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The map label for this gene is czcD [H]

Identifier: 183219722

GI number: 183219722

Start: 292658

End: 293581

Strand: Reverse

Name: czcD [H]

Synonym: LEPBI_I0298

Alternate gene names: 183219722

Gene position: 293581-292658 (Counterclockwise)

Preceding gene: 183219723

Following gene: 183219719

Centisome position: 8.16

GC content: 36.8

Gene sequence:

>924_bases
ATGGGACAAGGCCACGATCATACGAATCACAAAACAAAACACCATGACCATTCGCACCATCATTCTTCTGCTTCCAAAAA
TTTAGCTTTGGCGTTTGTTTTAAATTTATTTTTTTCGATTTTTGAATTGGTTGGTGGGATTTACTCCAATAGTATCGCCA
TCATTTCTGATGCTTTTCATGATTTTGGAGATGCTCTCTCGCTTGCATTTGTTTGGTATCTACAAAAAGTTTCCGCAAGA
CCCATTGATCGCCATTTTGATTATGGGTACAAACGTTTTTCTATCTTAGGTGCCCTCATCATTTCAGTTTTATTATCTGT
TGGATCCATCTTTATGATCATCGAATCCATCAAACGGTTCATCACTCCCGTTGAGTCAAAAGCAGATGTGATGTTTCTAT
TAGCGATTGTTGGTGTTCTAGTAAATGGGATTGCCATGCTTCGATTGCAACATGGATCAAGCTTTTCCGAAAAAGCAGTC
TTTTTACATTTTTTGGAGGATATCCTCGGGTGGATTGCCGTCCTCGTTGGAAGTGTGATTATGTACTTTTGGGACGTACC
ATGGTTTGATCCAATGTTATCACTAGCGATTGCGATTTGGATTTTGTACAACGCTTATGGAAACACCAAACAAGTGATGC
GTGTATTTTTACAAGCCGTTCCCGTATCACTCAATCGATCTGATTTAATTTCTGATTGGAATAAAATCAAAGGTGTGAAG
TCAATACACGATATCAAAATTTGGAGTTTGGATGGAAATCACCATGTGGCTTCACTTCATGTCTTGTTAGATCAAAAAAT
AAAATTAAACCAATTTCAAAAAATCAAAGAACAAATCCGAAAGATAGCGCTTCAATATGAGATCATTCACACAACCATTG
AATTAGAAACTGACGAAGAAAAATGTAATCTACATATCAATTGA

Upstream 100 bases:

>100_bases
TTTTGATTGAAATCGAGTTGCATCATTTTCAAATTCACTCTGGAACCAAATCTTTTCTTTCCTAGTTGCAACCTTTCAAG
ATAAATTCAATTCTATCCAC

Downstream 100 bases:

>100_bases
TTTCATTGGAATGAATTGTTTTTGATTTTTAATTCTTTCAATCCATTGATTGATTTTTGGATATTGCGACAAATCAAATC
CACCTTCGTTTGCCACATGT

Product: cation efflux protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 307; Mature: 306

Protein sequence:

>307_residues
MGQGHDHTNHKTKHHDHSHHHSSASKNLALAFVLNLFFSIFELVGGIYSNSIAIISDAFHDFGDALSLAFVWYLQKVSAR
PIDRHFDYGYKRFSILGALIISVLLSVGSIFMIIESIKRFITPVESKADVMFLLAIVGVLVNGIAMLRLQHGSSFSEKAV
FLHFLEDILGWIAVLVGSVIMYFWDVPWFDPMLSLAIAIWILYNAYGNTKQVMRVFLQAVPVSLNRSDLISDWNKIKGVK
SIHDIKIWSLDGNHHVASLHVLLDQKIKLNQFQKIKEQIRKIALQYEIIHTTIELETDEEKCNLHIN

Sequences:

>Translated_307_residues
MGQGHDHTNHKTKHHDHSHHHSSASKNLALAFVLNLFFSIFELVGGIYSNSIAIISDAFHDFGDALSLAFVWYLQKVSAR
PIDRHFDYGYKRFSILGALIISVLLSVGSIFMIIESIKRFITPVESKADVMFLLAIVGVLVNGIAMLRLQHGSSFSEKAV
FLHFLEDILGWIAVLVGSVIMYFWDVPWFDPMLSLAIAIWILYNAYGNTKQVMRVFLQAVPVSLNRSDLISDWNKIKGVK
SIHDIKIWSLDGNHHVASLHVLLDQKIKLNQFQKIKEQIRKIALQYEIIHTTIELETDEEKCNLHIN
>Mature_306_residues
GQGHDHTNHKTKHHDHSHHHSSASKNLALAFVLNLFFSIFELVGGIYSNSIAIISDAFHDFGDALSLAFVWYLQKVSARP
IDRHFDYGYKRFSILGALIISVLLSVGSIFMIIESIKRFITPVESKADVMFLLAIVGVLVNGIAMLRLQHGSSFSEKAVF
LHFLEDILGWIAVLVGSVIMYFWDVPWFDPMLSLAIAIWILYNAYGNTKQVMRVFLQAVPVSLNRSDLISDWNKIKGVKS
IHDIKIWSLDGNHHVASLHVLLDQKIKLNQFQKIKEQIRKIALQYEIIHTTIELETDEEKCNLHIN

Specific function: Involved in divalent cation and potassium homeostasis in the cell. Catalyzes the active efflux of zinc, cadmium and cobalt, in exchange for potassium and H(+) ions [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI52352805, Length=314, Percent_Identity=24.5222929936306, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI20070323, Length=321, Percent_Identity=26.1682242990654, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI21359890, Length=289, Percent_Identity=26.643598615917, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI64762489, Length=311, Percent_Identity=26.0450160771704, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI289803013, Length=312, Percent_Identity=25.6410256410256, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI289803009, Length=312, Percent_Identity=25.6410256410256, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI289803007, Length=312, Percent_Identity=25.6410256410256, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI289803003, Length=312, Percent_Identity=25.6410256410256, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI21361112, Length=272, Percent_Identity=25.3676470588235, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI52351208, Length=161, Percent_Identity=27.3291925465839, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI222080086, Length=124, Percent_Identity=30.6451612903226, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI40255009, Length=124, Percent_Identity=30.6451612903226, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1786966, Length=291, Percent_Identity=29.2096219931272, Blast_Score=103, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI193210990, Length=334, Percent_Identity=28.7425149700599, Blast_Score=124, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI17555794, Length=320, Percent_Identity=25.3125, Blast_Score=109, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17555796, Length=315, Percent_Identity=25.0793650793651, Blast_Score=105, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI32564488, Length=299, Percent_Identity=25.0836120401338, Blast_Score=95, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6324892, Length=181, Percent_Identity=29.2817679558011, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6323899, Length=146, Percent_Identity=30.8219178082192, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24583858, Length=340, Percent_Identity=23.2352941176471, Blast_Score=88, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24656728, Length=337, Percent_Identity=24.9258160237389, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24656724, Length=337, Percent_Identity=24.9258160237389, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24656720, Length=337, Percent_Identity=24.9258160237389, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24656715, Length=337, Percent_Identity=24.9258160237389, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI21357035, Length=337, Percent_Identity=24.9258160237389, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24585900, Length=158, Percent_Identity=31.6455696202532, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24585898, Length=158, Percent_Identity=31.6455696202532, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24585896, Length=158, Percent_Identity=31.6455696202532, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI19921672, Length=158, Percent_Identity=31.6455696202532, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28574430, Length=153, Percent_Identity=22.8758169934641, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24584409, Length=153, Percent_Identity=22.8758169934641, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24645863, Length=105, Percent_Identity=33.3333333333333, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 34957; Mature: 34826

Theoretical pI: Translated: 7.65; Mature: 7.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGQGHDHTNHKTKHHDHSHHHSSASKNLALAFVLNLFFSIFELVGGIYSNSIAIISDAFH
CCCCCCCCCCCCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
DFGDALSLAFVWYLQKVSARPIDRHFDYGYKRFSILGALIISVLLSVGSIFMIIESIKRF
HHHHHHHHHHHHHHHHHHCCCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ITPVESKADVMFLLAIVGVLVNGIAMLRLQHGSSFSEKAVFLHFLEDILGWIAVLVGSVI
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
MYFWDVPWFDPMLSLAIAIWILYNAYGNTKQVMRVFLQAVPVSLNRSDLISDWNKIKGVK
HHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCC
SIHDIKIWSLDGNHHVASLHVLLDQKIKLNQFQKIKEQIRKIALQYEIIHTTIELETDEE
CHHCEEEEEECCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCC
KCNLHIN
CCCEECC
>Mature Secondary Structure 
GQGHDHTNHKTKHHDHSHHHSSASKNLALAFVLNLFFSIFELVGGIYSNSIAIISDAFH
CCCCCCCCCCCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
DFGDALSLAFVWYLQKVSARPIDRHFDYGYKRFSILGALIISVLLSVGSIFMIIESIKRF
HHHHHHHHHHHHHHHHHHCCCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ITPVESKADVMFLLAIVGVLVNGIAMLRLQHGSSFSEKAVFLHFLEDILGWIAVLVGSVI
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
MYFWDVPWFDPMLSLAIAIWILYNAYGNTKQVMRVFLQAVPVSLNRSDLISDWNKIKGVK
HHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCC
SIHDIKIWSLDGNHHVASLHVLLDQKIKLNQFQKIKEQIRKIALQYEIIHTTIELETDEE
CHHCEEEEEECCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCC
KCNLHIN
CCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA