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The map label for this gene is rnc [H]

Identifier: 182679393

GI number: 182679393

Start: 2783393

End: 2784100

Strand: Reverse

Name: rnc [H]

Synonym: Bind_2441

Alternate gene names: 182679393

Gene position: 2784100-2783393 (Counterclockwise)

Preceding gene: 182679394

Following gene: 182679392

Centisome position: 66.76

GC content: 60.17

Gene sequence:

>708_bases
ATGTCGAGATTCAAGCAAGATCTGGAGCCGCTCGAGACGCGCATCGGTCACCGGTTCGTGGAGGCGGATTTGCTCACCAC
GGCCCTGACCCATGTCAGCGTCACCGTTGGCGCGCGGCGCGAAACCTATCAAAGGCTCGAATTTCTGGGTGACCGCGTGC
TCGGCCTGGTCATCGCGGAAATGCTTTATGCGACTTTCCCTGAGGCGGAAGAGGGGGAGTTGTCGCGCCGTCTCGCCGAC
CTTGTCCGCAAGGAAAGCTGTGCCGAGGTTGCGCTTGAATGGGGAGTTGGGCCTTTCGTGCGCCTCGGTGAAAGCGAACG
CCAGATCGGGACGACCAAAAAGGCCATTCTTGGCGATGTCTGTGAATCGATCATAGGCGCGGTGTTTCTCGATGCCGGCT
ATACGGTCGCGCAACAGGTCATCGTCAAAGCCTTCGACGCCAGGATGCGTTCGCCGCGCCGGCCTCTACGCGATGCGAAA
ACGGTGTTGCAGGAATGGGCGCAATCGCGTGGCCATCCGACACCGCTCTACCGTGAAATTTGCCGTTGTGGTCCTGATCA
CGCGCCGGAATTCACCATTTCCGTCTGTATTCCAGGCTATGCGGATGCACAGGCCAAAGGGCCGTCCAAACGGCTTGCCG
AACAGGCGGCGGCGGCGCATTTTATCGAGCGCGAGGGCATTCAGGAAAAACAGAAGGGCGCCGCGTGA

Upstream 100 bases:

>100_bases
AATCATCTTCTTCTCCCTCGATAAAGACACGCCCGGCTGGGCGTTCTGGAAATGGCCCTGGACGGTGCGGTGGAGCCGGA
TGTTCCAGTCCGTGAAATAA

Downstream 100 bases:

>100_bases
CAACGCCCGAACCAATCACCCGCTGCGGCTTCGTTGCCTTGATCGGTGCACCCAATGCCGGGAAATCGACTCTCATCAAC
CGGCTTGTCGGCGCCAAAAT

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 235; Mature: 234

Protein sequence:

>235_residues
MSRFKQDLEPLETRIGHRFVEADLLTTALTHVSVTVGARRETYQRLEFLGDRVLGLVIAEMLYATFPEAEEGELSRRLAD
LVRKESCAEVALEWGVGPFVRLGESERQIGTTKKAILGDVCESIIGAVFLDAGYTVAQQVIVKAFDARMRSPRRPLRDAK
TVLQEWAQSRGHPTPLYREICRCGPDHAPEFTISVCIPGYADAQAKGPSKRLAEQAAAAHFIEREGIQEKQKGAA

Sequences:

>Translated_235_residues
MSRFKQDLEPLETRIGHRFVEADLLTTALTHVSVTVGARRETYQRLEFLGDRVLGLVIAEMLYATFPEAEEGELSRRLAD
LVRKESCAEVALEWGVGPFVRLGESERQIGTTKKAILGDVCESIIGAVFLDAGYTVAQQVIVKAFDARMRSPRRPLRDAK
TVLQEWAQSRGHPTPLYREICRCGPDHAPEFTISVCIPGYADAQAKGPSKRLAEQAAAAHFIEREGIQEKQKGAA
>Mature_234_residues
SRFKQDLEPLETRIGHRFVEADLLTTALTHVSVTVGARRETYQRLEFLGDRVLGLVIAEMLYATFPEAEEGELSRRLADL
VRKESCAEVALEWGVGPFVRLGESERQIGTTKKAILGDVCESIIGAVFLDAGYTVAQQVIVKAFDARMRSPRRPLRDAKT
VLQEWAQSRGHPTPLYREICRCGPDHAPEFTISVCIPGYADAQAKGPSKRLAEQAAAAHFIEREGIQEKQKGAA

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030236, Length=229, Percent_Identity=30.1310043668122, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI155030234, Length=229, Percent_Identity=30.1310043668122, Blast_Score=90, Evalue=2e-18,
Organism=Escherichia coli, GI1788920, Length=205, Percent_Identity=38.5365853658537, Blast_Score=127, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI17506883, Length=223, Percent_Identity=30.0448430493274, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI193202651, Length=223, Percent_Identity=30.0448430493274, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17137682, Length=234, Percent_Identity=29.0598290598291, Blast_Score=75, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 26064; Mature: 25933

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRFKQDLEPLETRIGHRFVEADLLTTALTHVSVTVGARRETYQRLEFLGDRVLGLVIAE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MLYATFPEAEEGELSRRLADLVRKESCAEVALEWGVGPFVRLGESERQIGTTKKAILGDV
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHHH
CESIIGAVFLDAGYTVAQQVIVKAFDARMRSPRRPLRDAKTVLQEWAQSRGHPTPLYREI
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHH
CRCGPDHAPEFTISVCIPGYADAQAKGPSKRLAEQAAAAHFIEREGIQEKQKGAA
HHCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCHHHHHCCCC
>Mature Secondary Structure 
SRFKQDLEPLETRIGHRFVEADLLTTALTHVSVTVGARRETYQRLEFLGDRVLGLVIAE
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MLYATFPEAEEGELSRRLADLVRKESCAEVALEWGVGPFVRLGESERQIGTTKKAILGDV
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHHH
CESIIGAVFLDAGYTVAQQVIVKAFDARMRSPRRPLRDAKTVLQEWAQSRGHPTPLYREI
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHH
CRCGPDHAPEFTISVCIPGYADAQAKGPSKRLAEQAAAAHFIEREGIQEKQKGAA
HHCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA