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The map label for this gene is ilvD [H]

Identifier: 182679733

GI number: 182679733

Start: 3213698

End: 3215428

Strand: Reverse

Name: ilvD [H]

Synonym: Bind_2821

Alternate gene names: 182679733

Gene position: 3215428-3213698 (Counterclockwise)

Preceding gene: 182679734

Following gene: 182679729

Centisome position: 77.11

GC content: 59.68

Gene sequence:

>1731_bases
ATGGCCAAATCCGCCGCAGAGCTGCGCAGCGCGCGCTATTTCGAACCAGATGACTTCCGCTCGTTCGGCCATCGCTCACG
CATGGCGCAAATGGGATATACAGGCGAAGAATATCGTGGCAAGCCGGTGATCGCCATCATCAACACATGGTCCGATCTCA
ACCAGTGCCATGCGCATTTCAAGCAGCGCGTCGACGATGTGAAGCGCGGCATTCTTCAGGCCGGCGGCTTTCCGGTGGAA
CTTCCGGCGTTGTCCCTATCCGAGAGCAAGGTGAAACCGACCACCATGCTCTACCGCAATTTTCTGGCGATGGAGACGGA
AGAACTCATCCGGTCGCATCCGGTGGATGGTGCGGTCTTGATGGGTGGCTGCGACAAGACCACGCCCGGTCTCATCCTTG
GCGCGACCAGTGCCGGTGTGCCGGCCATCTATCTGCCCGCCGGTCCGATGTTGCGCGGCAATTGGCACGGCAAGGTCCTG
GGGTCAGGCTCCGACGCCTTCAAATATTGGGATGAGCGGCGCGCCGGCAATATTTCGGCGGAGGACTGGAACGAGATGGA
AGTCGGGATCGCGCGATCCTACGGCCATTGCATGACCATGGGCACGGCCTCCACCATGACGGCGCTTGCCGATGTGCTGG
GCCTGACATTGCCCGGAACCTCCTCCATTCCGGCGGCTGATGCGAACCATATCCGCATGGCTTCGGCGGCCGGGCGGCGT
GTGGTGGATATGGTCTGGGAGGATTTGACGCCGGGGAAGATCCAGACCGAAGCCGCCTATCGCAATGTCATTGTGGTGGC
GATGGCGATGGGCTGTTCCACCAATGCGGTCATCCATATCATCGCCATGGCACGGCGGGCGGGCCATGCCATCAGTCTCG
ATGATTTCGATGCCATGAGCCGCAAAGTGCCTGTGCTCGCCAATGTCCGCCCGTCCGGCGACACCTATCTTATGGAGGAT
TTCTATTATGCCGGCGGTCTCCTTGGCCTGATGACAAGGCTCGCACCCTTTCTCGATCTCTCCCAGATCAATGCCAGCGG
CCGGACCTGGGCCCAGAGCCTCGCGGAGGCCAAAGTTTACAATGAGGATGTCATCCGGCCGCTCGACAAGCCGATCTATG
AGGAAGGCGCGCTGGCGGTACTGCGTGGTAATCTCGCGCCAAACGGTTGCGTCATGAAGCCATCGGCAGCTGCGTCGCAT
CTTTTGCGTCATATAGGGCCGGCACTGGTGTTCGACAATTATGCCGCGCTCAAGGAATCGATCGATCGCGATGATCTCGA
CGTTACGCCCGACCATGTCCTGGTCTTGCGCAATGCCGGCCCCCTCGGTGGCCCTGGCATGCCGGAATGGGGCATGCTGC
CGATCCCGAAAAAACTGGTGAAACAAGGTGTGCGTGACATGGTGAGGATTTCCGACGCACGCATGAGCGGCACCTCCTAT
GGTGCCTGTATCCTTCATGTCTCGCCTGAGAGCTACATTGGTGGTCCTCTGTCTCTTGTTGAGACAGGCGACATGATCAG
CGTGGACGTGCCGTCCCGCACCATCAATCTCGACGTGCCGGAAGAAGAGCTCGCCCGCCGACGCGCGGTACAAGCAATTC
CCAAAAAGCGCTATGAACGTGGCTATGGCTGGATGTTTTCCCAGCATATCCGTCAGGCCGATGAGGGCTGTGATTTCGAC
TTTCTGGAAACCACCTTCGGACGGCCCGTTGCCGAACCGGACATCCATTAG

Upstream 100 bases:

>100_bases
TCATCTGTGTGGTTTGAAATCATCCTATATCCGAAGCGGATGGTGAGCCTGGTCTTGTGGGTTTCGCCGTCCGGGTTGGA
AAGAATTGTGGAATCTTCTC

Downstream 100 bases:

>100_bases
GGTGCCACAAGGCCCTCCGATGAAGCCGAAGCCTTTGTGCACGATAATAAATAGGGAGCCTTTGTTGCCAAAGACTCCCT
GCAATCCGCGCACCCTATTC

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 576; Mature: 575

Protein sequence:

>576_residues
MAKSAAELRSARYFEPDDFRSFGHRSRMAQMGYTGEEYRGKPVIAIINTWSDLNQCHAHFKQRVDDVKRGILQAGGFPVE
LPALSLSESKVKPTTMLYRNFLAMETEELIRSHPVDGAVLMGGCDKTTPGLILGATSAGVPAIYLPAGPMLRGNWHGKVL
GSGSDAFKYWDERRAGNISAEDWNEMEVGIARSYGHCMTMGTASTMTALADVLGLTLPGTSSIPAADANHIRMASAAGRR
VVDMVWEDLTPGKIQTEAAYRNVIVVAMAMGCSTNAVIHIIAMARRAGHAISLDDFDAMSRKVPVLANVRPSGDTYLMED
FYYAGGLLGLMTRLAPFLDLSQINASGRTWAQSLAEAKVYNEDVIRPLDKPIYEEGALAVLRGNLAPNGCVMKPSAAASH
LLRHIGPALVFDNYAALKESIDRDDLDVTPDHVLVLRNAGPLGGPGMPEWGMLPIPKKLVKQGVRDMVRISDARMSGTSY
GACILHVSPESYIGGPLSLVETGDMISVDVPSRTINLDVPEEELARRRAVQAIPKKRYERGYGWMFSQHIRQADEGCDFD
FLETTFGRPVAEPDIH

Sequences:

>Translated_576_residues
MAKSAAELRSARYFEPDDFRSFGHRSRMAQMGYTGEEYRGKPVIAIINTWSDLNQCHAHFKQRVDDVKRGILQAGGFPVE
LPALSLSESKVKPTTMLYRNFLAMETEELIRSHPVDGAVLMGGCDKTTPGLILGATSAGVPAIYLPAGPMLRGNWHGKVL
GSGSDAFKYWDERRAGNISAEDWNEMEVGIARSYGHCMTMGTASTMTALADVLGLTLPGTSSIPAADANHIRMASAAGRR
VVDMVWEDLTPGKIQTEAAYRNVIVVAMAMGCSTNAVIHIIAMARRAGHAISLDDFDAMSRKVPVLANVRPSGDTYLMED
FYYAGGLLGLMTRLAPFLDLSQINASGRTWAQSLAEAKVYNEDVIRPLDKPIYEEGALAVLRGNLAPNGCVMKPSAAASH
LLRHIGPALVFDNYAALKESIDRDDLDVTPDHVLVLRNAGPLGGPGMPEWGMLPIPKKLVKQGVRDMVRISDARMSGTSY
GACILHVSPESYIGGPLSLVETGDMISVDVPSRTINLDVPEEELARRRAVQAIPKKRYERGYGWMFSQHIRQADEGCDFD
FLETTFGRPVAEPDIH
>Mature_575_residues
AKSAAELRSARYFEPDDFRSFGHRSRMAQMGYTGEEYRGKPVIAIINTWSDLNQCHAHFKQRVDDVKRGILQAGGFPVEL
PALSLSESKVKPTTMLYRNFLAMETEELIRSHPVDGAVLMGGCDKTTPGLILGATSAGVPAIYLPAGPMLRGNWHGKVLG
SGSDAFKYWDERRAGNISAEDWNEMEVGIARSYGHCMTMGTASTMTALADVLGLTLPGTSSIPAADANHIRMASAAGRRV
VDMVWEDLTPGKIQTEAAYRNVIVVAMAMGCSTNAVIHIIAMARRAGHAISLDDFDAMSRKVPVLANVRPSGDTYLMEDF
YYAGGLLGLMTRLAPFLDLSQINASGRTWAQSLAEAKVYNEDVIRPLDKPIYEEGALAVLRGNLAPNGCVMKPSAAASHL
LRHIGPALVFDNYAALKESIDRDDLDVTPDHVLVLRNAGPLGGPGMPEWGMLPIPKKLVKQGVRDMVRISDARMSGTSYG
ACILHVSPESYIGGPLSLVETGDMISVDVPSRTINLDVPEEELARRRAVQAIPKKRYERGYGWMFSQHIRQADEGCDFDF
LETTFGRPVAEPDIH

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=564, Percent_Identity=31.5602836879433, Blast_Score=255, Evalue=6e-69,
Organism=Escherichia coli, GI1788157, Length=517, Percent_Identity=29.7872340425532, Blast_Score=171, Evalue=8e-44,
Organism=Escherichia coli, GI2367371, Length=487, Percent_Identity=28.7474332648871, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1786464, Length=569, Percent_Identity=28.2952548330404, Blast_Score=147, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6322476, Length=547, Percent_Identity=29.7989031078611, Blast_Score=238, Evalue=2e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 62823; Mature: 62692

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: PS00886 ILVD_EDD_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKSAAELRSARYFEPDDFRSFGHRSRMAQMGYTGEEYRGKPVIAIINTWSDLNQCHAHF
CCCCHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHCCCCEEEEEECHHHHHHHHHHH
KQRVDDVKRGILQAGGFPVELPALSLSESKVKPTTMLYRNFLAMETEELIRSHPVDGAVL
HHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEE
MGGCDKTTPGLILGATSAGVPAIYLPAGPMLRGNWHGKVLGSGSDAFKYWDERRAGNISA
ECCCCCCCCCEEEEECCCCCCEEEECCCCEEECCCCCEEEECCCHHHHHHHHHCCCCCCC
EDWNEMEVGIARSYGHCMTMGTASTMTALADVLGLTLPGTSSIPAADANHIRMASAAGRR
CCCCHHHHHHHHCCCCEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEHHHCCHH
VVDMVWEDLTPGKIQTEAAYRNVIVVAMAMGCSTNAVIHIIAMARRAGHAISLDDFDAMS
HHHHHHHCCCCCCEEHHHHHHHEEEEEEECCCCCHHHHHHHHHHHHCCCEECCCCHHHHH
RKVPVLANVRPSGDTYLMEDFYYAGGLLGLMTRLAPFLDLSQINASGRTWAQSLAEAKVY
CCCCEEEECCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
NEDVIRPLDKPIYEEGALAVLRGNLAPNGCVMKPSAAASHLLRHIGPALVFDNYAALKES
HHHHHHHCCCCHHHCCCEEEEECCCCCCCCEECCHHHHHHHHHHHCHHHHHCCHHHHHHH
IDRDDLDVTPDHVLVLRNAGPLGGPGMPEWGMLPIPKKLVKQGVRDMVRISDARMSGTSY
CCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCC
GACILHVSPESYIGGPLSLVETGDMISVDVPSRTINLDVPEEELARRRAVQAIPKKRYER
CEEEEEECCHHHCCCCEEEEECCCEEEEECCCEEEECCCCHHHHHHHHHHHHHHHHHHHC
GYGWMFSQHIRQADEGCDFDFLETTFGRPVAEPDIH
CCCHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
AKSAAELRSARYFEPDDFRSFGHRSRMAQMGYTGEEYRGKPVIAIINTWSDLNQCHAHF
CCCHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHCCCCEEEEEECHHHHHHHHHHH
KQRVDDVKRGILQAGGFPVELPALSLSESKVKPTTMLYRNFLAMETEELIRSHPVDGAVL
HHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEE
MGGCDKTTPGLILGATSAGVPAIYLPAGPMLRGNWHGKVLGSGSDAFKYWDERRAGNISA
ECCCCCCCCCEEEEECCCCCCEEEECCCCEEECCCCCEEEECCCHHHHHHHHHCCCCCCC
EDWNEMEVGIARSYGHCMTMGTASTMTALADVLGLTLPGTSSIPAADANHIRMASAAGRR
CCCCHHHHHHHHCCCCEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEHHHCCHH
VVDMVWEDLTPGKIQTEAAYRNVIVVAMAMGCSTNAVIHIIAMARRAGHAISLDDFDAMS
HHHHHHHCCCCCCEEHHHHHHHEEEEEEECCCCCHHHHHHHHHHHHCCCEECCCCHHHHH
RKVPVLANVRPSGDTYLMEDFYYAGGLLGLMTRLAPFLDLSQINASGRTWAQSLAEAKVY
CCCCEEEECCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
NEDVIRPLDKPIYEEGALAVLRGNLAPNGCVMKPSAAASHLLRHIGPALVFDNYAALKES
HHHHHHHCCCCHHHCCCEEEEECCCCCCCCEECCHHHHHHHHHHHCHHHHHCCHHHHHHH
IDRDDLDVTPDHVLVLRNAGPLGGPGMPEWGMLPIPKKLVKQGVRDMVRISDARMSGTSY
CCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCC
GACILHVSPESYIGGPLSLVETGDMISVDVPSRTINLDVPEEELARRRAVQAIPKKRYER
CEEEEEECCHHHCCCCEEEEECCCEEEEECCCEEEECCCCHHHHHHHHHHHHHHHHHHHC
GYGWMFSQHIRQADEGCDFDFLETTFGRPVAEPDIH
CCCHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA