate protein names: NADH dehydrogenase I subunit L; NDH-1 subunit L [H]

Number of amino acids: Translated: 642; Mature: 642

Protein sequence:

>642_residues
MLDLFPIVVLLPLLGFLHNGLLKDKIPHRFAGAIGTLAVFIPFLITLGAFNEFNPMERTAPHLVSVFDWIVIGNFKSSFG
YQIDQLSLYMTLIITGIGSLIHLYSMGYMKGNKGYNRFFAYLNLFIFCMLNLVLSDNLVLTFLGWEGVGLASYLLIGFDY
DKVSAAEAGMKAFILNRIGDVGFILGTGFLFWLGGSLEYLTLQTNLSGHSNLSEYANIIALFFFIAAMGKSAQIPLYVWL
PDAMAGPTPVSALIHAATMVTAGVFLIVRLNFVFYLAPETSFFIACIGALTALFAATIGILQNDIKKILAYSTVSQLGFM
FLAMGSMSYVAGLFHLMTHAFFKALLFLGAGSVIHALHHEQNIKHMGKLFGKIKITSITFLLGTLAIAGFFPFSGFFSKD
LILEKAYTYGAYGSILWTMGVVAAFFTSFYMFRLVFVVFFGKDNTDSHHKIHESPWTMTLPLMILAIGAVFAGFLQTPHF
FLQIDTLERYFAPVLTSGYQLAIGKGTLAKHIELSHNIEFSLAMFSVIIASIGFLLAYFLYQRNQNPILEEHTGFRKILF
HKYYIDEIYEVLFVKPFVFVSKAIAYYFDTKILDRFFIGIGGSFGVIANGLRRLQSGFIGDYALYVVLGTFCILAYLLTR
GV

Sequences:

>Translated_642_residues
MLDLFPIVVLLPLLGFLHNGLLKDKIPHRFAGAIGTLAVFIPFLITLGAFNEFNPMERTAPHLVSVFDWIVIGNFKSSFG
YQIDQLSLYMTLIITGIGSLIHLYSMGYMKGNKGYNRFFAYLNLFIFCMLNLVLSDNLVLTFLGWEGVGLASYLLIGFDY
DKVSAAEAGMKAFILNRIGDVGFILGTGFLFWLGGSLEYLTLQTNLSGHSNLSEYANIIALFFFIAAMGKSAQIPLYVWL
PDAMAGPTPVSALIHAATMVTAGVFLIVRLNFVFYLAPETSFFIACIGALTALFAATIGILQNDIKKILAYSTVSQLGFM
FLAMGSMSYVAGLFHLMTHAFFKALLFLGAGSVIHALHHEQNIKHMGKLFGKIKITSITFLLGTLAIAGFFPFSGFFSKD
LILEKAYTYGAYGSILWTMGVVAAFFTSFYMFRLVFVVFFGKDNTDSHHKIHESPWTMTLPLMILAIGAVFAGFLQTPHF
FLQIDTLERYFAPVLTSGYQLAIGKGTLAKHIELSHNIEFSLAMFSVIIASIGFLLAYFLYQRNQNPILEEHTGFRKILF
HKYYIDEIYEVLFVKPFVFVSKAIAYYFDTKILDRFFIGIGGSFGVIANGLRRLQSGFIGDYALYVVLGTFCILAYLLTR
GV
>Mature_642_residues
MLDLFPIVVLLPLLGFLHNGLLKDKIPHRFAGAIGTLAVFIPFLITLGAFNEFNPMERTAPHLVSVFDWIVIGNFKSSFG
YQIDQLSLYMTLIITGIGSLIHLYSMGYMKGNKGYNRFFAYLNLFIFCMLNLVLSDNLVLTFLGWEGVGLASYLLIGFDY
DKVSAAEAGMKAFILNRIGDVGFILGTGFLFWLGGSLEYLTLQTNLSGHSNLSEYANIIALFFFIAAMGKSAQIPLYVWL
PDAMAGPTPVSALIHAATMVTAGVFLIVRLNFVFYLAPETSFFIACIGALTALFAATIGILQNDIKKILAYSTVSQLGFM
FLAMGSMSYVAGLFHLMTHAFFKALLFLGAGSVIHALHHEQNIKHMGKLFGKIKITSITFLLGTLAIAGFFPFSGFFSKD
LILEKAYTYGAYGSILWTMGVVAAFFTSFYMFRLVFVVFFGKDNTDSHHKIHESPWTMTLPLMILAIGAVFAGFLQTPHF
FLQIDTLERYFAPVLTSGYQLAIGKGTLAKHIELSHNIEFSLAMFSVIIASIGFLLAYFLYQRNQNPILEEHTGFRKILF
HKYYIDEIYEVLFVKPFVFVSKAIAYYFDTKILDRFFIGIGGSFGVIANGLRRLQSGFIGDYALYVVLGTFCILAYLLTR
GV

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cyto

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=469, Percent_Identity=36.8869936034115, Blast_Score=278, Evalue=1e-74,
Organism=Escherichia coli, GI1788614, Length=594, Percent_Identity=40.0673400673401, Blast_Score=380, Evalue=1e-106,
Organism=Escherichia coli, GI1788829, Length=418, Percent_Identity=33.2535885167464, Blast_Score=166, Evalue=4e-42,
Organism=Escherichia coli, GI1788827, Length=416, Percent_Identity=30.0480769230769, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI1788831, Length=349, Percent_Identity=28.6532951289398, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI2367154, Length=209, Percent_Identity=27.7511961722488, Blast_Score=84, Evalue=4e-17,
Organism=Escherichia coli, GI1788613, Length=414, Percent_Identity=27.536231884058, Blast_Score=82, Evalue=2e-16,
Organism=Escherichia coli, GI145693160, Length=195, Percent_Identity=26.1538461538462, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 71466; Mature: 71466

Theoretical pI: Translated: 8.77; Mature: 8.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDLFPIVVLLPLLGFLHNGLLKDKIPHRFAGAIGTLAVFIPFLITLGAFNEFNPMERTA
CCCHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
PHLVSVFDWIVIGNFKSSFGYQIDQLSLYMTLIITGIGSLIHLYSMGYMKGNKGYNRFFA
HHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
YLNLFIFCMLNLVLSDNLVLTFLGWEGVGLASYLLIGFDYDKVSAAEAGMKAFILNRIGD
HHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHEECCCHHHHHHHHHHHHHHHHHCCC
VGFILGTGFLFWLGGSLEYLTLQTNLSGHSNLSEYANIIALFFFIAAMGKSAQIPLYVWL
HHHHHHHHHHHHHCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEC
PDAMAGPTPVSALIHAATMVTAGVFLIVRLNFVFYLAPETSFFIACIGALTALFAATIGI
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHHH
LQNDIKKILAYSTVSQLGFMFLAMGSMSYVAGLFHLMTHAFFKALLFLGAGSVIHALHHE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
QNIKHMGKLFGKIKITSITFLLGTLAIAGFFPFSGFFSKDLILEKAYTYGAYGSILWTMG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCHHHHHHHHHH
VVAAFFTSFYMFRLVFVVFFGKDNTDSHHKIHESPWTMTLPLMILAIGAVFAGFLQTPHF
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEE
FLQIDTLERYFAPVLTSGYQLAIGKGTLAKHIELSHNIEFSLAMFSVIIASIGFLLAYFL
EEEEHHHHHHHHHHHCCCCEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
YQRNQNPILEEHTGFRKILFHKYYIDEIYEVLFVKPFVFVSKAIAYYFDTKILDRFFIGI
HHCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GGSFGVIANGLRRLQSGFIGDYALYVVLGTFCILAYLLTRGV
CCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLDLFPIVVLLPLLGFLHNGLLKDKIPHRFAGAIGTLAVFIPFLITLGAFNEFNPMERTA
CCCHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
PHLVSVFDWIVIGNFKSSFGYQIDQLSLYMTLIITGIGSLIHLYSMGYMKGNKGYNRFFA
HHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
YLNLFIFCMLNLVLSDNLVLTFLGWEGVGLASYLLIGFDYDKVSAAEAGMKAFILNRIGD
HHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHEECCCHHHHHHHHHHHHHHHHHCCC
VGFILGTGFLFWLGGSLEYLTLQTNLSGHSNLSEYANIIALFFFIAAMGKSAQIPLYVWL
HHHHHHHHHHHHHCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEC
PDAMAGPTPVSALIHAATMVTAGVFLIVRLNFVFYLAPETSFFIACIGALTALFAATIGI
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHHH
LQNDIKKILAYSTVSQLGFMFLAMGSMSYVAGLFHLMTHAFFKALLFLGAGSVIHALHHE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
QNIKHMGKLFGKIKITSITFLLGTLAIAGFFPFSGFFSKDLILEKAYTYGAYGSILWTMG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCHHHHHHHHHH
VVAAFFTSFYMFRLVFVVFFGKDNTDSHHKIHESPWTMTLPLMILAIGAVFAGFLQTPHF
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEE
FLQIDTLERYFAPVLTSGYQLAIGKGTLAKHIELSHNIEFSLAMFSVIIASIGFLLAYFL
EEEEHHHHHHHHHHHCCCCEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
YQRNQNPILEEHTGFRKILFHKYYIDEIYEVLFVKPFVFVSKAIAYYFDTKILDRFFIGI
HHCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GGSFGVIANGLRRLQSGFIGDYALYVVLGTFCILAYLLTRGV
CCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA